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Entry version 138 (31 Jul 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32

Gene

DHX32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi85 – 92ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 (EC:3.6.4.13)
Alternative name(s):
DEAD/H box 32
DEAD/H helicase-like protein 1
Short name:
DHLP1
DEAH box protein 32
HuDDX32
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DHX32
Synonyms:DDX32
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16717 DHX32

Online Mendelian Inheritance in Man (OMIM)

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MIMi
607960 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7L7V1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55760

Open Targets

More...
OpenTargetsi
ENSG00000089876

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27219

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DHX32

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74759011

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002926631 – 743Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7L7V1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7L7V1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7L7V1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7L7V1

PeptideAtlas

More...
PeptideAtlasi
Q7L7V1

PRoteomics IDEntifications database

More...
PRIDEi
Q7L7V1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68827 [Q7L7V1-1]
68828 [Q7L7V1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7L7V1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7L7V1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lymphoid tissues (at protein level). Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung, lymphoid tissues and blood leukocytes.2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by ionomycin in T-lymphocytes. Down-regulated in acute lymphoblastic leukemia.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000089876 Expressed in 229 organ(s), highest expression level in epithelium of bronchus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7L7V1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7L7V1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048872

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FAM161AQ3B8207EBI-2807297,EBI-719941

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120878, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q7L7V1, 7 interactors

Molecular INTeraction database

More...
MINTi
Q7L7V1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000284690

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7L7V1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 238Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST167

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi185 – 188DEAH box4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0925 Eukaryota
COG1643 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157227

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7L7V1

KEGG Orthology (KO)

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KOi
K18994

Identification of Orthologs from Complete Genome Data

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OMAi
VTAPNCF

Database of Orthologous Groups

More...
OrthoDBi
354219at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7L7V1

TreeFam database of animal gene trees

More...
TreeFami
TF105735

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04408 HA2, 1 hit
PF07717 OB_NTP_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00847 HA2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7L7V1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEEGLECPN SSSEKRYFPE SLDSSDGDEE EVLACEDLEL NPFDGLPYSS
60 70 80 90 100
RYYKLLKERE DLPIWKEKYS FMENLLQNQI VIVSGDAKCG KSAQVPQWCA
110 120 130 140 150
EYCLSIHYQH GGVICTQVHK QTVVQLALRV ADEMDVNIGH EVGYVIPFEN
160 170 180 190 200
CCTNETILRY CTDDMLQREM MSNPFLGSYG VIILDDIHER SIATDVLLGL
210 220 230 240 250
LKDVLLARPE LKLIINSSPH LISKLNSYYG NVPVIEVKNK HPVEVVYLSE
260 270 280 290 300
AQKDSFESIL RLIFEIHHSG EKGDIVVFLA CEQDIEKVCE TVYQGSNLNP
310 320 330 340 350
DLGELVVVPL YPKEKCSLFK PLDETEKRCQ VYQRRVVLTT SSGEFLIWSN
360 370 380 390 400
SVRFVIDVGV ERRKVYNPRI RANSLVMQPI SQSQAEIRKQ ILGSSSSGKF
410 420 430 440 450
FCLYTEEFAS KDMTPLKPAE MQEANLTSMV LFMKRIDIAG LGHCDFMNRP
460 470 480 490 500
APESLMQALE DLDYLAALDN DGNLSEFGII MSEFPLDPQL SKSILASCEF
510 520 530 540 550
DCVDEVLTIA AMVTAPNCFS HVPHGAEEAA LTCWKTFLHP EGDHFTLISI
560 570 580 590 600
YKAYQDTTLN SSSEYCVEKW CRDYFLNCSA LRMADVIRAE LLEIIKRIEL
610 620 630 640 650
PYAEPAFGSK ENTLNIKKAL LSGYFMQIAR DVDGSGNYLM LTHKQVAQLH
660 670 680 690 700
PLSGYSITKK MPEWVLFHKF SISENNYIRI TSEISPELFM QLVPQYYFSN
710 720 730 740
LPPSESKDIL QQVVDHLSPV STMNKEQQMC ETCPETEQRC TLQ
Length:743
Mass (Da):84,419
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6D5C570561C468A
GO
Isoform 2 (identifier: Q7L7V1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-364: Missing.

Show »
Length:662
Mass (Da):75,088
Checksum:i32A872984FC00460
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
X6R717X6R717_HUMAN
Putative pre-mRNA-splicing factor A...
DHX32
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RHK1X6RHK1_HUMAN
Putative pre-mRNA-splicing factor A...
DHX32
112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH37925 differs from that shown. Reason: Frameshift at position 439.Curated
The sequence BAB15029 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26D → G in BAA91754 (PubMed:14702039).Curated1
Sequence conflicti123V → M in BAA91882 (PubMed:14702039).Curated1
Sequence conflicti171M → V in BAA91754 (PubMed:14702039).Curated1
Sequence conflicti231N → F in AAL26551 (PubMed:12163057).Curated1
Sequence conflicti459L → S in BAA91882 (PubMed:14702039).Curated1
Sequence conflicti496A → G in BAA91882 (PubMed:14702039).Curated1
Sequence conflicti499E → G in AAH37925 (PubMed:15489334).Curated1
Sequence conflicti567V → A in BAB15029 (PubMed:14702039).Curated1
Sequence conflicti590E → G in AAH37925 (PubMed:15489334).Curated1
Sequence conflicti686P → L in BAA91882 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035843209P → R in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_052181271E → D. Corresponds to variant dbSNP:rs11244674Ensembl.1
Natural variantiVAR_052182301D → A. Corresponds to variant dbSNP:rs35772239Ensembl.1
Natural variantiVAR_052183430V → L. Corresponds to variant dbSNP:rs17153669Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_026427284 – 364Missing in isoform 2. 1 PublicationAdd BLAST81

