UniProtKB - Q7L9L4 (MOB1B_HUMAN)
Protein
MOB kinase activator 1B
Gene
MOB1B
Organism
Homo sapiens (Human)
Status
Functioni
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 79 | ZincBy similarity | 1 | |
Metal bindingi | 84 | ZincBy similarity | 1 | |
Metal bindingi | 161 | ZincBy similarity | 1 | |
Metal bindingi | 166 | ZincBy similarity | 1 |
GO - Molecular functioni
- kinase activator activity Source: UniProtKB
- kinase binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- hippo signaling Source: UniProtKB
- regulation of protein autophosphorylation Source: UniProtKB
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q7L9L4 |
Reactomei | R-HSA-2028269, Signaling by Hippo |
SIGNORi | Q7L9L4 |
Names & Taxonomyi
Protein namesi | Recommended name: MOB kinase activator 1BAlternative name(s): Mob1 homolog 1A Short name: Mob1A Mob1B Mps one binder kinase activator-like 1A |
Gene namesi | Name:MOB1B Synonyms:MOB4A, MOBKL1A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000173542.8 |
HGNCi | HGNC:29801, MOB1B |
MIMi | 609282, gene |
neXtProti | NX_Q7L9L4 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 92597 |
OpenTargetsi | ENSG00000173542 |
PharmGKBi | PA134871841 |
Miscellaneous databases
Pharosi | Q7L9L4, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295878 |
Polymorphism and mutation databases
BioMutai | MOB1B |
DMDMi | 56749324 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000193564 | 2 – 216 | MOB kinase activator 1BAdd BLAST | 215 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 12 | Phosphothreonine; by STK4/MST11 Publication | 1 | |
Modified residuei | 35 | Phosphothreonine; by STK4/MST11 Publication | 1 |
Post-translational modificationi
Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q7L9L4 |
jPOSTi | Q7L9L4 |
MassIVEi | Q7L9L4 |
MaxQBi | Q7L9L4 |
PaxDbi | Q7L9L4 |
PeptideAtlasi | Q7L9L4 |
PRIDEi | Q7L9L4 |
ProteomicsDBi | 4978 68845 [Q7L9L4-1] |
PTM databases
iPTMneti | Q7L9L4 |
PhosphoSitePlusi | Q7L9L4 |
Expressioni
Tissue specificityi
Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.1 Publication
Gene expression databases
Bgeei | ENSG00000173542, Expressed in renal medulla and 222 other tissues |
ExpressionAtlasi | Q7L9L4, baseline and differential |
Genevisiblei | Q7L9L4, HS |
Organism-specific databases
HPAi | ENSG00000173542, Low tissue specificity |
Interactioni
Subunit structurei
Binds STK38L.
Interacts with LATS1 and LATS2.
2 PublicationsBinary interactionsi
Hide detailsQ7L9L4
GO - Molecular functioni
- kinase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 124960, 40 interactors |
IntActi | Q7L9L4, 40 interactors |
MINTi | Q7L9L4 |
STRINGi | 9606.ENSP00000379366 |
Miscellaneous databases
RNActi | Q7L9L4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the MOB1/phocein family.Curated
Phylogenomic databases
eggNOGi | KOG0440, Eukaryota |
GeneTreei | ENSGT01000000214382 |
HOGENOMi | CLU_038321_3_2_1 |
InParanoidi | Q7L9L4 |
OMAi | ECPIMSA |
OrthoDBi | 1127941at2759 |
PhylomeDBi | Q7L9L4 |
TreeFami | TF300789 |
Family and domain databases
Gene3Di | 1.20.140.30, 1 hit |
InterProi | View protein in InterPro IPR005301, MOB_kinase_act_fam IPR036703, MOB_kinase_act_sf |
PANTHERi | PTHR22599, PTHR22599, 1 hit |
Pfami | View protein in Pfam PF03637, Mob1_phocein, 1 hit |
SMARTi | View protein in SMART SM01388, Mob1_phocein, 1 hit |
SUPFAMi | SSF101152, SSF101152, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7L9L4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG
60 70 80 90 100
EDLNEWVAVN TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG
110 120 130 140 150
TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT
160 170 180 190 200
ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN TSFKHFIFFV QEFNLIDRRE
210
