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Entry version 131 (12 Aug 2020)
Sequence version 1 (24 May 2005)
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Protein

Mitochondrial enolase superfamily member 1

Gene

ENOSF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329).1 Publication

Caution

Was originally (PubMed:8493092) identified as a gene coding for an antisense RNA to thymidylate synthase, and was proposed to down-regulate TYMS activity (PubMed:8869746), possibly by promoting the degradation of TYMS mRNA via an antisense RNA-based mechanism (PubMed:12084460).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.5 sec(-1) for L-fuconate. kcat is 0.3 sec(-1) for L-galactonate. kcat is 0.3 sec(-1) for L-arabinonate. kcat is 0.04 sec(-1) for D-arabinonate. kcat is 0.002 sec(-1) for D-ribonate.
  1. KM=0.2 mM for L-fuconate1 Publication
  2. KM=3.0 mM for L-galactonate1 Publication
  3. KM=2.0 mM for D-arabinonate1 Publication
  4. KM=4.0 mM for L-arabinonate1 Publication
  5. KM=0.4 mM for D-ribonate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei34SubstrateBy similarity1
    Binding sitei220SubstrateBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei222Proton donor/acceptorBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi250Magnesium1 Publication1
    Binding sitei252SubstrateBy similarity1
    Metal bindingi276Magnesium1 Publication1
    Binding sitei276SubstrateBy similarity1
    Metal bindingi305Magnesium1 Publication1
    Binding sitei305SubstrateBy similarity1
    Active sitei355Sequence analysis1
    Binding sitei386SubstrateBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionIsomerase, Lyase
    LigandMagnesium, Metal-binding

    Enzyme and pathway databases

    Pathway Commons web resource for biological pathway data

    More...
    PathwayCommonsi
    Q7L5Y1

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Mitochondrial enolase superfamily member 1 (EC:4.2.1.681 Publication)
    Alternative name(s):
    Antisense RNA to thymidylate synthase
    Short name:
    rTS
    L-fuconate dehydratase
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ENOSF1
    Synonyms:RTS, TYMSAS
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000132199.18

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:30365, ENOSF1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    607427, gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q7L5Y1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Mitochondrion

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1 – 27Missing : Impairs protein solubility. Abolishes catalytic activity. 1 PublicationAdd BLAST27

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    55556

    Open Targets

    More...
    OpenTargetsi
    ENSG00000132199

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134897613

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q7L5Y1, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ENOSF1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    74739173

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003316521 – 443Mitochondrial enolase superfamily member 1Add BLAST443

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei148Phosphoserine1 Publication1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Could be sumoylated.1 Publication

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q7L5Y1

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q7L5Y1

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q7L5Y1

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q7L5Y1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q7L5Y1

    PeptideAtlas

    More...
    PeptideAtlasi
    Q7L5Y1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q7L5Y1

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    1550
    3646
    68814 [Q7L5Y1-1]
    68815 [Q7L5Y1-2]
    68816 [Q7L5Y1-3]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q7L5Y1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q7L5Y1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000132199, Expressed in left lobe of thyroid gland and 236 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q7L5Y1, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q7L5Y1, HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    ENSG00000132199, Low tissue specificity

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    120716, 8 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q7L5Y1, 3 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000345974

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q7L5Y1, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1443
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q7L5Y1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 26Substrate bindingBy similarity3
    Regioni355 – 357Substrate bindingBy similarity3

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG502QU7C, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000014290

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_030273_2_2_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q7L5Y1

    KEGG Orthology (KO)

    More...
    KOi
    K18334

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    KTWRYLV

    Database of Orthologous Groups

    More...
    OrthoDBi
    933480at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q7L5Y1

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF300529

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd03324, rTSbeta_L-fuconate_dehydratase, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.20.20.120, 1 hit
    3.30.390.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR036849, Enolase-like_C_sf
    IPR029017, Enolase-like_N
    IPR029065, Enolase_C-like
    IPR034610, L-fuconate_dehydratase
    IPR018110, Mandel_Rmase/mucon_lact_enz_CS
    IPR013342, Mandelate_racemase_C
    IPR013341, Mandelate_racemase_N_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR13794:SF58, PTHR13794:SF58, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF13378, MR_MLE_C, 1 hit
    PF02746, MR_MLE_N, 1 hit

