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Entry version 124 (17 Jun 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Tubulinyl-Tyr carboxypeptidase 1

Gene

VASH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869, PubMed:31270470, PubMed:31235910, PubMed:31171830, PubMed:31235911). Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis (PubMed:15467828, PubMed:16488400, PubMed:16707096, PubMed:19204325). This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts (PubMed:15467828, PubMed:16488400, PubMed:16707096).9 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Kcat is 44.5 (min-1) for alpha-tubulin C-terminal tail.1 Publication
  1. KM=7.9 µM for alpha-tubulin C-terminal tail1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1691 Publication1 Publication1
    Active sitei2041 Publication1
    Active sitei2211 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionCarboxypeptidase, Hydrolase, Protease
    Biological processCell cycle, Growth arrest

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Tubulinyl-Tyr carboxypeptidase 1Curated (EC:3.4.17.173 Publications)
    Alternative name(s):
    Tubulin carboxypeptidase 11 Publication
    Tyrosine carboxypeptidase 1Curated
    Short name:
    TTCP 1Curated
    Vasohibin-11 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:VASH1Imported
    Synonyms:KIAA10361 Publication, VASH
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000071246.10

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:19964 VASH1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    609011 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q7L8A9

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm, Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi29R → A: Disappearance of 42 kDa processed form. 1 Publication1
    Mutagenesisi74 – 78WERMW → AERMA: Strongly reduced interaction with SVBP. 1 Publication5
    Mutagenesisi76R → A: Disappearance of 36, 32 and 27 kDa processed forms. 1 Publication1
    Mutagenesisi77 – 81MWKHV → RWKHR: No effect on tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication5
    Mutagenesisi77M → R: No effect on tyrosine carboxypeptidase activity on alpha-tubulin. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-141. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-81 and R-141. 1 Publication1
    Mutagenesisi81V → R: No effect on tyrosine carboxypeptidase activity on alpha-tubulin. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-141. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-77 and R-141. 1 Publication1
    Mutagenesisi134Y → A or F: Abolished tyrosine carboxypeptidase activity on alpha-tubulin. 3 Publications1
    Mutagenesisi141F → R: No effect on tyrosine carboxypeptidase activity on alpha-tubulin. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-77. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-81. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with R-77 and R-81. 1 Publication1
    Mutagenesisi145K → A or E: Reduced tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
    Mutagenesisi146K → A or E: Abolished tyrosine carboxypeptidase activity on alpha-tubulin. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with A-222. 3 Publications1
    Mutagenesisi165 – 166LP → EE: Almost abolished interaction with VASH1. 1 Publication2
    Mutagenesisi168K → E: Abolished tyrosine carboxypeptidase activity on alpha-tubulin. 2 Publications1
    Mutagenesisi169C → A or S: Abolished tyrosine carboxypeptidase activity on alpha-tubulin. 4 Publications1
    Mutagenesisi194K → E: No effect on tyrosine carboxypeptidase activity on alpha-tubulin. No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-256. No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-258. No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-276. 2 Publications1
    Mutagenesisi203R → E: No effect on tyrosine carboxypeptidase activity on alpha-tubulin. Strongly reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-258. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-258. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-256. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-276. 2 Publications1
    Mutagenesisi204H → A: Abolished tyrosine carboxypeptidase activity on alpha-tubulin. 3 Publications1
    Mutagenesisi221S → A: Abolished tyrosine carboxypeptidase activity on alpha-tubulin. 3 Publications1
    Mutagenesisi222R → A or E: Abolished tyrosine carboxypeptidase activity on alpha-tubulin. Abolished tyrosine carboxypeptidase activity on alpha-tubulin; when associated with A-146. 4 Publications1
    Mutagenesisi222R → Q: Reduced tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
    Mutagenesisi223R → E: Slightly reduced tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
    Mutagenesisi226L → A: Slightly reduced tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
    Mutagenesisi247Y → F: Slightly reduced tyrosine carboxypeptidase activity on alpha-tubulin. 1 Publication1
    Mutagenesisi256K → E: No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-194. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-203. 1 Publication1
    Mutagenesisi258K → E: No effect on tyrosine carboxypeptidase activity on alpha-tubulin. No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-194. Strognly reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-203. 2 Publications1
    Mutagenesisi276K → E: No effect on tyrosine carboxypeptidase activity on alpha-tubulin. No effect on tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-194. Reduced tyrosine carboxypeptidase activity on alpha-tubulin; when associated with E-203. 2 Publications1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    22846

    Open Targets

    More...
    OpenTargetsi
    ENSG00000071246

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134941450

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q7L8A9 Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    VASH1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    62511163

