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UniProtKB - Q7LGC8 (CHST3_HUMAN)

Entry version 146 (16 Oct 2019)
Sequence version 3 (17 Oct 2006)
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Protein

Carbohydrate sulfotransferase 3

Gene

CHST3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues of keratan sulfate, another glycosaminoglycan, and the Gal residues in sialyl N-acetyllactosamine (sialyl LacNAc) oligosaccharides. May play a role in the maintenance of naive T-lymphocytes in the spleen.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi141 – 147PAPSBy similarity7
Nucleotide bindingi301 – 309PAPSBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processCarbohydrate metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS04610-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.8.2.17 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-3595172 Defective CHST3 causes SEDCJD

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carbohydrate sulfotransferase 3 (EC:2.8.2.17)
Alternative name(s):
Chondroitin 6-O-sulfotransferase 1
Short name:
C6ST-1
Chondroitin 6-sulfotransferase
Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 0
Short name:
GST-0
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHST3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1971 CHST3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603799 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7LGC8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini39 – 479LumenalSequence analysisAdd BLAST441

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spondyloepiphyseal dysplasia with congenital joint dislocations (SEDCJD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA bone dysplasia clinically characterized by dislocation of the knees and/or hips at birth, clubfoot, elbow joint dysplasia with subluxation and limited extension, short stature, and progressive kyphosis developing in late childhood. The disorder is usually evident at birth, with short stature and multiple joint dislocations or subluxations that dominate the neonatal clinical and radiographic picture. During childhood, the dislocations improve, both spontaneously and with surgical treatment, and features of spondyloepiphyseal dysplasia become apparent, leading to arthritis of the hips and spine with intervertebral disk degeneration, rigid kyphoscoliosis, and trunk shortening by late childhood.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047856222R → W in SEDCJD; severely impairs or abolishes the enzyme function. 1 PublicationCorresponds to variant dbSNP:rs121908617EnsemblClinVar.1
Natural variantiVAR_047857259L → P in SEDCJD; severely impairs or abolishes the enzyme function. 1 PublicationCorresponds to variant dbSNP:rs121908616EnsemblClinVar.1
Natural variantiVAR_021413304R → Q in SEDCJD; abolishes enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs28937593EnsemblClinVar.1
Natural variantiVAR_047858307L → P in SEDCJD. 1 PublicationCorresponds to variant dbSNP:rs121908618EnsemblClinVar.1
Natural variantiVAR_047859372E → K in SEDCJD. 1 PublicationCorresponds to variant dbSNP:rs267606734EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		9469

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		CHST3

MalaCards human disease database

More...MalaCardsi		CHST3
MIMi143095 phenotype

Open Targets

More...OpenTargetsi		ENSG00000122863

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		263463 CHST3-related skeletal dysplasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26503

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7LGC8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CHST3

Domain mapping of disease mutations (DMDM)

More...DMDMi		116241297

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000851881 – 479Carbohydrate sulfotransferase 3Add BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi420N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi464N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-1483

Encyclopedia of Proteome Dynamics

More...EPDi		Q7LGC8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7LGC8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7LGC8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7LGC8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7LGC8

PeptideAtlas

More...PeptideAtlasi		Q7LGC8

PRoteomics IDEntifications database

More...PRIDEi		Q7LGC8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68868

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7LGC8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7LGC8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed in adult tissues. Expressed in heart, placenta, skeletal muscle and pancreas. Also expressed in various immune tissues such as spleen, lymph node, thymus and appendix.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000122863 Expressed in 176 organ(s), highest expression level in tibia

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7LGC8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA047523
HPA055704

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		114855, 7 interactors

Protein interaction database and analysis system

More...IntActi		Q7LGC8, 5 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362207

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IIAV Eukaryota
ENOG410YDA4 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161045

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000261614

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7LGC8

KEGG Orthology (KO)

More...KOi		K01020

Identification of Orthologs from Complete Genome Data

More...OMAi		DPRLDMR

Database of Orthologous Groups

More...OrthoDBi		1246608at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7LGC8

