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Protein

Charged multivesicular body protein 1b

Gene

CHMP1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release.2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein domain specific binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Charged multivesicular body protein 1b
Alternative name(s):
CHMP1.5
Chromatin-modifying protein 1b
Short name:
CHMP1b
Vacuolar protein sorting-associated protein 46-2
Short name:
Vps46-2
Short name:
hVps46-2
Gene namesi
Name:CHMP1B
Synonyms:C18orf2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000255112.2
HGNCiHGNC:24287 CHMP1B
MIMi606486 gene
neXtProtiNX_Q7LBR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi158 – 159DE → AA: Diminishes interaction with VPS4B. 1 Publication2
Mutagenesisi178T → R: Abolishes interaction with SPAST and no effect on interaction with VPS4A; when associated with R-181 and R-184. 1 Publication1
Mutagenesisi181A → R: Abolishes interaction with SPAScT and no effect on interaction with VPS4A; when associated with R-178 and R-184. 1 Publication1
Mutagenesisi184E → A: Decreases interaction with SPAST. 1 Publication1
Mutagenesisi184E → R: Abolishes interaction with SPAST and no effect on interaction with VPS4A; when associated with R-178 and R-181. 1 Publication1
Mutagenesisi188L → A: Abolishes interaction with SPAST and VPS4A; when associated with A-192. 1 Publication1
Mutagenesisi192L → A: Abolishes interaction with SPAST and VPS4A; when associated with A-188. 2 Publications1
Mutagenesisi192L → A: Abolishes interaction with VPS4B. 2 Publications1
Mutagenesisi195L → A: Abolishes interaction with VPS4B. 1 Publication1

Organism-specific databases

DisGeNETi57132
OpenTargetsiENSG00000255112
PharmGKBiPA142672110

Polymorphism and mutation databases

BioMutaiCHMP1B
DMDMi73917735

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002114541 – 199Charged multivesicular body protein 1bAdd BLAST199

Proteomic databases

EPDiQ7LBR1
MaxQBiQ7LBR1
PaxDbiQ7LBR1
PeptideAtlasiQ7LBR1
PRIDEiQ7LBR1
ProteomicsDBi68850

PTM databases

iPTMnetiQ7LBR1
PhosphoSitePlusiQ7LBR1

Expressioni

Tissue specificityi

Widely expressed. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta and brain.1 Publication

Gene expression databases

BgeeiENSG00000255112 Expressed in 226 organ(s), highest expression level in gastrocnemius
CleanExiHS_C18orf2
HS_CHMP1B
GenevisibleiQ7LBR1 HS

Organism-specific databases

HPAiHPA061997
HPA062896

Interactioni

Subunit structurei

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III). ESCRT-III components are thought to multimerize to form a flat lattice on the perimeter membrane of the endosome. Several assembly forms of ESCRT-III may exist that interact and act sequentially. Interacts with CHMP1A. Interacts with VTA1; the interaction probably involves the open conformation of CHMP1B. Interacts with CHMP2A. Interacts with VPS4A; the interaction is direct. Interacts with VPS4B; the interaction is direct. Interacts with SPAST (via MIT domain); the interaction is direct. Interacts with IST1. Interacts with MITD1. Interacts with STAMBP.11 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121394, 33 interactors
ComplexPortaliCPX-329 ESCRT-III complex
CORUMiQ7LBR1
DIPiDIP-48534N
IntActiQ7LBR1, 36 interactors
MINTiQ7LBR1
STRINGi9606.ENSP00000432279

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7LBR1
SMRiQ7LBR1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7LBR1

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni132 – 156Interaction with IST1Add BLAST25
Regioni174 – 199Interaction with SPAST1 PublicationAdd BLAST26
Regioni180 – 199Interaction with VTA1Add BLAST20
Regioni180 – 196Interaction with VPS4A, MITD1 and STAMBP1 PublicationAdd BLAST17
Regioni183 – 199Interaction with VPS4BAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili26 – 48Sequence analysisAdd BLAST23
Coiled coili178 – 199Sequence analysisAdd BLAST22

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi186 – 196MIT-interacting motifAdd BLAST11

Sequence similaritiesi

Belongs to the SNF7 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3232 Eukaryota
COG5491 LUCA
GeneTreeiENSGT00550000074957
HOVERGENiHBG080200
InParanoidiQ7LBR1
KOiK12197
OMAiDKAMESM
OrthoDBiEOG091G0S04
PhylomeDBiQ7LBR1
TreeFamiTF300076

Family and domain databases

InterProiView protein in InterPro
IPR005024 Snf7_fam
PfamiView protein in Pfam
PF03357 Snf7, 1 hit

Sequencei

Sequence statusi: Complete.