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001899801 – 365Tubulinyl-Tyr carboxypeptidase 1Add BLAST365

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    2 major forms (42 and 36 kDa) and 2 minors (32 and 27 kDa) may be processed by proteolytic cleavage (PubMed:16488400). The largest form (42 kDa) seems to be secreted and the other major form (63 kDa) seems to accumulate within the cells or pericellular milieu (PubMed:16488400). Polypeptide consisting of Met-77 to Arg-318 may correspond to the 27 kDa form and that consisting of Met-77 to Val-365 may correspond to the 36 kDa form (PubMed:16488400).1 Publication
    Ubiquitinated in vitro.1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei29 – 30Cleavage1 Publication2
    Sitei76 – 77Cleavage1 Publication2

    Keywords - PTMi

    Ubl conjugation

    Proteomic databases

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q7L8A9

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q7L8A9

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q7L8A9

    PeptideAtlas

    More...
    PeptideAtlasi
    Q7L8A9

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q7L8A9

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    68834 [Q7L8A9-1]
    68835 [Q7L8A9-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q7L8A9

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q7L8A9

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Preferentially expressed in endothelial cells (PubMed:15467828, PubMed:16707096). Highly expressed in fetal organs (PubMed:15467828). Expressed in brain and placenta, and at lower level in heart and kidney (PubMed:15467828). Highly detected in microvessels endothelial cells of atherosclerotic lesions (PubMed:16707096).2 Publications

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By VEGF.2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000071246 Expressed in substantia nigra and 135 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q7L8A9 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q7L8A9 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000071246 Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Interacts with SVBP; interaction enhances VASH1 tyrosine carboxypeptidase activity.

    6 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    GO - Molecular functioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    116518, 12 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q7L8A9, 8 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000167106

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q7L8A9 protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1365
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q7L8A9

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni319 – 365Involved in heparin-binding and antiangiogenic activity1 PublicationAdd BLAST47

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IFRP Eukaryota
    ENOG410ZG80 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000012703

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_061405_0_1_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q7L8A9

    KEGG Orthology (KO)

    More...
    KOi
    K23355

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    AYRRCWH

    Database of Orthologous Groups

    More...
    OrthoDBi
    908291at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q7L8A9

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF329370

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR028131 VASH1
    IPR028132 Vasohibin-1

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR15750 PTHR15750, 1 hit
    PTHR15750:SF5 PTHR15750:SF5, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF14822 Vasohibin, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q7L8A9-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MPGGKKVAGG GSSGATPTSA AATAPSGVRR LETSEGTSAQ RDEEPEEEGE
    60 70 80 90 100
    EDLRDGGVPF FVNRGGLPVD EATWERMWKH VAKIHPDGEK VAQRIRGATD
    110 120 130 140 150
    LPKIPIPSVP TFQPSTPVPE RLEAVQRYIR ELQYNHTGTQ FFEIKKSRPL
    160 170 180 190 200
    TGLMDLAKEM TKEALPIKCL EAVILGIYLT NSMPTLERFP ISFKTYFSGN
    210 220 230 240 250
    YFRHIVLGVN FAGRYGALGM SRREDLMYKP PAFRTLSELV LDFEAAYGRC
    260 270 280 290 300
    WHVLKKVKLG QSVSHDPHSV EQIEWKHSVL DVERLGRDDF RKELERHARD
    310 320 330 340 350
    MRLKIGKGTG PPSPTKDRKK DVSSPQRAQS SPHRRNSRSE RRPSGDKKTS
    360
    EPKAMPDLNG YQIRV
    Length:365
    Mass (Da):40,957
    Last modified:July 5, 2004 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCEE39875FA9DA70B
    GO
    Isoform 2 (identifier: Q7L8A9-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         177-204: IYLTNSMPTLERFPISFKTYFSGNYFRH → MYPSSPEGEGSGLLWASASCSESEGGVG
         205-365: Missing.

