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Entry version 137 (29 Sep 2021)
Sequence version 1 (24 May 2005)
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Protein

Mitochondrial enolase superfamily member 1

Gene

ENOSF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329).

1 Publication

Caution

Was originally (PubMed:8493092) identified as a gene coding for an antisense RNA to thymidylate synthase, and was proposed to down-regulate TYMS activity (PubMed:8869746), possibly by promoting the degradation of TYMS mRNA via an antisense RNA-based mechanism (PubMed:12084460).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+1 PublicationNote: Binds 1 Mg2+ ion per subunit.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 0.5 sec(-1) for L-fuconate. kcat is 0.3 sec(-1) for L-galactonate. kcat is 0.3 sec(-1) for L-arabinonate. kcat is 0.04 sec(-1) for D-arabinonate. kcat is 0.002 sec(-1) for D-ribonate.
  1. KM=0.2 mM for L-fuconate1 Publication
  2. KM=3.0 mM for L-galactonate1 Publication
  3. KM=2.0 mM for D-arabinonate1 Publication
  4. KM=4.0 mM for L-arabinonate1 Publication
  5. KM=0.4 mM for D-ribonate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei34SubstrateBy similarity1
Binding sitei220SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei222Proton donor/acceptorBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi250Magnesium1 Publication1
Binding sitei252SubstrateBy similarity1
Metal bindingi276Magnesium1 Publication1
Binding sitei276SubstrateBy similarity1
Metal bindingi305Magnesium1 Publication1
Binding sitei305SubstrateBy similarity1
Active sitei355Sequence analysis1
Binding sitei386SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Lyase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7L5Y1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial enolase superfamily member 1 (EC:4.2.1.681 Publication)
Alternative name(s):
Antisense RNA to thymidylate synthase
Short name:
rTS
L-fuconate dehydratase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ENOSF1
Synonyms:RTS, TYMSAS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30365, ENOSF1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607427, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7L5Y1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000132199

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1 – 27Missing : Impairs protein solubility. Abolishes catalytic activity. 1 PublicationAdd BLAST27

Organism-specific databases

DisGeNET

More...
DisGeNETi
55556

Open Targets

More...
OpenTargetsi
ENSG00000132199

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134897613

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7L5Y1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ENOSF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74739173

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003316521 – 443Mitochondrial enolase superfamily member 1Add BLAST443

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei148Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Could be sumoylated.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7L5Y1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7L5Y1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7L5Y1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7L5Y1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7L5Y1

PeptideAtlas

More...
PeptideAtlasi
Q7L5Y1

PRoteomics IDEntifications database

More...
PRIDEi
Q7L5Y1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
1550
3646
68814 [Q7L5Y1-1]
68815 [Q7L5Y1-2]
68816 [Q7L5Y1-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q7L5Y1, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7L5Y1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7L5Y1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132199, Expressed in left lobe of thyroid gland and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7L5Y1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7L5Y1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000132199, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120716, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q7L5Y1, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000345974

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7L5Y1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1443
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7L5Y1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni24 – 26Substrate bindingBy similarity3
Regioni355 – 357Substrate bindingBy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QU7C, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014290

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030273_2_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7L5Y1

Identification of Orthologs from Complete Genome Data

More...
OMAi
KTWRYLV

Database of Orthologous Groups

More...
OrthoDBi
933480at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7L5Y1

TreeFam database of animal gene trees

More...
TreeFami
TF300529

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03324, rTSbeta_L-fuconate_dehydratase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.120, 1 hit
3.30.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036849, Enolase-like_C_sf
IPR029017, Enolase-like_N
IPR029065, Enolase_C-like
IPR034610, L-fuconate_dehydratase
IPR018110, Mandel_Rmase/mucon_lact_enz_CS
IPR013342, Mandelate_racemase_C
IPR013341, Mandelate_racemase_N_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13378, MR_MLE_C, 1 hit
PF02746, MR_MLE_N, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDF00111, L-fuconate_dehydratase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00922, MR_MLE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51604, SSF51604, 1 hit
SSF54826, SSF54826, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00909, MR_MLE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7L5Y1-1) [UniParc]FASTAAdd to basket
Also known as: rTSgamma

