UniProtKB - Q7L513 (FCRLA_HUMAN)
Fc receptor-like A
FCRLA
Functioni
Caution
GO - Molecular functioni
- transmembrane signaling receptor activity Source: GO_Central
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- cell surface receptor signaling pathway Source: GO_Central
Keywordsi
Biological process | Differentiation |
Enzyme and pathway databases
PathwayCommonsi | Q7L513 |
Names & Taxonomyi
Protein namesi | Recommended name: Fc receptor-like AAlternative name(s): Fc receptor homolog expressed in B-cells Fc receptor-like and mucin-like protein 1 Fc receptor-like protein Fc receptor-related protein X Short name: FcRX |
Gene namesi | Name:FCRLA Synonyms:FCRL, FCRL1, FCRLM1, FCRX, FREB ORF Names:UNQ291/PRO329 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18504, FCRLA |
MIMi | 606891, gene |
neXtProti | NX_Q7L513 |
VEuPathDBi | HostDB:ENSG00000132185.16 |
Subcellular locationi
Other locations
- Cytoplasm 3 Publications
Note: Seems not to be secreted.1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: MGI
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 84824 |
OpenTargetsi | ENSG00000132185 |
PharmGKBi | PA162388180 |
Miscellaneous databases
Pharosi | Q7L513, Tbio |
Genetic variation databases
BioMutai | FCRLA |
DMDMi | 90101291 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | 1 PublicationAdd BLAST | 27 | |
ChainiPRO_0000227935 | 28 – 359 | Fc receptor-like AAdd BLAST | 332 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 99 ↔ 143 | PROSITE-ProRule annotation | ||
Disulfide bondi | 192 ↔ 240 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | Q7L513 |
MaxQBi | Q7L513 |
PaxDbi | Q7L513 |
PeptideAtlasi | Q7L513 |
PRIDEi | Q7L513 |
ProteomicsDBi | 1444 27358 29885 32350 65585 68782 [Q7L513-1] 68783 [Q7L513-2] 68784 [Q7L513-3] 68785 [Q7L513-4] 68786 [Q7L513-5] 68787 [Q7L513-6] 68788 [Q7L513-7] 68789 [Q7L513-8] 68790 [Q7L513-9] 793 |
PTM databases
iPTMneti | Q7L513 |
PhosphoSitePlusi | Q7L513 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000132185, Expressed in tonsil and 125 other tissues |
ExpressionAtlasi | Q7L513, baseline and differential |
Genevisiblei | Q7L513, HS |
Organism-specific databases
HPAi | ENSG00000132185, Group enriched (blood, lymphoid tissue) |
Interactioni
Subunit structurei
Monomer or homodimer; disulfide-linked.
Protein-protein interaction databases
BioGRIDi | 124282, 2 interactors |
IntActi | Q7L513, 4 interactors |
STRINGi | 9606.ENSP00000356936 |
Miscellaneous databases
RNActi | Q7L513, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q7L513 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 70 – 159 | Ig-like C2-type 1Add BLAST | 90 | |
Domaini | 170 – 257 | Ig-like C2-type 2Add BLAST | 88 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 269 – 315 | Pro-richAdd BLAST | 47 |
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502T149, Eukaryota |
GeneTreei | ENSGT01000000214497 |
HOGENOMi | CLU_1824654_0_0_1 |
InParanoidi | Q7L513 |
OMAi | AHSGSYW |
PhylomeDBi | Q7L513 |
TreeFami | TF335097 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF13895, Ig_2, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
s (15+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 15 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 15 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED
60 70 80 90 100
DLTDAREAGF QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ
110 120 130 140 150
AWQDWPLTQV TFYRDGSALG PPGPNREFSI TVVQKADSGH YHCSGIFQSP
160 170 180 190 200
GPGIPETASV VAITVQELFP APILRAVPSA EPQAGSPMTL SCQTKLPLQR
210 220 230 240 250
SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC EAATEDNQVW
260 270 280 290 300
KQSPQLEIRV QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS
310 320 330 340 350
SEDPGFSSPL GMPDPHLYHQ MGLLLKHMQD VRVLLGHLLM ELRELSGHRK
PGTTKATAE
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLKKISVGVAGDLNTVTM
28-28: A → AGCHAAA
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLKKISVGVAGDLNTVTM
29-166: SFETLQCEGP...TASVVAITVQ → GCHA
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLKKISVGVAGDLNTVTM
