UniProtKB - Q7LG56 (RIR2B_HUMAN)
Protein
Ribonucleoside-diphosphate reductase subunit M2 B
Gene
RRM2B
Organism
Homo sapiens (Human)
Status
Functioni
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.3 Publications
Catalytic activityi
- [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphatePROSITE-ProRule annotation1 PublicationEC:1.17.4.1PROSITE-ProRule annotation1 Publication
Cofactori
Fe cation1 PublicationNote: Binds 2 iron ions per subunit.1 Publication
: DNA replication Pathwayi
This protein is involved in the pathway DNA replication, which is part of Genetic information processing.View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 100 | Iron 1 | 1 | |
Metal bindingi | 131 | Iron 1 | 1 | |
Metal bindingi | 131 | Iron 2 | 1 | |
Metal bindingi | 134 | Iron 1 | 1 | |
Active sitei | 138 | PROSITE-ProRule annotation | 1 | |
Metal bindingi | 194 | Iron 2 | 1 | |
Metal bindingi | 228 | Iron 2 | 1 | |
Metal bindingi | 231 | Iron 2 | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: GO_Central
GO - Biological processi
- deoxyribonucleoside triphosphate metabolic process Source: Ensembl
- deoxyribonucleotide biosynthetic process Source: GO_Central
- DNA repair Source: UniProtKB-KW
- kidney development Source: Ensembl
- mitochondrial DNA replication Source: Ensembl
- negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator Source: Ensembl
- nucleobase-containing small molecule interconversion Source: Reactome
- renal system process Source: Ensembl
- response to amine Source: Ensembl
- response to oxidative stress Source: Ensembl
Keywordsi
Molecular function | Oxidoreductase |
Biological process | DNA damage, DNA repair, DNA replication |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.17.4.1 2681 |
Reactomei | R-HSA-499943 Interconversion of nucleotide di- and triphosphates R-HSA-5628897 TP53 Regulates Metabolic Genes |
SIGNORi | Q7LG56 |
UniPathwayi | UPA00326 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribonucleoside-diphosphate reductase subunit M2 B (EC:1.17.4.1)Alternative name(s): TP53-inducible ribonucleotide reductase M2 B p53-inducible ribonucleotide reductase small subunit 2-like protein Short name: p53R2 |
Gene namesi | Name:RRM2B Synonyms:P53R2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17296 RRM2B |
MIMi | 604712 gene |
neXtProti | NX_Q7LG56 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
- ribonucleoside-diphosphate reductase complex Source: InterPro
Mitochondrion
- mitochondrion Source: GOC
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Mitochondrial DNA depletion syndrome 8A (MTDPS8A)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder due to mitochondrial dysfunction characterized by various combinations of neonatal hypotonia, neurological deterioration, respiratory distress, lactic acidosis, and renal tubulopathy.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046217 | 64 | W → R in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs515726182Ensembl. | 1 | |
Natural variantiVAR_046218 | 85 | Missing in MTDPS8A. 1 Publication | 1 | |
Natural variantiVAR_046219 | 194 | E → G in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs515726191Ensembl. | 1 | |
Natural variantiVAR_046220 | 194 | E → K in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs121918308Ensembl. | 1 | |
Natural variantiVAR_046221 | 224 | I → S in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs515726196Ensembl. | 1 | |