Q7LBR1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNMEKHLFN LKFAAKELSR SAKKCDKEEK AEKAKIKKAI QKGNMEVARI
60 70 80 90 100
HAENAIRQKN QAVNFLRMSA RVDAVAARVQ TAVTMGKVTK SMAGVVKSMD
110 120 130 140 150
ATLKTMNLEK ISALMDKFEH QFETLDVQTQ QMEDTMSSTT TLTTPQNQVD
160 170 180 190
MLLQEMADEA GLDLNMELPQ GQTGSVGTSV ASAEQDELSQ RLARLRDQV
Length:199
Mass (Da):22,109
Last modified:July 5, 2004 - v1
Checksum:i8071E94D20D85AB5
GO

Sequence cautioni

The sequence AAG01449 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306520 Genomic DNA Translation: AAL48200.1
AF281064 mRNA Translation: AAG01449.1 Different initiation.
BC065933 mRNA Translation: AAH65933.1
BC012733 mRNA Translation: AAH12733.3
CCDSiCCDS54180.1
RefSeqiNP_065145.2, NM_020412.4
UniGeneiHs.656244

Genome annotation databases

EnsembliENST00000526991; ENSP00000432279; ENSG00000255112
GeneIDi57132
KEGGihsa:57132
UCSCiuc002kqe.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF306520 Genomic DNA Translation: AAL48200.1
AF281064 mRNA Translation: AAG01449.1 Different initiation.
BC065933 mRNA Translation: AAH65933.1
BC012733 mRNA Translation: AAH12733.3
CCDSiCCDS54180.1
RefSeqiNP_065145.2, NM_020412.4
UniGeneiHs.656244

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3EABX-ray2.50G/H/I/J/K/L148-197[»]
3JC1electron microscopy4.00Ab/Ad/Af/Ah/Aj/Al/An/Ap/Ar/At/Av/Ax/Az/Bb/Bd/Bf/Bh/Bj/Bl/Bn/Bp/Br/Bt/Bv/Bx/Bz/Cb/Cd/Cf/Ch4-163[»]
4TXQX-ray2.21C/D176-199[»]
4TXRX-ray1.00B176-199[»]
ProteinModelPortaliQ7LBR1
SMRiQ7LBR1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121394, 33 interactors
ComplexPortaliCPX-329 ESCRT-III complex
CORUMiQ7LBR1
DIPiDIP-48534N
IntActiQ7LBR1, 36 interactors
MINTiQ7LBR1
STRINGi9606.ENSP00000432279

PTM databases

iPTMnetiQ7LBR1
PhosphoSitePlusiQ7LBR1

Polymorphism and mutation databases

BioMutaiCHMP1B
DMDMi73917735

Proteomic databases

EPDiQ7LBR1
MaxQBiQ7LBR1
PaxDbiQ7LBR1
PeptideAtlasiQ7LBR1
PRIDEiQ7LBR1
ProteomicsDBi68850

Protocols and materials databases

DNASUi57132
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000526991; ENSP00000432279; ENSG00000255112
GeneIDi57132
KEGGihsa:57132
UCSCiuc002kqe.4 human

Organism-specific databases

CTDi57132
DisGeNETi57132
EuPathDBiHostDB:ENSG00000255112.2
GeneCardsiCHMP1B
HGNCiHGNC:24287 CHMP1B
HPAiHPA061997
HPA062896
MIMi606486 gene
neXtProtiNX_Q7LBR1
OpenTargetsiENSG00000255112
PharmGKBiPA142672110
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3232 Eukaryota
COG5491 LUCA
GeneTreeiENSGT00550000074957
HOVERGENiHBG080200
InParanoidiQ7LBR1
KOiK12197
OMAiDKAMESM
OrthoDBiEOG091G0S04
PhylomeDBiQ7LBR1
TreeFamiTF300076

Miscellaneous databases

EvolutionaryTraceiQ7LBR1
GeneWikiiCHMP1B
GenomeRNAii57132
PROiPR:Q7LBR1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000255112 Expressed in 226 organ(s), highest expression level in gastrocnemius
CleanExiHS_C18orf2
HS_CHMP1B
GenevisibleiQ7LBR1 HS

Family and domain databases

InterProiView protein in InterPro
IPR005024 Snf7_fam
PfamiView protein in Pfam
PF03357 Snf7, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCHM1B_HUMAN
AccessioniPrimary (citable) accession number: Q7LBR1
Secondary accession number(s): Q96E89, Q9HD41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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