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Entry version 126 (17 Jun 2020)
Sequence version 3 (11 Jan 2011)
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Protein

Diphthine--ammonia ligase

Gene

DPH6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity).By similarity1 Publication

Miscellaneous

When transfected in S.cerevisiae, able to restore diphthamide biosynthesis in a strain lacking DPH6.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidyl-diphthamide biosynthesis

This protein is involved in the pathway peptidyl-diphthamide biosynthesis, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway peptidyl-diphthamide biosynthesis and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5358493 Synthesis of diphthamide-EEF2

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00559

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Diphthine--ammonia ligase (EC:6.3.1.14)
Alternative name(s):
ATP-binding domain-containing protein 4
Diphthamide synthase
Diphthamide synthetase
Protein DPH6 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DPH6
Synonyms:ATPBD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000134146.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30543 DPH6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618391 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7L8W6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000134146

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672572

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7L8W6 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DPH6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373478

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002823971 – 267Diphthine--ammonia ligaseAdd BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei97PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7L8W6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7L8W6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7L8W6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7L8W6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7L8W6

PeptideAtlas

More...
PeptideAtlasi
Q7L8W6

PRoteomics IDEntifications database

More...
PRIDEi
Q7L8W6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68840 [Q7L8W6-1]
68841 [Q7L8W6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7L8W6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7L8W6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134146 Expressed in corpus callosum and 158 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7L8W6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7L8W6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000134146 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124651, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q7L8W6, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000256538

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7L8W6 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7L8W6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Diphthine--ammonia ligase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2316 Eukaryota
COG2102 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00420000029820

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010289_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7L8W6

KEGG Orthology (KO)

More...
KOi
K06927

Identification of Orthologs from Complete Genome Data

More...
OMAi
LDESWLG

Database of Orthologous Groups

More...
OrthoDBi
1362375at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7L8W6

TreeFam database of animal gene trees

More...
TreeFami
TF313566

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01994 Alpha_ANH_like_IV, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002761 Diphthami_syn_dom
IPR030662 DPH6/MJ0570
IPR014729 Rossmann-like_a/b/a_fold

The PANTHER Classification System

More...
PANTHERi
PTHR12196 PTHR12196, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01902 Diphthami_syn_2, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF039123 Diphthamide_synthase, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00290 MJ0570_dom, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7L8W6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVAALISGG KDSCYNMMQC IAAGHQIVAL ANLRPAENQV GSDELDSYMY
60 70 80 90 100
QTVGHHAIDL YAEAMALPLY RRTIRGRSLD TRQVYTKCEG DEVEDLYELL
110 120 130 140 150
KLVKEKEEVE GISVGAILSD YQRIRVENVC KRLNLQPLAY LWQRNQEDLL
160 170 180 190 200
REMISSNIQA MIIKVAALGL DPDKHLGKTL DQMEPYLIEL SKKYGVHVCG
210 220 230 240 250
EGGEYETFTL DCPLFKKKII VDSSEVVIHS ADAFAPVAYL RFLELHLEDK
260
VSSVPDNYRT SNYIYNF
Length:267
Mass (Da):30,307
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i16BB1094F4D3513D
GO
Isoform 2 (identifier: Q7L8W6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-267: EKEEVEGISV...YRTSNYIYNF → GITRMTLLAE...FISEIAKCEV

Show »
Length:165
Mass (Da):18,657
Checksum:i14398C0D0ABC39AE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YND7H0YND7_HUMAN
Diphthine--ammonia ligase
DPH6
169Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNH5H0YNH5_HUMAN
Diphthine--ammonia ligase
DPH6
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03140341G → E. Corresponds to variant dbSNP:rs34907758Ensembl.1
Natural variantiVAR_031404236P → R. Corresponds to variant dbSNP:rs10519996Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042933105 – 267EKEEV…YIYNF → GITRMTLLAEYDALNLQDFH MHLKVGSQAIVYRTPNELCT HSKFDKHTFPPFISEIAKCE V in isoform 2. 1 PublicationAdd BLAST163

