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UniProtKB - Q7L513 (FCRLA_HUMAN)

Entry version 145 (10 Feb 2021)
Sequence version 2 (21 Mar 2006)
Previous versions | rss
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Protein

Fc receptor-like A

Gene

FCRLA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be implicated in B-cell differentiation and lymphomagenesis.2 Publications

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7L513

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fc receptor-like A
Alternative name(s):
Fc receptor homolog expressed in B-cells
Fc receptor-like and mucin-like protein 1
Fc receptor-like protein
Fc receptor-related protein X
Short name:
FcRX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FCRLA
Synonyms:FCRL, FCRL1, FCRLM1, FCRX, FREB
ORF Names:UNQ291/PRO329
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18504, FCRLA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606891, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7L513

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000132185.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		84824

Open Targets

More...OpenTargetsi		ENSG00000132185

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162388180

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7L513, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FCRLA

Domain mapping of disease mutations (DMDM)

More...DMDMi		90101291

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 271 PublicationAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022793528 – 359Fc receptor-like AAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi99 ↔ 143PROSITE-ProRule annotation
Disulfide bondi192 ↔ 240PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7L513

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7L513

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7L513

PeptideAtlas

More...PeptideAtlasi		Q7L513

PRoteomics IDEntifications database

More...PRIDEi		Q7L513

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1444
27358
29885
32350
65585
68782 [Q7L513-1]
68783 [Q7L513-2]
68784 [Q7L513-3]
68785 [Q7L513-4]
68786 [Q7L513-5]
68787 [Q7L513-6]
68788 [Q7L513-7]
68789 [Q7L513-8]
68790 [Q7L513-9]
793

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7L513

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7L513

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed specifically in primary and secondary lymphoid tissues like lymph node, spleen and tonsil. Specifically expressed in B-cells with a high level in normal germinal center B-cells, centroblasts and in a subset of diffuse large B-cell lymphomas. Highly expressed in bone marrow B-cells and weakly in earlier B lineage cells. Expressed in pre-germinal and germinal center B-cells in secondary lymphoid tissues. Also expressed in melanoma and melanocytes.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132185, Expressed in tonsil and 125 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7L513, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7L513, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132185, Group enriched (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer or homodimer; disulfide-linked.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124282, 2 interactors

Protein interaction database and analysis system

More...IntActi		Q7L513, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356936

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7L513, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7L513

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini70 – 159Ig-like C2-type 1Add BLAST90
Domaini170 – 257Ig-like C2-type 2Add BLAST88

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi269 – 315Pro-richAdd BLAST47

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502T149, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214497

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1824654_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7L513

Identification of Orthologs from Complete Genome Data

More...OMAi		AHSGSYW

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7L513

TreeFam database of animal gene trees

More...TreeFami		TF335097

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13895, Ig_2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (15+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 15 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 15 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7L513-1) [UniParc]FASTAAdd to basket
Also known as: FCRLa

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLGCVLMAW ALYLSLGVLW VAQMLLAASF ETLQCEGPVC TEESSCHTED 
        60         70         80         90        100
DLTDAREAGF QVKAYTFSEP FHLIVSYDWL ILQGPAKPVF EGDLLVLRCQ 
       110        120        130        140        150
AWQDWPLTQV TFYRDGSALG PPGPNREFSI TVVQKADSGH YHCSGIFQSP 
       160        170        180        190        200
GPGIPETASV VAITVQELFP APILRAVPSA EPQAGSPMTL SCQTKLPLQR 
       210        220        230        240        250
SAARLLFSFY KDGRIVQSRG LSSEFQIPTA SEDHSGSYWC EAATEDNQVW 
       260        270        280        290        300
KQSPQLEIRV QGASSSAAPP TLNPAPQKSA APGTAPEEAP GPLPPPPTPS 
       310        320        330        340        350
SEDPGFSSPL GMPDPHLYHQ MGLLLKHMQD VRVLLGHLLM ELRELSGHRK 

PGTTKATAE
Length:359
Mass (Da):38,927
Last modified:March 21, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i76821DADB121499F
GO
Isoform 2 (identifier: Q7L513-2) [UniParc]FASTAAdd to basket
Also known as: FCRLa1

The sequence of this isoform differs from the canonical sequence as follows:
     28-28: A → AGCHAAA

Show »
Length:365
Mass (Da):39,438
Checksum:iCCE4864CD4C54490
GO
Isoform 3 (identifier: Q7L513-3) [UniParc]FASTAAdd to basket
Also known as: FCRLb

The sequence of this isoform differs from the canonical sequence as follows:
     78-166: Missing.

Show »
Length:270
Mass (Da):29,281
Checksum:i5C8206F2AD581FEF
GO
Isoform 4 (identifier: Q7L513-4) [UniParc]FASTAAdd to basket
Also known as: FCRLc1

The sequence of this isoform differs from the canonical sequence as follows:
     29-166: SFETLQCEGP...TASVVAITVQ → GCHA

Show »
Length:225
Mass (Da):24,149
Checksum:i004B85CFCA2232C8
GO
Isoform 5 (identifier: Q7L513-5) [UniParc]FASTAAdd to basket
Also known as: FCRLc2

The sequence of this isoform differs from the canonical sequence as follows:
     27-166: Missing.