Natural variantiVAR_046222 | 236 | C → F in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs121918309Ensembl. | 1 | |
Natural variantiVAR_046223 | 282 | M → I in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs182614164Ensembl. | 1 | |
Natural variantiVAR_046224 | 317 | L → V in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs515726198Ensembl. | 1 |
Mitochondrial DNA depletion syndrome 8B (MTDPS8B)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease due to mitochondrial dysfunction and characterized by ophthalmoplegia, ptosis, gastrointestinal dysmotility, cachexia, peripheral neuropathy.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065122 | 110 | R → H in MTDPS8B. 1 PublicationCorresponds to variant dbSNP:rs267607025Ensembl. | 1 | |
Natural variantiVAR_065123 | 121 | R → H in MTDPS8B. 1 PublicationCorresponds to variant dbSNP:rs267607024Ensembl. | 1 |
Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant, 5 (PEOA5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
Related information in OMIMKeywords - Diseasei
Disease mutation, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegiaOrganism-specific databases
DisGeNETi | 50484 |
GeneReviewsi | RRM2B |
MalaCardsi | RRM2B |
MIMi | 612075 phenotype 613077 phenotype |
OpenTargetsi | ENSG00000048392 |
Orphaneti | 329336 Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy 254892 Autosomal dominant progressive external ophthalmoplegia 480 Kearns-Sayre syndrome 255235 Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy 298 Mitochondrial neurogastrointestinal encephalomyopathy |
PharmGKBi | PA34866 |
Miscellaneous databases
Pharosi | Q7LG56 |
Chemistry databases
ChEMBLi | CHEMBL3301398 |
DrugBanki | DB00242 Cladribine |
Polymorphism and mutation databases
BioMutai | RRM2B |
DMDMi | 74727333 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000228150 | 1 – 351 | Ribonucleoside-diphosphate reductase subunit M2 BAdd BLAST | 351 |
Proteomic databases
EPDi | Q7LG56 |
jPOSTi | Q7LG56 |
MassIVEi | Q7LG56 |
MaxQBi | Q7LG56 |
PaxDbi | Q7LG56 |
PeptideAtlasi | Q7LG56 |
PRIDEi | Q7LG56 |
ProteomicsDBi | 5837 68860 [Q7LG56-1] 68861 [Q7LG56-2] 68862 [Q7LG56-3] 68863 [Q7LG56-4] 68864 [Q7LG56-5] |
PTM databases
iPTMneti | Q7LG56 |
PhosphoSitePlusi | Q7LG56 |
Expressioni
Tissue specificityi
Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma.1 Publication
Inductioni
In response to DNA damage in a wild-type p53/TP53-dependent manner.1 Publication
Gene expression databases
Bgeei | ENSG00000048392 Expressed in 202 organ(s), highest expression level in quadriceps femoris |
ExpressionAtlasi | Q7LG56 baseline and differential |
Genevisiblei | Q7LG56 HS |
Organism-specific databases
HPAi | CAB006854 HPA028812 |
Interactioni
Subunit structurei
Heterotetramer with large (RRM1) subunit.
Interacts with p53/TP53.
Interacts with RRM1 in response to DNA damage.
5 PublicationsBinary interactionsi
Protein-protein interaction databases
BioGridi | 119071, 19 interactors |
ComplexPortali | CPX-369 Ribonucleoside-diphosphate reductase RR1 complex, RRM2B variant |
DIPi | DIP-24264N DIP-48627N |
IntActi | Q7LG56, 16 interactors |
STRINGi | 9606.ENSP00000251810 |
Chemistry databases
BindingDBi | Q7LG56 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q7LG56 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q7LG56 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ribonucleoside diphosphate reductase small chain family.Curated
Phylogenomic databases
