UniProtKB - Q7LFL8 (CXXC5_HUMAN)
Protein
CXXC-type zinc finger protein 5
Gene
CXXC5
Organism
Homo sapiens (Human)
Status
Functioni
May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034).By similarity4 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 263 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 266 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 269 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 275 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 278 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 281 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 291 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 296 | ZincCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 256 – 297 | CXXC-typePROSITE-ProRule annotation1 PublicationAdd BLAST | 42 |
GO - Molecular functioni
- methyl-CpG binding Source: UniProtKB
- sequence-specific DNA binding Source: UniProtKB
- transcription factor binding Source: UniProtKB
- zinc ion binding Source: UniProtKB
GO - Biological processi
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q7LFL8 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression |
Names & Taxonomyi
Protein namesi | Recommended name: CXXC-type zinc finger protein 5Short name: CF5 Alternative name(s): Putative MAPK-activating protein PM08 Putative NF-kappa-B-activating protein 102 Retinoid-inducible nuclear factor Short name: RINF |
Gene namesi | Name:CXXC5 ORF Names:HSPC195, TCCCIA00297 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26943, CXXC5 |
MIMi | 612752, gene |
neXtProti | NX_Q7LFL8 |
VEuPathDBi | HostDB:ENSG00000171604.11 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51523 |
OpenTargetsi | ENSG00000171604 |
PharmGKBi | PA128394661 |
Miscellaneous databases
Pharosi | Q7LFL8, Tbio |
Genetic variation databases
BioMutai | CXXC5 |
DMDMi | 167011303 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000317548 | 1 – 322 | CXXC-type zinc finger protein 5Add BLAST | 322 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 53 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q7LFL8 |
jPOSTi | Q7LFL8 |
MassIVEi | Q7LFL8 |
MaxQBi | Q7LFL8 |
PaxDbi | Q7LFL8 |
PeptideAtlasi | Q7LFL8 |
PRIDEi | Q7LFL8 |
ProteomicsDBi | 68856 [Q7LFL8-1] 68857 [Q7LFL8-2] |
PTM databases
iPTMneti | Q7LFL8 |
PhosphoSitePlusi | Q7LFL8 |
Expressioni
Inductioni
By retinoic acid.1 Publication
Gene expression databases
Bgeei | ENSG00000171604, Expressed in cerebellum and 227 other tissues |
ExpressionAtlasi | Q7LFL8, baseline and differential |
Genevisiblei | Q7LFL8, HS |
Organism-specific databases
HPAi | ENSG00000171604, Tissue enhanced (brain) |
Interactioni
Subunit structurei
GO - Molecular functioni
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119586, 11 interactors |
IntActi | Q7LFL8, 9 interactors |
MINTi | Q7LFL8 |
STRINGi | 9606.ENSP00000302543 |
Miscellaneous databases
RNActi | Q7LFL8, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q7LFL8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 257 – 262 | Nuclear localization signalSequence analysis | 6 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 18 | Poly-Ser | 5 |
Domaini
The CXXC zinc finger mediates binding to CpG-DNA.1 Publication
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 256 – 297 | CXXC-typePROSITE-ProRule annotation1 PublicationAdd BLAST | 42 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QT2M, Eukaryota |
GeneTreei | ENSGT00940000154108 |
HOGENOMi | CLU_074593_0_0_1 |
InParanoidi | Q7LFL8 |
OMAi | QYTAACP |
OrthoDBi | 946583at2759 |
PhylomeDBi | Q7LFL8 |
TreeFami | TF326617 |
Family and domain databases
InterProi | View protein in InterPro IPR040388, CXXC4/CXXC5 IPR002857, Znf_CXXC |
PANTHERi | PTHR13419, PTHR13419, 1 hit |
Pfami | View protein in Pfam PF02008, zf-CXXC, 1 hit |
PROSITEi | View protein in PROSITE PS51058, ZF_CXXC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7LFL8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSLGGGSQD AGGSSSSSTN GSGGSGSSGP KAGAADKSAV VAAAAPASVA
60 70 80 90 100
DDTPPPERRN KSGIISEPLN KSLRRSRPLS HYSSFGSSGG SGGGSMMGGE
110 120 130 140 150
SADKATAAAA AASLLANGHD LAAAMAVDKS NPTSKHKSGA VASLLSKAER
160 170 180 190 200
ATELAAEGQL TLQQFAQSTE MLKRVVQEHL PLMSEAGAGL PDMEAVAGAE
210 220 230 240 250
ALNGQSDFPY LGAFPINPGL FIMTPAGVFL AESALHMAGL AEYPMQGELA
260 270 280 290 300
SAISSGKKKR KRCGMCAPCR RRINCEQCSS CRNRKTGHQI CKFRKCEELK
310 320
KKPSAALEKV MLPTGAAFRW FQ