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK094007 mRNA Translation: BAC04266.1
AK125017 mRNA Translation: BAG54123.1
AC015994 Genomic DNA No translation available.
AC019288 Genomic DNA No translation available.
BC008485 mRNA Translation: AAH08485.2
BC066652 mRNA Translation: AAH66652.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10043.1 [Q7L8W6-1]
CCDS45213.1 [Q7L8W6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001135444.1, NM_001141972.1 [Q7L8W6-2]
NP_542381.1, NM_080650.3 [Q7L8W6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000256538; ENSP00000256538; ENSG00000134146 [Q7L8W6-1]
ENST00000440392; ENSP00000406976; ENSG00000134146 [Q7L8W6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
89978

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:89978

UCSC genome browser

More...
UCSCi
uc001zja.4 human [Q7L8W6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094007 mRNA Translation: BAC04266.1
AK125017 mRNA Translation: BAG54123.1
AC015994 Genomic DNA No translation available.
AC019288 Genomic DNA No translation available.
BC008485 mRNA Translation: AAH08485.2
BC066652 mRNA Translation: AAH66652.1
CCDSiCCDS10043.1 [Q7L8W6-1]
CCDS45213.1 [Q7L8W6-2]
RefSeqiNP_001135444.1, NM_001141972.1 [Q7L8W6-2]
NP_542381.1, NM_080650.3 [Q7L8W6-1]

3D structure databases

SMRiQ7L8W6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124651, 11 interactors
IntActiQ7L8W6, 9 interactors
STRINGi9606.ENSP00000256538

PTM databases

iPTMnetiQ7L8W6
PhosphoSitePlusiQ7L8W6

Polymorphism and mutation databases

BioMutaiDPH6
DMDMi317373478

Proteomic databases

EPDiQ7L8W6
jPOSTiQ7L8W6
MassIVEiQ7L8W6
MaxQBiQ7L8W6
PaxDbiQ7L8W6
PeptideAtlasiQ7L8W6
PRIDEiQ7L8W6
ProteomicsDBi68840 [Q7L8W6-1]
68841 [Q7L8W6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
51931 50 antibodies

Genome annotation databases

EnsembliENST00000256538; ENSP00000256538; ENSG00000134146 [Q7L8W6-1]
ENST00000440392; ENSP00000406976; ENSG00000134146 [Q7L8W6-2]
GeneIDi89978
KEGGihsa:89978
UCSCiuc001zja.4 human [Q7L8W6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
89978
EuPathDBiHostDB:ENSG00000134146.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DPH6
HGNCiHGNC:30543 DPH6
HPAiENSG00000134146 Low tissue specificity
MIMi618391 gene
neXtProtiNX_Q7L8W6
OpenTargetsiENSG00000134146
PharmGKBiPA142672572

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2316 Eukaryota
COG2102 LUCA
GeneTreeiENSGT00420000029820
HOGENOMiCLU_010289_0_1_1
InParanoidiQ7L8W6
KOiK06927
OMAiLDESWLG
OrthoDBi1362375at2759
PhylomeDBiQ7L8W6
TreeFamiTF313566

Enzyme and pathway databases

UniPathwayiUPA00559
ReactomeiR-HSA-5358493 Synthesis of diphthamide-EEF2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
89978 259 hits in 779 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DPH6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
89978
PharosiQ7L8W6 Tbio

Protein Ontology

More...
PROi
PR:Q7L8W6
RNActiQ7L8W6 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134146 Expressed in corpus callosum and 158 other tissues
ExpressionAtlasiQ7L8W6 baseline and differential
GenevisibleiQ7L8W6 HS

Family and domain databases

CDDicd01994 Alpha_ANH_like_IV, 1 hit
Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR002761 Diphthami_syn_dom
IPR030662 DPH6/MJ0570
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR12196 PTHR12196, 1 hit
PfamiView protein in Pfam
PF01902 Diphthami_syn_2, 1 hit
PIRSFiPIRSF039123 Diphthamide_synthase, 1 hit
TIGRFAMsiTIGR00290 MJ0570_dom, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPH6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L8W6
Secondary accession number(s): B3KWG1, Q96HJ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 11, 2011
Last modified: June 17, 2020
This is version 126 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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