CXXC5

Functionⁱ

May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788).By similarity3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	256 – 297	CXXC-typePROSITE-ProRule annotationAdd BLAST		42

GO - Molecular functionⁱ

sequence-specific DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23303788
transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23303788
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 23303788
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from high throughput mutant phenotypeⁱ
- 12761501

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	Transcription
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9018519 Estrogen-dependent gene expression

Reactomeⁱ

R-HSA-9018519 Estrogen-dependent gene expression

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CXXC-type zinc finger protein 5 Short name: CF5 Alternative name(s): Putative MAPK-activating protein PM08 Putative NF-kappa-B-activating protein 102 Retinoid-inducible nuclear factor Short name: RINF
Gene namesⁱ	Name:CXXC5 ORF Names:HSPC195, TCCCIA00297
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171604.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:26943 CXXC5
MIMⁱ	612752 gene
neXtProtⁱ	NX_Q7LFL8

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51523
Open Targets More...OpenTargetsⁱ	ENSG00000171604
PharmGKBⁱ	PA128394661

Polymorphism and mutation databases

BioMutaⁱ	CXXC5
DMDMⁱ	167011303

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000317548	1 – 322	CXXC-type zinc finger protein 5Add BLAST		322

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	53	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q7LFL8
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7LFL8
PaxDbⁱ	Q7LFL8
PeptideAtlas More...PeptideAtlasⁱ	Q7LFL8
PRIDEⁱ	Q7LFL8
ProteomicsDBⁱ	68856 68857 [Q7LFL8-2]

PTM databases

iPTMnetⁱ	Q7LFL8
PhosphoSitePlusⁱ	Q7LFL8

Expressionⁱ

Inductionⁱ

By retinoic acid.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000171604 Expressed in 215 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_CXXC5
ExpressionAtlasⁱ	Q7LFL8 baseline and differential
Genevisibleⁱ	Q7LFL8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036508 HPA058148

HPAⁱ

HPA036508
HPA058148

Interactionⁱ

Subunit structureⁱ

Interacts with DVL1. Interacts with RBPJ (PubMed:23303788).By similarity1 Publication

GO - Molecular functionⁱ

transcription factor binding
Source: UniProtKB
Inferred from direct assayⁱ
- 23303788

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	119586, 9 interactors
IntActⁱ	Q7LFL8, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q7LFL8
STRINGⁱ	9606.ENSP00000302543

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	267 – 270	Combined sources	4
Beta strandⁱ	276 – 278	Combined sources	3
Helixⁱ	279 – 282	Combined sources	4
Helixⁱ	284 – 287	Combined sources	4
Turnⁱ	292 – 294	Combined sources	3
Helixⁱ	297 – 299	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q7LFL8
SMRⁱ	Q7LFL8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	257 – 262	Nuclear localization signalSequence analysis		6

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	14 – 18	Poly-Ser		5

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	256 – 297	CXXC-typePROSITE-ProRule annotationAdd BLAST		42

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IGNJ Eukaryota ENOG4110UND LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144072
HOGENOMⁱ	HOG000112118
HOVERGENⁱ	HBG095668
InParanoidⁱ	Q7LFL8
KEGG Orthology (KO) More...KOⁱ	K22760
OMAⁱ	PMQNELA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FYR
PhylomeDBⁱ	Q7LFL8
TreeFamⁱ	TF326617

Family and domain databases

InterProⁱ	View protein in InterPro IPR002857 Znf_CXXC
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02008 zf-CXXC, 1 hit
PROSITEⁱ	View protein in PROSITE PS51058 ZF_CXXC, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q7LFL8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLGGGSQD AGGSSSSSTN GSGGSGSSGP KAGAADKSAV VAAAAPASVA 
        60         70         80         90        100
DDTPPPERRN KSGIISEPLN KSLRRSRPLS HYSSFGSSGG SGGGSMMGGE 
       110        120        130        140        150
SADKATAAAA AASLLANGHD LAAAMAVDKS NPTSKHKSGA VASLLSKAER 
       160        170        180        190        200
ATELAAEGQL TLQQFAQSTE MLKRVVQEHL PLMSEAGAGL PDMEAVAGAE 
       210        220        230        240        250
ALNGQSDFPY LGAFPINPGL FIMTPAGVFL AESALHMAGL AEYPMQGELA 
       260        270        280        290        300
SAISSGKKKR KRCGMCAPCR RRINCEQCSS CRNRKTGHQI CKFRKCEELK 
       310        320 
KKPSAALEKV MLPTGAAFRW FQ

Length:322

Mass (Da):32,977

Last modified:April 17, 2007 - v1

Checksum:ⁱECC19B4DE9872BC5

GO

Isoform 2 (identifier: Q7LFL8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-95: Missing.

