RRM2B

Functionⁱ

Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.3 Publications

Catalytic activityⁱ

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H₂O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation1 Publication

Cofactorⁱ

Pathwayⁱ: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	100	Iron 1	1
Metal bindingⁱ	131	Iron 1	1
Metal bindingⁱ	131	Iron 2	1
Metal bindingⁱ	134	Iron 1	1
Active siteⁱ	138	PROSITE-ProRule annotation	1
Metal bindingⁱ	194	Iron 2	1
Metal bindingⁱ	228	Iron 2	1
Metal bindingⁱ	231	Iron 2	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

deoxyribonucleoside triphosphate metabolic process Source: Ensembl
deoxyribonucleotide biosynthetic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA repair Source: UniProtKB-KW
kidney development Source: Ensembl
mitochondrial DNA replication Source: Ensembl
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
renal system process Source: Ensembl
response to amine Source: Ensembl
response to oxidative stress Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	DNA damage, DNA repair, DNA replication
Ligand	Iron, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	1.17.4.1 2681
Reactomeⁱ	R-HSA-499943 Interconversion of nucleotide di- and triphosphates R-HSA-5628897 TP53 Regulates Metabolic Genes
SIGNORⁱ	Q7LG56
UniPathwayⁱ	UPA00326

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribonucleoside-diphosphate reductase subunit M2 B (EC:1.17.4.1) Alternative name(s): TP53-inducible ribonucleotide reductase M2 B p53-inducible ribonucleotide reductase small subunit 2-like protein Short name: p53R2
Gene namesⁱ	Name:RRM2B Synonyms:P53R2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000048392.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17296 RRM2B
MIMⁱ	604712 gene
neXtProtⁱ	NX_Q7LG56

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Mitochondrial DNA depletion syndrome 8A (MTDPS8A)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder due to mitochondrial dysfunction characterized by various combinations of neonatal hypotonia, neurological deterioration, respiratory distress, lactic acidosis, and renal tubulopathy.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_046217	64	W → R in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs515726182EnsemblClinVar.	1
Natural variantⁱVAR_046218	85	Missing in MTDPS8A. 1 Publication	1
Natural variantⁱVAR_046219	194	E → G in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs515726191EnsemblClinVar.	1
Natural variantⁱVAR_046220	194	E → K in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs121918308EnsemblClinVar.	1
Natural variantⁱVAR_046221	224	I → S in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs515726196EnsemblClinVar.	1
Natural variantⁱVAR_046222	236	C → F in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs121918309EnsemblClinVar.	1
Natural variantⁱVAR_046223	282	M → I in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs182614164EnsemblClinVar.	1
Natural variantⁱVAR_046224	317	L → V in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs515726198EnsemblClinVar.	1

Mitochondrial DNA depletion syndrome 8B (MTDPS8B)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease due to mitochondrial dysfunction and characterized by ophthalmoplegia, ptosis, gastrointestinal dysmotility, cachexia, peripheral neuropathy.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_065122	110	R → H in MTDPS8B. 1 PublicationCorresponds to variant dbSNP:rs267607025EnsemblClinVar.		1
Natural variantⁱVAR_065123	121	R → H in MTDPS8B. 1 PublicationCorresponds to variant dbSNP:rs267607024EnsemblClinVar.		1

Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5 (PEOA5)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.

Keywords - Diseaseⁱ

Disease mutation, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	50484
MalaCards human disease database More...MalaCardsⁱ	RRM2B
MIMⁱ	612075 phenotype 613077 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000048392
Orphanetⁱ	329336 Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy 254892 Autosomal dominant progressive external ophthalmoplegia 480 Kearns-Sayre syndrome 255235 Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy 298 Mitochondrial neurogastrointestinal encephalomyopathy
PharmGKBⁱ	PA34866

Chemistry databases

ChEMBLⁱ	CHEMBL3301398
Drug and drug target database More...DrugBankⁱ	DB00242 Cladribine

Polymorphism and mutation databases

BioMutaⁱ	RRM2B
DMDMⁱ	74727333

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000228150	1 – 351	Ribonucleoside-diphosphate reductase subunit M2 BAdd BLAST		351