    Show »
    Length:204
    Mass (Da):21,845
    Checksum:iCE4652CF401BBA85
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    G3V4N9G3V4N9_HUMAN
    Tubulinyl-Tyr carboxypeptidase 1
    VASH1
    91Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAD44361 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence BAA82988 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013324177 – 204IYLTN…NYFRH → MYPSSPEGEGSGLLWASASC SESEGGVG in isoform 2. 1 PublicationAdd BLAST28
    Alternative sequenceiVSP_013325205 – 365Missing in isoform 2. 1 PublicationAdd BLAST161

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB028959 mRNA Translation: BAA82988.2 Different initiation.
    AL832588 mRNA Translation: CAD89941.1
    AC007376 Genomic DNA Translation: AAF02829.1
    AF111169 Genomic DNA Translation: AAD44361.1 Sequence problems.
    BC009031 mRNA Translation: AAH09031.1
    BC051896 mRNA Translation: AAH51896.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS9851.1 [Q7L8A9-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_055724.1, NM_014909.4 [Q7L8A9-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000167106; ENSP00000167106; ENSG00000071246 [Q7L8A9-1]
    ENST00000554237; ENSP00000451613; ENSG00000071246 [Q7L8A9-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    22846

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:22846

    UCSC genome browser

    More...
    UCSCi
    uc001xss.4 human [Q7L8A9-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB028959 mRNA Translation: BAA82988.2 Different initiation.
    AL832588 mRNA Translation: CAD89941.1
    AC007376 Genomic DNA Translation: AAF02829.1
    AF111169 Genomic DNA Translation: AAD44361.1 Sequence problems.
    BC009031 mRNA Translation: AAH09031.1
    BC051896 mRNA Translation: AAH51896.1
    CCDSiCCDS9851.1 [Q7L8A9-1]
    RefSeqiNP_055724.1, NM_014909.4 [Q7L8A9-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6J4UX-ray2.00A57-307[»]
    6J7BX-ray1.62A57-306[»]
    6J8FX-ray2.28B69-306[»]
    6J8NX-ray1.95B/D69-306[»]
    6J8OX-ray1.85B69-306[»]
    6J91X-ray3.50B69-306[»]
    6J9HX-ray2.31B/D69-306[»]
    6K81X-ray2.28A1-365[»]
    6NVQX-ray2.10C1-315[»]
    6OCFX-ray2.10A58-305[»]
    6OCGX-ray1.83A59-305[»]
    6OCHX-ray2.00A/C61-302[»]
    SMRiQ7L8A9
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi116518, 12 interactors
    IntActiQ7L8A9, 8 interactors
    STRINGi9606.ENSP00000167106

    PTM databases

    iPTMnetiQ7L8A9
    PhosphoSitePlusiQ7L8A9

    Polymorphism and mutation databases

    BioMutaiVASH1
    DMDMi62511163

    Proteomic databases

    jPOSTiQ7L8A9
    MassIVEiQ7L8A9
    PaxDbiQ7L8A9
    PeptideAtlasiQ7L8A9
    PRIDEiQ7L8A9
    ProteomicsDBi68834 [Q7L8A9-1]
    68835 [Q7L8A9-2]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    10 273 antibodies

    Genome annotation databases

    EnsembliENST00000167106; ENSP00000167106; ENSG00000071246 [Q7L8A9-1]
    ENST00000554237; ENSP00000451613; ENSG00000071246 [Q7L8A9-2]
    GeneIDi22846
    KEGGihsa:22846
    UCSCiuc001xss.4 human [Q7L8A9-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    22846
    DisGeNETi22846
    EuPathDBiHostDB:ENSG00000071246.10

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    VASH1
    HGNCiHGNC:19964 VASH1
    HPAiENSG00000071246 Low tissue specificity
    MIMi609011 gene
    neXtProtiNX_Q7L8A9
    OpenTargetsiENSG00000071246
    PharmGKBiPA134941450

    Human Unidentified Gene-Encoded large proteins database

    More...
    HUGEi
    Search...

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiENOG410IFRP Eukaryota
    ENOG410ZG80 LUCA
    GeneTreeiENSGT00390000012703
    HOGENOMiCLU_061405_0_1_1
    InParanoidiQ7L8A9
    KOiK23355
    OMAiAYRRCWH
    OrthoDBi908291at2759
    PhylomeDBiQ7L8A9
    TreeFamiTF329370

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    22846 0 hits in 790 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    VASH1 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    VASH1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    22846
    PharosiQ7L8A9 Tbio

    Protein Ontology

    More...
    PROi
    PR:Q7L8A9
    RNActiQ7L8A9 protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000071246 Expressed in substantia nigra and 135 other tissues
    ExpressionAtlasiQ7L8A9 baseline and differential
    GenevisibleiQ7L8A9 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR028131 VASH1
    IPR028132 Vasohibin-1
    PANTHERiPTHR15750 PTHR15750, 1 hit
    PTHR15750:SF5 PTHR15750:SF5, 1 hit
    PfamiView protein in Pfam
    PF14822 Vasohibin, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVASH1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L8A9
    Secondary accession number(s): Q96H02, Q9UBF4, Q9Y629
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: July 5, 2004
    Last modified: June 17, 2020
    This is version 124 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
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