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Entry version 128 (13 Feb 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Golgi to ER traffic protein 4 homolog

Gene

GET4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892, PubMed:25535373). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum (PubMed:21743475). The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome (PubMed:21636303).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chaperone binding Source: BHF-UCL

GO - Biological processi

  • cytoplasmic sequestering of protein Source: ParkinsonsUK-UCL
  • maintenance of unfolded protein involved in ERAD pathway Source: ParkinsonsUK-UCL
  • protein insertion into ER membrane Source: GO_Central
  • tail-anchored membrane protein insertion into ER membrane Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
Q7L5D6 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Golgi to ER traffic protein 4 homologCurated
Alternative name(s):
Conserved edge-expressed protein
Transmembrane domain recognition complex 35 kDa subunit
Short name:
TRC35
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GET4Imported
Synonyms:C7orf20, CEE, TRC35
ORF Names:CGI-20
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000239857.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21690 GET4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612056 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7L5D6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi84D → K: Reduces tail-anchored protein delivery. 1 Publication1
Mutagenesisi182Y → A: No effect on interaction with BAG6. 1 Publication1
Mutagenesisi188F → A: No effect on interaction with BAG6. 1 Publication1
Mutagenesisi195F → A: No effect on interaction with BAG6. 1 Publication1
Mutagenesisi241W → A: No effect on interaction with BAG6. 1 Publication1
Mutagenesisi242F → A: No effect on interaction with BAG6. 1 Publication1
Mutagenesisi257V → A: No effect on interaction with BAG6. 1 Publication1
Mutagenesisi258L → A: No effect on interaction with BAG6. 1 Publication1
Mutagenesisi259C → A: No effect on interaction with BAG6. 1 Publication1
Mutagenesisi262Y → A: Inhibits interaction with BAG6. 1 Publication1
Mutagenesisi266L → A: No effect on interaction with BAG6. 1 Publication1

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000239857

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165618100

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GET4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74738593

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002281042 – 327Golgi to ER traffic protein 4 homologAdd BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei12PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated by RNF12, leading to proteasomal degradation. When unassembled from BAG6; ubiquitinylation is modulated by BAG6 quality control role and effectuated by RNF126.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q7L5D6

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7L5D6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7L5D6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7L5D6

PeptideAtlas

More...
PeptideAtlasi
Q7L5D6

PRoteomics IDEntifications database

More...
PRIDEi
Q7L5D6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68807
68808 [Q7L5D6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7L5D6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7L5D6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000239857 Expressed in 88 organ(s), highest expression level in right adrenal gland

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7L5D6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7L5D6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019765

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the BAG6/BAT3 complex, at least composed of BAG6, UBL4A and GET4/TRC35 (PubMed:20676083, PubMed:25535373). Interacts with BAG6; the interaction is direct and localizes BAG6 to the cytosol (PubMed:21636303, PubMed:29042515, PubMed:25535373).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
119636, 70 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-132 BAT3 complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q7L5D6

Protein interaction database and analysis system

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IntActi
Q7L5D6, 46 interactors

Molecular INTeraction database

More...
MINTi
Q7L5D6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000265857

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1327
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6AU8X-ray1.80A23-305[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q7L5D6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7L5D6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni195 – 271Interacts with BAG62 PublicationsAdd BLAST77

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GET4 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3024 Eukaryota
ENOG410XRWE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015750

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000264232

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG059877

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7L5D6

Identification of Orthologs from Complete Genome Data

More...
OMAi
RYMSQGK

Database of Orthologous Groups

More...
OrthoDBi
1030907at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7L5D6