LAPLQELIEK LTSKDR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD6RCK3 | D6RCK3_HUMAN | MOB kinase activator 1B | MOB1B | 130 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045097 | 1 – 5 | MSFLF → MEGATDVNES in isoform 2. 1 Publication | 5 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ577473 mRNA Translation: CAE12091.1 AK299481 mRNA Translation: BAG61445.1 AK313513 mRNA Translation: BAG36293.1 AC021989 Genomic DNA No translation available. AC093851 Genomic DNA No translation available. AC108014 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05636.1 BC038112 mRNA Translation: AAH38112.1 |
CCDSi | CCDS34002.1 [Q7L9L4-1] CCDS58903.1 [Q7L9L4-2] |
RefSeqi | NP_001231695.1, NM_001244766.1 [Q7L9L4-2] NP_775739.1, NM_173468.3 [Q7L9L4-1] XP_005265766.1, XM_005265709.2 [Q7L9L4-2] |
Genome annotation databases
Ensembli | ENST00000309395; ENSP00000310189; ENSG00000173542 [Q7L9L4-1] ENST00000396051; ENSP00000379366; ENSG00000173542 [Q7L9L4-2] |
GeneIDi | 92597 |
KEGGi | hsa:92597 |
UCSCi | uc003hfw.4, human [Q7L9L4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ577473 mRNA Translation: CAE12091.1 AK299481 mRNA Translation: BAG61445.1 AK313513 mRNA Translation: BAG36293.1 AC021989 Genomic DNA No translation available. AC093851 Genomic DNA No translation available. AC108014 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05636.1 BC038112 mRNA Translation: AAH38112.1 |
CCDSi | CCDS34002.1 [Q7L9L4-1] CCDS58903.1 [Q7L9L4-2] |
RefSeqi | NP_001231695.1, NM_001244766.1 [Q7L9L4-2] NP_775739.1, NM_173468.3 [Q7L9L4-1] XP_005265766.1, XM_005265709.2 [Q7L9L4-2] |
3D structure databases
SMRi | Q7L9L4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124960, 40 interactors |
IntActi | Q7L9L4, 40 interactors |
MINTi | Q7L9L4 |
STRINGi | 9606.ENSP00000379366 |
Chemistry databases
ChEMBLi | CHEMBL4295878 |
PTM databases
iPTMneti | Q7L9L4 |
PhosphoSitePlusi | Q7L9L4 |
Polymorphism and mutation databases
BioMutai | MOB1B |
DMDMi | 56749324 |
Proteomic databases
EPDi | Q7L9L4 |
jPOSTi | Q7L9L4 |
MassIVEi | Q7L9L4 |
MaxQBi | Q7L9L4 |
PaxDbi | Q7L9L4 |
PeptideAtlasi | Q7L9L4 |
PRIDEi | Q7L9L4 |
ProteomicsDBi | 4978 68845 [Q7L9L4-1] |
Protocols and materials databases
Antibodypediai | 24395, 363 antibodies |
Genome annotation databases
Ensembli | ENST00000309395; ENSP00000310189; ENSG00000173542 [Q7L9L4-1] ENST00000396051; ENSP00000379366; ENSG00000173542 [Q7L9L4-2] |
GeneIDi | 92597 |
KEGGi | hsa:92597 |
UCSCi | uc003hfw.4, human [Q7L9L4-1] |
Organism-specific databases
CTDi | 92597 |
DisGeNETi | 92597 |
EuPathDBi | HostDB:ENSG00000173542.8 |
GeneCardsi | MOB1B |
HGNCi | HGNC:29801, MOB1B |
HPAi | ENSG00000173542, Low tissue specificity |
MIMi | 609282, gene |
neXtProti | NX_Q7L9L4 |
OpenTargetsi | ENSG00000173542 |
PharmGKBi | PA134871841 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0440, Eukaryota |
GeneTreei | ENSGT01000000214382 |
HOGENOMi | CLU_038321_3_2_1 |
InParanoidi | Q7L9L4 |
OMAi | ECPIMSA |
OrthoDBi | 1127941at2759 |
PhylomeDBi | Q7L9L4 |
TreeFami | TF300789 |
Enzyme and pathway databases
PathwayCommonsi | Q7L9L4 |
Reactomei | R-HSA-2028269, Signaling by Hippo |
SIGNORi | Q7L9L4 |
Miscellaneous databases
BioGRID-ORCSi | 92597, 8 hits in 849 CRISPR screens |
ChiTaRSi | MOB1B, human |
GeneWikii | MOBKL1A |
GenomeRNAii | 92597 |
Pharosi | Q7L9L4, Tbio |
PROi | PR:Q7L9L4 |
RNActi | Q7L9L4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173542, Expressed in renal medulla and 222 other tissues |
ExpressionAtlasi | Q7L9L4, baseline and differential |
Genevisiblei | Q7L9L4, HS |
Family and domain databases
Gene3Di | 1.20.140.30, 1 hit |
InterProi | View protein in InterPro IPR005301, MOB_kinase_act_fam IPR036703, MOB_kinase_act_sf |
PANTHERi | PTHR22599, PTHR22599, 1 hit |
Pfami | View protein in Pfam PF03637, Mob1_phocein, 1 hit |
SMARTi | View protein in SMART SM01388, Mob1_phocein, 1 hit |
SUPFAMi | SSF101152, SSF101152, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MOB1B_HUMAN | |
Accessioni | Q7L9L4Primary (citable) accession number: Q7L9L4 Secondary accession number(s): B2R8U6, B4DRY3, Q8IY23 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families