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Protein

Fc receptor-like A

Gene

FCRLA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be implicated in B-cell differentiation and lymphomagenesis.2 Publications

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated

GO - Biological processi

Keywordsi

Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Fc receptor-like A
Alternative name(s):
Fc receptor homolog expressed in B-cells
Fc receptor-like and mucin-like protein 1
Fc receptor-like protein
Fc receptor-related protein X
Short name:
FcRX
Gene namesi
Name:FCRLA
Synonyms:FCRL, FCRL1, FCRLM1, FCRX, FREB
ORF Names:UNQ291/PRO329
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000132185.16
HGNCiHGNC:18504 FCRLA
MIMi606891 gene
neXtProtiNX_Q7L513

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi84824
OpenTargetsiENSG00000132185
PharmGKBiPA162388180

Polymorphism and mutation databases

BioMutaiFCRLA
DMDMi90101291

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000022793528 – 359Fc receptor-like AAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi99 ↔ 143PROSITE-ProRule annotation
Disulfide bondi192 ↔ 240PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ7L513
PaxDbiQ7L513
PeptideAtlasiQ7L513
PRIDEiQ7L513
ProteomicsDBi68782
68783 [Q7L513-2]
68784 [Q7L513-3]
68785 [Q7L513-4]
68786 [Q7L513-5]
68787 [Q7L513-6]
68788 [Q7L513-7]
68789 [Q7L513-8]
68790 [Q7L513-9]

PTM databases

iPTMnetiQ7L513
PhosphoSitePlusiQ7L513

Expressioni

Tissue specificityi

Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes.4 Publications

Gene expression databases

BgeeiENSG00000132185 Expressed in 104 organ(s), highest expression level in lymph node
CleanExiHS_FCRL1
ExpressionAtlasiQ7L513 baseline and differential
GenevisibleiQ7L513 HS

Organism-specific databases

HPAiCAB016545

Interactioni

Subunit structurei

Monomer or homodimer; disulfide-linked.

Protein-protein interaction databases

BioGridi124282, 1 interactor
IntActiQ7L513, 4 interactors
STRINGi9606.ENSP00000356936

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7L513
SMRiQ7L513
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 159Ig-like C2-type 1Add BLAST90
Domaini170 – 257Ig-like C2-type 2Add BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi269 – 315Pro-richAdd BLAST47

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IHSR Eukaryota
ENOG4111EGY LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000036934
HOVERGENiHBG059243
InParanoidiQ7L513
OMAiPPGPNKE
OrthoDBiEOG091G0ETN
PhylomeDBiQ7L513
TreeFamiTF335097

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (15+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 15 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 15 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7L513-1) [UniParc]FASTAAdd to basket
Also known as: FCRLa

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED
60 70 80 90 100
DLTDAREAGF QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ
110 120 130 140 150
AWQDWPLTQV TFYRDGSALG PPGPNREFSI TVVQKADSGH YHCSGIFQSP
160 170 180 190 200
GPGIPETASV VAITVQELFP APILRAVPSA EPQAGSPMTL SCQTKLPLQR
210 220 230 240 250
SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC EAATEDNQVW
260 270 280 290 300
KQSPQLEIRV QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS
310 320 330 340 350
SEDPGFSSPL GMPDPHLYHQ MGLLLKHMQD VRVLLGHLLM ELRELSGHRK

PGTTKATAE
Length:359
Mass (Da):38,927
Last modified:March 21, 2006 - v2
Checksum:i76821DADB121499F
GO
Isoform 2 (identifier: Q7L513-2) [UniParc]FASTAAdd to basket
Also known as: FCRLa1

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: A → AGCHAAA

Show »
Length:365
Mass (Da):39,438
Checksum:iCCE4864CD4C54490
GO
Isoform 3 (identifier: Q7L513-3) [UniParc]FASTAAdd to basket
Also known as: FCRLb

The sequence of this isoform differs from the canonical sequence as follows:
     78-166: Missing.

