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Entry version 119 (07 Apr 2021)
Sequence version 1 (17 Apr 2007)
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Protein

CXXC-type zinc finger protein 5

Gene

CXXC5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034).By similarity4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi263ZincCombined sources1 Publication1
Metal bindingi266ZincCombined sources1 Publication1
Metal bindingi269ZincCombined sources1 Publication1
Metal bindingi275ZincCombined sources1 Publication1
Metal bindingi278ZincCombined sources1 Publication1
Metal bindingi281ZincCombined sources1 Publication1
Metal bindingi291ZincCombined sources1 Publication1
Metal bindingi296ZincCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri256 – 297CXXC-typePROSITE-ProRule annotation1 PublicationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7LFL8

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9018519, Estrogen-dependent gene expression

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CXXC-type zinc finger protein 5
Short name:
CF5
Alternative name(s):
Putative MAPK-activating protein PM08
Putative NF-kappa-B-activating protein 102
Retinoid-inducible nuclear factor
Short name:
RINF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CXXC5
ORF Names:HSPC195, TCCCIA00297
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26943, CXXC5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612752, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7LFL8

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000171604.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51523

Open Targets

More...
OpenTargetsi
ENSG00000171604

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394661

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7LFL8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CXXC5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
167011303

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003175481 – 322CXXC-type zinc finger protein 5Add BLAST322

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei53PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7LFL8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7LFL8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7LFL8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7LFL8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7LFL8

PeptideAtlas

More...
PeptideAtlasi
Q7LFL8

PRoteomics IDEntifications database

More...
PRIDEi
Q7LFL8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68856 [Q7LFL8-1]
68857 [Q7LFL8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7LFL8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7LFL8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By retinoic acid.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171604, Expressed in cerebellum and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7LFL8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7LFL8, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000171604, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DVL1.

Interacts with RBPJ (PubMed:23303788).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119586, 11 interactors

Protein interaction database and analysis system

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IntActi
Q7LFL8, 9 interactors

Molecular INTeraction database

More...
MINTi
Q7LFL8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000302543

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7LFL8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1322
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7LFL8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi257 – 262Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi14 – 18Poly-Ser5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CXXC zinc finger mediates binding to CpG-DNA.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri256 – 297CXXC-typePROSITE-ProRule annotation1 PublicationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QT2M, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154108

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_074593_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7LFL8

Identification of Orthologs from Complete Genome Data

More...
OMAi
QYTAACP

Database of Orthologous Groups

More...
OrthoDBi
946583at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7LFL8

TreeFam database of animal gene trees

More...
TreeFami
TF326617

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040388, CXXC4/CXXC5
IPR002857, Znf_CXXC

The PANTHER Classification System

More...
PANTHERi
PTHR13419, PTHR13419, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02008, zf-CXXC, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51058, ZF_CXXC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7LFL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSLGGGSQD AGGSSSSSTN GSGGSGSSGP KAGAADKSAV VAAAAPASVA
60 70 80 90 100
DDTPPPERRN KSGIISEPLN KSLRRSRPLS HYSSFGSSGG SGGGSMMGGE
110 120 130 140 150
SADKATAAAA AASLLANGHD LAAAMAVDKS NPTSKHKSGA VASLLSKAER
160 170 180 190 200
ATELAAEGQL TLQQFAQSTE MLKRVVQEHL PLMSEAGAGL PDMEAVAGAE
210 220 230 240 250
ALNGQSDFPY LGAFPINPGL FIMTPAGVFL AESALHMAGL AEYPMQGELA
260 270 280 290 300
SAISSGKKKR KRCGMCAPCR RRINCEQCSS CRNRKTGHQI CKFRKCEELK
310 320
KKPSAALEKV MLPTGAAFRW FQ
Length:322
Mass (Da):32,977
Last modified:April 17, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECC19B4DE9872BC5
GO
Isoform 2 (identifier: Q7LFL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-95: Missing.

