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Entry version 143 (02 Dec 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Solute carrier family 26 member 9

Gene

SLC26A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport (PubMed:11834742). Mediates chloride/bicarbonate exchange or chloride-independent bicarbonate extrusion thus assuring bicarbonate secretion (PubMed:15800055). May prefer chloride anions and mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane (By similarity).By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by ammonium and thiosulfate.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7LBE3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-427601, Multifunctional anion exchangers

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.53.2.15, the sulfate permease (sulp) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Solute carrier family 26 member 9
Alternative name(s):
Anion transporter/exchanger protein 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC26A9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
HostDB:ENSG00000174502.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14469, SLC26A9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608481, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7LBE3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 70CytoplasmicBy similarityAdd BLAST70
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei71 – 96HelicalBy similarityAdd BLAST26
Topological domaini97 – 100ExtracellularBy similarity4
Transmembranei101 – 109HelicalBy similarity9
Topological domaini110 – 129CytoplasmicBy similarityAdd BLAST20
Transmembranei130 – 142HelicalBy similarityAdd BLAST13
Topological domaini143 – 162ExtracellularBy similarityAdd BLAST20
Transmembranei163 – 191HelicalBy similarityAdd BLAST29
Topological domaini192 – 201CytoplasmicBy similarity10
Transmembranei202 – 224HelicalBy similarityAdd BLAST23
Topological domaini225 – 237ExtracellularBy similarityAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei238 – 246HelicalBy similarity9
Topological domaini247 – 254ExtracellularBy similarity8
Transmembranei255 – 275HelicalBy similarityAdd BLAST21
Topological domaini276 – 286CytoplasmicBy similarityAdd BLAST11
Transmembranei287 – 299HelicalBy similarityAdd BLAST13
Topological domaini300 – 334ExtracellularBy similarityAdd BLAST35
Transmembranei335 – 358HelicalBy similarityAdd BLAST24
Topological domaini359 – 365CytoplasmicBy similarity7
Transmembranei366 – 379HelicalBy similarityAdd BLAST14
Topological domaini380 – 390ExtracellularBy similarityAdd BLAST11
Transmembranei391 – 400HelicalBy similarity10
Topological domaini401 – 405CytoplasmicBy similarity5
Transmembranei406 – 419HelicalBy similarityAdd BLAST14
Topological domaini420 – 431ExtracellularBy similarityAdd BLAST12
Transmembranei432 – 457HelicalBy similarityAdd BLAST26
Topological domaini458 – 461CytoplasmicBy similarity4
Transmembranei462 – 476HelicalBy similarityAdd BLAST15
Topological domaini477 – 479ExtracellularBy similarity3
Transmembranei480 – 498HelicalBy similarityAdd BLAST19
Topological domaini499 – 791CytoplasmicBy similarityAdd BLAST293

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
115019

Open Targets

More...
OpenTargetsi
ENSG00000174502

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37886

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7LBE3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC26A9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749908

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003244921 – 791Solute carrier family 26 member 9Add BLAST791

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7LBE3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7LBE3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7LBE3

PeptideAtlas

More...
PeptideAtlasi
Q7LBE3

PRoteomics IDEntifications database

More...
PRIDEi
Q7LBE3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68849 [Q7LBE3-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7LBE3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7LBE3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in lung at the luminal side of the bronchiolar and alveolar epithelium of lung. To a lower extent, also expressed in pancreas and prostate.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000174502, Expressed in saliva-secreting gland and 117 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7LBE3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000174502, Tissue enriched (salivary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homodimers (in vitro).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
125409, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000356102

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7LBE3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7LBE3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini519 – 737STASPROSITE-ProRule annotationAdd BLAST219

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi290 – 293Poly-Val4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0236, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT01000000214410

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_003182_9_4_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7LBE3

Identification of Orthologs from Complete Genome Data

More...
OMAi
YHMDIVG

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7LBE3

TreeFam database of animal gene trees

More...
TreeFami
TF313784

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR030306, SLC26A9
IPR002645, STAS_dom
IPR036513, STAS_dom_sf

