MOB1B

Functionⁱ

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	79	ZincBy similarity	1
Metal bindingⁱ	84	ZincBy similarity	1
Metal bindingⁱ	161	ZincBy similarity	1
Metal bindingⁱ	166	ZincBy similarity	1

GO - Molecular functionⁱ

kinase activator activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15197186
kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15197186
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

hippo signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 19739119
regulation of protein autophosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 15197186

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2028269 Signaling by Hippo
SIGNORⁱ	Q7L9L4

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: MOB kinase activator 1B Alternative name(s): Mob1 homolog 1A Short name: Mob1A Mob1B Mps one binder kinase activator-like 1A
Gene namesⁱ	Name:MOB1B Synonyms:MOB4A, MOBKL1A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173542.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29801 MOB1B
MIMⁱ	609282 gene
neXtProtⁱ	NX_Q7L9L4

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	92597
Open Targets More...OpenTargetsⁱ	ENSG00000173542
PharmGKBⁱ	PA134871841

Polymorphism and mutation databases

BioMutaⁱ	MOB1B
DMDMⁱ	56749324

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000193564	2 – 216	MOB kinase activator 1BAdd BLAST		215

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylserineCombined sources	1
Modified residueⁱ	12	Phosphothreonine; by STK4/MST11 Publication	1
Modified residueⁱ	35	Phosphothreonine; by STK4/MST11 Publication	1

Post-translational modificationⁱ

Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q7L9L4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7L9L4
PaxDbⁱ	Q7L9L4
PeptideAtlas More...PeptideAtlasⁱ	Q7L9L4
PRIDEⁱ	Q7L9L4
ProteomicsDBⁱ	68845

PTM databases

iPTMnetⁱ	Q7L9L4
PhosphoSitePlusⁱ	Q7L9L4

Expressionⁱ

Tissue specificityⁱ

Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000173542 Expressed in 208 organ(s), highest expression level in renal medulla
CleanExⁱ	HS_MOBKL1A
ExpressionAtlasⁱ	Q7L9L4 baseline and differential
Genevisibleⁱ	Q7L9L4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047088 HPA071690

HPAⁱ

HPA047088
HPA071690

Interactionⁱ

Subunit structureⁱ

Binds STK38L. Interacts with LATS1 and LATS2.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
LATS1	O95835	6	EBI-2558745,EBI-444209
LATS2	Q9NRM7	3	EBI-2558745,EBI-3506895
NT5C2	P49902	3	EBI-2558745,EBI-742084
STK3	Q13188	4	EBI-2558745,EBI-992580
STK4	Q13043	4	EBI-2558745,EBI-367376
TNIP1	Q15025	3	EBI-2558745,EBI-357849
WASHC3	Q9Y3C0	3	EBI-2558745,EBI-712969

GO - Molecular functionⁱ

kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15197186

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	124960, 39 interactors
IntActⁱ	Q7L9L4, 38 interactors
Molecular INTeraction database More...MINTⁱ	Q7L9L4
STRINGⁱ	9606.ENSP00000310189

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7L9L4
SMRⁱ	Q7L9L4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0440 Eukaryota ENOG410XSUJ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074456
HOGENOMⁱ	HOG000164685
HOVERGENⁱ	HBG052489
InParanoidⁱ	Q7L9L4
KEGG Orthology (KO) More...KOⁱ	K06685
OMAⁱ	DFFNHLN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0LDA
PhylomeDBⁱ	Q7L9L4
TreeFamⁱ	TF300789

Family and domain databases

Gene3Dⁱ	1.20.140.30, 1 hit
InterProⁱ	View protein in InterPro IPR005301 MOB_kinase_act_fam IPR036703 MOB_kinase_act_sf
PANTHERⁱ	PTHR22599 PTHR22599, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03637 Mob1_phocein, 1 hit
SMARTⁱ	View protein in SMART SM01388 Mob1_phocein, 1 hit
SUPFAMⁱ	SSF101152 SSF101152, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q7L9L4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFLFGSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRMAVMLPEG 
        60         70         80         90        100
EDLNEWVAVN TVDFFNQINM LYGTITDFCT EESCPVMSAG PKYEYHWADG 
       110        120        130        140        150
TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT 
       160        170        180        190        200
ILKRLFRVYA HIYHQHFDPV IQLQEEAHLN TSFKHFIFFV QEFNLIDRRE 
       210 
LAPLQELIEK LTSKDR