Proteomic databases

EPDⁱ	Q7LG56
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7LG56
PaxDbⁱ	Q7LG56
PeptideAtlas More...PeptideAtlasⁱ	Q7LG56
PRIDEⁱ	Q7LG56
ProteomicsDBⁱ	68860 68861 [Q7LG56-2] 68862 [Q7LG56-3] 68863 [Q7LG56-4] 68864 [Q7LG56-5]

PTM databases

iPTMnetⁱ	Q7LG56
PhosphoSitePlusⁱ	Q7LG56

Expressionⁱ

Tissue specificityⁱ

Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma.1 Publication

Inductionⁱ

In response to DNA damage in a wild-type p53/TP53-dependent manner.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000048392 Expressed in 202 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasⁱ	Q7LG56 baseline and differential
Genevisibleⁱ	Q7LG56 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB006854 HPA028812

HPAⁱ

CAB006854
HPA028812

Interactionⁱ

Subunit structureⁱ

Heterotetramer with large (RRM1) subunit. Interacts with p53/TP53. Interacts with RRM1 in response to DNA damage.5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ATM	Q13315	3	EBI-9009083,EBI-495465
MDM2	Q00987	2	EBI-15741413,EBI-389668
ORC4	O43929	4	EBI-9009083,EBI-374889
RNF41	Q9H4P4	3	EBI-9009083,EBI-2130266

Protein-protein interaction databases

BioGridⁱ	119071, 17 interactors
ComplexPortalⁱ	CPX-369 Ribonucleoside-diphosphate reductase RR1 complex, RRM2B variant
Database of interacting proteins More...DIPⁱ	DIP-24264N DIP-48627N
IntActⁱ	Q7LG56, 9 interactors
STRINGⁱ	9606.ENSP00000251810

Chemistry databases

BindingDBⁱ

Q7LG56

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	29 – 31	Combined sources	3
Turnⁱ	33 – 35	Combined sources	3
Helixⁱ	37 – 39	Combined sources	3
Beta strandⁱ	42 – 44	Combined sources	3
Helixⁱ	50 – 61	Combined sources	12
Helixⁱ	66 – 68	Combined sources	3
Helixⁱ	74 – 78	Combined sources	5
Helixⁱ	83 – 109	Combined sources	27
Helixⁱ	111 – 114	Combined sources	4
Helixⁱ	118 – 145	Combined sources	28
Helixⁱ	149 – 156	Combined sources	8
Helixⁱ	158 – 161	Combined sources	4
Helixⁱ	163 – 177	Combined sources	15
Beta strandⁱ	179 – 181	Combined sources	3
Helixⁱ	183 – 195	Combined sources	13
Turnⁱ	196 – 198	Combined sources	3
Helixⁱ	199 – 210	Combined sources	12
Helixⁱ	215 – 240	Combined sources	26
Helixⁱ	248 – 267	Combined sources	20
Helixⁱ	272 – 275	Combined sources	4
Helixⁱ	279 – 296	Combined sources	18
Helixⁱ	310 – 312	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q7LG56
SMRⁱ	Q7LG56
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q7LG56

EvolutionaryTraceⁱ

Q7LG56

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ribonucleoside diphosphate reductase small chain family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1567 Eukaryota COG0208 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013305
HOVERGENⁱ	HBG001647
InParanoidⁱ	Q7LG56
KEGG Orthology (KO) More...KOⁱ	K10808
PhylomeDBⁱ	Q7LG56
TreeFamⁱ	TF300465

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01049 RNRR2, 1 hit
Gene3Dⁱ	1.10.620.20, 1 hit
InterProⁱ	View protein in InterPro IPR009078 Ferritin-like_SF IPR012348 RNR-like IPR033909 RNR_small IPR030475 RNR_small_AS IPR000358 RNR_small_fam
PANTHERⁱ	PTHR23409 PTHR23409, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00268 Ribonuc_red_sm, 1 hit
SUPFAMⁱ	SSF47240 SSF47240, 1 hit
PROSITEⁱ	View protein in PROSITE PS00368 RIBORED_SMALL, 1 hit