« Hide

        10         20         30         40         50
MMGGESADKA TAAAAAASLL ANGHDLAAAM AVDKSNPTSK HKSGAVASLL 
        60         70         80         90        100
SKAERATELA AEGQLTLQQF AQSTEMLKRV VQEHLPLMSE AGAGLPDMEA 
       110        120        130        140        150
VAGAEALNGQ SDFPYLGAFP INPGLFIMTP AGVFLAESAL HMAGLAEYPM 
       160        170        180        190        200
QGELASAISS GKKKRKRCGM CAPCRRRINC EQCSSCRNRK TGHQICKFRK 
       210        220 
CEELKKKPSA ALEKVMLPTG AAFRWFQ

Show »

Length:227

Mass (Da):24,072

Checksum:ⁱ03146D66E6FC4E30

GO

Computationally mapped potential isoform sequencesⁱ

There are 12 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	D6RBE0	D6RBE0_HUMAN	CXXC-type zinc finger protein 5 CXXC-type zinc finger protein 5	CXXC5	181	Annotation score:
	E7EVI8	E7EVI8_HUMAN	CXXC-type zinc finger protein 5 CXXC-type zinc finger protein 5	CXXC5	196	Annotation score:
	D6R966	D6R966_HUMAN	CXXC-type zinc finger protein 5 CXXC-type zinc finger protein 5	CXXC5	73	Annotation score:
	D6RHG9	D6RHG9_HUMAN	CXXC-type zinc finger protein 5 CXXC-type zinc finger protein 5	CXXC5	80	Annotation score:
	D6RIR8	D6RIR8_HUMAN	CXXC-type zinc finger protein 5 CXXC-type zinc finger protein 5	CXXC5	98	Annotation score:
	E7EV55	E7EV55_HUMAN	CXXC-type zinc finger protein 5 CXXC-type zinc finger protein 5	CXXC5	137	Annotation score:
	D6RHC6	D6RHC6_HUMAN	CXXC-type zinc finger protein 5 CXXC-type zinc finger protein 5	CXXC5	83	Annotation score:
	D6RDY2	D6RDY2_HUMAN	CXXC-type zinc finger protein 5 CXXC-type zinc finger protein 5	CXXC5	161	Annotation score:
	D6RCN9	D6RCN9_HUMAN	CXXC-type zinc finger protein 5 CXXC-type zinc finger protein 5	CXXC5	68	Annotation score:
	D6R9V1	D6R9V1_HUMAN	CXXC-type zinc finger protein 5 CXXC-type zinc finger protein 5	CXXC5	102	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAF36115 differs from that shown. Reason: Frameshift at positions 32, 102, 119, 250 and 265.Curated

The sequence AAH02490 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH06428 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH17439 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH24040 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAH41013 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	111 – 112	AA → WP in AAF36115 (PubMed:11042152).Curated		2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_031013	1 – 95	Missing in isoform 2. 2 PublicationsAdd BLAST		95