TreeFam database of animal gene trees

More...
TreeFami
TF315163

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR007317 UPF0363

The PANTHER Classification System

More...
PANTHERi
PTHR12875 PTHR12875, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04190 DUF410, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7L5D6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAAMAEQ ESARNGGRNR GGVQRVEGKL RASVEKGDYY EAHQMYRTLF
60 70 80 90 100
FRYMSQSKHT EARELMYSGA LLFFSHGQQN SAADLSMLVL ESLEKAEVEV
110 120 130 140 150
ADELLENLAK VFSLMDPNSP ERVTFVSRAL KWSSGGSGKL GHPRLHQLLA
160 170 180 190 200
LTLWKEQNYC ESRYHFLHSA DGEGCANMLV EYSTSRGFRS EVDMFVAQAV
210 220 230 240 250
LQFLCLKNKS SASVVFTTYT QKHPSIEDGP PFVEPLLNFI WFLLLAVDGG
260 270 280 290 300
KLTVFTVLCE QYQPSLRRDP MYNEYLDRIG QLFFGVPPKQ TSSYGGLLGN
310 320
LLTSLMGSSE QEDGEESPSD GSPIELD
Note: No experimental confirmation available.
Length:327
Mass (Da):36,504
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D6C4233181B0512
GO
Isoform 2 (identifier: Q7L5D6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:274
Mass (Da):30,523
Checksum:iCDCA760B2B2E1473
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JPA8C9JPA8_HUMAN
Golgi to ER traffic protein 4 homol...
GET4
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JY46C9JY46_HUMAN
Golgi to ER traffic protein 4 homol...
GET4
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JHN8C9JHN8_HUMAN
Golgi to ER traffic protein 4 homol...
GET4
167Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9 – 22EQESA…RNRGG → DRRAPATALQPRA in AAD27729 (PubMed:10810093).CuratedAdd BLAST14
Sequence conflicti177N → D in AAD27729 (PubMed:10810093).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0176521 – 53Missing in isoform 2. 2 PublicationsAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK024305 mRNA Translation: BAG51289.1
AK097899 mRNA Translation: BAG53546.1
AK125863 mRNA Translation: BAG54258.1
AL133014 mRNA Translation: CAB61355.1
CH236965 Genomic DNA Translation: EAL23708.1
BC003550 mRNA Translation: AAH03550.2
AF132954 mRNA Translation: AAD27729.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5317.1 [Q7L5D6-1]

Protein sequence database of the Protein Information Resource

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PIRi
T42648

NCBI Reference Sequences

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RefSeqi
NP_057033.2, NM_015949.2 [Q7L5D6-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.107387
Hs.743756

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265857; ENSP00000265857; ENSG00000239857 [Q7L5D6-1]
ENST00000407192; ENSP00000385646; ENSG00000239857 [Q7L5D6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
51608

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:51608

UCSC genome browser

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UCSCi
uc003sjl.2 human [Q7L5D6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024305 mRNA Translation: BAG51289.1
AK097899 mRNA Translation: BAG53546.1
AK125863 mRNA Translation: BAG54258.1
AL133014 mRNA Translation: CAB61355.1
CH236965 Genomic DNA Translation: EAL23708.1
BC003550 mRNA Translation: AAH03550.2
AF132954 mRNA Translation: AAD27729.1
CCDSiCCDS5317.1 [Q7L5D6-1]
PIRiT42648
RefSeqiNP_057033.2, NM_015949.2 [Q7L5D6-1]
UniGeneiHs.107387
Hs.743756

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6AU8X-ray1.80A23-305[»]
ProteinModelPortaliQ7L5D6
SMRiQ7L5D6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119636, 70 interactors
ComplexPortaliCPX-132 BAT3 complex
CORUMiQ7L5D6
IntActiQ7L5D6, 46 interactors
MINTiQ7L5D6
STRINGi9606.ENSP00000265857

Protein family/group databases

MoonDBiQ7L5D6 Predicted

PTM databases

iPTMnetiQ7L5D6
PhosphoSitePlusiQ7L5D6

Polymorphism and mutation databases

BioMutaiGET4
DMDMi74738593

Proteomic databases

EPDiQ7L5D6
jPOSTiQ7L5D6
MaxQBiQ7L5D6
PaxDbiQ7L5D6
PeptideAtlasiQ7L5D6
PRIDEiQ7L5D6
ProteomicsDBi68807
68808 [Q7L5D6-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
51608
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265857; ENSP00000265857; ENSG00000239857 [Q7L5D6-1]
ENST00000407192; ENSP00000385646; ENSG00000239857 [Q7L5D6-2]
GeneIDi51608
KEGGihsa:51608
UCSCiuc003sjl.2 human [Q7L5D6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51608
EuPathDBiHostDB:ENSG00000239857.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GET4

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0033841
HIX0201122
HGNCiHGNC:21690 GET4
HPAiHPA019765
MIMi612056 gene
neXtProtiNX_Q7L5D6
OpenTargetsiENSG00000239857
PharmGKBiPA165618100

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3024 Eukaryota
ENOG410XRWE LUCA
GeneTreeiENSGT00390000015750
HOGENOMiHOG000264232
HOVERGENiHBG059877
InParanoidiQ7L5D6
OMAiRYMSQGK
OrthoDBi1030907at2759
PhylomeDBiQ7L5D6
TreeFamiTF315163

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
C7orf20

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
51608

Protein Ontology

More...
PROi
PR:Q7L5D6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000239857 Expressed in 88 organ(s), highest expression level in right adrenal gland
ExpressionAtlasiQ7L5D6 baseline and differential
GenevisibleiQ7L5D6 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR011990 TPR-like_helical_dom_sf
IPR007317 UPF0363
PANTHERiPTHR12875 PTHR12875, 1 hit
PfamiView protein in Pfam
PF04190 DUF410, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGET4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L5D6
Secondary accession number(s): A4D2Q1
, B3KNC7, Q9UFC9, Q9Y309
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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