The PANTHER Classification System

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PANTHERi
PTHR11814, PTHR11814, 1 hit
PTHR11814:SF17, PTHR11814:SF17, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52091, SSF52091, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00815, sulP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50801, STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7LBE3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSQPRPRYVV DRAAYSLTLF DDEFEKKDRT YPVGEKLRNA FRCSSAKIKA
60 70 80 90 100
VVFGLLPVLS WLPKYKIKDY IIPDLLGGLS GGSIQVPQGM AFALLANLPA
110 120 130 140 150
VNGLYSSFFP LLTYFFLGGV HQMVPGTFAV ISILVGNICL QLAPESKFQV
160 170 180 190 200
FNNATNESYV DTAAMEAERL HVSATLACLT AIIQMGLGFM QFGFVAIYLS
210 220 230 240 250
ESFIRGFMTA AGLQILISVL KYIFGLTIPS YTGPGSIVFT FIDICKNLPH
260 270 280 290 300
TNIASLIFAL ISGAFLVLVK ELNARYMHKI RFPIPTEMIV VVVATAISGG
310 320 330 340 350
CKMPKKYHMQ IVGEIQRGFP TPVSPVVSQW KDMIGTAFSL AIVSYVINLA
360 370 380 390 400
MGRTLANKHG YDVDSNQEMI ALGCSNFFGS FFKIHVICCA LSVTLAVDGA
410 420 430 440 450
GGKSQVASLC VSLVVMITML VLGIYLYPLP KSVLGALIAV NLKNSLKQLT
460 470 480 490 500
DPYYLWRKSK LDCCIWVVSF LSSFFLSLPY GVAVGVAFSV LVVVFQTQFR
510 520 530 540 550
NGYALAQVMD TDIYVNPKTY NRAQDIQGIK IITYCSPLYF ANSEIFRQKV
560 570 580 590 600
IAKTGMDPQK VLLAKQKYLK KQEKRRMRPT QQRRSLFMKT KTVSLQELQQ
610 620 630 640 650
DFENAPPTDP NNNQTPANGT SVSYITFSPD SSSPAQSEPP ASAEAPGEPS
660 670 680 690 700
DMLASVPPFV TFHTLILDMS GVSFVDLMGI KALAKLSSTY GKIGVKVFLV
710 720 730 740 750
NIHAQVYNDI SHGGVFEDGS LECKHVFPSI HDAVLFAQAN ARDVTPGHNF
760 770 780 790
QGAPGDAELS LYDSEEDIRS YWDLEQEMFG SMFHAETLTA L
Length:791
Mass (Da):86,988
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC651F4E8DF2BF77
GO
Isoform 2 (identifier: Q7LBE3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     791-791: L → LESLSAAGGC...VSDGVRLSRT

Show »
Length:887
Mass (Da):97,288
Checksum:iFF83D3F708A6AD62
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti64K → N in AAI51209 (PubMed:15489334).Curated1
Isoform 2 (identifier: Q7LBE3-2)
Sequence conflicti804R → G in AAL26867 (Ref. 2) Curated1
Sequence conflicti804R → G in EAW91587 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06868370Y → N Displays higher channel activity and enhanced chloride-bicarbonate ion exchange. 1 PublicationCorresponds to variant dbSNP:rs75021701Ensembl.1
Natural variantiVAR_068684127T → N Results in smaller halide currents but not for thiocyanate ion. 1 PublicationCorresponds to variant dbSNP:rs77497889Ensembl.1
Natural variantiVAR_068685384I → T1 PublicationCorresponds to variant dbSNP:rs112659452Ensembl.1
Natural variantiVAR_068686575R → W1 PublicationCorresponds to variant dbSNP:rs201823199Ensembl.1
Natural variantiVAR_068687606P → L1 PublicationCorresponds to variant dbSNP:rs74146719Ensembl.1
Natural variantiVAR_068688622V → L Decreased plasma membrane expression which partially accounts for decreased whole cell currents; transport is reduced to about 50%. 1 PublicationCorresponds to variant dbSNP:rs34992672Ensembl.1
Natural variantiVAR_039801744V → M Decreased plasma membrane expression which partially accounts for decreased whole cell currents. 1 PublicationCorresponds to variant dbSNP:rs3811428Ensembl.1
Natural variantiVAR_039802748H → R1 PublicationCorresponds to variant dbSNP:rs16856462EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_054056791L → LESLSAAGGCYPYRSESLVS PLFTRQALAAMDKPPAHSTP PTSALSLAAEGHLDFQLLRV SQKQKDKYNCAGLLYKLQKV SQSPHGSVSDGVRLSRT in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF331525 mRNA Translation: AAK95667.1
AF314958 mRNA Translation: AAL26867.1
AL713965 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91587.1
CH471067 Genomic DNA Translation: EAW91588.1
BC136538 mRNA Translation: AAI36539.1
BC151208 mRNA Translation: AAI51209.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30989.1 [Q7LBE3-2]
CCDS30990.1 [Q7LBE3-1]