eggNOGi | KOG1567 Eukaryota COG0208 LUCA |
GeneTreei | ENSGT00390000013305 |
InParanoidi | Q7LG56 |
KOi | K10808 |
OrthoDBi | 388324at2759 |
PhylomeDBi | Q7LG56 |
TreeFami | TF300465 |
Family and domain databases
CDDi | cd01049 RNRR2, 1 hit |
Gene3Di | 1.10.620.20, 1 hit |
InterProi | View protein in InterPro IPR009078 Ferritin-like_SF IPR012348 RNR-like IPR033909 RNR_small IPR030475 RNR_small_AS IPR000358 RNR_small_fam |
PANTHERi | PTHR23409 PTHR23409, 1 hit |
Pfami | View protein in Pfam PF00268 Ribonuc_red_sm, 1 hit |
SUPFAMi | SSF47240 SSF47240, 1 hit |
PROSITEi | View protein in PROSITE PS00368 RIBORED_SMALL, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7LG56-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDPERPEAA GLDQDERSSS DTNESEIKSN EEPLLRKSSR RFVIFPIQYP
60 70 80 90 100
DIWKMYKQAQ ASFWTAEEVD LSKDLPHWNK LKADEKYFIS HILAFFAASD
110 120 130 140 150
GIVNENLVER FSQEVQVPEA RCFYGFQILI ENVHSEMYSL LIDTYIRDPK
160 170 180 190 200
KREFLFNAIE TMPYVKKKAD WALRWIADRK STFGERVVAF AAVEGVFFSG
210 220 230 240 250
SFAAIFWLKK RGLMPGLTFS NELISRDEGL HCDFACLMFQ YLVNKPSEER
260 270 280 290 300
VREIIVDAVK IEQEFLTEAL PVGLIGMNCI LMKQYIEFVA DRLLVELGFS
310 320 330 340 350
KVFQAENPFD FMENISLEGK TNFFEKRVSE YQRFAVMAET TDNVFTLDAD
F
Isoform 5 (identifier: Q7LG56-5) [UniParc]FASTAAdd to basket
Also known as: Short form
The sequence of this isoform differs from the canonical sequence as follows:
42-43: FV → SF
44-351: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YAV1 | H0YAV1_HUMAN | Ribonucleoside-diphosphate reductas... | RRM2B | 408 | Annotation score: | ||
A0A0C4DGZ6 | A0A0C4DGZ6_HUMAN | Ribonucleoside-diphosphate reductas... | RRM2B | 297 | Annotation score: | ||
E5RG52 | E5RG52_HUMAN | Ribonucleoside-diphosphate reductas... | RRM2B | 65 | Annotation score: |
Sequence cautioni
The sequence BAG65196 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAW91842 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 277 | M → V in BAA92005 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076280 | 33 | P → S Found in a patient with combined respiratory complex deficiencies, muscle weakness and hearing loss; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs387906892Ensembl. | 1 | |
Natural variantiVAR_046217 | 64 | W → R in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs515726182Ensembl. | 1 | |
Natural variantiVAR_046218 | 85 | Missing in MTDPS8A. 1 Publication | 1 | |
Natural variantiVAR_065122 | 110 | R → H in MTDPS8B. 1 PublicationCorresponds to variant dbSNP:rs267607025Ensembl. | 1 | |
Natural variantiVAR_025699 | 115 | V → L in colorectal adenocarcinomas cell line; loss of ribonucleotide reductase activity. 1 Publication | 1 | |
Natural variantiVAR_065123 | 121 | R → H in MTDPS8B. 1 PublicationCorresponds to variant dbSNP:rs267607024Ensembl. | 1 | |
Natural variantiVAR_046219 | 194 | E → G in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs515726191Ensembl. | 1 | |
Natural variantiVAR_046220 | 194 | E → K in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs121918308Ensembl. | 1 | |
Natural variantiVAR_046221 | 224 | I → S in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs515726196Ensembl. | 1 | |
Natural variantiVAR_046222 | 236 | C → F in MTDPS8A. 1 PublicationCorresponds to variant dbSNP:rs121918309Ensembl. | 1 | |
Natural variantiVAR_046223 | 282 | M → I in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs182614164Ensembl. | 1 | |