78-166: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLKKISVGVAGDLNTVTM
78-261: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLKKISVGVAGDLNTVTM
27-166: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLKKISVGVAGDLNTVTM
27-261: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5VXA5 | Q5VXA5_HUMAN | Fc receptor-like A | FCRLA | 165 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 265 | S → N in AAL23904 (PubMed:11754007).Curated | 1 | |
Sequence conflicti | 308 | S → P in AAL23903 (PubMed:11754007).Curated | 1 | |
Sequence conflicti | 317 | L → P in AAL27307 (PubMed:11754007).Curated | 1 | |
Sequence conflicti | 343 | R → G in AAL23905 (PubMed:11754007).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025646 | 349 | R → Q6 PublicationsCorresponds to variant dbSNP:rs11746Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038297 | 1 | M → MLKKISVGVAGDLNTVTM in isoform 9, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14 and isoform 15. 3 Publications | 1 | |
Alternative sequenceiVSP_017603 | 27 – 261 | Missing in isoform 7 and isoform 15. 2 PublicationsAdd BLAST | 235 | |
Alternative sequenceiVSP_017604 | 27 – 166 | Missing in isoform 5 and isoform 14. 2 PublicationsAdd BLAST | 140 | |
Alternative sequenceiVSP_017605 | 28 | A → AGCHAAA in isoform 2 and isoform 10. 1 Publication | 1 | |
Alternative sequenceiVSP_017606 | 29 – 166 | SFETL…AITVQ → GCHA in isoform 4 and isoform 11. 1 PublicationAdd BLAST | 138 | |
Alternative sequenceiVSP_017607 | 78 – 261 | Missing in isoform 6 and isoform 13. 2 PublicationsAdd BLAST | 184 | |
Alternative sequenceiVSP_017608 | 78 – 166 | Missing in isoform 3 and isoform 12. 2 PublicationsAdd BLAST | 89 | |
Alternative sequenceiVSP_017609 | 167 – 261 | Missing in isoform 8. 1 PublicationAdd BLAST | 95 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4HWN | X-ray | 2.01 | A | 169-264 | [»] | |
SMRi | Q7L513 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 124282, 2 interactors |
IntActi | Q7L513, 4 interactors |
STRINGi | 9606.ENSP00000356936 |
PTM databases
iPTMneti | Q7L513 |
PhosphoSitePlusi | Q7L513 |
Genetic variation databases
BioMutai | FCRLA |
DMDMi | 90101291 |
Proteomic databases
MassIVEi | Q7L513 |
MaxQBi | Q7L513 |
PaxDbi | Q7L513 |
PeptideAtlasi | Q7L513 |
PRIDEi | Q7L513 |
ProteomicsDBi | 1444 27358 29885 32350 65585 68782 [Q7L513-1] 68783 [Q7L513-2] 68784 [Q7L513-3] 68785 [Q7L513-4] 68786 [Q7L513-5] 68787 [Q7L513-6] 68788 [Q7L513-7] 68789 [Q7L513-8] 68790 [Q7L513-9] 793 |
Protocols and materials databases
Antibodypediai | 34314, 110 antibodies |
DNASUi | 84824 |
Genome annotation databases
Organism-specific databases
CTDi | 84824 |
DisGeNETi | 84824 |
GeneCardsi | FCRLA |
HGNCi | HGNC:18504, FCRLA |
HPAi | ENSG00000132185, Group enriched (blood, lymphoid tissue) |
MIMi | 606891, gene |
neXtProti | NX_Q7L513 |
OpenTargetsi | ENSG00000132185 |
PharmGKBi | PA162388180 |
VEuPathDBi | HostDB:ENSG00000132185.16 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502T149, Eukaryota |
GeneTreei | ENSGT01000000214497 |
HOGENOMi | CLU_1824654_0_0_1 |
InParanoidi | Q7L513 |
OMAi | AHSGSYW |
PhylomeDBi | Q7L513 |
TreeFami | TF335097 |
Enzyme and pathway databases
PathwayCommonsi | Q7L513 |
Miscellaneous databases
BioGRID-ORCSi | 84824, 5 hits in 867 CRISPR screens |
ChiTaRSi | FCRLA, human |
GeneWikii | FCRLA |
GenomeRNAii | 84824 |
Pharosi | Q7L513, Tbio |
PROi | PR:Q7L513 |
RNActi | Q7L513, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000132185, Expressed in tonsil and 125 other tissues |
ExpressionAtlasi | Q7L513, baseline and differential |
Genevisiblei | Q7L513, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF13895, Ig_2, 2 hits |
SMARTi | View protein in SMART SM00409, IG, 2 hits |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FCRLA_HUMAN | |
Accessioni | Q7L513Primary (citable) accession number: Q7L513 Secondary accession number(s): A0N0M1 Q9BR57 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 21, 2006 |
Last sequence update: | March 21, 2006 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references