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Entry version 154 (13 Feb 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Rab11 family-interacting protein 2

Gene

RAB11FIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • Rab GTPase binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins

SIGNOR Signaling Network Open Resource

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SIGNORi
Q7L804

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rab11 family-interacting protein 2
Short name:
Rab11-FIP2
Alternative name(s):
NRip11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RAB11FIP2
Synonyms:KIAA0941
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000107560.10

Human Gene Nomenclature Database

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HGNCi
HGNC:29152 RAB11FIP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608599 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7L804

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi223S → A: No effect. 1 Publication1
Mutagenesisi224S → A: No effect. 1 Publication1
Mutagenesisi227S → A: Abolishes phosphorylation by MARK2 and induces defects in the reestablishment of junctional complexes. 1 Publication1
Mutagenesisi229S → A: No effect. 1 Publication1
Mutagenesisi406 – 408NPF → AAA: Severe reduction of the interaction with REPS1 and AP2A1. No effects on its subcellular location. Modifies the endocytosis activity. 1 Publication3
Mutagenesisi480 – 482YID → AAA: Abolishes the interaction with REPS1 and AP2A1. Modifies its subcellular location and the endocytosis activity. Enhances homooligomerization. 1 Publication3
Mutagenesisi480Y → F: No effect on the interaction with RAB11A. Abolishes the vesicular localization. 1 Publication1
Mutagenesisi481I → E: Abolishes the interaction with RAB11A and the vesicular localization. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
22841

Open Targets

More...
OpenTargetsi
ENSG00000107560

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134961225

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RAB11FIP2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
67472131

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000973061 – 512Rab11 family-interacting protein 2Add BLAST512

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei227Phosphoserine; by MARK2Combined sources1 Publication1
Modified residuei277PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-227 by MARK2 regulates epithelial cell polarity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q7L804

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7L804

MaxQB - The MaxQuant DataBase

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MaxQBi
Q7L804

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7L804

PeptideAtlas

More...
PeptideAtlasi
Q7L804

PRoteomics IDEntifications database

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PRIDEi
Q7L804

ProteomicsDB human proteome resource

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ProteomicsDBi
68832

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7L804

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q7L804

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000107560 Expressed in 237 organ(s), highest expression level in cauda epididymis

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7L804 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA037726

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomerizes in a Rab11-independent manner. Forms a heterooligomeric complex with RAB11FIP4. Interacts with AP2A1, MYO5B, RAB25 and REPS1. Interacts with RAB11A and RAB11B (activated GTP-bound form). Interacts with NPC1L1. Interacts (via NPF motifs) with EHD1 and EHD3.10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116514, 54 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q7L804

Database of interacting proteins

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DIPi
DIP-29139N

Protein interaction database and analysis system

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IntActi
Q7L804, 35 interactors

Molecular INTeraction database

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MINTi
Q7L804

STRING: functional protein association networks

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STRINGi
9606.ENSP00000347839

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1512
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GZDX-ray2.44C/D410-512[»]
2GZHX-ray2.47B410-512[»]
2K6SNMR-A/B450-489[»]
3TSOX-ray1.80C/D440-512[»]
4C4PX-ray2.00B410-512[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q7L804

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7L804

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7L804

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 102C2PROSITE-ProRule annotationAdd BLAST102
Domaini437 – 499FIP-RBDPROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni15 – 102Necessary for its cellular translocation to the plasma membraneAdd BLAST88
Regioni465 – 512Necessary for interaction with AP2A1, RAB11A, subcellular location, endocytosis activity and homooligomerization1 PublicationAdd BLAST48

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi323 – 325NPF 13
Motifi406 – 408NPF 23
Motifi440 – 442NPF 33

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEZZ Eukaryota
ENOG410Z26C LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158482

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234700

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG054920

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7L804

KEGG Orthology (KO)

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KOi
K12484

Identification of Orthologs from Complete Genome Data

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OMAi
HMNPTSN

Database of Orthologous Groups

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OrthoDBi
567750at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7L804

TreeFam database of animal gene trees

More...
TreeFami
TF326172

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037245 FIP-RBD_C_sf
IPR037789 FIP_classI
IPR019018 Rab-bd_FIP-RBD

The PANTHER Classification System

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PANTHERi
PTHR15746 PTHR15746, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168 C2, 1 hit
PF09457 RBD-FIP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00239 C2, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF144270 SSF144270, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004 C2, 1 hit
PS51511 FIP_RBD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7L804-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMLSEQAQKW FPTHVQVTVL QAKDLKPKGK SGTNDTYTII QLGKEKYSTS
60 70 80 90 100
VAEKTLEPVW KEEASFELPG LLIQGSPEKY ILFLIVMHRS LVGLDKFLGQ
110 120 130 140 150
VAINLNDIFE DKQRRKTEWF RLESKQGKRI KNRGEIKVNI QFMRNNMTAS
160 170 180 190 200
MFDLSMKDKT RSPFAKLKDK MKGRKNDGTF SDTSSAIIPS THMPDANSEF
210 220 230 240 250
SSGEIQMKSK PKKPFLLGPQ RLSSAHSMSD LSGSHMSSEK LKAGTIGQTH
260 270 280 290 300
LLGHQLDSFG TVPESGSLKS PHRRTLSFDT SKMNQPDSIV DEGELCFGRQ
310 320 330 340 350
NDPFTNVTAS LPQKFATLPR KKNPFEESSE TWDSSMNLFS KPIEIRKENK
360 370 380 390 400
REKREKVSLF ERVTGKKDSR RSDKLNNGGS DSPCDLKSPN AFSENRQDYF
410 420 430 440 450
DYESTNPFTA KFRASNIMPS SSFHMSPTSN EDLRKIPDSN PFDATAGYRS
460 470 480 490 500
LTYEEVLQEL VKHKELLRRK DTHIRELEDY IDNLLVRVME ETPSILRVPY
510
EPSRKAGKFS NS
Length:512
Mass (Da):58,279
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9EC2DAB0A585BCD3
GO
Isoform 2 (identifier: Q7L804-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     422-422: S → RNTLLTPAVAEWRGSLRWAEL

