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UniProtKB - Q7L5Y6 (DET1_HUMAN)

Entry version 129 (07 Apr 2021)
Sequence version 2 (23 Nov 2004)
Previous versions | rss
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Protein

DET1 homolog

Gene

DET1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7L5Y6

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q7L5Y6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DET1 homolog
Alternative name(s):
De-etiolated-1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DET1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25477, DET1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608727, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7L5Y6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140543.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55070

Open Targets

More...OpenTargetsi		ENSG00000140543

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134943899

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7L5Y6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DET1

Domain mapping of disease mutations (DMDM)

More...DMDMi		55976471

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001290261 – 550DET1 homologAdd BLAST550

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7L5Y6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7L5Y6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7L5Y6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7L5Y6

PeptideAtlas

More...PeptideAtlasi		Q7L5Y6

PRoteomics IDEntifications database

More...PRIDEi		Q7L5Y6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68817 [Q7L5Y6-1]
68818 [Q7L5Y6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7L5Y6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7L5Y6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the ovary, some lymphoid organs and resting leukocytes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140543, Expressed in secondary oocyte and 185 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7L5Y6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7L5Y6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140543, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120387, 37 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q7L5Y6

Protein interaction database and analysis system

More...IntActi		Q7L5Y6, 37 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000456340

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7L5Y6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DET1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2558, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005224

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_036725_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7L5Y6

Identification of Orthologs from Complete Genome Data

More...OMAi		IPPVYLR

Database of Orthologous Groups

More...OrthoDBi		603320at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7L5Y6

TreeFam database of animal gene trees

More...TreeFami		TF324729

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019138, De-etiolated_protein_1_Det1

The PANTHER Classification System

More...PANTHERi		PTHR13374, PTHR13374, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09737, Det1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7L5Y6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDHHVSTIKP RRIQNQNVIH RLERRRISSG KAGTHWHQVR VFHQNVFPNF 
        60         70         80         90        100
TVVNVEKPPC FLRKFSPDGR YFIAFSSDQT SLEIYEYQGC QAAEDLLQGY 
       110        120        130        140        150
EGEILSNGND QRSVNIRGRL FERFFVLLHI TNVAANGEHL NRECSLFTDD 
       160        170        180        190        200
CRCVIVGSAA YLPDEPHPPF FEVYRNSESV TPNPRSPLED YSLHIIDLHT 
       210        220        230        240        250
GRLCDTRTFK CDKVVLSHNQ GLYLYKNILA ILSVQQQTIH VFQVTPEGTF 
       260        270        280        290        300
IDVRTIGRFC YEDDLLTVSA VFPEVQRDSQ TGMANPFRDP FINSLKHRLL 
       310        320        330        340        350
VYLWRRAEQD GSAMAKRRFF QYFDQLRQLR MWKMQLLDEN HLFIKYTSED 
       360        370        380        390        400
VVTLRVTDPS QASFFVVYNM VTTEVIAVFE NTSDELLELF ENFCDLFRNA 
       410        420        430        440        450
TLHSEVQFPC SASSNNFARQ IQRRFKDTII NAKYGGHTEA VRRLLGQLPI 
       460        470        480        490        500
SAQSYSGSPY LDLSLFSYDD KWVSVMERPK TCGDHPIRFY ARDSGLLKFE 
       510        520        530        540        550
IQAGLLGRPI NHTVRRLVAF TFHPFEPFAI SVQRTNAEYV VNFHMRHCCT
Length:550
Mass (Da):63,848
Last modified:November 23, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA164AC844F897DF7
GO
Isoform 2 (identifier: Q7L5Y6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MVGQILKRDVIM