Natural variantiVAR_046224 | 317 | L → V in MTDPS8A; without tubulopathy. 1 PublicationCorresponds to variant dbSNP:rs515726198Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053585 | 1 – 16 | MGDPE…LDQDE → MLLLRLPPHRSHASPLDCKL QDRCRKCYSPRSGQACPPAL AAAWLRRCERRGGRPRGGRR KELTLGLRPARCSAPGPAKD DAWRPQAG in isoform 6. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_017668 | 17 – 301 | Missing in isoform 4. 1 PublicationAdd BLAST | 285 | |
Alternative sequenceiVSP_017669 | 17 – 228 | Missing in isoform 3. 1 PublicationAdd BLAST | 212 | |
Alternative sequenceiVSP_017670 | 17 – 68 | Missing in isoform 2. 1 PublicationAdd BLAST | 52 | |
Alternative sequenceiVSP_017671 | 42 – 43 | FV → SF in isoform 5. 1 Publication | 2 | |
Alternative sequenceiVSP_017672 | 44 – 351 | Missing in isoform 5. 1 PublicationAdd BLAST | 308 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB036063 mRNA Translation: BAA92434.1 AB036532 Genomic DNA Translation: BAA92493.1 AB163437 mRNA Translation: BAD11774.1 AB163438 mRNA Translation: BAD11775.1 AB166669 mRNA Translation: BAD12265.1 AB166670 mRNA Translation: BAD12266.1 AB166671 mRNA Translation: BAD12267.1 AK001965 mRNA Translation: BAA92005.1 AK304354 mRNA Translation: BAG65196.1 Different initiation. DC308409 mRNA No translation available. AL137348 mRNA Translation: CAB70703.2 DQ027001 Genomic DNA Translation: AAY29059.1 AP001328 Genomic DNA No translation available. AP002907 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91842.1 Sequence problems. BC042468 mRNA Translation: AAH42468.1 BC108261 mRNA Translation: AAI08262.1 BC117496 mRNA Translation: AAI17497.1 BC130628 mRNA Translation: AAI30629.1 |
CCDSi | CCDS34932.1 [Q7LG56-1] CCDS55267.1 [Q7LG56-2] |
PIRi | T46249 |
RefSeqi | NP_001165948.1, NM_001172477.1 [Q7LG56-6] NP_001165949.1, NM_001172478.1 [Q7LG56-2] NP_056528.2, NM_015713.4 [Q7LG56-1] |
Genome annotation databases
Ensembli | ENST00000251810; ENSP00000251810; ENSG00000048392 [Q7LG56-1] ENST00000395912; ENSP00000379248; ENSG00000048392 [Q7LG56-2] ENST00000519317; ENSP00000430641; ENSG00000048392 [Q7LG56-3] ENST00000519962; ENSP00000429140; ENSG00000048392 [Q7LG56-4] ENST00000522394; ENSP00000429578; ENSG00000048392 [Q7LG56-5] |
GeneIDi | 50484 |
KEGGi | hsa:50484 |
UCSCi | uc003ykn.4 human [Q7LG56-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB036063 mRNA Translation: BAA92434.1 AB036532 Genomic DNA Translation: BAA92493.1 AB163437 mRNA Translation: BAD11774.1 AB163438 mRNA Translation: BAD11775.1 AB166669 mRNA Translation: BAD12265.1 AB166670 mRNA Translation: BAD12266.1 AB166671 mRNA Translation: BAD12267.1 AK001965 mRNA Translation: BAA92005.1 AK304354 mRNA Translation: BAG65196.1 Different initiation. DC308409 mRNA No translation available. AL137348 mRNA Translation: CAB70703.2 DQ027001 Genomic DNA Translation: AAY29059.1 AP001328 Genomic DNA No translation available. AP002907 Genomic DNA No translation available. CH471060 Genomic DNA Translation: EAW91842.1 Sequence problems. BC042468 mRNA Translation: AAH42468.1 BC108261 mRNA Translation: AAI08262.1 BC117496 mRNA Translation: AAI17497.1 BC130628 mRNA Translation: AAI30629.1 |
CCDSi | CCDS34932.1 [Q7LG56-1] CCDS55267.1 [Q7LG56-2] |
PIRi | T46249 |
RefSeqi | NP_001165948.1, NM_001172477.1 [Q7LG56-6] NP_001165949.1, NM_001172478.1 [Q7LG56-2] NP_056528.2, NM_015713.4 [Q7LG56-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2VUX | X-ray | 2.80 | A/B | 20-322 | [»] | |
3HF1 | X-ray | 2.60 | A/B | 1-351 | [»] | |
4DJN | X-ray | 2.20 | A/B | 13-322 | [»] | |
