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Protein

Zinc finger protein 627

Gene

ZNF627

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri99 – 123C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri167 – 189C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 217C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 627
Gene namesi
Name:ZNF627
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000198551.9
HGNCiHGNC:30570 ZNF627
MIMi612248 gene
neXtProtiNX_Q7L945

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi199692
OpenTargetsiENSG00000198551
PharmGKBiPA134903355

Polymorphism and mutation databases

BioMutaiZNF627
DMDMi74759019

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804251 – 461Zinc finger protein 627Add BLAST461

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki439Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ7L945
MaxQBiQ7L945
PaxDbiQ7L945
PeptideAtlasiQ7L945
PRIDEiQ7L945
ProteomicsDBi68842

PTM databases

iPTMnetiQ7L945
PhosphoSitePlusiQ7L945

Expressioni

Gene expression databases

BgeeiENSG00000198551 Expressed in 197 organ(s), highest expression level in kidney
CleanExiHS_ZNF627
ExpressionAtlasiQ7L945 baseline and differential
GenevisibleiQ7L945 HS

Organism-specific databases

HPAiHPA049770
HPA073463

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-2797561,EBI-748961

Protein-protein interaction databases

BioGridi128262, 8 interactors
IntActiQ7L945, 3 interactors
STRINGi9606.ENSP00000354414

Structurei

3D structure databases

ProteinModelPortaliQ7L945
SMRiQ7L945
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 80KRABPROSITE-ProRule annotationAdd BLAST77

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri99 – 123C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri167 – 189C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri195 – 217C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri223 – 245C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri251 – 273C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri279 – 301C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 357C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri363 – 385C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri391 – 413C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri419 – 441C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ7L945
KOiK09228
OMAiKPCERSV
OrthoDBiEOG091G02KC
PhylomeDBiQ7L945
TreeFamiTF338854

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q7L945-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSVAFEDVA VNFTLEEWAL LDPSQKNLYR DVMRETFRNL ASVGKQWEDQ
60 70 80 90 100
NIEDPFKIPR RNISHIPERL CESKEGGQGE ETFSQIPDGI LNKKTPGVKP
110 120 130 140 150
CESSVCGEVG MGPSSLNRHI RDHTGREPNE YQEYGKKSYT RNQCGRALSY
160 170 180 190 200
HRSFPVRERT HPGGKPYDCK ECGETFISLV SIRRHMLTHR GGVPYKCKVC
210 220 230 240 250
GKAFDYPSLF RIHERSHTGE KPYECKQCGK AFSCSSYIRI HERTHTGDKP
260 270 280 290 300
YECKQCGKAF SCSKYIRIHE RTHTGEKPYE CKQCGKAFRC ASSVRSHERT
310 320 330 340 350
HTGEKLFECK ECGKALTCLA SVRRHMIKHT GNGPYKCKVC GKAFDFPSSF
360 370 380 390 400
RIHERTHTGE KPYDCKQCGK AFSCSSSFRK HERIHTGEKP YKCTKCGKAF
410 420 430 440 450
SRSSYFRIHE RTHTGEKPYE CKQCGKAFSR STYFRVHEKI HTGEKPYENP
460
NPNASVVPVL S
Length:461
Mass (Da):52,853
Last modified:July 5, 2004 - v1
Checksum:i3440788DBB79A24A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EKY8K7EKY8_HUMAN
Zinc finger protein 627
ZNF627
67Annotation score:
K7ELG4K7ELG4_HUMAN
Zinc finger protein 627
ZNF627
58Annotation score:
K7EJ27K7EJ27_HUMAN
Zinc finger protein 627
ZNF627
17Annotation score:

Sequence cautioni

The sequence AAH06279 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH98416 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172C → V in AAB81084 (PubMed:12016960).Curated1
Sequence conflicti194P → T in AAB81084 (PubMed:12016960).Curated1
Sequence conflicti269H → R in AAH98416 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074846 mRNA Translation: BAC11240.1
BC006279 mRNA Translation: AAH06279.2 Different initiation.
BC069232 mRNA Translation: AAH69232.2
BC098416 mRNA Translation: AAH98416.1 Different initiation.
AF024694 mRNA Translation: AAB81084.1
CCDSiCCDS42502.1
RefSeqiNP_001277012.1, NM_001290083.1
NP_001277013.1, NM_001290084.1
NP_001277014.1, NM_001290085.1
NP_660338.1, NM_145295.3
UniGeneiHs.526665

Genome annotation databases

EnsembliENST00000361113; ENSP00000354414; ENSG00000198551
GeneIDi199692
KEGGihsa:199692
UCSCiuc002msk.3 human

Similar proteinsi

Entry informationi

Entry nameiZN627_HUMAN
AccessioniPrimary (citable) accession number: Q7L945
Secondary accession number(s): O14846
, Q4KMP9, Q6NT81, Q9BRG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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