TreeFam database of animal gene trees

More...TreeFami		TF342871

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016469 Carbohydrate_sulfotransferase
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00685 Sulfotransfer_1, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005883 Carbohydrate_sulfotransferase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7LGC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKGLTLPQD CRDFVHSLKM RSKYALFLVF VVIVFVFIEK ENKIISRVSD 
        60         70         80         90        100
KLKQIPQALA DANSTDPALI LAENASLLSL SELDSAFSQL QSRLRNLSLQ 
       110        120        130        140        150
LGVEPAMEAA GEEEEEQRKE EEPPRPAVAG PRRHVLLMAT TRTGSSFVGE 
       160        170        180        190        200
FFNQQGNIFY LFEPLWHIER TVSFEPGGAN AAGSALVYRD VLKQLFLCDL 
       210        220        230        240        250
YVLEHFITPL PEDHLTQFMF RRGSSRSLCE DPVCTPFVKK VFEKYHCKNR 
       260        270        280        290        300
RCGPLNVTLA AEACRRKEHM ALKAVRIRQL EFLQPLAEDP RLDLRVIQLV 
       310        320        330        340        350
RDPRAVLASR MVAFAGKYKT WKKWLDDEGQ DGLREEEVQR LRGNCESIRL 
       360        370        380        390        400
SAELGLRQPA WLRGRYMLVR YEDVARGPLQ KAREMYRFAG IPLTPQVEDW 
       410        420        430        440        450
IQKNTQAAHD GSGIYSTQKN SSEQFEKWRF SMPFKLAQVV QAACGPAMRL 
       460        470 
FGYKLARDAA ALTNRSVSLL EERGTFWVT
Length:479
Mass (Da):54,706
Last modified:October 17, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C290DC4970F66E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti387R → P in BAA32576 (PubMed:9714738).Curated1
Sequence conflicti443A → P in BAA32576 (PubMed:9714738).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047856222R → W in SEDCJD; severely impairs or abolishes the enzyme function. 1 PublicationCorresponds to variant dbSNP:rs121908617EnsemblClinVar.1
Natural variantiVAR_047857259L → P in SEDCJD; severely impairs or abolishes the enzyme function. 1 PublicationCorresponds to variant dbSNP:rs121908616EnsemblClinVar.1
Natural variantiVAR_021413304R → Q in SEDCJD; abolishes enzyme activity. 1 PublicationCorresponds to variant dbSNP:rs28937593EnsemblClinVar.1
Natural variantiVAR_047858307L → P in SEDCJD. 1 PublicationCorresponds to variant dbSNP:rs121908618EnsemblClinVar.1
Natural variantiVAR_021414348I → M. Corresponds to variant dbSNP:rs3740128Ensembl.1
Natural variantiVAR_021415357R → Q2 PublicationsCorresponds to variant dbSNP:rs3740129EnsemblClinVar.1
Natural variantiVAR_047859372E → K in SEDCJD. 1 PublicationCorresponds to variant dbSNP:rs267606734EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB012192 mRNA Translation: BAA32576.1
AB017915 mRNA Translation: BAA36348.1
BC093690 mRNA Translation: AAH93690.1
BC104856 mRNA Translation: AAI04857.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7312.1

NCBI Reference Sequences

More...RefSeqi		NP_004264.2, NM_004273.4
XP_006718138.1, XM_006718075.3
XP_011538671.1, XM_011540369.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373115; ENSP00000362207; ENSG00000122863

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9469

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9469

UCSC genome browser

More...UCSCi		uc001jsn.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012192 mRNA Translation: BAA32576.1
AB017915 mRNA Translation: BAA36348.1
BC093690 mRNA Translation: AAH93690.1
BC104856 mRNA Translation: AAI04857.1
CCDSiCCDS7312.1
RefSeqiNP_004264.2, NM_004273.4
XP_006718138.1, XM_006718075.3
XP_011538671.1, XM_011540369.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi114855, 7 interactors
IntActiQ7LGC8, 5 interactors
STRINGi9606.ENSP00000362207

PTM databases

iPTMnetiQ7LGC8
PhosphoSitePlusiQ7LGC8

Polymorphism and mutation databases

BioMutaiCHST3
DMDMi116241297

Proteomic databases

CPTACiCPTAC-1483
EPDiQ7LGC8
jPOSTiQ7LGC8
MassIVEiQ7LGC8
MaxQBiQ7LGC8
PaxDbiQ7LGC8
PeptideAtlasiQ7LGC8
PRIDEiQ7LGC8
ProteomicsDBi68868

Genome annotation databases

EnsembliENST00000373115; ENSP00000362207; ENSG00000122863
GeneIDi9469
KEGGihsa:9469
UCSCiuc001jsn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9469
DisGeNETi9469

GeneCards: human genes, protein and diseases

More...GeneCardsi		CHST3
GeneReviewsiCHST3
HGNCiHGNC:1971 CHST3
HPAiHPA047523
HPA055704
MalaCardsiCHST3
MIMi143095 phenotype
603799 gene
neXtProtiNX_Q7LGC8
OpenTargetsiENSG00000122863
Orphaneti263463 CHST3-related skeletal dysplasia
PharmGKBiPA26503

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IIAV Eukaryota
ENOG410YDA4 LUCA
GeneTreeiENSGT00940000161045
HOGENOMiHOG000261614
InParanoidiQ7LGC8
KOiK01020
OMAiDPRLDMR
OrthoDBi1246608at2759
PhylomeDBiQ7LGC8
TreeFamiTF342871

Enzyme and pathway databases

BioCyciMetaCyc:HS04610-MONOMER
BRENDAi2.8.2.17 2681
ReactomeiR-HSA-2022870 Chondroitin sulfate biosynthesis
R-HSA-3595172 Defective CHST3 causes SEDCJD

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CHST3 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9469
PharosiQ7LGC8

Protein Ontology

More...PROi		PR:Q7LGC8

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000122863 Expressed in 176 organ(s), highest expression level in tibia
GenevisibleiQ7LGC8 HS

Family and domain databases

InterProiView protein in InterPro
IPR016469 Carbohydrate_sulfotransferase
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
PIRSFiPIRSF005883 Carbohydrate_sulfotransferase, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHST3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7LGC8
Secondary accession number(s): O75099, Q52M30
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: October 17, 2006
Last modified: October 16, 2019
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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