SMRi | Q7LG56 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 119071, 19 interactors |
ComplexPortali | CPX-369 Ribonucleoside-diphosphate reductase RR1 complex, RRM2B variant |
DIPi | DIP-24264N DIP-48627N |
IntActi | Q7LG56, 16 interactors |
STRINGi | 9606.ENSP00000251810 |
Chemistry databases
BindingDBi | Q7LG56 |
ChEMBLi | CHEMBL3301398 |
DrugBanki | DB00242 Cladribine |
PTM databases
iPTMneti | Q7LG56 |
PhosphoSitePlusi | Q7LG56 |
Polymorphism and mutation databases
BioMutai | RRM2B |
DMDMi | 74727333 |
Proteomic databases
EPDi | Q7LG56 |
jPOSTi | Q7LG56 |
MassIVEi | Q7LG56 |
MaxQBi | Q7LG56 |
PaxDbi | Q7LG56 |
PeptideAtlasi | Q7LG56 |
PRIDEi | Q7LG56 |
ProteomicsDBi | 5837 68860 [Q7LG56-1] 68861 [Q7LG56-2] 68862 [Q7LG56-3] 68863 [Q7LG56-4] 68864 [Q7LG56-5] |
Protocols and materials databases
DNASUi | 50484 |
Genome annotation databases
Ensembli | ENST00000251810; ENSP00000251810; ENSG00000048392 [Q7LG56-1] ENST00000395912; ENSP00000379248; ENSG00000048392 [Q7LG56-2] ENST00000519317; ENSP00000430641; ENSG00000048392 [Q7LG56-3] ENST00000519962; ENSP00000429140; ENSG00000048392 [Q7LG56-4] ENST00000522394; ENSP00000429578; ENSG00000048392 [Q7LG56-5] |
GeneIDi | 50484 |
KEGGi | hsa:50484 |
UCSCi | uc003ykn.4 human [Q7LG56-1] |
Organism-specific databases
CTDi | 50484 |
DisGeNETi | 50484 |
GeneCardsi | RRM2B |
GeneReviewsi | RRM2B |
HGNCi | HGNC:17296 RRM2B |
HPAi | CAB006854 HPA028812 |
MalaCardsi | RRM2B |
MIMi | 604712 gene 612075 phenotype 613077 phenotype |
neXtProti | NX_Q7LG56 |
OpenTargetsi | ENSG00000048392 |
Orphaneti | 329336 Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy 254892 Autosomal dominant progressive external ophthalmoplegia 480 Kearns-Sayre syndrome 255235 Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy 298 Mitochondrial neurogastrointestinal encephalomyopathy |
PharmGKBi | PA34866 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1567 Eukaryota COG0208 LUCA |
GeneTreei | ENSGT00390000013305 |
InParanoidi | Q7LG56 |
KOi | K10808 |
OrthoDBi | 388324at2759 |
PhylomeDBi | Q7LG56 |
TreeFami | TF300465 |
Enzyme and pathway databases
UniPathwayi | UPA00326 |
BRENDAi | 1.17.4.1 2681 |
Reactomei | R-HSA-499943 Interconversion of nucleotide di- and triphosphates R-HSA-5628897 TP53 Regulates Metabolic Genes |
SIGNORi | Q7LG56 |
Miscellaneous databases
ChiTaRSi | RRM2B human |
EvolutionaryTracei | Q7LG56 |
GeneWikii | RRM2B |
GenomeRNAii | 50484 |
Pharosi | Q7LG56 |
PROi | PR:Q7LG56 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000048392 Expressed in 202 organ(s), highest expression level in quadriceps femoris |
ExpressionAtlasi | Q7LG56 baseline and differential |
Genevisiblei | Q7LG56 HS |
Family and domain databases
CDDi | cd01049 RNRR2, 1 hit |
Gene3Di | 1.10.620.20, 1 hit |
InterProi | View protein in InterPro IPR009078 Ferritin-like_SF IPR012348 RNR-like IPR033909 RNR_small IPR030475 RNR_small_AS IPR000358 RNR_small_fam |
PANTHERi | PTHR23409 PTHR23409, 1 hit |
Pfami | View protein in Pfam PF00268 Ribonuc_red_sm, 1 hit |
SUPFAMi | SSF47240 SSF47240, 1 hit |
PROSITEi | View protein in PROSITE PS00368 RIBORED_SMALL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RIR2B_HUMAN | |
Accessioni | Q7LG56Primary (citable) accession number: Q7LG56 Secondary accession number(s): B4E2N4 Q9NUW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | November 13, 2019 | |
This is version 167 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references