UniProtKB - Q7L5Y6 (DET1_HUMAN)
Protein
DET1 homolog
Gene
DET1
Organism
Homo sapiens (Human)
Status
Functioni
Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.1 Publication
GO - Molecular functioni
- protein-containing complex binding Source: UniProtKB
- ubiquitin ligase-substrate adaptor activity Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein-containing complex assembly Source: UniProtKB
- protein ubiquitination Source: UniProtKB
Keywordsi
Biological process | Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q7L5Y6 |
Reactomei | R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q7L5Y6 |
Names & Taxonomyi
Protein namesi | Recommended name: DET1 homologAlternative name(s): De-etiolated-1 homolog |
Gene namesi | Name:DET1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25477, DET1 |
MIMi | 608727, gene |
neXtProti | NX_Q7L5Y6 |
VEuPathDBi | HostDB:ENSG00000140543.13 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Other locations
- Cul4-RING E3 ubiquitin ligase complex Source: UniProtKB
- Cul4A-RING E3 ubiquitin ligase complex Source: UniProtKB
- cullin-RING ubiquitin ligase complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 55070 |
OpenTargetsi | ENSG00000140543 |
PharmGKBi | PA134943899 |
Miscellaneous databases
Pharosi | Q7L5Y6, Tbio |
Genetic variation databases
BioMutai | DET1 |
DMDMi | 55976471 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000129026 | 1 – 550 | DET1 homologAdd BLAST | 550 |
Proteomic databases
EPDi | Q7L5Y6 |
MassIVEi | Q7L5Y6 |
MaxQBi | Q7L5Y6 |
PaxDbi | Q7L5Y6 |
PeptideAtlasi | Q7L5Y6 |
PRIDEi | Q7L5Y6 |
ProteomicsDBi | 68817 [Q7L5Y6-1] 68818 [Q7L5Y6-2] |
PTM databases
iPTMneti | Q7L5Y6 |
PhosphoSitePlusi | Q7L5Y6 |
Expressioni
Tissue specificityi
Highly expressed in the ovary, some lymphoid organs and resting leukocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000140543, Expressed in secondary oocyte and 185 other tissues |
ExpressionAtlasi | Q7L5Y6, baseline and differential |
Genevisiblei | Q7L5Y6, HS |
Organism-specific databases
HPAi | ENSG00000140543, Low tissue specificity |
Interactioni
Subunit structurei
Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1.
1 PublicationGO - Molecular functioni
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 120387, 37 interactors |
CORUMi | Q7L5Y6 |
IntActi | Q7L5Y6, 37 interactors |
STRINGi | 9606.ENSP00000456340 |
Miscellaneous databases
RNActi | Q7L5Y6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the DET1 family.Curated
Phylogenomic databases
eggNOGi | KOG2558, Eukaryota |
GeneTreei | ENSGT00390000005224 |
HOGENOMi | CLU_036725_1_0_1 |
InParanoidi | Q7L5Y6 |
OMAi | IPPVYLR |
OrthoDBi | 603320at2759 |
PhylomeDBi | Q7L5Y6 |
TreeFami | TF324729 |
Family and domain databases
InterProi | View protein in InterPro IPR019138, De-etiolated_protein_1_Det1 |
PANTHERi | PTHR13374, PTHR13374, 1 hit |
Pfami | View protein in Pfam PF09737, Det1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7L5Y6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDHHVSTIKP RRIQNQNVIH RLERRRISSG KAGTHWHQVR VFHQNVFPNF
60 70 80 90 100
TVVNVEKPPC FLRKFSPDGR YFIAFSSDQT SLEIYEYQGC QAAEDLLQGY
110 120 130 140 150
EGEILSNGND QRSVNIRGRL FERFFVLLHI TNVAANGEHL NRECSLFTDD
160 170 180 190 200
CRCVIVGSAA YLPDEPHPPF FEVYRNSESV TPNPRSPLED YSLHIIDLHT
210 220 230 240 250
GRLCDTRTFK CDKVVLSHNQ GLYLYKNILA ILSVQQQTIH VFQVTPEGTF
260 270 280 290 300
IDVRTIGRFC YEDDLLTVSA VFPEVQRDSQ TGMANPFRDP FINSLKHRLL
310 320 330 340 350
VYLWRRAEQD GSAMAKRRFF QYFDQLRQLR MWKMQLLDEN HLFIKYTSED
360 370 380 390 400
VVTLRVTDPS QASFFVVYNM VTTEVIAVFE NTSDELLELF ENFCDLFRNA
410 420 430 440 450
TLHSEVQFPC SASSNNFARQ IQRRFKDTII NAKYGGHTEA VRRLLGQLPI
460 470 480 490 500
SAQSYSGSPY LDLSLFSYDD KWVSVMERPK TCGDHPIRFY ARDSGLLKFE
510 520 530 540 550
IQAGLLGRPI NHTVRRLVAF TFHPFEPFAI SVQRTNAEYV VNFHMRHCCT
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YK09 | H0YK09_HUMAN | DET1 homolog | DET1 | 67 | Annotation score: | ||