Sequences (6+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 6 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q7LG56-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDPERPEAA GLDQDERSSS DTNESEIKSN EEPLLRKSSR RFVIFPIQYP 
        60         70         80         90        100
DIWKMYKQAQ ASFWTAEEVD LSKDLPHWNK LKADEKYFIS HILAFFAASD 
       110        120        130        140        150
GIVNENLVER FSQEVQVPEA RCFYGFQILI ENVHSEMYSL LIDTYIRDPK 
       160        170        180        190        200
KREFLFNAIE TMPYVKKKAD WALRWIADRK STFGERVVAF AAVEGVFFSG 
       210        220        230        240        250
SFAAIFWLKK RGLMPGLTFS NELISRDEGL HCDFACLMFQ YLVNKPSEER 
       260        270        280        290        300
VREIIVDAVK IEQEFLTEAL PVGLIGMNCI LMKQYIEFVA DRLLVELGFS 
       310        320        330        340        350
KVFQAENPFD FMENISLEGK TNFFEKRVSE YQRFAVMAET TDNVFTLDAD 

F

Length:351

Mass (Da):40,737

Last modified:July 5, 2004 - v1

Checksum:ⁱ6D008687EEF40994

GO

Isoform 2 (identifier: Q7LG56-2) [UniParc]FASTA Add to basket

Also known as: Long form

The sequence of this isoform differs from the canonical sequence as follows:
17-68: Missing.

« Hide

        10         20         30         40         50
MGDPERPEAA GLDQDEVDLS KDLPHWNKLK ADEKYFISHI LAFFAASDGI 
        60         70         80         90        100
VNENLVERFS QEVQVPEARC FYGFQILIEN VHSEMYSLLI DTYIRDPKKR 
       110        120        130        140        150
EFLFNAIETM PYVKKKADWA LRWIADRKST FGERVVAFAA VEGVFFSGSF 
       160        170        180        190        200
AAIFWLKKRG LMPGLTFSNE LISRDEGLHC DFACLMFQYL VNKPSEERVR 
       210        220        230        240        250
EIIVDAVKIE QEFLTEALPV GLIGMNCILM KQYIEFVADR LLVELGFSKV 
       260        270        280        290 
FQAENPFDFM ENISLEGKTN FFEKRVSEYQ RFAVMAETTD NVFTLDADF

Show »

Length:299

Mass (Da):34,529

Checksum:ⁱ4705C44389EB689B

GO

Isoform 3 (identifier: Q7LG56-3) [UniParc]FASTA Add to basket

Also known as: Short form gamma

The sequence of this isoform differs from the canonical sequence as follows:
17-228: Missing.

« Hide

        10         20         30         40         50
MGDPERPEAA GLDQDEGLHC DFACLMFQYL VNKPSEERVR EIIVDAVKIE 
        60         70         80         90        100
QEFLTEALPV GLIGMNCILM KQYIEFVADR LLVELGFSKV FQAENPFDFM 
       110        120        130 
ENISLEGKTN FFEKRVSEYQ RFAVMAETTD NVFTLDADF

Show »

Length:139

Mass (Da):15,963

Checksum:ⁱE80F65CB030E89B5

GO

Isoform 4 (identifier: Q7LG56-4) [UniParc]FASTA Add to basket

Also known as: Short form beta

The sequence of this isoform differs from the canonical sequence as follows:
17-301: Missing.

« Hide

        10         20         30         40         50
MGDPERPEAA GLDQDEVFQA ENPFDFMENI SLEGKTNFFE KRVSEYQRFA 
        60 
VMAETTDNVF TLDADF

Show »

Length:66

Mass (Da):7,602

Checksum:ⁱD432147F4FC35499

GO

Isoform 5 (identifier: Q7LG56-5) [UniParc]FASTA Add to basket

Also known as: Short form

The sequence of this isoform differs from the canonical sequence as follows:
42-43: FV → SF
44-351: Missing.

« Hide

        10         20         30         40 
MGDPERPEAA GLDQDERSSS DTNESEIKSN EEPLLRKSSR RSF

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:43

Mass (Da):4,852

Checksum:ⁱ29373C73112CBE75

GO

Isoform 6 (identifier: Q7LG56-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-16: MGDPERPEAAGLDQDE → MLLLRLPPHR...KDDAWRPQAG