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVRGRISRLS VRDVRFPTSL GGHGADAMHT DPDYSAAYVV IETDAEDGIK
60 70 80 90 100
GCGITFTLGK GTEVVVCAVN ALAHHVLNKD LKDIVGDFRG FYRQLTSDGQ
110 120 130 140 150
LRWIGPEKGV VHLATAAVLN AVWDLWAKQE GKPVWKLLVD MDPRMLVSCI
160 170 180 190 200
DFRYITDVLT EEDALEILQK GQIGKKEREK QMLAQGYPAY TTSCAWLGYS
210 220 230 240 250
DDTLKQLCAQ ALKDGWTRFK VKVGADLQDD MRRCQIIRDM IGPEKTLMMD
260 270 280 290 300
ANQRWDVPEA VEWMSKLAKF KPLWIEEPTS PDDILGHATI SKALVPLGIG
310 320 330 340 350
IATGEQCHNR VIFKQLLQAK ALQFLQIDSC RLGSVNENLS VLLMAKKFEI
360 370 380 390 400
PVCPHAGGVG LCELVQHLII FDYISVSASL ENRVCEYVDH LHEHFKYPVM
410 420 430 440
IQRASYMPPK DPGYSTEMKE ESVKKHQYPD GEVWKKLLPA QEN
Length:443
Mass (Da):49,786
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i82BEDAC229D1A729
GO
Isoform 2 (identifier: Q7L5Y1-2) [UniParc]FASTAAdd to basket
Also known as: rTSalpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-102: Missing.
     103-103: W → MQKMESRGVELPSLWEKALKL

Show »
Length:361
Mass (Da):41,024
Checksum:i73B469F1C9C7E144
GO
Isoform 3 (identifier: Q7L5Y1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     65-117: VVCAVNALAH...KGVVHLATAA → DWSRKGRGAP...GILHRFQVHH
     118-443: Missing.

Show »
Length:117
Mass (Da):12,286
Checksum:iB277BFA534E7DAF2
GO
Isoform 4 (identifier: Q7L5Y1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MVRGRISRLSVRDVRFPTSLGGHG → MVSADAMVSADAMVSADAMVSADAMVSADAMVSADAMVSADAMVS
     293-306: Missing.

Show »
Length:450
Mass (Da):50,170
Checksum:i7D6BD13DF0F12AD0
GO
Isoform 5 (identifier: Q7L5Y1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-24: MVRGRISRLSVRDVRFPTSLGGHG → MVSADAMVSA...AMVSADAMVS
     293-306: Missing.

Show »
Length:474
Mass (Da):52,468
Checksum:i97FA6018CAADF8CB
GO
Isoform 6 (identifier: Q7L5Y1-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-181: Missing.

Show »
Length:262
Mass (Da):29,710
Checksum:i5296CB2DCA806273
GO
Isoform 7 (identifier: Q7L5Y1-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-230: Missing.

