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Protein

Protein FAM214B

Gene

FAM214B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM214B
Gene namesi
Name:FAM214B
Synonyms:KIAA1539
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000005238.19
HGNCiHGNC:25666 FAM214B
neXtProtiNX_Q7L5A3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi80256
OpenTargetsiENSG00000005238
PharmGKBiPA134880815

Polymorphism and mutation databases

BioMutaiFAM214B
DMDMi74749892

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003136201 – 538Protein FAM214BAdd BLAST538

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei254PhosphoserineBy similarity1
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7L5A3
PeptideAtlasiQ7L5A3
PRIDEiQ7L5A3
ProteomicsDBi68803
68804 [Q7L5A3-2]
68805 [Q7L5A3-3]

PTM databases

iPTMnetiQ7L5A3
PhosphoSitePlusiQ7L5A3

Expressioni

Gene expression databases

BgeeiENSG00000005238 Expressed in 226 organ(s), highest expression level in blood
CleanExiHS_KIAA1539
GenevisibleiQ7L5A3 HS

Organism-specific databases

HPAiHPA048831
HPA055751

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123202, 11 interactors
IntActiQ7L5A3, 58 interactors
MINTiQ7L5A3

Structurei

3D structure databases

ProteinModelPortaliQ7L5A3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM214 family.Curated

Phylogenomic databases

eggNOGiKOG2306 Eukaryota
ENOG41115V6 LUCA
GeneTreeiENSGT00530000063568
HOGENOMiHOG000049081
HOVERGENiHBG097397
InParanoidiQ7L5A3
OMAiTHRLLCY
OrthoDBiEOG091G09N8
PhylomeDBiQ7L5A3
TreeFamiTF325496

Family and domain databases

InterProiView protein in InterPro
IPR025261 DUF4210
IPR033473 FAM214/SPAC3H8.04_C
PfamiView protein in Pfam
PF13889 Chromosome_seg, 1 hit
PF13915 DUF4210, 1 hit
SMARTiView protein in SMART
SM01177 DUF4210, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7L5A3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRHVQAEPSP SSEPEAGPSQ PPVRQGALQG GLLMGYSPAG GATSPGVYQV
60 70 80 90 100
SIFSPPAGTS EPHRALKRQA PSTEGPRELK RGPGLGAREG LPPEEPSTVG
110 120 130 140 150
LLGPEGPGLG LGVASQHFSH RGLCVVEQRS SVTSSWTSGA WSPPCPPSNA
160 170 180 190 200
SCNTLHTRDW ASPDPGGQGS LGESPGPAPP GQLHTLDTDL HSLAQIGGKS
210 220 230 240 250
PVAGVGNGGS LWPRESPGTA NGHSPEHTPP GPGPPGPCPT KRRLLPAGEA
260 270 280 290 300
PDVSSEEEGP APRRRRGSLG HPTAANSSDA KATPFWSHLL PGPKEPVLDP
310 320 330 340 350
TDCGPMGRRL KGARRLKLSP LRSLRKGPGL LSPPSASPVP TPAVSRTLLG
360 370 380 390 400
NFEESLLRGR FAPSGHIEGF TAEIGASGSY CPQHVTLPVT VTFFDVSEQN
410 420 430 440 450
APAPFLGIVD LNPLGRKGYS VPKVGTVQVT LFNPNQTVVK MFLVTFDFSD
460 470 480 490 500
MPAAHMTFLR HRLFLVPVGE EGNANPTHRL LCYLLHLRFR SSRSGRLSLH
510 520 530
GDIRLLFSRR SLELDTGLPY ELQAVTEAPH NPRYSPLP
Length:538
Mass (Da):56,690
Last modified:July 5, 2004 - v1
Checksum:i7BF7E9EB38167BDC
GO
Isoform 2 (identifier: Q7L5A3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-538: NQTVVKMFLV...PHNPRYSPLP → NPFTSPTL

Show »
Length:442
Mass (Da):45,578
Checksum:i6124D4A4B8B10505
GO
Isoform 3 (identifier: Q7L5A3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-305: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):25,691
Checksum:i295C286A5A5AAAD3
GO

Sequence cautioni

The sequence AAC07982 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA96063 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q7L5A3-2)
Sequence conflicti435N → S in BAB13857 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0424371 – 305Missing in isoform 3. 1 PublicationAdd BLAST305
Alternative sequenceiVSP_030063435 – 538NQTVV…YSPLP → NPFTSPTL in isoform 2. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040972 mRNA Translation: BAA96063.1 Different initiation.
AK021622 mRNA Translation: BAB13857.1
AK022837 mRNA Translation: BAG51123.1
AL583909 mRNA Translation: CAC29493.1
AC004472 Genomic DNA Translation: AAC07982.1 Sequence problems.
AL353795 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58387.1
CH471071 Genomic DNA Translation: EAW58388.1
CH471071 Genomic DNA Translation: EAW58389.1
CH471071 Genomic DNA Translation: EAW58391.1
CH471071 Genomic DNA Translation: EAW58392.1
BC004406 mRNA Translation: AAH04406.1
CCDSiCCDS6578.1 [Q7L5A3-1]
PIRiT02247
RefSeqiNP_001304920.1, NM_001317991.1 [Q7L5A3-1]
NP_079458.2, NM_025182.3 [Q7L5A3-1]
XP_005251645.1, XM_005251588.1 [Q7L5A3-1]
XP_005251647.1, XM_005251590.1 [Q7L5A3-1]
XP_005251648.1, XM_005251591.1 [Q7L5A3-1]
XP_011516339.1, XM_011518037.1 [Q7L5A3-1]
XP_011516345.1, XM_011518043.1
XP_011516346.1, XM_011518044.1
XP_016870659.1, XM_017015170.1
UniGeneiHs.301696