Show »
Length:227
Mass (Da):24,072
Checksum:i03146D66E6FC4E30
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EVI8E7EVI8_HUMAN
CXXC-type zinc finger protein 5
CXXC5
196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBE0D6RBE0_HUMAN
CXXC-type zinc finger protein 5
CXXC5
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R9V1D6R9V1_HUMAN
CXXC-type zinc finger protein 5
CXXC5
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHG9D6RHG9_HUMAN
CXXC-type zinc finger protein 5
CXXC5
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RDY2D6RDY2_HUMAN
CXXC-type zinc finger protein 5
CXXC5
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RHC6D6RHC6_HUMAN
CXXC-type zinc finger protein 5
CXXC5
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RIR8D6RIR8_HUMAN
CXXC-type zinc finger protein 5
CXXC5
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EV55E7EV55_HUMAN
CXXC-type zinc finger protein 5
CXXC5
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R966D6R966_HUMAN
CXXC-type zinc finger protein 5
CXXC5
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RCN9D6RCN9_HUMAN
CXXC-type zinc finger protein 5
CXXC5
68Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF36115 differs from that shown. Reason: Frameshift.Curated
The sequence AAH02490 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH06428 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH17439 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH24040 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH41013 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti111 – 112AA → WP in AAF36115 (PubMed:11042152).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0310131 – 95Missing in isoform 2. 2 PublicationsAdd BLAST95

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GQ379202 mRNA Translation: ACU80469.1
AB097005 mRNA Translation: BAC77358.1
AB097032 mRNA Translation: BAC77385.1
AK001782 mRNA Translation: BAA91907.1
AK024338 mRNA Translation: BAG51292.1
AY007103 mRNA Translation: AAG01986.1
AC113361 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62090.1
CH471062 Genomic DNA Translation: EAW62091.1
CH471062 Genomic DNA Translation: EAW62092.1
CH471062 Genomic DNA Translation: EAW62093.1
BC002490 mRNA Translation: AAH02490.3 Different initiation.
BC006428 mRNA Translation: AAH06428.1 Different initiation.
BC017439 mRNA Translation: AAH17439.2 Different initiation.
BC024040 mRNA Translation: AAH24040.2 Different initiation.
BC041013 mRNA Translation: AAH41013.2 Different initiation.
AF151029 mRNA Translation: AAF36115.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS43370.1 [Q7LFL8-1]

NCBI Reference Sequences

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RefSeqi
NP_001304128.1, NM_001317199.1 [Q7LFL8-1]
NP_001304129.1, NM_001317200.1 [Q7LFL8-1]
NP_001304130.1, NM_001317201.1 [Q7LFL8-1]
NP_001304131.1, NM_001317202.1 [Q7LFL8-1]
NP_001304132.1, NM_001317203.1 [Q7LFL8-1]
NP_001304133.1, NM_001317204.1 [Q7LFL8-1]
NP_001304134.1, NM_001317205.1 [Q7LFL8-1]
NP_001304135.1, NM_001317206.1 [Q7LFL8-1]
NP_001304136.1, NM_001317207.1 [Q7LFL8-1]
NP_001304137.1, NM_001317208.1 [Q7LFL8-1]
NP_001304138.1, NM_001317209.1 [Q7LFL8-1]
NP_001304139.1, NM_001317210.1 [Q7LFL8-1]
NP_001304140.1, NM_001317211.1 [Q7LFL8-1]
NP_057547.5, NM_016463.8 [Q7LFL8-1]
XP_016865062.1, XM_017009573.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000302517; ENSP00000302543; ENSG00000171604 [Q7LFL8-1]
ENST00000511048; ENSP00000427379; ENSG00000171604 [Q7LFL8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51523