Show »
Length:532
Mass (Da):60,614
Checksum:i24B23A356BCCC409
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76785 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051316152F → V. Corresponds to variant dbSNP:rs34028100Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056649422S → RNTLLTPAVAEWRGSLRWAE L in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ013303 mRNA Translation: AAY67796.1
AY037299 mRNA Translation: AAK68635.1
AB023158 mRNA Translation: BAA76785.2 Different initiation.
AC022395 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49423.1
BC075073 mRNA Translation: AAH75073.1
BC075074 mRNA Translation: AAH75074.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7602.1 [Q7L804-1]
CCDS81512.1 [Q7L804-2]

NCBI Reference Sequences

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RefSeqi
NP_001317096.1, NM_001330167.1 [Q7L804-2]
NP_055719.1, NM_014904.2 [Q7L804-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.173656

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355624; ENSP00000347839; ENSG00000107560 [Q7L804-1]
ENST00000369199; ENSP00000358200; ENSG00000107560 [Q7L804-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22841

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22841

UCSC genome browser

More...
UCSCi
uc001ldj.2 human [Q7L804-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ013303 mRNA Translation: AAY67796.1
AY037299 mRNA Translation: AAK68635.1
AB023158 mRNA Translation: BAA76785.2 Different initiation.
AC022395 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49423.1
BC075073 mRNA Translation: AAH75073.1
BC075074 mRNA Translation: AAH75074.1
CCDSiCCDS7602.1 [Q7L804-1]
CCDS81512.1 [Q7L804-2]
RefSeqiNP_001317096.1, NM_001330167.1 [Q7L804-2]
NP_055719.1, NM_014904.2 [Q7L804-1]
UniGeneiHs.173656

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GZDX-ray2.44C/D410-512[»]
2GZHX-ray2.47B410-512[»]
2K6SNMR-A/B450-489[»]
3TSOX-ray1.80C/D440-512[»]
4C4PX-ray2.00B410-512[»]
ProteinModelPortaliQ7L804
SMRiQ7L804
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116514, 54 interactors
CORUMiQ7L804
DIPiDIP-29139N
IntActiQ7L804, 35 interactors
MINTiQ7L804
STRINGi9606.ENSP00000347839

PTM databases

iPTMnetiQ7L804
PhosphoSitePlusiQ7L804

Polymorphism and mutation databases

BioMutaiRAB11FIP2
DMDMi67472131

Proteomic databases

EPDiQ7L804
jPOSTiQ7L804
MaxQBiQ7L804
PaxDbiQ7L804
PeptideAtlasiQ7L804
PRIDEiQ7L804
ProteomicsDBi68832

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355624; ENSP00000347839; ENSG00000107560 [Q7L804-1]
ENST00000369199; ENSP00000358200; ENSG00000107560 [Q7L804-2]
GeneIDi22841
KEGGihsa:22841
UCSCiuc001ldj.2 human [Q7L804-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22841
DisGeNETi22841
EuPathDBiHostDB:ENSG00000107560.10

GeneCards: human genes, protein and diseases

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GeneCardsi
RAB11FIP2
HGNCiHGNC:29152 RAB11FIP2
HPAiHPA037726
MIMi608599 gene
neXtProtiNX_Q7L804
OpenTargetsiENSG00000107560
PharmGKBiPA134961225

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEZZ Eukaryota
ENOG410Z26C LUCA
GeneTreeiENSGT00940000158482
HOGENOMiHOG000234700
HOVERGENiHBG054920
InParanoidiQ7L804
KOiK12484
OMAiHMNPTSN
OrthoDBi567750at2759
PhylomeDBiQ7L804
TreeFamiTF326172

Enzyme and pathway databases

ReactomeiR-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
SIGNORiQ7L804

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RAB11FIP2 human
EvolutionaryTraceiQ7L804

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RAB11FIP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22841

Protein Ontology

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PROi
PR:Q7L804

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107560 Expressed in 237 organ(s), highest expression level in cauda epididymis
GenevisibleiQ7L804 HS

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR037245 FIP-RBD_C_sf
IPR037789 FIP_classI
IPR019018 Rab-bd_FIP-RBD
PANTHERiPTHR15746 PTHR15746, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09457 RBD-FIP, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SUPFAMiSSF144270 SSF144270, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS51511 FIP_RBD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRFIP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L804
Secondary accession number(s): A6NEI4, Q3I768, Q9Y2F0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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