Show »
Length:270
Mass (Da):29,281
Checksum:i5C8206F2AD581FEF
GO
Isoform 4 (identifier: Q7L513-4) [UniParc]FASTAAdd to basket
Also known as: FCRLc1

The sequence of this isoform differs from the canonical sequence as follows:
     29-166: SFETLQCEGP...TASVVAITVQ → GCHA

Show »
Length:225
Mass (Da):24,149
Checksum:i004B85CFCA2232C8
GO
Isoform 5 (identifier: Q7L513-5) [UniParc]FASTAAdd to basket
Also known as: FCRLc2

The sequence of this isoform differs from the canonical sequence as follows:
     27-166: Missing.

Show »
Length:219
Mass (Da):23,638
Checksum:i7221B95E05E01932
GO
Isoform 6 (identifier: Q7L513-6) [UniParc]FASTAAdd to basket
Also known as: FCRLd

The sequence of this isoform differs from the canonical sequence as follows:
     78-261: Missing.

Show »
Length:175
Mass (Da):18,719
Checksum:i1EB948BC1FD4EB45
GO
Isoform 7 (identifier: Q7L513-7) [UniParc]FASTAAdd to basket
Also known as: FCRLe

The sequence of this isoform differs from the canonical sequence as follows:
     27-261: Missing.

Show »
Length:124
Mass (Da):13,076
Checksum:iDA62850F76758F70
GO
Isoform 8 (identifier: Q7L513-8) [UniParc]FASTAAdd to basket
Also known as: FCRLf

The sequence of this isoform differs from the canonical sequence as follows:
     167-261: Missing.

Show »
Length:264
Mass (Da):28,365
Checksum:iC3FC5FC795C82CD0
GO
Isoform 9 (identifier: Q7L513-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM

Show »
Length:376
Mass (Da):40,655
Checksum:iA8EEAF71347126DE
GO
Isoform 10 (identifier: Q7L513-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     28-28: A → AGCHAAA

Note: No experimental confirmation available.
Show »
Length:382
Mass (Da):41,166
Checksum:i3A20194B87382AFC
GO
Isoform 11 (identifier: Q7L513-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     29-166: SFETLQCEGP...TASVVAITVQ → GCHA

Note: No experimental confirmation available.
Show »
Length:242
Mass (Da):25,877
Checksum:iFCFE2BFCD6328F00
GO
Isoform 12 (identifier: Q7L513-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     78-166: Missing.

Note: No experimental confirmation available.
Show »
Length:287
Mass (Da):31,009
Checksum:iC3F802DDA6EAF181
GO
Isoform 13 (identifier: Q7L513-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     78-261: Missing.

Note: No experimental confirmation available.
Show »
Length:192
Mass (Da):20,448
Checksum:iB0CDC702FB3B4F09
GO
Isoform 14 (identifier: Q7L513-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     27-166: Missing.

Note: No experimental confirmation available.
Show »
Length:236
Mass (Da):25,366
Checksum:i3FE90660ECE2455F
GO
Isoform 15 (identifier: Q7L513-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     27-261: Missing.