Show »
Length:213
Mass (Da):24,284
Checksum:iF2CF0580E05E10BA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3F2YNX7A0A3F2YNX7_HUMAN
L-fuconate dehydratase
ENOSF1
477Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL81J3QL81_HUMAN
Mitochondrial enolase superfamily m...
ENOSF1
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RM24X6RM24_HUMAN
Mitochondrial enolase superfamily m...
ENOSF1
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QL99J3QL99_HUMAN
Mitochondrial enolase superfamily m...
ENOSF1
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GNF8R4GNF8_HUMAN
Mitochondrial enolase superfamily m...
ENOSF1
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QSB6J3QSB6_HUMAN
Mitochondrial enolase superfamily m...
ENOSF1
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG29537 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA47471 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04293331D → E. Corresponds to variant dbSNP:rs34724061Ensembl.1
Natural variantiVAR_042934145M → T4 PublicationsCorresponds to variant dbSNP:rs2612086Ensembl.1
Natural variantiVAR_042935428Y → S. Corresponds to variant dbSNP:rs2847620Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0552411 – 230Missing in isoform 7. 1 PublicationAdd BLAST230
Alternative sequenceiVSP_0552421 – 181Missing in isoform 6. 1 PublicationAdd BLAST181
Alternative sequenceiVSP_0333111 – 102Missing in isoform 2. 1 PublicationAdd BLAST102
Alternative sequenceiVSP_0471531 – 24MVRGR…LGGHG → MVSADAMVSADAMVSADAMV SADAMVSADAMVSADAMVSA DAMVS in isoform 4. CuratedAdd BLAST24
Alternative sequenceiVSP_0552431 – 24MVRGR…LGGHG → MVSADAMVSADAMVSADAMV SADAMVSADAMVSADAMVSA DAMVSADAMVSADAMVSADA MVSADAMVS in isoform 5. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_03331265 – 117VVCAV…LATAA → DWSRKGRGAPGDSGRPKRGV GLVGQAGGKACLEVTCGHGS QDAGILHRFQVHH in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_033313103W → MQKMESRGVELPSLWEKALK L in isoform 2. 1 Publication1
Alternative sequenceiVSP_033314118 – 443Missing in isoform 3. 1 PublicationAdd BLAST326
Alternative sequenceiVSP_047154293 – 306Missing in isoform 4 and isoform 5. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF305057 Genomic DNA Translation: AAG29536.1
X67098 mRNA Translation: CAA47472.1
AF305057 Genomic DNA Translation: AAG29537.1 Different initiation.
X67098 mRNA Translation: CAA47471.1 Different initiation.
X89602 mRNA Translation: CAA61761.1
AK127818 mRNA Translation: BAC87148.1
AK093873 mRNA Translation: BAG52778.1
AK127219 mRNA Translation: BAG54456.1
AK292780 mRNA Translation: BAF85469.1
AP001178 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01713.1
CH471113 Genomic DNA Translation: EAX01714.1
CH471113 Genomic DNA Translation: EAX01715.1
BC001285 mRNA Translation: AAH01285.2

The Consensus CDS (CCDS) project

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CCDSi
CCDS11822.1 [Q7L5Y1-1]
CCDS45821.1 [Q7L5Y1-2]

NCBI Reference Sequences

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RefSeqi
NP_001119595.1, NM_001126123.3
NP_001305688.1, NM_001318759.1
NP_001305689.1, NM_001318760.1 [Q7L5Y1-6]
NP_059982.2, NM_017512.5 [Q7L5Y1-1]
NP_974487.1, NM_202758.3
XP_016881324.1, XM_017025835.1
XP_016881325.1, XM_017025836.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383578; ENSP00000373072; ENSG00000132199 [Q7L5Y1-2]
ENST00000647584; ENSP00000497230; ENSG00000132199 [Q7L5Y1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55556

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55556

UCSC genome browser

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UCSCi
uc002kkt.4, human [Q7L5Y1-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF305057 Genomic DNA Translation: AAG29536.1
X67098 mRNA Translation: CAA47472.1
AF305057 Genomic DNA Translation: AAG29537.1 Different initiation.
X67098 mRNA Translation: CAA47471.1 Different initiation.
X89602 mRNA Translation: CAA61761.1
AK127818 mRNA Translation: BAC87148.1
AK093873 mRNA Translation: BAG52778.1
AK127219 mRNA Translation: BAG54456.1
AK292780 mRNA Translation: BAF85469.1
AP001178 Genomic DNA No translation available.
CH471113 Genomic DNA Translation: EAX01713.1
CH471113 Genomic DNA Translation: EAX01714.1
CH471113 Genomic DNA Translation: EAX01715.1
BC001285 mRNA Translation: AAH01285.2
CCDSiCCDS11822.1 [Q7L5Y1-1]
CCDS45821.1 [Q7L5Y1-2]
RefSeqiNP_001119595.1, NM_001126123.3
NP_001305688.1, NM_001318759.1
NP_001305689.1, NM_001318760.1 [Q7L5Y1-6]
NP_059982.2, NM_017512.5 [Q7L5Y1-1]
NP_974487.1, NM_202758.3
XP_016881324.1, XM_017025835.1
XP_016881325.1, XM_017025836.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A35X-ray1.74A1-440[»]
SMRiQ7L5Y1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120716, 8 interactors
IntActiQ7L5Y1, 3 interactors
STRINGi9606.ENSP00000345974

