UniProtKB - Q7L945 (ZN627_HUMAN)
Protein
Zinc finger protein 627
Gene
ZNF627
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 99 – 123 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 167 – 189 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 195 – 217 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 223 – 245 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 251 – 273 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 307 – 329 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 335 – 357 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 363 – 385 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 391 – 413 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 419 – 441 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q7L945 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 627 |
Gene namesi | Name:ZNF627 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30570, ZNF627 |
MIMi | 612248, gene |
neXtProti | NX_Q7L945 |
VEuPathDBi | HostDB:ENSG00000198551.9 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 199692 |
OpenTargetsi | ENSG00000198551 |
PharmGKBi | PA134903355 |
Miscellaneous databases
Pharosi | Q7L945, Tdark |
Genetic variation databases
BioMutai | ZNF627 |
DMDMi | 74759019 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280425 | 1 – 461 | Zinc finger protein 627Add BLAST | 461 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 99 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 439 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q7L945 |
jPOSTi | Q7L945 |
MassIVEi | Q7L945 |
MaxQBi | Q7L945 |
PaxDbi | Q7L945 |
PeptideAtlasi | Q7L945 |
PRIDEi | Q7L945 |
ProteomicsDBi | 68842 |
PTM databases
iPTMneti | Q7L945 |
PhosphoSitePlusi | Q7L945 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198551, Expressed in kidney and 211 other tissues |
ExpressionAtlasi | Q7L945, baseline and differential |
Genevisiblei | Q7L945, HS |
Organism-specific databases
HPAi | ENSG00000198551, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 128262, 9 interactors |
IntActi | Q7L945, 9 interactors |
STRINGi | 9606.ENSP00000354414 |
Miscellaneous databases
RNActi | Q7L945, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 80 | KRABPROSITE-ProRule annotationAdd BLAST | 77 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 99 – 123 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 167 – 189 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 195 – 217 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 223 – 245 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 251 – 273 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 279 – 301 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 307 – 329 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 335 – 357 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 363 – 385 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 391 – 413 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 419 – 441 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164244 |
HOGENOMi | CLU_002678_0_10_1 |
InParanoidi | Q7L945 |
OMAi | RSTYFRI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q7L945 |
TreeFami | TF338854 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q7L945-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSVAFEDVA VNFTLEEWAL LDPSQKNLYR DVMRETFRNL ASVGKQWEDQ
60 70 80 90 100
NIEDPFKIPR RNISHIPERL CESKEGGQGE ETFSQIPDGI LNKKTPGVKP
110 120 130 140 150
CESSVCGEVG MGPSSLNRHI RDHTGREPNE YQEYGKKSYT RNQCGRALSY
160 170 180 190 200
HRSFPVRERT HPGGKPYDCK ECGETFISLV SIRRHMLTHR GGVPYKCKVC
210 220 230 240 250
GKAFDYPSLF RIHERSHTGE KPYECKQCGK AFSCSSYIRI HERTHTGDKP
260 270 280 290 300
YECKQCGKAF SCSKYIRIHE RTHTGEKPYE CKQCGKAFRC ASSVRSHERT
310 320 330 340 350
HTGEKLFECK ECGKALTCLA SVRRHMIKHT GNGPYKCKVC GKAFDFPSSF
360 370 380 390 400