    Structure-Function Linkage Database

    More...
    SFLDi
    SFLDF00111, L-fuconate_dehydratase, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00922, MR_MLE, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51604, SSF51604, 1 hit
    SSF54826, SSF54826, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00909, MR_MLE_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q7L5Y1-1) [UniParc]FASTAAdd to basket
    Also known as: rTSgamma

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MVRGRISRLS VRDVRFPTSL GGHGADAMHT DPDYSAAYVV IETDAEDGIK
    60 70 80 90 100
    GCGITFTLGK GTEVVVCAVN ALAHHVLNKD LKDIVGDFRG FYRQLTSDGQ
    110 120 130 140 150
    LRWIGPEKGV VHLATAAVLN AVWDLWAKQE GKPVWKLLVD MDPRMLVSCI
    160 170 180 190 200
    DFRYITDVLT EEDALEILQK GQIGKKEREK QMLAQGYPAY TTSCAWLGYS
    210 220 230 240 250
    DDTLKQLCAQ ALKDGWTRFK VKVGADLQDD MRRCQIIRDM IGPEKTLMMD
    260 270 280 290 300
    ANQRWDVPEA VEWMSKLAKF KPLWIEEPTS PDDILGHATI SKALVPLGIG
    310 320 330 340 350
    IATGEQCHNR VIFKQLLQAK ALQFLQIDSC RLGSVNENLS VLLMAKKFEI
    360 370 380 390 400
    PVCPHAGGVG LCELVQHLII FDYISVSASL ENRVCEYVDH LHEHFKYPVM
    410 420 430 440
    IQRASYMPPK DPGYSTEMKE ESVKKHQYPD GEVWKKLLPA QEN
    Length:443
    Mass (Da):49,786
    Last modified:May 24, 2005 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82BEDAC229D1A729
    GO
    Isoform 2 (identifier: Q7L5Y1-2) [UniParc]FASTAAdd to basket
    Also known as: rTSalpha

    The sequence of this isoform differs from the canonical sequence as follows:
         1-102: Missing.
         103-103: W → MQKMESRGVELPSLWEKALKL

    Show »
    Length:361
    Mass (Da):41,024
    Checksum:i73B469F1C9C7E144
    GO
    Isoform 3 (identifier: Q7L5Y1-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         65-117: VVCAVNALAH...KGVVHLATAA → DWSRKGRGAP...GILHRFQVHH
         118-443: Missing.

    Show »
    Length:117
    Mass (Da):12,286
    Checksum:iB277BFA534E7DAF2
    GO
    Isoform 4 (identifier: Q7L5Y1-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-24: MVRGRISRLSVRDVRFPTSLGGHG → MVSADAMVSADAMVSADAMVSADAMVSADAMVSADAMVSADAMVS
         293-306: Missing.

    Show »
    Length:450
    Mass (Da):50,170
    Checksum:i7D6BD13DF0F12AD0
    GO
    Isoform 5 (identifier: Q7L5Y1-5) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-24: MVRGRISRLSVRDVRFPTSLGGHG → MVSADAMVSA...AMVSADAMVS
         293-306: Missing.

    Show »
    Length:474
    Mass (Da):52,468
    Checksum:i97FA6018CAADF8CB
    GO
    Isoform 6 (identifier: Q7L5Y1-6) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-181: Missing.

    Show »
    Length:262
    Mass (Da):29,710
    Checksum:i5296CB2DCA806273
    GO
    Isoform 7 (identifier: Q7L5Y1-7) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-230: Missing.