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):14,804
Checksum:iA481C1809EA0F67F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VXA5Q5VXA5_HUMAN
Fc receptor-like A
FCRLA
152Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265S → N in AAL23904 (PubMed:11754007).Curated1
Sequence conflicti308S → P in AAL23903 (PubMed:11754007).Curated1
Sequence conflicti317L → P in AAL27307 (PubMed:11754007).Curated1
Sequence conflicti343R → G in AAL23905 (PubMed:11754007).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025646349R → Q6 PublicationsCorresponds to variant dbSNP:rs11746Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0382971M → MLKKISVGVAGDLNTVTM in isoform 9, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14 and isoform 15. 3 Publications1
Alternative sequenceiVSP_01760327 – 261Missing in isoform 7 and isoform 15. 2 PublicationsAdd BLAST235
Alternative sequenceiVSP_01760427 – 166Missing in isoform 5 and isoform 14. 2 PublicationsAdd BLAST140
Alternative sequenceiVSP_01760528A → AGCHAAA in isoform 2 and isoform 10. 1 Publication1
Alternative sequenceiVSP_01760629 – 166SFETL…AITVQ → GCHA in isoform 4 and isoform 11. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_01760778 – 261Missing in isoform 6 and isoform 13. 2 PublicationsAdd BLAST184
Alternative sequenceiVSP_01760878 – 166Missing in isoform 3 and isoform 12. 2 PublicationsAdd BLAST89
Alternative sequenceiVSP_017609167 – 261Missing in isoform 8. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329489 mRNA Translation: AAL23899.1
AF329491 mRNA Translation: AAL23901.1
AF329493 mRNA Translation: AAL23903.1
AF329494 mRNA Translation: AAL23904.1
AF329495 mRNA Translation: AAL23905.1
AF390036 mRNA Translation: AAL27307.1
AF426461 mRNA Translation: AAL58111.1
AF531423 mRNA Translation: AAM97591.1
AY091642 mRNA Translation: AAM13980.2
EF064729 Genomic DNA Translation: ABK41912.1
AY358348 mRNA Translation: AAQ88714.1
AL359541 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90683.1
CH471067 Genomic DNA Translation: EAW90684.1
CH471067 Genomic DNA Translation: EAW90685.1
BC006521 mRNA Translation: AAH06521.2
CCDSiCCDS30926.1 [Q7L513-9]
CCDS53415.1 [Q7L513-10]
CCDS53416.1 [Q7L513-11]
CCDS53417.1 [Q7L513-12]
CCDS53418.1 [Q7L513-13]
CCDS53419.1 [Q7L513-14]
CCDS53420.1 [Q7L513-15]
RefSeqiNP_001171795.1, NM_001184866.1 [Q7L513-10]
NP_001171796.1, NM_001184867.1 [Q7L513-12]
NP_001171799.1, NM_001184870.1 [Q7L513-11]
NP_001171800.1, NM_001184871.1 [Q7L513-15]
NP_001171801.1, NM_001184872.1 [Q7L513-14]
NP_001171802.1, NM_001184873.1 [Q7L513-13]
NP_116127.3, NM_032738.3 [Q7L513-9]
UniGeneiHs.266331

Genome annotation databases

EnsembliENST00000236938; ENSP00000236938; ENSG00000132185 [Q7L513-9]
ENST00000294796; ENSP00000294796; ENSG00000132185 [Q7L513-4]
ENST00000309691; ENSP00000309596; ENSG00000132185 [Q7L513-3]
ENST00000349527; ENSP00000294798; ENSG00000132185 [Q7L513-8]
ENST00000350710; ENSP00000344808; ENSG00000132185 [Q7L513-15]
ENST00000367949; ENSP00000356926; ENSG00000132185 [Q7L513-13]
ENST00000367953; ENSP00000356930; ENSG00000132185 [Q7L513-2]
ENST00000367957; ENSP00000356934; ENSG00000132185 [Q7L513-14]
ENST00000367959; ENSP00000356936; ENSG00000132185 [Q7L513-10]
ENST00000540521; ENSP00000442870; ENSG00000132185 [Q7L513-11]
ENST00000546024; ENSP00000439838; ENSG00000132185 [Q7L513-12]
GeneIDi84824
KEGGihsa:84824
UCSCiuc001gbd.4 human [Q7L513-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329489 mRNA Translation: AAL23899.1
AF329491 mRNA Translation: AAL23901.1
AF329493 mRNA Translation: AAL23903.1
AF329494 mRNA Translation: AAL23904.1
AF329495 mRNA Translation: AAL23905.1
AF390036 mRNA Translation: AAL27307.1
AF426461 mRNA Translation: AAL58111.1
AF531423 mRNA Translation: AAM97591.1
AY091642 mRNA Translation: AAM13980.2
EF064729 Genomic DNA Translation: ABK41912.1
AY358348 mRNA Translation: AAQ88714.1
AL359541 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90683.1
CH471067 Genomic DNA Translation: EAW90684.1
CH471067 Genomic DNA Translation: EAW90685.1
BC006521 mRNA Translation: AAH06521.2
CCDSiCCDS30926.1 [Q7L513-9]
CCDS53415.1 [Q7L513-10]
CCDS53416.1 [Q7L513-11]
CCDS53417.1 [Q7L513-12]
CCDS53418.1 [Q7L513-13]
CCDS53419.1 [Q7L513-14]
CCDS53420.1 [Q7L513-15]
RefSeqiNP_001171795.1, NM_001184866.1 [Q7L513-10]
NP_001171796.1, NM_001184867.1 [Q7L513-12]
NP_001171799.1, NM_001184870.1 [Q7L513-11]
NP_001171800.1, NM_001184871.1 [Q7L513-15]
NP_001171801.1, NM_001184872.1 [Q7L513-14]
NP_001171802.1, NM_001184873.1 [Q7L513-13]
NP_116127.3, NM_032738.3 [Q7L513-9]
UniGeneiHs.266331