Length:216

Mass (Da):25,091

Last modified:January 23, 2007 - v3

Checksum:ⁱ29EBA287B0CDAF90

GO

Isoform 2 (identifier: Q7L9L4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-5: MSFLF → MEGATDVNES

« Hide

        10         20         30         40         50
MEGATDVNES GSRSSKTFKP KKNIPEGSHQ YELLKHAEAT LGSGNLRMAV 
        60         70         80         90        100
MLPEGEDLNE WVAVNTVDFF NQINMLYGTI TDFCTEESCP VMSAGPKYEY 
       110        120        130        140        150
HWADGTNIKK PIKCSAPKYI DYLMTWVQDQ LDDETLFPSK IGVPFPKNFM 
       160        170        180        190        200
SVAKTILKRL FRVYAHIYHQ HFDPVIQLQE EAHLNTSFKH FIFFVQEFNL 
       210        220 
IDRRELAPLQ ELIEKLTSKD R

Show »

Length:221

Mass (Da):25,499

Checksum:ⁱ4DF1286311C0BC5F

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D6RCK3	D6RCK3_HUMAN		MOB kinase activator 1B MOB kinase activator 1B	MOB1B	130	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045097	1 – 5	MSFLF → MEGATDVNES in isoform 2. 1 Publication		5

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ577473 mRNA Translation: CAE12091.1 AK299481 mRNA Translation: BAG61445.1 AK313513 mRNA Translation: BAG36293.1 AC021989 Genomic DNA No translation available. AC093851 Genomic DNA No translation available. AC108014 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05636.1 BC038112 mRNA Translation: AAH38112.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34002.1 [Q7L9L4-1] CCDS58903.1 [Q7L9L4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001231695.1, NM_001244766.1 [Q7L9L4-2] NP_775739.1, NM_173468.3 [Q7L9L4-1] XP_005265766.1, XM_005265709.2 [Q7L9L4-2]
UniGeneⁱ	Hs.691454 Hs.744715

Genome annotation databases

Ensemblⁱ	ENST00000309395; ENSP00000310189; ENSG00000173542 [Q7L9L4-1] ENST00000396051; ENSP00000379366; ENSG00000173542 [Q7L9L4-2]
GeneIDⁱ	92597
KEGGⁱ	hsa:92597
UCSC genome browser More...UCSCⁱ	uc003hfw.4 human [Q7L9L4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7L9L4	MOB kinase activator 1B	)	MOUSE		216	UniRef100_Q7L9L4
MOB kinase activator 1B		PANTR		216
Mps one binder kinase activator-like 1A		MACMU		216
MOB kinase activator 1B isoform 2		CALJA		216
MOB kinase activator 1B		PONAB		216
+41
Q7L9L4-2	MOB kinase activator 1B		PANTR		221	UniRef100_H2RCF2
Uncharacterized protein		PANPA		221
MOB kinase activator 1B (Fragment)		HUMAN		130
MOB1B isoform 1 (Fragment)		PANTR		130

Protein	Similar proteins		Species	Score	Length	Source
Q7L9L4	MOB kinase activator 1B	)	MOUSE		216	UniRef90_Q7L9L4
MOB kinase activator 1B		PANTR		216
Mps one binder kinase activator-like 1A		MACMU		216
MOB kinase activator 1B isoform 2		CALJA		216
MOB kinase activator 1B		PONAB		216
+64
Q7L9L4-2	MOB kinase activator 1B		PANTR		221	UniRef90_H2RCF2
Uncharacterized protein		PANPA		221
MOB kinase activator 1B (Fragment)		HUMAN		130
MOB kinase activator 1A		SCOMX		276
MOB kinase activator 1A		GASAC		225
+40

Protein	Similar proteins		Species	Score	Length	Source
Q7L9L4	MOB kinase activator 1A	)	HUMAN		216	UniRef50_Q9H8S9
MOB kinase activator 1A		MOUSE		216
MOB kinase activator 1A		PONAB		216
MOB kinase activator 1A		RAT		216
Uncharacterized protein		SHEEP		230
+252