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EVI8 | E7EVI8_HUMAN | CXXC-type zinc finger protein 5 | CXXC5 | 196 | Annotation score: | ||
D6RBE0 | D6RBE0_HUMAN | CXXC-type zinc finger protein 5 | CXXC5 | 181 | Annotation score: | ||
D6R9V1 | D6R9V1_HUMAN | CXXC-type zinc finger protein 5 | CXXC5 | 102 | Annotation score: | ||
D6RHG9 | D6RHG9_HUMAN | CXXC-type zinc finger protein 5 | CXXC5 | 80 | Annotation score: | ||
D6RDY2 | D6RDY2_HUMAN | CXXC-type zinc finger protein 5 | CXXC5 | 161 | Annotation score: | ||
D6RHC6 | D6RHC6_HUMAN | CXXC-type zinc finger protein 5 | CXXC5 | 83 | Annotation score: | ||
D6RIR8 | D6RIR8_HUMAN | CXXC-type zinc finger protein 5 | CXXC5 | 98 | Annotation score: | ||
E7EV55 | E7EV55_HUMAN | CXXC-type zinc finger protein 5 | CXXC5 | 137 | Annotation score: | ||
D6R966 | D6R966_HUMAN | CXXC-type zinc finger protein 5 | CXXC5 | 73 | Annotation score: | ||
D6RCN9 | D6RCN9_HUMAN | CXXC-type zinc finger protein 5 | CXXC5 | 68 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence AAF36115 differs from that shown. Reason: Frameshift.Curated
The sequence AAH02490 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH06428 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH17439 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH24040 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH41013 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 111 – 112 | AA → WP in AAF36115 (PubMed:11042152).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_031013 | 1 – 95 | Missing in isoform 2. 2 PublicationsAdd BLAST | 95 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000302517; ENSP00000302543; ENSG00000171604 [Q7LFL8-1] ENST00000511048; ENSP00000427379; ENSG00000171604 [Q7LFL8-1] |
GeneIDi | 51523 |
KEGGi | hsa:51523 |
UCSCi | uc003let.3, human [Q7LFL8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5W9S | X-ray | 2.10 | C | 254-306 | [»] | |
SMRi | Q7LFL8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119586, 11 interactors |
IntActi | Q7LFL8, 9 interactors |
MINTi | Q7LFL8 |
STRINGi | 9606.ENSP00000302543 |
PTM databases
iPTMneti | Q7LFL8 |
PhosphoSitePlusi | Q7LFL8 |
Genetic variation databases
BioMutai | CXXC5 |
DMDMi | 167011303 |
Proteomic databases
EPDi | Q7LFL8 |
jPOSTi | Q7LFL8 |
MassIVEi | Q7LFL8 |
MaxQBi | Q7LFL8 |
PaxDbi | Q7LFL8 |
PeptideAtlasi | Q7LFL8 |
PRIDEi | Q7LFL8 |
ProteomicsDBi | 68856 [Q7LFL8-1] 68857 [Q7LFL8-2] |
Protocols and materials databases
Antibodypediai | 49849, 144 antibodies |
DNASUi | 51523 |
Genome annotation databases
Ensembli | ENST00000302517; ENSP00000302543; ENSG00000171604 [Q7LFL8-1] ENST00000511048; ENSP00000427379; ENSG00000171604 [Q7LFL8-1] |
GeneIDi | 51523 |
KEGGi | hsa:51523 |
UCSCi | uc003let.3, human [Q7LFL8-1] |
Organism-specific databases
CTDi | 51523 |
DisGeNETi | 51523 |
GeneCardsi | CXXC5 |
HGNCi | HGNC:26943, CXXC5 |
HPAi | ENSG00000171604, Tissue enhanced (brain) |
MIMi | 612752, gene |
neXtProti | NX_Q7LFL8 |
OpenTargetsi | ENSG00000171604 |
PharmGKBi | PA128394661 |
VEuPathDBi | HostDB:ENSG00000171604.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT2M, Eukaryota |
GeneTreei | ENSGT00940000154108 |
HOGENOMi | CLU_074593_0_0_1 |
InParanoidi | Q7LFL8 |
OMAi | QYTAACP |
OrthoDBi | 946583at2759 |
PhylomeDBi | Q7LFL8 |
TreeFami | TF326617 |
Enzyme and pathway databases
PathwayCommonsi | Q7LFL8 |
Reactomei | R-HSA-9018519, Estrogen-dependent gene expression |
Miscellaneous databases
BioGRID-ORCSi | 51523, 12 hits in 1001 CRISPR screens |
ChiTaRSi | CXXC5, human |
GeneWikii | CXXC5 |
GenomeRNAii | 51523 |
Pharosi | Q7LFL8, Tbio |
PROi | PR:Q7LFL8 |
RNActi | Q7LFL8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171604, Expressed in cerebellum and 227 other tissues |
ExpressionAtlasi | Q7LFL8, baseline and differential |
Genevisiblei | Q7LFL8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR040388, CXXC4/CXXC5 IPR002857, Znf_CXXC |
PANTHERi | PTHR13419, PTHR13419, 1 hit |
Pfami | View protein in Pfam PF02008, zf-CXXC, 1 hit |
PROSITEi | View protein in PROSITE PS51058, ZF_CXXC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CXXC5_HUMAN | |
Accessioni | Q7LFL8Primary (citable) accession number: Q7LFL8 Secondary accession number(s): B3KND0 Q9P0S8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 5, 2008 |
Last sequence update: | April 17, 2007 | |
Last modified: | April 7, 2021 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references