H0YN79 | H0YN79_HUMAN | DET1 homolog | DET1 | 94 | Annotation score: |
Sequence cautioni
The sequence BAA91447 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043012 | 1 | M → MVGQILKRDVIM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000965 mRNA Translation: BAA91447.1 Different initiation. AK054603 mRNA Translation: BAG51398.1 BC001242 mRNA Translation: AAH01242.2 BC109060 mRNA Translation: AAI09061.1 BC109061 mRNA Translation: AAI09062.1 |
CCDSi | CCDS45343.1 [Q7L5Y6-2] CCDS45344.1 [Q7L5Y6-1] |
RefSeqi | NP_001137546.1, NM_001144074.2 [Q7L5Y6-1] NP_001308525.1, NM_001321596.1 [Q7L5Y6-1] NP_060466.2, NM_017996.4 [Q7L5Y6-2] |
Genome annotation databases
Ensembli | ENST00000268148; ENSP00000268148; ENSG00000140543 [Q7L5Y6-1] ENST00000444300; ENSP00000408994; ENSG00000140543 [Q7L5Y6-2] ENST00000564406; ENSP00000456340; ENSG00000140543 [Q7L5Y6-2] |
GeneIDi | 55070 |
KEGGi | hsa:55070 |
UCSCi | uc002bmq.3, human [Q7L5Y6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK000965 mRNA Translation: BAA91447.1 Different initiation. AK054603 mRNA Translation: BAG51398.1 BC001242 mRNA Translation: AAH01242.2 BC109060 mRNA Translation: AAI09061.1 BC109061 mRNA Translation: AAI09062.1 |
CCDSi | CCDS45343.1 [Q7L5Y6-2] CCDS45344.1 [Q7L5Y6-1] |
RefSeqi | NP_001137546.1, NM_001144074.2 [Q7L5Y6-1] NP_001308525.1, NM_001321596.1 [Q7L5Y6-1] NP_060466.2, NM_017996.4 [Q7L5Y6-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 120387, 37 interactors |
CORUMi | Q7L5Y6 |
IntActi | Q7L5Y6, 37 interactors |
STRINGi | 9606.ENSP00000456340 |
PTM databases
iPTMneti | Q7L5Y6 |
PhosphoSitePlusi | Q7L5Y6 |
Genetic variation databases
BioMutai | DET1 |
DMDMi | 55976471 |
Proteomic databases
EPDi | Q7L5Y6 |
MassIVEi | Q7L5Y6 |
MaxQBi | Q7L5Y6 |
PaxDbi | Q7L5Y6 |
PeptideAtlasi | Q7L5Y6 |
PRIDEi | Q7L5Y6 |
ProteomicsDBi | 68817 [Q7L5Y6-1] 68818 [Q7L5Y6-2] |
Protocols and materials databases
Antibodypediai | 43705, 66 antibodies |
Genome annotation databases
Ensembli | ENST00000268148; ENSP00000268148; ENSG00000140543 [Q7L5Y6-1] ENST00000444300; ENSP00000408994; ENSG00000140543 [Q7L5Y6-2] ENST00000564406; ENSP00000456340; ENSG00000140543 [Q7L5Y6-2] |
GeneIDi | 55070 |
KEGGi | hsa:55070 |
UCSCi | uc002bmq.3, human [Q7L5Y6-1] |
Organism-specific databases
CTDi | 55070 |
DisGeNETi | 55070 |
GeneCardsi | DET1 |
HGNCi | HGNC:25477, DET1 |
HPAi | ENSG00000140543, Low tissue specificity |
MIMi | 608727, gene |
neXtProti | NX_Q7L5Y6 |
OpenTargetsi | ENSG00000140543 |
PharmGKBi | PA134943899 |
VEuPathDBi | HostDB:ENSG00000140543.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2558, Eukaryota |
GeneTreei | ENSGT00390000005224 |
HOGENOMi | CLU_036725_1_0_1 |
InParanoidi | Q7L5Y6 |
OMAi | IPPVYLR |
OrthoDBi | 603320at2759 |
PhylomeDBi | Q7L5Y6 |
TreeFami | TF324729 |
Enzyme and pathway databases
PathwayCommonsi | Q7L5Y6 |
Reactomei | R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SIGNORi | Q7L5Y6 |
Miscellaneous databases
BioGRID-ORCSi | 55070, 169 hits in 1002 CRISPR screens |
ChiTaRSi | DET1, human |
GenomeRNAii | 55070 |
Pharosi | Q7L5Y6, Tbio |
PROi | PR:Q7L5Y6 |
RNActi | Q7L5Y6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000140543, Expressed in secondary oocyte and 185 other tissues |
ExpressionAtlasi | Q7L5Y6, baseline and differential |
Genevisiblei | Q7L5Y6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019138, De-etiolated_protein_1_Det1 |
PANTHERi | PTHR13374, PTHR13374, 1 hit |
Pfami | View protein in Pfam PF09737, Det1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DET1_HUMAN | |
Accessioni | Q7L5Y6Primary (citable) accession number: Q7L5Y6 Secondary accession number(s): B3KNN6, Q2VPC0, Q9NWD5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 23, 2004 |
Last sequence update: | November 23, 2004 | |
Last modified: | April 7, 2021 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families