    Show »
    Length:213
    Mass (Da):24,284
    Checksum:iF2CF0580E05E10BA
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A3F2YNX7A0A3F2YNX7_HUMAN
    L-fuconate dehydratase
    ENOSF1
    477Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QL81J3QL81_HUMAN
    Mitochondrial enolase superfamily m...
    ENOSF1
    367Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    X6RM24X6RM24_HUMAN
    Mitochondrial enolase superfamily m...
    ENOSF1
    96Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QL99J3QL99_HUMAN
    Mitochondrial enolase superfamily m...
    ENOSF1
    179Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    R4GNF8R4GNF8_HUMAN
    Mitochondrial enolase superfamily m...
    ENOSF1
    98Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    J3QSB6J3QSB6_HUMAN
    Mitochondrial enolase superfamily m...
    ENOSF1
    204Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAG29537 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
    The sequence CAA47471 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04293331D → E. Corresponds to variant dbSNP:rs34724061Ensembl.1
    Natural variantiVAR_042934145M → T4 PublicationsCorresponds to variant dbSNP:rs2612086Ensembl.1
    Natural variantiVAR_042935428Y → S. Corresponds to variant dbSNP:rs2847620Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0552411 – 230Missing in isoform 7. 1 PublicationAdd BLAST230
    Alternative sequenceiVSP_0552421 – 181Missing in isoform 6. 1 PublicationAdd BLAST181
    Alternative sequenceiVSP_0333111 – 102Missing in isoform 2. 1 PublicationAdd BLAST102
    Alternative sequenceiVSP_0471531 – 24MVRGR…LGGHG → MVSADAMVSADAMVSADAMV SADAMVSADAMVSADAMVSA DAMVS in isoform 4. CuratedAdd BLAST24
    Alternative sequenceiVSP_0552431 – 24MVRGR…LGGHG → MVSADAMVSADAMVSADAMV SADAMVSADAMVSADAMVSA DAMVSADAMVSADAMVSADA MVSADAMVS in isoform 5. 1 PublicationAdd BLAST24
    Alternative sequenceiVSP_03331265 – 117VVCAV…LATAA → DWSRKGRGAPGDSGRPKRGV GLVGQAGGKACLEVTCGHGS QDAGILHRFQVHH in isoform 3. 1 PublicationAdd BLAST53
    Alternative sequenceiVSP_033313103W → MQKMESRGVELPSLWEKALK L in isoform 2. 1 Publication1
    Alternative sequenceiVSP_033314118 – 443Missing in isoform 3. 1 PublicationAdd BLAST326
    Alternative sequenceiVSP_047154293 – 306Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST14

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF305057 Genomic DNA Translation: AAG29536.1
    X67098 mRNA Translation: CAA47472.1
    AF305057 Genomic DNA Translation: AAG29537.1 Different initiation.
    X67098 mRNA Translation: CAA47471.1 Different initiation.
    X89602 mRNA Translation: CAA61761.1
    AK127818 mRNA Translation: BAC87148.1
    AK093873 mRNA Translation: BAG52778.1
    AK127219 mRNA Translation: BAG54456.1
    AK292780 mRNA Translation: BAF85469.1
    AP001178 Genomic DNA No translation available.
    CH471113 Genomic DNA Translation: EAX01713.1
    CH471113 Genomic DNA Translation: EAX01714.1
    CH471113 Genomic DNA Translation: EAX01715.1
    BC001285 mRNA Translation: AAH01285.2

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS11822.1 [Q7L5Y1-1]
    CCDS45821.1 [Q7L5Y1-2]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001119595.1, NM_001126123.3
    NP_001305688.1, NM_001318759.1
    NP_001305689.1, NM_001318760.1 [Q7L5Y1-6]
    NP_059982.2, NM_017512.5 [Q7L5Y1-1]
    NP_974487.1, NM_202758.3
    XP_016881324.1, XM_017025835.1
    XP_016881325.1, XM_017025836.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000383578; ENSP00000373072; ENSG00000132199 [Q7L5Y1-2]
    ENST00000647584; ENSP00000497230; ENSG00000132199 [Q7L5Y1-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    55556

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:55556

    UCSC genome browser

    More...
    UCSCi
    uc002kkt.4, human [Q7L5Y1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF305057 Genomic DNA Translation: AAG29536.1
    X67098 mRNA Translation: CAA47472.1
    AF305057 Genomic DNA Translation: AAG29537.1 Different initiation.
    X67098 mRNA Translation: CAA47471.1 Different initiation.
    X89602 mRNA Translation: CAA61761.1
    AK127818 mRNA Translation: BAC87148.1
    AK093873 mRNA Translation: BAG52778.1
    AK127219 mRNA Translation: BAG54456.1
    AK292780 mRNA Translation: BAF85469.1
    AP001178 Genomic DNA No translation available.
    CH471113 Genomic DNA Translation: EAX01713.1
    CH471113 Genomic DNA Translation: EAX01714.1
    CH471113 Genomic DNA Translation: EAX01715.1
    BC001285 mRNA Translation: AAH01285.2
    CCDSiCCDS11822.1 [Q7L5Y1-1]
    CCDS45821.1 [Q7L5Y1-2]
    RefSeqiNP_001119595.1, NM_001126123.3
    NP_001305688.1, NM_001318759.1
    NP_001305689.1, NM_001318760.1 [Q7L5Y1-6]
    NP_059982.2, NM_017512.5 [Q7L5Y1-1]
    NP_974487.1, NM_202758.3
    XP_016881324.1, XM_017025835.1
    XP_016881325.1, XM_017025836.1