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	GQ379202 mRNA Translation: ACU80469.1 AB097005 mRNA Translation: BAC77358.1 AB097032 mRNA Translation: BAC77385.1 AK001782 mRNA Translation: BAA91907.1 AK024338 mRNA Translation: BAG51292.1 AY007103 mRNA Translation: AAG01986.1 AC113361 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW62090.1 CH471062 Genomic DNA Translation: EAW62091.1 CH471062 Genomic DNA Translation: EAW62092.1 CH471062 Genomic DNA Translation: EAW62093.1 BC002490 mRNA Translation: AAH02490.3 Different initiation. BC006428 mRNA Translation: AAH06428.1 Different initiation. BC017439 mRNA Translation: AAH17439.2 Different initiation. BC024040 mRNA Translation: AAH24040.2 Different initiation. BC041013 mRNA Translation: AAH41013.2 Different initiation. AF151029 mRNA Translation: AAF36115.1 Frameshift.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS43370.1 [Q7LFL8-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001304128.1, NM_001317199.1 [Q7LFL8-1] NP_001304129.1, NM_001317200.1 [Q7LFL8-1] NP_001304130.1, NM_001317201.1 [Q7LFL8-1] NP_001304131.1, NM_001317202.1 [Q7LFL8-1] NP_001304132.1, NM_001317203.1 [Q7LFL8-1] NP_001304133.1, NM_001317204.1 [Q7LFL8-1] NP_001304134.1, NM_001317205.1 [Q7LFL8-1] NP_001304135.1, NM_001317206.1 [Q7LFL8-1] NP_001304136.1, NM_001317207.1 [Q7LFL8-1] NP_001304137.1, NM_001317208.1 [Q7LFL8-1] NP_001304138.1, NM_001317209.1 [Q7LFL8-1] NP_001304139.1, NM_001317210.1 [Q7LFL8-1] NP_001304140.1, NM_001317211.1 [Q7LFL8-1] NP_057547.5, NM_016463.8 [Q7LFL8-1] XP_016865062.1, XM_017009573.1
UniGeneⁱ	Hs.189119 Hs.744933

Genome annotation databases

Ensemblⁱ	ENST00000302517; ENSP00000302543; ENSG00000171604 [Q7LFL8-1] ENST00000511048; ENSP00000427379; ENSG00000171604 [Q7LFL8-1]
GeneIDⁱ	51523
KEGGⁱ	hsa:51523
UCSC genome browser More...UCSCⁱ	uc003let.3 human [Q7LFL8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7LFL8	CXXC finger protein 5		GORGO		322	UniRef100_Q7LFL8
Uncharacterized protein		PANPA		322
CXXC-type zinc finger protein 5 (Fragment)		HUMAN		83
CXXC-type zinc finger protein 5 (Fragment)		HUMAN		161
CXXC-type zinc finger protein 5 (Fragment)		HUMAN		196
+7
Q7LFL8-2	Uncharacterized protein		PAPAN		326	UniRef100_A0A096MRR2
CXXC finger 5 (Fragment)		MUSPF		208

Protein	Similar proteins		Species	Score	Length	Source
Q7LFL8	CXXC-type zinc finger protein 5		PONAB		322	UniRef90_Q7LFL8
CXXC-type zinc finger protein 5		BOVIN		317
CXXC-type zinc finger protein 5		MOUSE		317
CXXC-type zinc finger protein 5		RAT		316
CXXC finger protein 5		GORGO		322
+146

Protein	Similar proteins		Species	Score	Length	Source
Q7LFL8	CXXC-type zinc finger protein 5		PONAB		322	UniRef50_Q7LFL8
CXXC-type zinc finger protein 5		BOVIN		317
CXXC-type zinc finger protein 5		MOUSE		317
CXXC-type zinc finger protein 5		RAT		316
CXXC finger protein 5		GORGO		322
+148

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	GQ379202 mRNA Translation: ACU80469.1 AB097005 mRNA Translation: BAC77358.1 AB097032 mRNA Translation: BAC77385.1 AK001782 mRNA Translation: BAA91907.1 AK024338 mRNA Translation: BAG51292.1 AY007103 mRNA Translation: AAG01986.1 AC113361 Genomic DNA No translation available. CH471062 Genomic DNA Translation: EAW62090.1 CH471062 Genomic DNA Translation: EAW62091.1 CH471062 Genomic DNA Translation: EAW62092.1 CH471062 Genomic DNA Translation: EAW62093.1 BC002490 mRNA Translation: AAH02490.3 Different initiation. BC006428 mRNA Translation: AAH06428.1 Different initiation. BC017439 mRNA Translation: AAH17439.2 Different initiation. BC024040 mRNA Translation: AAH24040.2 Different initiation. BC041013 mRNA Translation: AAH41013.2 Different initiation. AF151029 mRNA Translation: AAF36115.1 Frameshift.
CCDSⁱ	CCDS43370.1 [Q7LFL8-1]
RefSeqⁱ	NP_001304128.1, NM_001317199.1 [Q7LFL8-1] NP_001304129.1, NM_001317200.1 [Q7LFL8-1] NP_001304130.1, NM_001317201.1 [Q7LFL8-1] NP_001304131.1, NM_001317202.1 [Q7LFL8-1] NP_001304132.1, NM_001317203.1 [Q7LFL8-1] NP_001304133.1, NM_001317204.1 [Q7LFL8-1] NP_001304134.1, NM_001317205.1 [Q7LFL8-1] NP_001304135.1, NM_001317206.1 [Q7LFL8-1] NP_001304136.1, NM_001317207.1 [Q7LFL8-1] NP_001304137.1, NM_001317208.1 [Q7LFL8-1] NP_001304138.1, NM_001317209.1 [Q7LFL8-1] NP_001304139.1, NM_001317210.1 [Q7LFL8-1] NP_001304140.1, NM_001317211.1 [Q7LFL8-1] NP_057547.5, NM_016463.8 [Q7LFL8-1] XP_016865062.1, XM_017009573.1
UniGeneⁱ	Hs.189119 Hs.744933