« Hide

        10         20         30         40         50
MLLLRLPPHR SHASPLDCKL QDRCRKCYSP RSGQACPPAL AAAWLRRCER 
        60         70         80         90        100
RGGRPRGGRR KELTLGLRPA RCSAPGPAKD DAWRPQAGRS SSDTNESEIK 
       110        120        130        140        150
SNEEPLLRKS SRRFVIFPIQ YPDIWKMYKQ AQASFWTAEE VDLSKDLPHW 
       160        170        180        190        200
NKLKADEKYF ISHILAFFAA SDGIVNENLV ERFSQEVQVP EARCFYGFQI 
       210        220        230        240        250
LIENVHSEMY SLLIDTYIRD PKKREFLFNA IETMPYVKKK ADWALRWIAD 
       260        270        280        290        300
RKSTFGERVV AFAAVEGVFF SGSFAAIFWL KKRGLMPGLT FSNELISRDE 
       310        320        330        340        350
GLHCDFACLM FQYLVNKPSE ERVREIIVDA VKIEQEFLTE ALPVGLIGMN 
       360        370        380        390        400
CILMKQYIEF VADRLLVELG FSKVFQAENP FDFMENISLE GKTNFFEKRV 
       410        420 
SEYQRFAVMA ETTDNVFTLD ADF

Note: No experimental confirmation available.

Show »

Length:423

Mass (Da):48,787

Checksum:ⁱ0D2B8471AE362D44

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YAV1	H0YAV1_HUMAN	Ribonucleoside-diphosphate reductas... Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	408	Annotation score:
A0A0C4DGZ6	A0A0C4DGZ6_HUMAN	Ribonucleoside-diphosphate reductas... Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	297	Annotation score:
E5RG52	E5RG52_HUMAN	Ribonucleoside-diphosphate reductas... Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	65	Annotation score:

Sequence cautionⁱ

The sequence BAG65196 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence EAW91842 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	277	M → V in BAA92005 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_076280	33	P → S Found in a patient with combined respiratory complex deficiencies, muscle weakness and hearing loss; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs387906892EnsemblClinVar.	1
Natural variantⁱVAR_046217	64	W → R in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs515726182EnsemblClinVar.	1
Natural variantⁱVAR_046218	85	Missing in MTDPS8A. 1 Publication	1
Natural variantⁱVAR_065122	110	R → H in MTDPS8B. 1 PublicationCorresponds to variant dbSNP:rs267607025EnsemblClinVar.	1
Natural variantⁱVAR_025699	115	V → L in colorectal adenocarcinomas cell line; loss of ribonucleotide reductase activity. 1 Publication	1
Natural variantⁱVAR_065123	121	R → H in MTDPS8B. 1 PublicationCorresponds to variant dbSNP:rs267607024EnsemblClinVar.	1
Natural variantⁱVAR_046219	194	E → G in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs515726191EnsemblClinVar.	1
Natural variantⁱVAR_046220	194	E → K in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs121918308EnsemblClinVar.	1
Natural variantⁱVAR_046221	224	I → S in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs515726196EnsemblClinVar.	1
Natural variantⁱVAR_046222	236	C → F in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs121918309EnsemblClinVar.	1
Natural variantⁱVAR_046223	282	M → I in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs182614164EnsemblClinVar.	1
Natural variantⁱVAR_046224	317	L → V in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs515726198EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053585	1 – 16	MGDPE…LDQDE → MLLLRLPPHRSHASPLDCKL QDRCRKCYSPRSGQACPPAL AAAWLRRCERRGGRPRGGRR KELTLGLRPARCSAPGPAKD DAWRPQAG in isoform 6. 1 PublicationAdd BLAST	16
Alternative sequenceⁱVSP_017668	17 – 301	Missing in isoform 4. 1 PublicationAdd BLAST	285
Alternative sequenceⁱVSP_017669	17 – 228	Missing in isoform 3. 1 PublicationAdd BLAST	212
Alternative sequenceⁱVSP_017670	17 – 68	Missing in isoform 2. 1 PublicationAdd BLAST	52
Alternative sequenceⁱVSP_017671	42 – 43	FV → SF in isoform 5. 1 Publication	2
Alternative sequenceⁱVSP_017672	44 – 351	Missing in isoform 5. 1 PublicationAdd BLAST	308