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF427340 mRNA Translation: AAL26550.1
AF427341 mRNA Translation: AAL26551.1
AY064247 Genomic DNA Translation: AAL55437.1
AY064250 mRNA Translation: AAL55441.1
AK001556 mRNA Translation: BAA91754.1
AK001751 mRNA Translation: BAA91882.1
AK024869 mRNA Translation: BAB15029.1 Different initiation.
AL360176 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49216.1
CH471066 Genomic DNA Translation: EAW49217.1
BC002473 mRNA Translation: AAH02473.3
BC037925 mRNA Translation: AAH37925.1 Frameshift.
BC068471 mRNA Translation: AAH68471.1
AL162051 mRNA Translation: CAB82394.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7652.1 [Q7L7V1-1]

Protein sequence database of the Protein Information Resource

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PIRi
T47184

NCBI Reference Sequences

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RefSeqi
NP_060650.2, NM_018180.2 [Q7L7V1-1]
XP_016871893.1, XM_017016404.1
XP_016871894.1, XM_017016405.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000284690; ENSP00000284690; ENSG00000089876 [Q7L7V1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55760

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55760

UCSC genome browser

More...
UCSCi
uc001ljf.1 human [Q7L7V1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF427340 mRNA Translation: AAL26550.1
AF427341 mRNA Translation: AAL26551.1
AY064247 Genomic DNA Translation: AAL55437.1
AY064250 mRNA Translation: AAL55441.1
AK001556 mRNA Translation: BAA91754.1
AK001751 mRNA Translation: BAA91882.1
AK024869 mRNA Translation: BAB15029.1 Different initiation.
AL360176 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49216.1
CH471066 Genomic DNA Translation: EAW49217.1
BC002473 mRNA Translation: AAH02473.3
BC037925 mRNA Translation: AAH37925.1 Frameshift.
BC068471 mRNA Translation: AAH68471.1
AL162051 mRNA Translation: CAB82394.1
CCDSiCCDS7652.1 [Q7L7V1-1]
PIRiT47184
RefSeqiNP_060650.2, NM_018180.2 [Q7L7V1-1]
XP_016871893.1, XM_017016404.1
XP_016871894.1, XM_017016405.1

3D structure databases

SMRiQ7L7V1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi120878, 11 interactors
IntActiQ7L7V1, 7 interactors
MINTiQ7L7V1
STRINGi9606.ENSP00000284690

PTM databases

iPTMnetiQ7L7V1
PhosphoSitePlusiQ7L7V1

Polymorphism and mutation databases

BioMutaiDHX32
DMDMi74759011

Proteomic databases

EPDiQ7L7V1
jPOSTiQ7L7V1
MaxQBiQ7L7V1
PaxDbiQ7L7V1
PeptideAtlasiQ7L7V1
PRIDEiQ7L7V1
ProteomicsDBi68827 [Q7L7V1-1]
68828 [Q7L7V1-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
55760
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284690; ENSP00000284690; ENSG00000089876 [Q7L7V1-1]
GeneIDi55760
KEGGihsa:55760
UCSCiuc001ljf.1 human [Q7L7V1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55760
DisGeNETi55760

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DHX32
HGNCiHGNC:16717 DHX32
HPAiHPA048872
MIMi607960 gene
neXtProtiNX_Q7L7V1
OpenTargetsiENSG00000089876
PharmGKBiPA27219

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0925 Eukaryota
COG1643 LUCA
GeneTreeiENSGT00940000157227
InParanoidiQ7L7V1
KOiK18994
OMAiVTAPNCF
OrthoDBi354219at2759
PhylomeDBiQ7L7V1
TreeFamiTF105735

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DHX32 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
DHX32

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55760

Protein Ontology

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PROi
PR:Q7L7V1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000089876 Expressed in 229 organ(s), highest expression level in epithelium of bronchus
ExpressionAtlasiQ7L7V1 baseline and differential
GenevisibleiQ7L7V1 HS

Family and domain databases

InterProiView protein in InterPro
IPR011709 DUF1605
IPR007502 Helicase-assoc_dom
IPR014001 Helicase_ATP-bd
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF04408 HA2, 1 hit
PF07717 OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00847 HA2, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHX32_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L7V1
Secondary accession number(s): A8MSV2
, D3DRF9, Q49AG5, Q5T3L0, Q5T3L5, Q96NY1, Q9BUN0, Q9H769, Q9NSL5, Q9NV74, Q9NVJ7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: July 31, 2019
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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