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5W9S	X-ray	2.10	C	254-306	[»]
ProteinModelPortalⁱ	Q7LFL8
SMRⁱ	Q7LFL8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119586, 9 interactors
IntActⁱ	Q7LFL8, 6 interactors
MINTⁱ	Q7LFL8
STRINGⁱ	9606.ENSP00000302543

PTM databases

iPTMnetⁱ	Q7LFL8
PhosphoSitePlusⁱ	Q7LFL8

Polymorphism and mutation databases

BioMutaⁱ	CXXC5
DMDMⁱ	167011303

Proteomic databases

EPDⁱ	Q7LFL8
MaxQBⁱ	Q7LFL8
PaxDbⁱ	Q7LFL8
PeptideAtlasⁱ	Q7LFL8
PRIDEⁱ	Q7LFL8
ProteomicsDBⁱ	68856 68857 [Q7LFL8-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51523
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000302517; ENSP00000302543; ENSG00000171604 [Q7LFL8-1] ENST00000511048; ENSP00000427379; ENSG00000171604 [Q7LFL8-1]
GeneIDⁱ	51523
KEGGⁱ	hsa:51523
UCSCⁱ	uc003let.3 human [Q7LFL8-1]

Organism-specific databases

CTDⁱ	51523
DisGeNETⁱ	51523
EuPathDBⁱ	HostDB:ENSG00000171604.11
GeneCardsⁱ	CXXC5
H-InvDBⁱ	HIX0005225
HGNCⁱ	HGNC:26943 CXXC5
HPAⁱ	HPA036508 HPA058148
MIMⁱ	612752 gene
neXtProtⁱ	NX_Q7LFL8
OpenTargetsⁱ	ENSG00000171604
PharmGKBⁱ	PA128394661
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGNJ Eukaryota ENOG4110UND LUCA
GeneTreeⁱ	ENSGT00910000144072
HOGENOMⁱ	HOG000112118
HOVERGENⁱ	HBG095668
InParanoidⁱ	Q7LFL8
KOⁱ	K22760
OMAⁱ	PMQNELA
OrthoDBⁱ	EOG091G0FYR
PhylomeDBⁱ	Q7LFL8
TreeFamⁱ	TF326617

Enzyme and pathway databases

Reactomeⁱ	R-HSA-9018519 Estrogen-dependent gene expression

Reactomeⁱ

R-HSA-9018519 Estrogen-dependent gene expression

Miscellaneous databases

ChiTaRSⁱ	CXXC5 human
GeneWikiⁱ	CXXC5
GenomeRNAiⁱ	51523
Protein Ontology More...PROⁱ	PR:Q7LFL8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171604 Expressed in 215 organ(s), highest expression level in cerebellum
CleanExⁱ	HS_CXXC5
ExpressionAtlasⁱ	Q7LFL8 baseline and differential
Genevisibleⁱ	Q7LFL8 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002857 Znf_CXXC
Pfamⁱ	View protein in Pfam PF02008 zf-CXXC, 1 hit
PROSITEⁱ	View protein in PROSITE PS51058 ZF_CXXC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXXC5_HUMAN
Accessionⁱ	Q7LFL8Primary (citable) accession number: Q7LFL8 Secondary accession number(s): B3KND0 , C8CBA8, Q8TB79, Q9NV51, Q9P0S8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
	Last sequence update:	April 17, 2007
	Last modified:	November 7, 2018
	This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

UniProtKB

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Supporting data

UniProtKB - Q7LFL8 (CXXC5_HUMAN)

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CXXC-type zinc finger protein 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