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB036063 mRNA Translation: BAA92434.1 AB036532 Genomic DNA Translation: BAA92493.1 AB163437 mRNA Translation: BAD11774.1 AB163438 mRNA Translation: BAD11775.1 AB166669 mRNA Translation: BAD12265.1 AB166670 mRNA Translation: BAD12266.1 AB166671 mRNA Translation: BAD12267.1 AK001965 mRNA Translation: BAA92005.1 AK304354 mRNA Translation: BAG65196.1 Different initiation. DC308409 mRNA No translation available. AL137348 mRNA Translation: CAB70703.2 DQ027001 Genomic DNA Translation: AAY29059.1 AP001328 Genomic DNA No translation available. AP002907 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91842.1 Sequence problems. BC042468 mRNA Translation: AAH42468.1 BC108261 mRNA Translation: AAI08262.1 BC117496 mRNA Translation: AAI17497.1 BC130628 mRNA Translation: AAI30629.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34932.1 [Q7LG56-1] CCDS55267.1 [Q7LG56-2]
PIRⁱ	T46249
NCBI Reference Sequences More...RefSeqⁱ	NP_001165948.1, NM_001172477.1 [Q7LG56-6] NP_001165949.1, NM_001172478.1 [Q7LG56-2] NP_056528.2, NM_015713.4 [Q7LG56-1]
UniGeneⁱ	Hs.512592

Genome annotation databases

Ensemblⁱ	ENST00000251810; ENSP00000251810; ENSG00000048392 [Q7LG56-1] ENST00000395912; ENSP00000379248; ENSG00000048392 [Q7LG56-2] ENST00000519317; ENSP00000430641; ENSG00000048392 [Q7LG56-3] ENST00000519962; ENSP00000429140; ENSG00000048392 [Q7LG56-4] ENST00000522394; ENSP00000429578; ENSG00000048392 [Q7LG56-5]
GeneIDⁱ	50484
KEGGⁱ	hsa:50484
UCSC genome browser More...UCSCⁱ	uc003ykn.4 human [Q7LG56-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7LG56	RRM2B isoform 1		PANTR		351	UniRef100_Q7LG56
Q7LG56-2	RRM2B isoform 6		PANTR		299	UniRef100_A0A2I3RZZ1
RRM2B isoform 6		PONAB		299
Q7LG56-3	RRM2B isoform 7		PANTR		139	UniRef100_A0A2I3SVY5
RRM2B isoform 7		PONAB		139
Ribonucleotide reductase regulatory TP53 inducible subunit M2B		GORGO		139
Q7LG56-4	RRM2B isoform 8		PANTR		66	UniRef100_A0A2I3T9X9
RRM2B isoform 8		PONAB		66
Ribonucleotide reductase regulatory TP53 inducible subunit M2B		GORGO		66
Q7LG56-5	RRM2B isoform 5		PANTR		43	UniRef100_A0A2J8PMP0
Q7LG56-6	Ribonucleoside-diphosphate reductase subunit M2 B		HUMAN		297	UniRef100_A0A0C4DGZ6
RRM2B isoform 2		PONAB		297
RRM2B isoform 3		PANTR		297

Protein	Similar proteins		Species	Score	Length	Source
Q7LG56	Ribonucleoside-diphosphate reductase subunit M2 B		PONAB		351	UniRef90_Q7LG56
Ribonucleoside-diphosphate reductase subunit M2 B		MOUSE		351
Ribonucleoside-diphosphate reductase subunit M2 B		MACFA		351
RRM2B isoform 1		PANTR		351
Uncharacterized protein		FELCA		438
+88
Q7LG56-2	Uncharacterized protein		ICTTR		299	UniRef90_I3MBT3
Uncharacterized protein		RHIBE		313
Uncharacterized protein		COLAP		306
Uncharacterized protein		RHIRO		301
ribonucleoside-diphosphate reductase subunit M2 B isoform X2		ODORO		299
+21
Q7LG56-3	Ribonucleoside-diphosphate reductase subunit M2 B		MOUSE		139	UniRef90_D3YXX2
RRM2B isoform 7		PANTR		139
RRM2B isoform 7		PONAB		139
Ribonucleotide reductase regulatory TP53 inducible subunit M2B		GORGO		139
Uncharacterized protein		PROCO		139
+14
Q7LG56-4	RRM2B isoform 8		PANTR		66	UniRef90_A0A2I3T9X9
RRM2B isoform 8		PONAB		66
Ribonucleotide reductase regulatory TP53 inducible subunit M2B		GORGO		66
Uncharacterized protein		PROCO		66
Ribonucleotide reductase regulatory TP53 inducible subunit M2B		SAIBB		66
+11
Q7LG56-5	RRM2B isoform 5		PANTR		43	UniRef90_A0A2J8PMP0
RRM2B isoform 5		PONAB		43
Q7LG56-6	Ribonucleotide reductase regulatory TP53 inducible subunit M2B		SAIBB		373	UniRef90_A0A2K6RYK1
Ribonucleoside-diphosphate reductase subunit M2 B (Fragment)		HUMAN		408
Uncharacterized protein		AOTNA		297
RRM2B isoform 2		PONAB		297
RRM2B isoform 3		PANTR		297
+9

