Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MOB kinase activator 1B

Gene

MOB1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79ZincBy similarity1
Metal bindingi84ZincBy similarity1
Metal bindingi161ZincBy similarity1
Metal bindingi166ZincBy similarity1

GO - Molecular functioni

  • kinase activator activity Source: UniProtKB
  • kinase binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-2028269 Signaling by Hippo
SIGNORiQ7L9L4

Names & Taxonomyi

Protein namesi
Recommended name:
MOB kinase activator 1B
Alternative name(s):
Mob1 homolog 1A
Short name:
Mob1A
Mob1B
Mps one binder kinase activator-like 1A
Gene namesi
Name:MOB1B
Synonyms:MOB4A, MOBKL1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000173542.8
HGNCiHGNC:29801 MOB1B
MIMi609282 gene
neXtProtiNX_Q7L9L4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi92597
OpenTargetsiENSG00000173542
PharmGKBiPA134871841

Polymorphism and mutation databases

BioMutaiMOB1B
DMDMi56749324

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001935642 – 216MOB kinase activator 1BAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei12Phosphothreonine; by STK4/MST11 Publication1
Modified residuei35Phosphothreonine; by STK4/MST11 Publication1

Post-translational modificationi

Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ7L9L4
MaxQBiQ7L9L4
PaxDbiQ7L9L4
PeptideAtlasiQ7L9L4
PRIDEiQ7L9L4
ProteomicsDBi68845

PTM databases

iPTMnetiQ7L9L4
PhosphoSitePlusiQ7L9L4

Expressioni

Tissue specificityi

Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.1 Publication

Gene expression databases

BgeeiENSG00000173542 Expressed in 208 organ(s), highest expression level in renal medulla
CleanExiHS_MOBKL1A
ExpressionAtlasiQ7L9L4 baseline and differential
GenevisibleiQ7L9L4 HS

Organism-specific databases

HPAiHPA047088
HPA071690

Interactioni

Subunit structurei

Binds STK38L. Interacts with LATS1 and LATS2.2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124960, 39 interactors
IntActiQ7L9L4, 38 interactors
MINTiQ7L9L4
STRINGi9606.ENSP00000310189

Structurei

3D structure databases

ProteinModelPortaliQ7L9L4
SMRiQ7L9L4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG0440 Eukaryota
ENOG410XSUJ LUCA
GeneTreeiENSGT00550000074456
HOGENOMiHOG000164685
HOVERGENiHBG052489
InParanoidiQ7L9L4
KOiK06685
OMAiDFFNHLN
OrthoDBiEOG091G0LDA
PhylomeDBiQ7L9L4
TreeFamiTF300789

Family and domain databases

Gene3Di1.20.140.30, 1 hit
InterProiView protein in InterPro
IPR005301 MOB_kinase_act_fam
IPR036703 MOB_kinase_act_sf
PANTHERiPTHR22599 PTHR22599, 1 hit
PfamiView protein in Pfam
PF03637 Mob1_phocein, 1 hit
SMARTiView protein in SMART
SM01388 Mob1_phocein, 1 hit
SUPFAMiSSF101152 SSF101152, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7L9L4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG
60 70 80 90 100
EDLNEWVAVN TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG
110 120 130 140 150
TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT
160 170 180 190 200
ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN TSFKHFIFFV QEFNLIDRRE
210
LAPLQELIEK LTSKDR
Length:216
Mass (Da):25,091
Last modified:January 23, 2007 - v3
Checksum:i29EBA287B0CDAF90
GO
Isoform 2 (identifier: Q7L9L4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MSFLF → MEGATDVNES

Show »
Length:221
Mass (Da):25,499
Checksum:i4DF1286311C0BC5F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCK3D6RCK3_HUMAN
MOB kinase activator 1B
MOB1B
130Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0450971 – 5MSFLF → MEGATDVNES in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ577473 mRNA Translation: CAE12091.1
AK299481 mRNA Translation: BAG61445.1
AK313513 mRNA Translation: BAG36293.1
AC021989 Genomic DNA No translation available.
AC093851 Genomic DNA No translation available.
AC108014 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05636.1
BC038112 mRNA Translation: AAH38112.1
CCDSiCCDS34002.1 [Q7L9L4-1]
CCDS58903.1 [Q7L9L4-2]
RefSeqiNP_001231695.1, NM_001244766.1 [Q7L9L4-2]
NP_775739.1, NM_173468.3 [Q7L9L4-1]
XP_005265766.1, XM_005265709.2 [Q7L9L4-2]
UniGeneiHs.691454
Hs.744715