RIHERTHTGE KPYDCKQCGK AFSCSSSFRK HERIHTGEKP YKCTKCGKAF
410 420 430 440 450
SRSSYFRIHE RTHTGEKPYE CKQCGKAFSR STYFRVHEKI HTGEKPYENP
460
NPNASVVPVL S
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EKY8 | K7EKY8_HUMAN | Zinc finger protein 627 | ZNF627 | 67 | Annotation score: | ||
K7ELG4 | K7ELG4_HUMAN | Zinc finger protein 627 | ZNF627 | 58 | Annotation score: | ||
K7EJ27 | K7EJ27_HUMAN | Zinc finger protein 627 | ZNF627 | 17 | Annotation score: |
Sequence cautioni
The sequence AAH06279 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH98416 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 172 | C → V in AAB81084 (PubMed:12016960).Curated | 1 | |
Sequence conflicti | 194 | P → T in AAB81084 (PubMed:12016960).Curated | 1 | |
Sequence conflicti | 269 | H → R in AAH98416 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074846 mRNA Translation: BAC11240.1 BC006279 mRNA Translation: AAH06279.2 Different initiation. BC069232 mRNA Translation: AAH69232.2 BC098416 mRNA Translation: AAH98416.1 Different initiation. AF024694 mRNA Translation: AAB81084.1 |
CCDSi | CCDS42502.1 |
RefSeqi | NP_001277012.1, NM_001290083.1 NP_001277013.1, NM_001290084.1 NP_001277014.1, NM_001290085.1 NP_660338.1, NM_145295.3 |
Genome annotation databases
Ensembli | ENST00000361113; ENSP00000354414; ENSG00000198551 |
GeneIDi | 199692 |
KEGGi | hsa:199692 |
UCSCi | uc002msk.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074846 mRNA Translation: BAC11240.1 BC006279 mRNA Translation: AAH06279.2 Different initiation. BC069232 mRNA Translation: AAH69232.2 BC098416 mRNA Translation: AAH98416.1 Different initiation. AF024694 mRNA Translation: AAB81084.1 |
CCDSi | CCDS42502.1 |
RefSeqi | NP_001277012.1, NM_001290083.1 NP_001277013.1, NM_001290084.1 NP_001277014.1, NM_001290085.1 NP_660338.1, NM_145295.3 |
3D structure databases
SMRi | Q7L945 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128262, 9 interactors |
IntActi | Q7L945, 9 interactors |
STRINGi | 9606.ENSP00000354414 |
PTM databases
iPTMneti | Q7L945 |
PhosphoSitePlusi | Q7L945 |
Genetic variation databases
BioMutai | ZNF627 |
DMDMi | 74759019 |
Proteomic databases
EPDi | Q7L945 |
jPOSTi | Q7L945 |
MassIVEi | Q7L945 |
MaxQBi | Q7L945 |
PaxDbi | Q7L945 |
PeptideAtlasi | Q7L945 |
PRIDEi | Q7L945 |
ProteomicsDBi | 68842 |
Protocols and materials databases
Antibodypediai | 6931, 68 antibodies |
DNASUi | 199692 |
Genome annotation databases
Ensembli | ENST00000361113; ENSP00000354414; ENSG00000198551 |
GeneIDi | 199692 |
KEGGi | hsa:199692 |
UCSCi | uc002msk.3, human |
Organism-specific databases
CTDi | 199692 |
DisGeNETi | 199692 |
GeneCardsi | ZNF627 |
HGNCi | HGNC:30570, ZNF627 |
HPAi | ENSG00000198551, Low tissue specificity |
MIMi | 612248, gene |
neXtProti | NX_Q7L945 |
OpenTargetsi | ENSG00000198551 |
PharmGKBi | PA134903355 |
VEuPathDBi | HostDB:ENSG00000198551.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164244 |
HOGENOMi | CLU_002678_0_10_1 |
InParanoidi | Q7L945 |
OMAi | RSTYFRI |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q7L945 |
TreeFami | TF338854 |
Enzyme and pathway databases
PathwayCommonsi | Q7L945 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 199692, 4 hits in 1012 CRISPR screens |
ChiTaRSi | ZNF627, human |
GenomeRNAii | 199692 |
Pharosi | Q7L945, Tdark |
PROi | PR:Q7L945 |
RNActi | Q7L945, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198551, Expressed in kidney and 211 other tissues |
ExpressionAtlasi | Q7L945, baseline and differential |
Genevisiblei | Q7L945, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 10 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN627_HUMAN | |
Accessioni | Q7L945Primary (citable) accession number: Q7L945 Secondary accession number(s): O14846 Q9BRG4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families