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AJ577473 mRNA Translation: CAE12091.1 AK299481 mRNA Translation: BAG61445.1 AK313513 mRNA Translation: BAG36293.1 AC021989 Genomic DNA No translation available. AC093851 Genomic DNA No translation available. AC108014 Genomic DNA No translation available. CH471057 Genomic DNA Translation: EAX05636.1 BC038112 mRNA Translation: AAH38112.1
CCDSⁱ	CCDS34002.1 [Q7L9L4-1] CCDS58903.1 [Q7L9L4-2]
RefSeqⁱ	NP_001231695.1, NM_001244766.1 [Q7L9L4-2] NP_775739.1, NM_173468.3 [Q7L9L4-1] XP_005265766.1, XM_005265709.2 [Q7L9L4-2]
UniGeneⁱ	Hs.691454 Hs.744715

3D structure databases

ProteinModelPortalⁱ	Q7L9L4
SMRⁱ	Q7L9L4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124960, 39 interactors
IntActⁱ	Q7L9L4, 38 interactors
MINTⁱ	Q7L9L4
STRINGⁱ	9606.ENSP00000310189

PTM databases

iPTMnetⁱ	Q7L9L4
PhosphoSitePlusⁱ	Q7L9L4

Polymorphism and mutation databases

BioMutaⁱ	MOB1B
DMDMⁱ	56749324

Proteomic databases

EPDⁱ	Q7L9L4
MaxQBⁱ	Q7L9L4
PaxDbⁱ	Q7L9L4
PeptideAtlasⁱ	Q7L9L4
PRIDEⁱ	Q7L9L4
ProteomicsDBⁱ	68845

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000309395; ENSP00000310189; ENSG00000173542 [Q7L9L4-1] ENST00000396051; ENSP00000379366; ENSG00000173542 [Q7L9L4-2]
GeneIDⁱ	92597
KEGGⁱ	hsa:92597
UCSCⁱ	uc003hfw.4 human [Q7L9L4-1]

Organism-specific databases

CTDⁱ	92597
DisGeNETⁱ	92597
EuPathDBⁱ	HostDB:ENSG00000173542.8
GeneCardsⁱ	MOB1B
HGNCⁱ	HGNC:29801 MOB1B
HPAⁱ	HPA047088 HPA071690
MIMⁱ	609282 gene
neXtProtⁱ	NX_Q7L9L4
OpenTargetsⁱ	ENSG00000173542
PharmGKBⁱ	PA134871841
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0440 Eukaryota ENOG410XSUJ LUCA
GeneTreeⁱ	ENSGT00550000074456
HOGENOMⁱ	HOG000164685
HOVERGENⁱ	HBG052489
InParanoidⁱ	Q7L9L4
KOⁱ	K06685
OMAⁱ	DFFNHLN
OrthoDBⁱ	EOG091G0LDA
PhylomeDBⁱ	Q7L9L4
TreeFamⁱ	TF300789

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2028269 Signaling by Hippo
SIGNORⁱ	Q7L9L4

Miscellaneous databases

ChiTaRSⁱ	MOB1B human
GeneWikiⁱ	MOBKL1A
GenomeRNAiⁱ	92597
Protein Ontology More...PROⁱ	PR:Q7L9L4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173542 Expressed in 208 organ(s), highest expression level in renal medulla
CleanExⁱ	HS_MOBKL1A
ExpressionAtlasⁱ	Q7L9L4 baseline and differential
Genevisibleⁱ	Q7L9L4 HS

Family and domain databases

Gene3Dⁱ	1.20.140.30, 1 hit
InterProⁱ	View protein in InterPro IPR005301 MOB_kinase_act_fam IPR036703 MOB_kinase_act_sf
PANTHERⁱ	PTHR22599 PTHR22599, 1 hit
Pfamⁱ	View protein in Pfam PF03637 Mob1_phocein, 1 hit
SMARTⁱ	View protein in SMART SM01388 Mob1_phocein, 1 hit
SUPFAMⁱ	SSF101152 SSF101152, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MOB1B_HUMAN
Accessionⁱ	Q7L9L4Primary (citable) accession number: Q7L9L4 Secondary accession number(s): B2R8U6, B4DRY3, Q8IY23
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
	Last sequence update:	January 23, 2007
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q7L9L4 (MOB1B_HUMAN)

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MOB kinase activator 1B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