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Protein

Endonuclease/exonuclease/phosphatase family domain-containing protein 1

Gene

EEPD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Endonuclease/exonuclease/phosphatase family domain-containing protein 1
Gene namesi
Name:EEPD1
Synonyms:KIAA1706
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122547.10
HGNCiHGNC:22223 EEPD1
neXtProtiNX_Q7L9B9

Pathology & Biotechi

Organism-specific databases

DisGeNETi80820
OpenTargetsiENSG00000122547
PharmGKBiPA162384303

Polymorphism and mutation databases

BioMutaiEEPD1
DMDMi296434489

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00003172612 – 569Endonuclease/exonuclease/phosphatase family domain-containing protein 1Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1
Modified residuei16PhosphoserineCombined sources1
Modified residuei21PhosphoserineBy similarity1
Modified residuei25PhosphoserineCombined sources1
Modified residuei106PhosphoserineBy similarity1
Modified residuei110PhosphoserineCombined sources1
Modified residuei160PhosphoserineCombined sources1
Modified residuei173PhosphoserineCombined sources1
Modified residuei265PhosphothreonineBy similarity1
Modified residuei428PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ7L9B9
MaxQBiQ7L9B9
PaxDbiQ7L9B9
PeptideAtlasiQ7L9B9
PRIDEiQ7L9B9
ProteomicsDBi68844

PTM databases

iPTMnetiQ7L9B9
PhosphoSitePlusiQ7L9B9
SwissPalmiQ7L9B9

Expressioni

Gene expression databases

BgeeiENSG00000122547 Expressed in 169 organ(s), highest expression level in gastrocnemius
CleanExiHS_EEPD1
ExpressionAtlasiQ7L9B9 baseline and differential
GenevisibleiQ7L9B9 HS

Organism-specific databases

HPAiHPA053668

Interactioni

Protein-protein interaction databases

BioGridi123317, 14 interactors
ELMiQ7L9B9
IntActiQ7L9B9, 1 interactor
STRINGi9606.ENSP00000242108

Structurei

3D structure databases

ProteinModelPortaliQ7L9B9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 67HhHAdd BLAST30

Phylogenomic databases

eggNOGiENOG410IUAK Eukaryota
COG1555 LUCA
GeneTreeiENSGT00390000009677
HOGENOMiHOG000112330
HOVERGENiHBG100313
InParanoidiQ7L9B9
OMAiKFCAELN
OrthoDBiEOG091G0FFB
PhylomeDBiQ7L9B9
TreeFamiTF328735

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR004509 Competence_ComEA_HhH
IPR036691 Endo/exonu/phosph_ase_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
SMARTiView protein in SMART
SM00278 HhH1, 3 hits
SUPFAMiSSF47781 SSF47781, 2 hits
SSF56219 SSF56219, 1 hit
TIGRFAMsiTIGR00426 TIGR00426, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7L9B9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSTLGCHRS IPRDPSDLSH SRKFSAACNF SNILVNQERL NINTATEEEL
60 70 80 90 100
MTLPGVTRAV ARSIVEYREY IGGFKKVEDL ALVSGVGATK LEQVKFEICV
110 120 130 140 150
SSKGSSAQHS PSSLRRDLLA EQQPHHLATA VPLTPRVNIN TATPAQLMSV
160 170 180 190 200
RGLSEKMALS IVDFRREHGP FRSVEDLVRM DGINAAFLDR IRHQVFAERS
210 220 230 240 250
RPPSTHTNGG LTFTAKPHPS PTSLSLQSED LDLPPGGPTQ IISTRPSVEA
260 270 280 290 300
FGGTRDGRPV LRLATWNLQG CSVEKANNPG VREVVCMTLL ENSIKLLAVQ
310 320 330 340 350
ELLDREALEK FCTELNQPTL PNIRKWKGPR GCWKAVVAEK PSSQLQKGAG
360 370 380 390 400
YAGFLWDAAA GMELRDAGSQ ESSPSNGHGK LAGPSPYLGR FKVGSHDLTL
410 420 430 440 450
VNLHLAALTL LGSENPSKNH SDGHRLASFA QTLQETLKGE KDVIILGDFG
460 470 480 490 500
QGPDSNDYDI LRKEKFHHLI PAHTFTNIST KNPQGSKSLD NIWISKSLKK
510 520 530 540 550
VFTGHWAVVR EGLTNPWIPD NWSWGGVASE HCPVLAEFYT EKDWSKKDAP
560
RNGSGVALER SEANIKHER
Length:569
Mass (Da):62,403
Last modified:May 18, 2010 - v2
Checksum:i6A1C1D106583E670
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4A5H7C4A5_HUMAN
Endonuclease/exonuclease/phosphatas...
EEPD1
34Annotation score:

Sequence cautioni

The sequence BAB21797 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060374343S → N5 PublicationsCorresponds to variant dbSNP:rs196586Ensembl.1
Natural variantiVAR_056867358A → S. Corresponds to variant dbSNP:rs3815682Ensembl.1
Natural variantiVAR_056868416P → S. Corresponds to variant dbSNP:rs196594Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051493 mRNA Translation: BAB21797.1 Different initiation.
AK027386 mRNA Translation: BAB55076.1
AC007327 Genomic DNA No translation available.
AC078841 Genomic DNA No translation available.
CH236951 Genomic DNA Translation: EAL23976.1
CH471073 Genomic DNA Translation: EAW94063.1
BC065518 mRNA Translation: AAH65518.1
CCDSiCCDS34619.1
RefSeqiNP_085139.2, NM_030636.2
UniGeneiHs.487994
Hs.670591

Genome annotation databases

EnsembliENST00000242108; ENSP00000242108; ENSG00000122547
ENST00000534978; ENSP00000442692; ENSG00000122547
GeneIDi80820
KEGGihsa:80820
UCSCiuc003tfa.4 human

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051493 mRNA Translation: BAB21797.1 Different initiation.
AK027386 mRNA Translation: BAB55076.1
AC007327 Genomic DNA No translation available.
AC078841 Genomic DNA No translation available.
CH236951 Genomic DNA Translation: EAL23976.1
CH471073 Genomic DNA Translation: EAW94063.1
BC065518 mRNA Translation: AAH65518.1
CCDSiCCDS34619.1
RefSeqiNP_085139.2, NM_030636.2
UniGeneiHs.487994
Hs.670591

3D structure databases

ProteinModelPortaliQ7L9B9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123317, 14 interactors
ELMiQ7L9B9
IntActiQ7L9B9, 1 interactor
STRINGi9606.ENSP00000242108

PTM databases

iPTMnetiQ7L9B9
PhosphoSitePlusiQ7L9B9
SwissPalmiQ7L9B9

Polymorphism and mutation databases

BioMutaiEEPD1
DMDMi296434489

Proteomic databases

EPDiQ7L9B9
MaxQBiQ7L9B9
PaxDbiQ7L9B9
PeptideAtlasiQ7L9B9
PRIDEiQ7L9B9
ProteomicsDBi68844

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242108; ENSP00000242108; ENSG00000122547
ENST00000534978; ENSP00000442692; ENSG00000122547
GeneIDi80820
KEGGihsa:80820
UCSCiuc003tfa.4 human

Organism-specific databases

CTDi80820
DisGeNETi80820
EuPathDBiHostDB:ENSG00000122547.10
GeneCardsiEEPD1
H-InvDBiHIX0006600
HGNCiHGNC:22223 EEPD1
HPAiHPA053668
neXtProtiNX_Q7L9B9
OpenTargetsiENSG00000122547
PharmGKBiPA162384303
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IUAK Eukaryota
COG1555 LUCA
GeneTreeiENSGT00390000009677
HOGENOMiHOG000112330
HOVERGENiHBG100313
InParanoidiQ7L9B9
OMAiKFCAELN
OrthoDBiEOG091G0FFB
PhylomeDBiQ7L9B9
TreeFamiTF328735

Miscellaneous databases

GenomeRNAii80820
PROiPR:Q7L9B9

Gene expression databases

BgeeiENSG00000122547 Expressed in 169 organ(s), highest expression level in gastrocnemius
CleanExiHS_EEPD1
ExpressionAtlasiQ7L9B9 baseline and differential
GenevisibleiQ7L9B9 HS

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR004509 Competence_ComEA_HhH
IPR036691 Endo/exonu/phosph_ase_sf
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR010994 RuvA_2-like
SMARTiView protein in SMART
SM00278 HhH1, 3 hits
SUPFAMiSSF47781 SSF47781, 2 hits
SSF56219 SSF56219, 1 hit
TIGRFAMsiTIGR00426 TIGR00426, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEEPD1_HUMAN
AccessioniPrimary (citable) accession number: Q7L9B9
Secondary accession number(s): Q96K64, Q9C0F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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