NCBI Reference Sequences

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RefSeqi
NP_443166.1, NM_052934.3 [Q7LBE3-1]
NP_599152.2, NM_134325.2 [Q7LBE3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000340781; ENSP00000341682; ENSG00000174502 [Q7LBE3-2]
ENST00000367134; ENSP00000356102; ENSG00000174502 [Q7LBE3-2]
ENST00000367135; ENSP00000356103; ENSG00000174502 [Q7LBE3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
115019

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:115019

UCSC genome browser

More...
UCSCi
uc001hdp.5, human [Q7LBE3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF331525 mRNA Translation: AAK95667.1
AF314958 mRNA Translation: AAL26867.1
AL713965 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91587.1
CH471067 Genomic DNA Translation: EAW91588.1
BC136538 mRNA Translation: AAI36539.1
BC151208 mRNA Translation: AAI51209.1
CCDSiCCDS30989.1 [Q7LBE3-2]
CCDS30990.1 [Q7LBE3-1]
RefSeqiNP_443166.1, NM_052934.3 [Q7LBE3-1]
NP_599152.2, NM_134325.2 [Q7LBE3-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
7CH1electron microscopy2.60A/B1-791[»]
SMRiQ7LBE3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi125409, 2 interactors
STRINGi9606.ENSP00000356102

Protein family/group databases

TCDBi2.A.53.2.15, the sulfate permease (sulp) family

PTM databases

iPTMnetiQ7LBE3
PhosphoSitePlusiQ7LBE3

Polymorphism and mutation databases

BioMutaiSLC26A9
DMDMi74749908

Proteomic databases

EPDiQ7LBE3
MassIVEiQ7LBE3
PaxDbiQ7LBE3
PeptideAtlasiQ7LBE3
PRIDEiQ7LBE3
ProteomicsDBi68849 [Q7LBE3-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
34575, 46 antibodies

Genome annotation databases

EnsembliENST00000340781; ENSP00000341682; ENSG00000174502 [Q7LBE3-2]
ENST00000367134; ENSP00000356102; ENSG00000174502 [Q7LBE3-2]
ENST00000367135; ENSP00000356103; ENSG00000174502 [Q7LBE3-1]
GeneIDi115019
KEGGihsa:115019
UCSCiuc001hdp.5, human [Q7LBE3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
115019
DisGeNETi115019
EuPathDBiHostDB:ENSG00000174502.18

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC26A9
HGNCiHGNC:14469, SLC26A9
HPAiENSG00000174502, Tissue enriched (salivary)
MIMi608481, gene
neXtProtiNX_Q7LBE3
OpenTargetsiENSG00000174502
PharmGKBiPA37886

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0236, Eukaryota
GeneTreeiENSGT01000000214410
HOGENOMiCLU_003182_9_4_1
InParanoidiQ7LBE3
OMAiYHMDIVG
PhylomeDBiQ7LBE3
TreeFamiTF313784

Enzyme and pathway databases

PathwayCommonsiQ7LBE3
ReactomeiR-HSA-427601, Multifunctional anion exchangers

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
115019, 4 hits in 847 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
115019
PharosiQ7LBE3, Tbio

Protein Ontology

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PROi
PR:Q7LBE3
RNActiQ7LBE3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000174502, Expressed in saliva-secreting gland and 117 other tissues
GenevisibleiQ7LBE3, HS

Family and domain databases

InterProiView protein in InterPro
IPR011547, SLC26A/SulP_dom
IPR001902, SLC26A/SulP_fam
IPR030306, SLC26A9
IPR002645, STAS_dom
IPR036513, STAS_dom_sf
PANTHERiPTHR11814, PTHR11814, 1 hit
PTHR11814:SF17, PTHR11814:SF17, 1 hit
PfamiView protein in Pfam
PF01740, STAS, 1 hit
PF00916, Sulfate_transp, 1 hit
SUPFAMiSSF52091, SSF52091, 1 hit
TIGRFAMsiTIGR00815, sulP, 1 hit
PROSITEiView protein in PROSITE
PS50801, STAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS26A9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7LBE3
Secondary accession number(s): A7E2V6
, B1AVM8, B1AVM9, B7ZKK2, Q96PK9, Q96RN0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: December 2, 2020
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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