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4A35X-ray1.74A1-440[»]
    SMRiQ7L5Y1
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi120716, 8 interactors
    IntActiQ7L5Y1, 3 interactors
    STRINGi9606.ENSP00000345974

    PTM databases

    iPTMnetiQ7L5Y1
    PhosphoSitePlusiQ7L5Y1

    Polymorphism and mutation databases

    BioMutaiENOSF1
    DMDMi74739173

    Proteomic databases

    EPDiQ7L5Y1
    jPOSTiQ7L5Y1
    MassIVEiQ7L5Y1
    MaxQBiQ7L5Y1
    PaxDbiQ7L5Y1
    PeptideAtlasiQ7L5Y1
    PRIDEiQ7L5Y1
    ProteomicsDBi1550
    3646
    68814 [Q7L5Y1-1]
    68815 [Q7L5Y1-2]
    68816 [Q7L5Y1-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    21907, 143 antibodies

    Genome annotation databases

    EnsembliENST00000383578; ENSP00000373072; ENSG00000132199 [Q7L5Y1-2]
    ENST00000647584; ENSP00000497230; ENSG00000132199 [Q7L5Y1-1]
    GeneIDi55556
    KEGGihsa:55556
    UCSCiuc002kkt.4, human [Q7L5Y1-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    55556
    DisGeNETi55556
    EuPathDBiHostDB:ENSG00000132199.18

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ENOSF1
    HGNCiHGNC:30365, ENOSF1
    HPAiENSG00000132199, Low tissue specificity
    MIMi607427, gene
    neXtProtiNX_Q7L5Y1
    OpenTargetsiENSG00000132199
    PharmGKBiPA134897613

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiENOG502QU7C, Eukaryota
    GeneTreeiENSGT00390000014290
    HOGENOMiCLU_030273_2_2_1
    InParanoidiQ7L5Y1
    KOiK18334
    OMAiKTWRYLV
    OrthoDBi933480at2759
    PhylomeDBiQ7L5Y1
    TreeFamiTF300529

    Enzyme and pathway databases

    PathwayCommonsiQ7L5Y1

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    55556, 5 hits in 871 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ENOSF1, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    55556
    PharosiQ7L5Y1, Tbio

    Protein Ontology

    More...
    PROi
    PR:Q7L5Y1
    RNActiQ7L5Y1, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000132199, Expressed in left lobe of thyroid gland and 236 other tissues
    ExpressionAtlasiQ7L5Y1, baseline and differential
    GenevisibleiQ7L5Y1, HS

    Family and domain databases

    CDDicd03324, rTSbeta_L-fuconate_dehydratase, 1 hit
    Gene3Di3.20.20.120, 1 hit
    3.30.390.10, 1 hit
    InterProiView protein in InterPro
    IPR036849, Enolase-like_C_sf
    IPR029017, Enolase-like_N
    IPR029065, Enolase_C-like
    IPR034610, L-fuconate_dehydratase
    IPR018110, Mandel_Rmase/mucon_lact_enz_CS
    IPR013342, Mandelate_racemase_C
    IPR013341, Mandelate_racemase_N_dom
    PANTHERiPTHR13794:SF58, PTHR13794:SF58, 1 hit
    PfamiView protein in Pfam
    PF13378, MR_MLE_C, 1 hit
    PF02746, MR_MLE_N, 1 hit
    SFLDiSFLDF00111, L-fuconate_dehydratase, 1 hit
    SMARTiView protein in SMART
    SM00922, MR_MLE, 1 hit
    SUPFAMiSSF51604, SSF51604, 1 hit
    SSF54826, SSF54826, 1 hit
    PROSITEiView protein in PROSITE
    PS00909, MR_MLE_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENOF1_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L5Y1
    Secondary accession number(s): A6NMP3
    , A8K9R5, B3KSL6, B3KXE4, D3DUH0, Q15407, Q15594, Q15595, Q6ZS08, Q9HAS5, Q9HAS6
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 24, 2005
    Last modified: August 12, 2020
    This is version 131 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families
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