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Protein

Charged multivesicular body protein 1b

Gene

CHMP1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein domain specific binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Protein transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Charged multivesicular body protein 1b
Alternative name(s):
CHMP1.5
Chromatin-modifying protein 1b
Short name:
CHMP1b
Vacuolar protein sorting-associated protein 46-2
Short name:
Vps46-2
Short name:
hVps46-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CHMP1B
Synonyms:C18orf2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000255112.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24287 CHMP1B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606486 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7LBR1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi158 – 159DE → AA: Diminishes interaction with VPS4B. 1 Publication2
Mutagenesisi178T → R: Abolishes interaction with SPAST and no effect on interaction with VPS4A; when associated with R-181 and R-184. 1 Publication1
Mutagenesisi181A → R: Abolishes interaction with SPAScT and no effect on interaction with VPS4A; when associated with R-178 and R-184. 1 Publication1
Mutagenesisi184E → A: Decreases interaction with SPAST. 1 Publication1
Mutagenesisi184E → R: Abolishes interaction with SPAST and no effect on interaction with VPS4A; when associated with R-178 and R-181. 1 Publication1
Mutagenesisi188L → A: Abolishes interaction with SPAST and VPS4A; when associated with A-192. 1 Publication1
Mutagenesisi192L → A: Abolishes interaction with SPAST and VPS4A; when associated with A-188. 2 Publications1
Mutagenesisi192L → A: Abolishes interaction with VPS4B. 2 Publications1
Mutagenesisi195L → A: Abolishes interaction with VPS4B. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
57132

Open Targets

More...
OpenTargetsi
ENSG00000255112

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672110

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CHMP1B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
73917735

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002114541 – 199Charged multivesicular body protein 1bAdd BLAST199

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7LBR1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7LBR1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7LBR1

PeptideAtlas

More...
PeptideAtlasi
Q7LBR1

PRoteomics IDEntifications database

More...
PRIDEi
Q7LBR1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68850

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7LBR1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7LBR1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000255112 Expressed in 226 organ(s), highest expression level in gastrocnemius

CleanEx database of gene expression profiles

More...
CleanExi
HS_C18orf2
HS_CHMP1B

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7LBR1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA061997
HPA062896

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with CHMP1A. Interacts with VTA1; the interaction probably involves the open conformation of CHMP1B. Interacts with CHMP2A. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with SPAST (via MIT domain); the interaction is direct. Interacts with IST1. Interacts with MITD1. Interacts with STAMBP.11 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121394, 33 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-329 ESCRT-III complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q7LBR1

Database of interacting proteins

More...
DIPi
DIP-48534N

Protein interaction database and analysis system

More...
IntActi
Q7LBR1, 36 interactors

Molecular INTeraction database

More...
MINTi
Q7LBR1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000432279

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q7LBR1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7LBR1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7LBR1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni132 – 156Interaction with IST1Add BLAST25
Regioni174 – 199Interaction with SPAST1 PublicationAdd BLAST26
Regioni180 – 199Interaction with VTA1Add BLAST20
Regioni180 – 196Interaction with VPS4A, MITD1 and STAMBP1 PublicationAdd BLAST17
Regioni183 – 199Interaction with VPS4BAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili26 – 48Sequence analysisAdd BLAST23
Coiled coili178 – 199Sequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi186 – 196MIT-interacting motifAdd BLAST11

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3232 Eukaryota
COG5491 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000074957

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080200

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7LBR1

KEGG Orthology (KO)

More...
KOi
K12197

Identification of Orthologs from Complete Genome Data

More...
OMAi
DKAMESM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0S04

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7LBR1

TreeFam database of animal gene trees

More...
TreeFami
TF300076

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005024 Snf7_fam

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03357 Snf7, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7LBR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNMEKHLFN LKFAAKELSR SAKKCDKEEK AEKAKIKKAI QKGNMEVARI
60 70 80 90 100
HAENAIRQKN QAVNFLRMSA RVDAVAARVQ TAVTMGKVTK SMAGVVKSMD
110 120 130 140 150
ATLKTMNLEK ISALMDKFEH QFETLDVQTQ QMEDTMSSTT TLTTPQNQVD
160 170 180 190
MLLQEMADEA GLDLNMELPQ GQTGSVGTSV ASAEQDELSQ RLARLRDQV
Length:199
Mass (Da):22,109
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8071E94D20D85AB5
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG01449 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF306520 Genomic DNA Translation: AAL48200.1
AF281064 mRNA Translation: AAG01449.1 Different initiation.
BC065933 mRNA Translation: AAH65933.1
BC012733 mRNA Translation: AAH12733.3