Show »
Length:561
Mass (Da):65,102
Checksum:i733F7156B8561988
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YK09H0YK09_HUMAN
DET1 homolog
DET1
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN79H0YN79_HUMAN
DET1 homolog
DET1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA91447 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430121M → MVGQILKRDVIM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK000965 mRNA Translation: BAA91447.1 Different initiation.
AK054603 mRNA Translation: BAG51398.1
BC001242 mRNA Translation: AAH01242.2
BC109060 mRNA Translation: AAI09061.1
BC109061 mRNA Translation: AAI09062.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45343.1 [Q7L5Y6-2]
CCDS45344.1 [Q7L5Y6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001137546.1, NM_001144074.2 [Q7L5Y6-1]
NP_001308525.1, NM_001321596.1 [Q7L5Y6-1]
NP_060466.2, NM_017996.4 [Q7L5Y6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000268148; ENSP00000268148; ENSG00000140543 [Q7L5Y6-1]
ENST00000444300; ENSP00000408994; ENSG00000140543 [Q7L5Y6-2]
ENST00000564406; ENSP00000456340; ENSG00000140543 [Q7L5Y6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55070

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55070

UCSC genome browser

More...UCSCi		uc002bmq.3, human [Q7L5Y6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000965 mRNA Translation: BAA91447.1 Different initiation.
AK054603 mRNA Translation: BAG51398.1
BC001242 mRNA Translation: AAH01242.2
BC109060 mRNA Translation: AAI09061.1
BC109061 mRNA Translation: AAI09062.1
CCDSiCCDS45343.1 [Q7L5Y6-2]
CCDS45344.1 [Q7L5Y6-1]
RefSeqiNP_001137546.1, NM_001144074.2 [Q7L5Y6-1]
NP_001308525.1, NM_001321596.1 [Q7L5Y6-1]
NP_060466.2, NM_017996.4 [Q7L5Y6-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120387, 37 interactors
CORUMiQ7L5Y6
IntActiQ7L5Y6, 37 interactors
STRINGi9606.ENSP00000456340

PTM databases

iPTMnetiQ7L5Y6
PhosphoSitePlusiQ7L5Y6

Genetic variation databases

BioMutaiDET1
DMDMi55976471

Proteomic databases

EPDiQ7L5Y6
MassIVEiQ7L5Y6
MaxQBiQ7L5Y6
PaxDbiQ7L5Y6
PeptideAtlasiQ7L5Y6
PRIDEiQ7L5Y6
ProteomicsDBi68817 [Q7L5Y6-1]
68818 [Q7L5Y6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		43705, 66 antibodies

Genome annotation databases

EnsembliENST00000268148; ENSP00000268148; ENSG00000140543 [Q7L5Y6-1]
ENST00000444300; ENSP00000408994; ENSG00000140543 [Q7L5Y6-2]
ENST00000564406; ENSP00000456340; ENSG00000140543 [Q7L5Y6-2]
GeneIDi55070
KEGGihsa:55070
UCSCiuc002bmq.3, human [Q7L5Y6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55070
DisGeNETi55070

GeneCards: human genes, protein and diseases

More...GeneCardsi		DET1
HGNCiHGNC:25477, DET1
HPAiENSG00000140543, Low tissue specificity
MIMi608727, gene
neXtProtiNX_Q7L5Y6
OpenTargetsiENSG00000140543
PharmGKBiPA134943899
VEuPathDBiHostDB:ENSG00000140543.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2558, Eukaryota
GeneTreeiENSGT00390000005224
HOGENOMiCLU_036725_1_0_1
InParanoidiQ7L5Y6
OMAiIPPVYLR
OrthoDBi603320at2759
PhylomeDBiQ7L5Y6
TreeFamiTF324729

Enzyme and pathway databases

PathwayCommonsiQ7L5Y6
ReactomeiR-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ7L5Y6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55070, 169 hits in 1002 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DET1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55070
PharosiQ7L5Y6, Tbio

Protein Ontology

More...PROi		PR:Q7L5Y6
RNActiQ7L5Y6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140543, Expressed in secondary oocyte and 185 other tissues
ExpressionAtlasiQ7L5Y6, baseline and differential
GenevisibleiQ7L5Y6, HS

Family and domain databases

InterProiView protein in InterPro
IPR019138, De-etiolated_protein_1_Det1
PANTHERiPTHR13374, PTHR13374, 1 hit
PfamiView protein in Pfam
PF09737, Det1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDET1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L5Y6
Secondary accession number(s): B3KNN6, Q2VPC0, Q9NWD5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: April 7, 2021
This is version 129 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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