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51523

UCSC genome browser

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UCSCi
uc003let.3, human [Q7LFL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GQ379202 mRNA Translation: ACU80469.1
AB097005 mRNA Translation: BAC77358.1
AB097032 mRNA Translation: BAC77385.1
AK001782 mRNA Translation: BAA91907.1
AK024338 mRNA Translation: BAG51292.1
AY007103 mRNA Translation: AAG01986.1
AC113361 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62090.1
CH471062 Genomic DNA Translation: EAW62091.1
CH471062 Genomic DNA Translation: EAW62092.1
CH471062 Genomic DNA Translation: EAW62093.1
BC002490 mRNA Translation: AAH02490.3 Different initiation.
BC006428 mRNA Translation: AAH06428.1 Different initiation.
BC017439 mRNA Translation: AAH17439.2 Different initiation.
BC024040 mRNA Translation: AAH24040.2 Different initiation.
BC041013 mRNA Translation: AAH41013.2 Different initiation.
AF151029 mRNA Translation: AAF36115.1 Frameshift.
CCDSiCCDS43370.1 [Q7LFL8-1]
RefSeqiNP_001304128.1, NM_001317199.1 [Q7LFL8-1]
NP_001304129.1, NM_001317200.1 [Q7LFL8-1]
NP_001304130.1, NM_001317201.1 [Q7LFL8-1]
NP_001304131.1, NM_001317202.1 [Q7LFL8-1]
NP_001304132.1, NM_001317203.1 [Q7LFL8-1]
NP_001304133.1, NM_001317204.1 [Q7LFL8-1]
NP_001304134.1, NM_001317205.1 [Q7LFL8-1]
NP_001304135.1, NM_001317206.1 [Q7LFL8-1]
NP_001304136.1, NM_001317207.1 [Q7LFL8-1]
NP_001304137.1, NM_001317208.1 [Q7LFL8-1]
NP_001304138.1, NM_001317209.1 [Q7LFL8-1]
NP_001304139.1, NM_001317210.1 [Q7LFL8-1]
NP_001304140.1, NM_001317211.1 [Q7LFL8-1]
NP_057547.5, NM_016463.8 [Q7LFL8-1]
XP_016865062.1, XM_017009573.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W9SX-ray2.10C254-306[»]
SMRiQ7LFL8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119586, 11 interactors
IntActiQ7LFL8, 9 interactors
MINTiQ7LFL8
STRINGi9606.ENSP00000302543

PTM databases

iPTMnetiQ7LFL8
PhosphoSitePlusiQ7LFL8

Genetic variation databases

BioMutaiCXXC5
DMDMi167011303

Proteomic databases

EPDiQ7LFL8
jPOSTiQ7LFL8
MassIVEiQ7LFL8
MaxQBiQ7LFL8
PaxDbiQ7LFL8
PeptideAtlasiQ7LFL8
PRIDEiQ7LFL8
ProteomicsDBi68856 [Q7LFL8-1]
68857 [Q7LFL8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
49849, 144 antibodies

The DNASU plasmid repository

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DNASUi
51523

Genome annotation databases

EnsembliENST00000302517; ENSP00000302543; ENSG00000171604 [Q7LFL8-1]
ENST00000511048; ENSP00000427379; ENSG00000171604 [Q7LFL8-1]
GeneIDi51523
KEGGihsa:51523
UCSCiuc003let.3, human [Q7LFL8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51523
DisGeNETi51523

GeneCards: human genes, protein and diseases

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GeneCardsi
CXXC5
HGNCiHGNC:26943, CXXC5
HPAiENSG00000171604, Tissue enhanced (brain)
MIMi612752, gene
neXtProtiNX_Q7LFL8
OpenTargetsiENSG00000171604
PharmGKBiPA128394661
VEuPathDBiHostDB:ENSG00000171604.11

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QT2M, Eukaryota
GeneTreeiENSGT00940000154108
HOGENOMiCLU_074593_0_0_1
InParanoidiQ7LFL8
OMAiQYTAACP
OrthoDBi946583at2759
PhylomeDBiQ7LFL8
TreeFamiTF326617

Enzyme and pathway databases

PathwayCommonsiQ7LFL8
ReactomeiR-HSA-9018519, Estrogen-dependent gene expression

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51523, 12 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CXXC5, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CXXC5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51523
PharosiQ7LFL8, Tbio

Protein Ontology

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PROi
PR:Q7LFL8
RNActiQ7LFL8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171604, Expressed in cerebellum and 227 other tissues
ExpressionAtlasiQ7LFL8, baseline and differential
GenevisibleiQ7LFL8, HS

Family and domain databases

InterProiView protein in InterPro
IPR040388, CXXC4/CXXC5
IPR002857, Znf_CXXC
PANTHERiPTHR13419, PTHR13419, 1 hit
PfamiView protein in Pfam
PF02008, zf-CXXC, 1 hit
PROSITEiView protein in PROSITE
PS51058, ZF_CXXC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCXXC5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7LFL8
Secondary accession number(s): B3KND0
, C8CBA8, Q8TB79, Q9NV51, Q9P0S8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: April 17, 2007
Last modified: April 7, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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