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS54180.1

NCBI Reference Sequences

More...
RefSeqi
NP_065145.2, NM_020412.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.656244

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000526991; ENSP00000432279; ENSG00000255112

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57132

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57132

UCSC genome browser

More...
UCSCi
uc002kqe.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306520 Genomic DNA Translation: AAL48200.1
AF281064 mRNA Translation: AAG01449.1 Different initiation.
BC065933 mRNA Translation: AAH65933.1
BC012733 mRNA Translation: AAH12733.3
CCDSiCCDS54180.1
RefSeqiNP_065145.2, NM_020412.4
UniGeneiHs.656244

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EABX-ray2.50G/H/I/J/K/L148-197[»]
3JC1electron microscopy4.00Ab/Ad/Af/Ah/Aj/Al/An/Ap/Ar/At/Av/Ax/Az/Bb/Bd/Bf/Bh/Bj/Bl/Bn/Bp/Br/Bt/Bv/Bx/Bz/Cb/Cd/Cf/Ch4-163[»]
4TXQX-ray2.21C/D176-199[»]
4TXRX-ray1.00B176-199[»]
6E8Gelectron microscopy2.90AA/AB/B/CA/CB/D/EA/EB/F/GA/GB/H/IA/IB/J/KA/KB/L/MA/MB/N/OA/OB/P/QA/QB/R/SA/SB/T1-199[»]
ProteinModelPortaliQ7LBR1
SMRiQ7LBR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121394, 33 interactors
ComplexPortaliCPX-329 ESCRT-III complex
CORUMiQ7LBR1
DIPiDIP-48534N
IntActiQ7LBR1, 36 interactors
MINTiQ7LBR1
STRINGi9606.ENSP00000432279

PTM databases

iPTMnetiQ7LBR1
PhosphoSitePlusiQ7LBR1

Polymorphism and mutation databases

BioMutaiCHMP1B
DMDMi73917735

Proteomic databases

EPDiQ7LBR1
MaxQBiQ7LBR1
PaxDbiQ7LBR1
PeptideAtlasiQ7LBR1
PRIDEiQ7LBR1
ProteomicsDBi68850

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
57132
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000526991; ENSP00000432279; ENSG00000255112
GeneIDi57132
KEGGihsa:57132
UCSCiuc002kqe.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57132
DisGeNETi57132
EuPathDBiHostDB:ENSG00000255112.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CHMP1B
HGNCiHGNC:24287 CHMP1B
HPAiHPA061997
HPA062896
MIMi606486 gene
neXtProtiNX_Q7LBR1
OpenTargetsiENSG00000255112
PharmGKBiPA142672110

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3232 Eukaryota
COG5491 LUCA
GeneTreeiENSGT00550000074957
HOVERGENiHBG080200
InParanoidiQ7LBR1
KOiK12197
OMAiDKAMESM
OrthoDBiEOG091G0S04
PhylomeDBiQ7LBR1
TreeFamiTF300076

Miscellaneous databases

EvolutionaryTraceiQ7LBR1

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CHMP1B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57132

Protein Ontology

More...
PROi
PR:Q7LBR1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000255112 Expressed in 226 organ(s), highest expression level in gastrocnemius
CleanExiHS_C18orf2
HS_CHMP1B
GenevisibleiQ7LBR1 HS

Family and domain databases

InterProiView protein in InterPro
IPR005024 Snf7_fam
PfamiView protein in Pfam
PF03357 Snf7, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHM1B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7LBR1
Secondary accession number(s): Q96E89, Q9HD41
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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