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Protein

Synaptotagmin-13

Gene

SYT13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transport vesicle docking to the plasma membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-13
Alternative name(s):
Synaptotagmin XIII
Short name:
SytXIII
Gene namesi
Name:SYT13
Synonyms:KIAA1427
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000019505.7
HGNCiHGNC:14962 SYT13
MIMi607716 gene
neXtProtiNX_Q7L8C5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6VesicularSequence analysis6
Transmembranei7 – 29HelicalSequence analysisAdd BLAST23
Topological domaini30 – 426CytoplasmicSequence analysisAdd BLAST397

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57586
OpenTargetsiENSG00000019505
PharmGKBiPA37942

Polymorphism and mutation databases

BioMutaiSYT13
DMDMi74749900

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839751 – 426Synaptotagmin-13Add BLAST426

Proteomic databases

EPDiQ7L8C5
PaxDbiQ7L8C5
PeptideAtlasiQ7L8C5
PRIDEiQ7L8C5
ProteomicsDBi68836

PTM databases

iPTMnetiQ7L8C5
PhosphoSitePlusiQ7L8C5

Expressioni

Tissue specificityi

Expressed in brain, pancreas and kidney.1 Publication

Gene expression databases

BgeeiENSG00000019505 Expressed in 150 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_SYT13
ExpressionAtlasiQ7L8C5 baseline and differential
GenevisibleiQ7L8C5 HS

Organism-specific databases

HPAiHPA046224
HPA056602

Interactioni

Subunit structurei

Interacts with NRXN1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121638, 2 interactors
STRINGi9606.ENSP00000020926

Structurei

Secondary structure

1426
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7L8C5
SMRiQ7L8C5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7L8C5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini175 – 259C2 1PROSITE-ProRule annotationAdd BLAST85
Domaini289 – 394C2 2PROSITE-ProRule annotationAdd BLAST106

Domaini

The first C2 domain/C2A does not mediate Ca2+-dependent phospholipid binding.By similarity
The second C2 domain/C2B domain binds phospholipids regardless of whether calcium is present.By similarity

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3H Eukaryota
ENOG4110ZXG LUCA
GeneTreeiENSGT00920000148994
HOGENOMiHOG000231448
HOVERGENiHBG098553
InParanoidiQ7L8C5
KOiK19913
OMAiVWNEMIM
OrthoDBiEOG091G0DPW
PhylomeDBiQ7L8C5
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028692 SYT13
PANTHERiPTHR10024:SF250 PTHR10024:SF250, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q7L8C5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLSVPVIAL GATLGTATSI LALCGVTCLC RHMHPKKGLL PRDQDPDLEK
60 70 80 90 100
AKPSLLGSAQ QFNVKKSTEP VQPRALLKFP DIYGPRPAVT APEVINYADY
110 120 130 140 150
SLRSTEEPTA PASPQPPNDS RLKRQVTEEL FILPQNGVVE DVCVMETWNP
160 170 180 190 200
EKAASWNQAP KLHYCLDYDC QKAELFVTRL EAVTSNHDGG CDCYVQGSVA
210 220 230 240 250
NRTGSVEAQT ALKKRQLHTT WEEGLVLPLA EEELPTATLT LTLRTCDRFS
260 270 280 290 300
RHSVAGELRL GLDGTSVPLG AAQWGELKTS AKEPSAGAGE VLLSISYLPA
310 320 330 340 350
ANRLLVVLIK AKNLHSNQSK ELLGKDVSVK VTLKHQARKL KKKQTKRAKH
360 370 380 390 400
KINPVWNEMI MFELPDDLLQ ASSVELEVLG QDDSGQSCAL GHCSLGLHTS
410 420
GSERSHWEEM LKNPRRQIAM WHQLHL
Length:426
Mass (Da):46,885
Last modified:July 5, 2004 - v1
Checksum:i9BD0AD533E0CE886
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YD47H0YD47_HUMAN
Synaptotagmin-13
SYT13
186Annotation score:
H0YE47H0YE47_HUMAN
Synaptotagmin-13
SYT13
20Annotation score:

Sequence cautioni

The sequence BAA92665 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037848 mRNA Translation: BAA92665.1 Different initiation.
AK291009 mRNA Translation: BAF83698.1
AL512743 mRNA Translation: CAC21669.1
CH471064 Genomic DNA Translation: EAW68043.1
CH471064 Genomic DNA Translation: EAW68044.1
BC093830 mRNA Translation: AAH93830.1
BC093832 mRNA Translation: AAH93832.1
AJ303362 mRNA Translation: CAC33884.1
CCDSiCCDS31470.1
RefSeqiNP_065877.1, NM_020826.2
UniGeneiHs.436643

Genome annotation databases

EnsembliENST00000020926; ENSP00000020926; ENSG00000019505
GeneIDi57586
KEGGihsa:57586
UCSCiuc001myq.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037848 mRNA Translation: BAA92665.1 Different initiation.
AK291009 mRNA Translation: BAF83698.1
AL512743 mRNA Translation: CAC21669.1
CH471064 Genomic DNA Translation: EAW68043.1
CH471064 Genomic DNA Translation: EAW68044.1
BC093830 mRNA Translation: AAH93830.1
BC093832 mRNA Translation: AAH93832.1
AJ303362 mRNA Translation: CAC33884.1
CCDSiCCDS31470.1
RefSeqiNP_065877.1, NM_020826.2
UniGeneiHs.436643

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WFMNMR-A155-279[»]
ProteinModelPortaliQ7L8C5
SMRiQ7L8C5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121638, 2 interactors
STRINGi9606.ENSP00000020926

PTM databases

iPTMnetiQ7L8C5
PhosphoSitePlusiQ7L8C5

Polymorphism and mutation databases

BioMutaiSYT13
DMDMi74749900

Proteomic databases

EPDiQ7L8C5
PaxDbiQ7L8C5
PeptideAtlasiQ7L8C5
PRIDEiQ7L8C5
ProteomicsDBi68836

Protocols and materials databases

DNASUi57586
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000020926; ENSP00000020926; ENSG00000019505
GeneIDi57586
KEGGihsa:57586
UCSCiuc001myq.3 human

Organism-specific databases

CTDi57586
DisGeNETi57586
EuPathDBiHostDB:ENSG00000019505.7
GeneCardsiSYT13
HGNCiHGNC:14962 SYT13
HPAiHPA046224
HPA056602
MIMi607716 gene
neXtProtiNX_Q7L8C5
OpenTargetsiENSG00000019505
PharmGKBiPA37942
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IT3H Eukaryota
ENOG4110ZXG LUCA
GeneTreeiENSGT00920000148994
HOGENOMiHOG000231448
HOVERGENiHBG098553
InParanoidiQ7L8C5
KOiK19913
OMAiVWNEMIM
OrthoDBiEOG091G0DPW
PhylomeDBiQ7L8C5
TreeFamiTF315600

Miscellaneous databases

ChiTaRSiSYT13 human
EvolutionaryTraceiQ7L8C5
GeneWikiiSYT13
GenomeRNAii57586
PROiPR:Q7L8C5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000019505 Expressed in 150 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_SYT13
ExpressionAtlasiQ7L8C5 baseline and differential
GenevisibleiQ7L8C5 HS

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR028692 SYT13
PANTHERiPTHR10024:SF250 PTHR10024:SF250, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
SMARTiView protein in SMART
SM00239 C2, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSYT13_HUMAN
AccessioniPrimary (citable) accession number: Q7L8C5
Secondary accession number(s): A8K4P4
, D3DQP1, Q9BQS3, Q9H041, Q9P2C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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