Genome annotation databases

EnsembliENST00000322813; ENSP00000319897; ENSG00000005238 [Q7L5A3-1]
ENST00000378557; ENSP00000367819; ENSG00000005238 [Q7L5A3-1]
ENST00000378561; ENSP00000367823; ENSG00000005238 [Q7L5A3-1]
ENST00000378566; ENSP00000367829; ENSG00000005238 [Q7L5A3-3]
ENST00000488109; ENSP00000475120; ENSG00000005238 [Q7L5A3-1]
ENST00000603301; ENSP00000474335; ENSG00000005238 [Q7L5A3-1]
ENST00000605244; ENSP00000474833; ENSG00000005238 [Q7L5A3-1]
GeneIDi80256
KEGGihsa:80256
UCSCiuc003zwl.4 human [Q7L5A3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040972 mRNA Translation: BAA96063.1 Different initiation.
AK021622 mRNA Translation: BAB13857.1
AK022837 mRNA Translation: BAG51123.1
AL583909 mRNA Translation: CAC29493.1
AC004472 Genomic DNA Translation: AAC07982.1 Sequence problems.
AL353795 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58387.1
CH471071 Genomic DNA Translation: EAW58388.1
CH471071 Genomic DNA Translation: EAW58389.1
CH471071 Genomic DNA Translation: EAW58391.1
CH471071 Genomic DNA Translation: EAW58392.1
BC004406 mRNA Translation: AAH04406.1
CCDSiCCDS6578.1 [Q7L5A3-1]
PIRiT02247
RefSeqiNP_001304920.1, NM_001317991.1 [Q7L5A3-1]
NP_079458.2, NM_025182.3 [Q7L5A3-1]
XP_005251645.1, XM_005251588.1 [Q7L5A3-1]
XP_005251647.1, XM_005251590.1 [Q7L5A3-1]
XP_005251648.1, XM_005251591.1 [Q7L5A3-1]
XP_011516339.1, XM_011518037.1 [Q7L5A3-1]
XP_011516345.1, XM_011518043.1
XP_011516346.1, XM_011518044.1
XP_016870659.1, XM_017015170.1
UniGeneiHs.301696

3D structure databases

ProteinModelPortaliQ7L5A3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123202, 11 interactors
IntActiQ7L5A3, 58 interactors
MINTiQ7L5A3

PTM databases

iPTMnetiQ7L5A3
PhosphoSitePlusiQ7L5A3

Polymorphism and mutation databases

BioMutaiFAM214B
DMDMi74749892

Proteomic databases

PaxDbiQ7L5A3
PeptideAtlasiQ7L5A3
PRIDEiQ7L5A3
ProteomicsDBi68803
68804 [Q7L5A3-2]
68805 [Q7L5A3-3]

Protocols and materials databases

DNASUi80256
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322813; ENSP00000319897; ENSG00000005238 [Q7L5A3-1]
ENST00000378557; ENSP00000367819; ENSG00000005238 [Q7L5A3-1]
ENST00000378561; ENSP00000367823; ENSG00000005238 [Q7L5A3-1]
ENST00000378566; ENSP00000367829; ENSG00000005238 [Q7L5A3-3]
ENST00000488109; ENSP00000475120; ENSG00000005238 [Q7L5A3-1]
ENST00000603301; ENSP00000474335; ENSG00000005238 [Q7L5A3-1]
ENST00000605244; ENSP00000474833; ENSG00000005238 [Q7L5A3-1]
GeneIDi80256
KEGGihsa:80256
UCSCiuc003zwl.4 human [Q7L5A3-1]

Organism-specific databases

CTDi80256
DisGeNETi80256
EuPathDBiHostDB:ENSG00000005238.19
GeneCardsiFAM214B
HGNCiHGNC:25666 FAM214B
HPAiHPA048831
HPA055751
neXtProtiNX_Q7L5A3
OpenTargetsiENSG00000005238
PharmGKBiPA134880815
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2306 Eukaryota
ENOG41115V6 LUCA
GeneTreeiENSGT00530000063568
HOGENOMiHOG000049081
HOVERGENiHBG097397
InParanoidiQ7L5A3
OMAiTHRLLCY
OrthoDBiEOG091G09N8
PhylomeDBiQ7L5A3
TreeFamiTF325496

Miscellaneous databases

ChiTaRSiFAM214B human
GeneWikiiKIAA1539
GenomeRNAii80256
PROiPR:Q7L5A3

Gene expression databases

BgeeiENSG00000005238 Expressed in 226 organ(s), highest expression level in blood
CleanExiHS_KIAA1539
GenevisibleiQ7L5A3 HS

Family and domain databases

InterProiView protein in InterPro
IPR025261 DUF4210
IPR033473 FAM214/SPAC3H8.04_C
PfamiView protein in Pfam
PF13889 Chromosome_seg, 1 hit
PF13915 DUF4210, 1 hit
SMARTiView protein in SMART
SM01177 DUF4210, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF214B_HUMAN
AccessioniPrimary (citable) accession number: Q7L5A3
Secondary accession number(s): B1AML4
, B1AML5, D3DRN5, O60377, Q9BQ60, Q9HAI9, Q9P1Y9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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