PTM databases

GlyGeniQ7L5Y1, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ7L5Y1
PhosphoSitePlusiQ7L5Y1

Genetic variation databases

BioMutaiENOSF1
DMDMi74739173

Proteomic databases

EPDiQ7L5Y1
jPOSTiQ7L5Y1
MassIVEiQ7L5Y1
MaxQBiQ7L5Y1
PaxDbiQ7L5Y1
PeptideAtlasiQ7L5Y1
PRIDEiQ7L5Y1
ProteomicsDBi1550
3646
68814 [Q7L5Y1-1]
68815 [Q7L5Y1-2]
68816 [Q7L5Y1-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
21907, 156 antibodies

The DNASU plasmid repository

More...
DNASUi
55556

Genome annotation databases

EnsembliENST00000383578; ENSP00000373072; ENSG00000132199 [Q7L5Y1-2]
ENST00000647584; ENSP00000497230; ENSG00000132199 [Q7L5Y1-1]
GeneIDi55556
KEGGihsa:55556
UCSCiuc002kkt.4, human [Q7L5Y1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55556
DisGeNETi55556

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ENOSF1
HGNCiHGNC:30365, ENOSF1
HPAiENSG00000132199, Low tissue specificity
MIMi607427, gene
neXtProtiNX_Q7L5Y1
OpenTargetsiENSG00000132199
PharmGKBiPA134897613
VEuPathDBiHostDB:ENSG00000132199

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QU7C, Eukaryota
GeneTreeiENSGT00390000014290
HOGENOMiCLU_030273_2_2_1
InParanoidiQ7L5Y1
OMAiKTWRYLV
OrthoDBi933480at2759
PhylomeDBiQ7L5Y1
TreeFamiTF300529

Enzyme and pathway databases

PathwayCommonsiQ7L5Y1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55556, 5 hits in 1016 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ENOSF1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55556
PharosiQ7L5Y1, Tbio

Protein Ontology

More...
PROi
PR:Q7L5Y1
RNActiQ7L5Y1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132199, Expressed in left lobe of thyroid gland and 236 other tissues
ExpressionAtlasiQ7L5Y1, baseline and differential
GenevisibleiQ7L5Y1, HS

Family and domain databases

CDDicd03324, rTSbeta_L-fuconate_dehydratase, 1 hit
Gene3Di3.20.20.120, 1 hit
3.30.390.10, 1 hit
InterProiView protein in InterPro
IPR036849, Enolase-like_C_sf
IPR029017, Enolase-like_N
IPR029065, Enolase_C-like
IPR034610, L-fuconate_dehydratase
IPR018110, Mandel_Rmase/mucon_lact_enz_CS
IPR013342, Mandelate_racemase_C
IPR013341, Mandelate_racemase_N_dom
PfamiView protein in Pfam
PF13378, MR_MLE_C, 1 hit
PF02746, MR_MLE_N, 1 hit
SFLDiSFLDF00111, L-fuconate_dehydratase, 1 hit
SMARTiView protein in SMART
SM00922, MR_MLE, 1 hit
SUPFAMiSSF51604, SSF51604, 1 hit
SSF54826, SSF54826, 1 hit
PROSITEiView protein in PROSITE
PS00909, MR_MLE_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiENOF1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L5Y1
Secondary accession number(s): A6NMP3
, A8K9R5, B3KSL6, B3KXE4, D3DUH0, Q15407, Q15594, Q15595, Q6ZS08, Q9HAS5, Q9HAS6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: September 29, 2021
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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