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HWNX-ray2.01A169-264[»]
ProteinModelPortaliQ7L513
SMRiQ7L513
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124282, 1 interactor
IntActiQ7L513, 4 interactors
STRINGi9606.ENSP00000356936

PTM databases

iPTMnetiQ7L513
PhosphoSitePlusiQ7L513

Polymorphism and mutation databases

BioMutaiFCRLA
DMDMi90101291

Proteomic databases

MaxQBiQ7L513
PaxDbiQ7L513
PeptideAtlasiQ7L513
PRIDEiQ7L513
ProteomicsDBi68782
68783 [Q7L513-2]
68784 [Q7L513-3]
68785 [Q7L513-4]
68786 [Q7L513-5]
68787 [Q7L513-6]
68788 [Q7L513-7]
68789 [Q7L513-8]
68790 [Q7L513-9]

Protocols and materials databases

DNASUi84824
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236938; ENSP00000236938; ENSG00000132185 [Q7L513-9]
ENST00000294796; ENSP00000294796; ENSG00000132185 [Q7L513-4]
ENST00000309691; ENSP00000309596; ENSG00000132185 [Q7L513-3]
ENST00000349527; ENSP00000294798; ENSG00000132185 [Q7L513-8]
ENST00000350710; ENSP00000344808; ENSG00000132185 [Q7L513-15]
ENST00000367949; ENSP00000356926; ENSG00000132185 [Q7L513-13]
ENST00000367953; ENSP00000356930; ENSG00000132185 [Q7L513-2]
ENST00000367957; ENSP00000356934; ENSG00000132185 [Q7L513-14]
ENST00000367959; ENSP00000356936; ENSG00000132185 [Q7L513-10]
ENST00000540521; ENSP00000442870; ENSG00000132185 [Q7L513-11]
ENST00000546024; ENSP00000439838; ENSG00000132185 [Q7L513-12]
GeneIDi84824
KEGGihsa:84824
UCSCiuc001gbd.4 human [Q7L513-1]

Organism-specific databases

CTDi84824
DisGeNETi84824
EuPathDBiHostDB:ENSG00000132185.16
GeneCardsiFCRLA
H-InvDBiHIX0001250
HGNCiHGNC:18504 FCRLA
HPAiCAB016545
MIMi606891 gene
neXtProtiNX_Q7L513
OpenTargetsiENSG00000132185
PharmGKBiPA162388180
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHSR Eukaryota
ENOG4111EGY LUCA
GeneTreeiENSGT00760000119130
HOGENOMiHOG000036934
HOVERGENiHBG059243
InParanoidiQ7L513
OMAiPPGPNKE
OrthoDBiEOG091G0ETN
PhylomeDBiQ7L513
TreeFamiTF335097

Miscellaneous databases

ChiTaRSiFCRLA human
GeneWikiiFCRLA
GenomeRNAii84824
PROiPR:Q7L513
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132185 Expressed in 104 organ(s), highest expression level in lymph node
CleanExiHS_FCRL1
ExpressionAtlasiQ7L513 baseline and differential
GenevisibleiQ7L513 HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
SMARTiView protein in SMART
SM00409 IG, 2 hits
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFCRLA_HUMAN
AccessioniPrimary (citable) accession number: Q7L513
Secondary accession number(s): A0N0M1
, A6NC03, A6NL20, F5H720, F8W743, G3V1J2, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXA4, Q5VXB0, Q5VXB1, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: November 7, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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