Genome annotation databases

EnsembliENST00000309395; ENSP00000310189; ENSG00000173542 [Q7L9L4-1]
ENST00000396051; ENSP00000379366; ENSG00000173542 [Q7L9L4-2]
GeneIDi92597
KEGGihsa:92597
UCSCiuc003hfw.4 human [Q7L9L4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ577473 mRNA Translation: CAE12091.1
AK299481 mRNA Translation: BAG61445.1
AK313513 mRNA Translation: BAG36293.1
AC021989 Genomic DNA No translation available.
AC093851 Genomic DNA No translation available.
AC108014 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX05636.1
BC038112 mRNA Translation: AAH38112.1
CCDSiCCDS34002.1 [Q7L9L4-1]
CCDS58903.1 [Q7L9L4-2]
RefSeqiNP_001231695.1, NM_001244766.1 [Q7L9L4-2]
NP_775739.1, NM_173468.3 [Q7L9L4-1]
XP_005265766.1, XM_005265709.2 [Q7L9L4-2]
UniGeneiHs.691454
Hs.744715

3D structure databases

ProteinModelPortaliQ7L9L4
SMRiQ7L9L4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124960, 39 interactors
IntActiQ7L9L4, 38 interactors
MINTiQ7L9L4
STRINGi9606.ENSP00000310189

PTM databases

iPTMnetiQ7L9L4
PhosphoSitePlusiQ7L9L4

Polymorphism and mutation databases

BioMutaiMOB1B
DMDMi56749324

Proteomic databases

EPDiQ7L9L4
MaxQBiQ7L9L4
PaxDbiQ7L9L4
PeptideAtlasiQ7L9L4
PRIDEiQ7L9L4
ProteomicsDBi68845

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309395; ENSP00000310189; ENSG00000173542 [Q7L9L4-1]
ENST00000396051; ENSP00000379366; ENSG00000173542 [Q7L9L4-2]
GeneIDi92597
KEGGihsa:92597
UCSCiuc003hfw.4 human [Q7L9L4-1]

Organism-specific databases

CTDi92597
DisGeNETi92597
EuPathDBiHostDB:ENSG00000173542.8
GeneCardsiMOB1B
HGNCiHGNC:29801 MOB1B
HPAiHPA047088
HPA071690
MIMi609282 gene
neXtProtiNX_Q7L9L4
OpenTargetsiENSG00000173542
PharmGKBiPA134871841
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0440 Eukaryota
ENOG410XSUJ LUCA
GeneTreeiENSGT00550000074456
HOGENOMiHOG000164685
HOVERGENiHBG052489
InParanoidiQ7L9L4
KOiK06685
OMAiDFFNHLN
OrthoDBiEOG091G0LDA
PhylomeDBiQ7L9L4
TreeFamiTF300789

Enzyme and pathway databases

ReactomeiR-HSA-2028269 Signaling by Hippo
SIGNORiQ7L9L4

Miscellaneous databases

ChiTaRSiMOB1B human
GeneWikiiMOBKL1A
GenomeRNAii92597
PROiPR:Q7L9L4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173542 Expressed in 208 organ(s), highest expression level in renal medulla
CleanExiHS_MOBKL1A
ExpressionAtlasiQ7L9L4 baseline and differential
GenevisibleiQ7L9L4 HS

Family and domain databases

Gene3Di1.20.140.30, 1 hit
InterProiView protein in InterPro
IPR005301 MOB_kinase_act_fam
IPR036703 MOB_kinase_act_sf
PANTHERiPTHR22599 PTHR22599, 1 hit
PfamiView protein in Pfam
PF03637 Mob1_phocein, 1 hit
SMARTiView protein in SMART
SM01388 Mob1_phocein, 1 hit
SUPFAMiSSF101152 SSF101152, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMOB1B_HUMAN
AccessioniPrimary (citable) accession number: Q7L9L4
Secondary accession number(s): B2R8U6, B4DRY3, Q8IY23
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again