Protein	Similar proteins		Species	Score	Length	Source
Q7LG56	Ribonucleoside-diphosphate reductase subunit M2 B		MOUSE		351	UniRef50_Q7LG56
Ribonucleoside-diphosphate reductase subunit M2 B		PONAB		351
Ribonucleoside-diphosphate reductase subunit M2 B		MACFA		351
Ribonucleoside-diphosphate reductase subunit M2		RAT		390
RRM2B isoform 1		PANTR		351
+261
Q7LG56-2	Uncharacterized protein		ICTTR		299	UniRef50_I3MBT3
Uncharacterized protein		RHIBE		313
Uncharacterized protein		COLAP		306
Uncharacterized protein		RHIRO		301
Uncharacterized protein		CAVPO		299
+39
Q7LG56-3	Ribonucleoside-diphosphate reductase subunit M2 B		MOUSE		139	UniRef50_D3YXX2
Uncharacterized protein		CERAT		139
Uncharacterized protein		COLAP		139
Ribonucleotide reductase regulatory TP53 inducible subunit M2B		CALJA		139
Uncharacterized protein		AOTNA		139
+15
Q7LG56-4	RRM2B isoform 8		PANTR		66	UniRef50_A0A2I3T9X9
RRM2B isoform 8		PONAB		66
Ribonucleotide reductase regulatory TP53 inducible subunit M2B		GORGO		66
Ribonucleotide reductase regulatory TP53 inducible subunit M2B		CALJA		66
Uncharacterized protein		AOTNA		66
+14
Q7LG56-5	Ribonucleoside-diphosphate reductase subunit M2 B		MOUSE		43	UniRef50_D6RFN4
RRM2B isoform 5		PANTR		43
RRM2B isoform 5		PONAB		43

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB036063 mRNA Translation: BAA92434.1 AB036532 Genomic DNA Translation: BAA92493.1 AB163437 mRNA Translation: BAD11774.1 AB163438 mRNA Translation: BAD11775.1 AB166669 mRNA Translation: BAD12265.1 AB166670 mRNA Translation: BAD12266.1 AB166671 mRNA Translation: BAD12267.1 AK001965 mRNA Translation: BAA92005.1 AK304354 mRNA Translation: BAG65196.1 Different initiation. DC308409 mRNA No translation available. AL137348 mRNA Translation: CAB70703.2 DQ027001 Genomic DNA Translation: AAY29059.1 AP001328 Genomic DNA No translation available. AP002907 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91842.1 Sequence problems. BC042468 mRNA Translation: AAH42468.1 BC108261 mRNA Translation: AAI08262.1 BC117496 mRNA Translation: AAI17497.1 BC130628 mRNA Translation: AAI30629.1
CCDSⁱ	CCDS34932.1 [Q7LG56-1] CCDS55267.1 [Q7LG56-2]
PIRⁱ	T46249
RefSeqⁱ	NP_001165948.1, NM_001172477.1 [Q7LG56-6] NP_001165949.1, NM_001172478.1 [Q7LG56-2] NP_056528.2, NM_015713.4 [Q7LG56-1]
UniGeneⁱ	Hs.512592

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2VUX	X-ray	2.80	A/B	20-322	[»]
	3HF1	X-ray	2.60	A/B	1-351	[»]
	4DJN	X-ray	2.20	A/B	13-322	[»]
ProteinModelPortalⁱ	Q7LG56
SMRⁱ	Q7LG56
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119071, 17 interactors
ComplexPortalⁱ	CPX-369 Ribonucleoside-diphosphate reductase RR1 complex, RRM2B variant
DIPⁱ	DIP-24264N DIP-48627N
IntActⁱ	Q7LG56, 9 interactors
STRINGⁱ	9606.ENSP00000251810

Chemistry databases

BindingDBⁱ	Q7LG56
ChEMBLⁱ	CHEMBL3301398
DrugBankⁱ	DB00242 Cladribine

PTM databases

iPTMnetⁱ	Q7LG56
PhosphoSitePlusⁱ	Q7LG56

Polymorphism and mutation databases

BioMutaⁱ	RRM2B
DMDMⁱ	74727333

Proteomic databases

EPDⁱ	Q7LG56
MaxQBⁱ	Q7LG56
PaxDbⁱ	Q7LG56
PeptideAtlasⁱ	Q7LG56
PRIDEⁱ	Q7LG56
ProteomicsDBⁱ	68860 68861 [Q7LG56-2] 68862 [Q7LG56-3] 68863 [Q7LG56-4] 68864 [Q7LG56-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	50484
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000251810; ENSP00000251810; ENSG00000048392 [Q7LG56-1] ENST00000395912; ENSP00000379248; ENSG00000048392 [Q7LG56-2] ENST00000519317; ENSP00000430641; ENSG00000048392 [Q7LG56-3] ENST00000519962; ENSP00000429140; ENSG00000048392 [Q7LG56-4] ENST00000522394; ENSP00000429578; ENSG00000048392 [Q7LG56-5]
GeneIDⁱ	50484
KEGGⁱ	hsa:50484
UCSCⁱ	uc003ykn.4 human [Q7LG56-1]

Organism-specific databases

CTDⁱ	50484
DisGeNETⁱ	50484
EuPathDBⁱ	HostDB:ENSG00000048392.11
GeneCardsⁱ	RRM2B
HGNCⁱ	HGNC:17296 RRM2B
HPAⁱ	CAB006854 HPA028812
MalaCardsⁱ	RRM2B
MIMⁱ	604712 gene 612075 phenotype 613077 phenotype
neXtProtⁱ	NX_Q7LG56
OpenTargetsⁱ	ENSG00000048392
Orphanetⁱ	329336 Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy 254892 Autosomal dominant progressive external ophthalmoplegia 480 Kearns-Sayre syndrome 255235 Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy 298 Mitochondrial neurogastrointestinal encephalomyopathy
PharmGKBⁱ	PA34866
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1567 Eukaryota COG0208 LUCA
GeneTreeⁱ	ENSGT00390000013305
HOVERGENⁱ	HBG001647
InParanoidⁱ	Q7LG56
KOⁱ	K10808
PhylomeDBⁱ	Q7LG56
TreeFamⁱ	TF300465

Enzyme and pathway databases

UniPathwayⁱ	UPA00326
BRENDAⁱ	1.17.4.1 2681
Reactomeⁱ	R-HSA-499943 Interconversion of nucleotide di- and triphosphates R-HSA-5628897 TP53 Regulates Metabolic Genes
SIGNORⁱ	Q7LG56

Miscellaneous databases

ChiTaRSⁱ	RRM2B human
EvolutionaryTraceⁱ	Q7LG56
GeneWikiⁱ	RRM2B
GenomeRNAiⁱ	50484
Protein Ontology More...PROⁱ	PR:Q7LG56
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000048392 Expressed in 202 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasⁱ	Q7LG56 baseline and differential
Genevisibleⁱ	Q7LG56 HS

Family and domain databases

CDDⁱ	cd01049 RNRR2, 1 hit
Gene3Dⁱ	1.10.620.20, 1 hit
InterProⁱ	View protein in InterPro IPR009078 Ferritin-like_SF IPR012348 RNR-like IPR033909 RNR_small IPR030475 RNR_small_AS IPR000358 RNR_small_fam
PANTHERⁱ	PTHR23409 PTHR23409, 1 hit
Pfamⁱ	View protein in Pfam PF00268 Ribonuc_red_sm, 1 hit
SUPFAMⁱ	SSF47240 SSF47240, 1 hit
PROSITEⁱ	View protein in PROSITE PS00368 RIBORED_SMALL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RIR2B_HUMAN
Accessionⁱ	Q7LG56Primary (citable) accession number: Q7LG56 Secondary accession number(s): B4E2N4 Q9NUW3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM

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UniProtKB - Q7LG56 (RIR2B_HUMAN)

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Ribonucleoside-diphosphate reductase subunit M2 B

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Sites

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Keywords - Cellular componenti

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Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

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Keywords - Coding sequence diversityi

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

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Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: DNA replication

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