Show »
Length:219
Mass (Da):23,638
Checksum:i7221B95E05E01932
GO
Isoform 6 (identifier: Q7L513-6) [UniParc]FASTAAdd to basket
Also known as: FCRLd

The sequence of this isoform differs from the canonical sequence as follows:
     78-261: Missing.

Show »
Length:175
Mass (Da):18,719
Checksum:i1EB948BC1FD4EB45
GO
Isoform 7 (identifier: Q7L513-7) [UniParc]FASTAAdd to basket
Also known as: FCRLe

The sequence of this isoform differs from the canonical sequence as follows:
     27-261: Missing.

Show »
Length:124
Mass (Da):13,076
Checksum:iDA62850F76758F70
GO
Isoform 8 (identifier: Q7L513-8) [UniParc]FASTAAdd to basket
Also known as: FCRLf

The sequence of this isoform differs from the canonical sequence as follows:
     167-261: Missing.

Show »
Length:264
Mass (Da):28,365
Checksum:iC3FC5FC795C82CD0
GO
Isoform 9 (identifier: Q7L513-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM

Show »
Length:376
Mass (Da):40,655
Checksum:iA8EEAF71347126DE
GO
Isoform 10 (identifier: Q7L513-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     28-28: A → AGCHAAA

Show »
Length:382
Mass (Da):41,166
Checksum:i3A20194B87382AFC
GO
Isoform 11 (identifier: Q7L513-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     29-166: SFETLQCEGP...TASVVAITVQ → GCHA

Show »
Length:242
Mass (Da):25,877
Checksum:iFCFE2BFCD6328F00
GO
Isoform 12 (identifier: Q7L513-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     78-166: Missing.

Show »
Length:287
Mass (Da):31,009
Checksum:iC3F802DDA6EAF181
GO
Isoform 13 (identifier: Q7L513-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     78-261: Missing.

Show »
Length:192
Mass (Da):20,448
Checksum:iB0CDC702FB3B4F09
GO
Isoform 14 (identifier: Q7L513-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     27-166: Missing.

Show »
Length:236
Mass (Da):25,366
Checksum:i3FE90660ECE2455F
GO
Isoform 15 (identifier: Q7L513-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLKKISVGVAGDLNTVTM
     27-261: Missing.

Show »
Length:141
Mass (Da):14,804
Checksum:iA481C1809EA0F67F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5VXA5Q5VXA5_HUMAN
Fc receptor-like A
FCRLA
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti265S → N in AAL23904 (PubMed:11754007).Curated1
Sequence conflicti308S → P in AAL23903 (PubMed:11754007).Curated1
Sequence conflicti317L → P in AAL27307 (PubMed:11754007).Curated1
Sequence conflicti343R → G in AAL23905 (PubMed:11754007).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025646349R → Q6 PublicationsCorresponds to variant dbSNP:rs11746Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0382971M → MLKKISVGVAGDLNTVTM in isoform 9, isoform 10, isoform 11, isoform 12, isoform 13, isoform 14 and isoform 15. 3 Publications1
Alternative sequenceiVSP_01760327 – 261Missing in isoform 7 and isoform 15. 2 PublicationsAdd BLAST235
Alternative sequenceiVSP_01760427 – 166Missing in isoform 5 and isoform 14. 2 PublicationsAdd BLAST140
Alternative sequenceiVSP_01760528A → AGCHAAA in isoform 2 and isoform 10. 1 Publication1
Alternative sequenceiVSP_01760629 – 166SFETL…AITVQ → GCHA in isoform 4 and isoform 11. 1 PublicationAdd BLAST138
Alternative sequenceiVSP_01760778 – 261Missing in isoform 6 and isoform 13. 2 PublicationsAdd BLAST184
Alternative sequenceiVSP_01760878 – 166Missing in isoform 3 and isoform 12. 2 PublicationsAdd BLAST89
Alternative sequenceiVSP_017609167 – 261Missing in isoform 8. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF329489 mRNA Translation: AAL23899.1
AF329491 mRNA Translation: AAL23901.1
AF329493 mRNA Translation: AAL23903.1
AF329494 mRNA Translation: AAL23904.1
AF329495 mRNA Translation: AAL23905.1
AF390036 mRNA Translation: AAL27307.1
AF426461 mRNA Translation: AAL58111.1
AF531423 mRNA Translation: AAM97591.1
AY091642 mRNA Translation: AAM13980.2
EF064729 Genomic DNA Translation: ABK41912.1
AY358348 mRNA Translation: AAQ88714.1
AL359541 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90683.1
CH471067 Genomic DNA Translation: EAW90684.1
CH471067 Genomic DNA Translation: EAW90685.1
BC006521 mRNA Translation: AAH06521.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30926.1 [Q7L513-1]
CCDS53415.1 [Q7L513-2]
CCDS53416.1 [Q7L513-4]
CCDS53417.1 [Q7L513-3]
CCDS53418.1 [Q7L513-6]
CCDS53419.1 [Q7L513-5]
CCDS53420.1 [Q7L513-7]

NCBI Reference Sequences

More...RefSeqi		NP_001171795.1, NM_001184866.1 [Q7L513-2]
NP_001171796.1, NM_001184867.1 [Q7L513-3]
NP_001171799.1, NM_001184870.1 [Q7L513-4]
NP_001171800.1, NM_001184871.1 [Q7L513-7]
NP_001171801.1, NM_001184872.1 [Q7L513-5]
NP_001171802.1, NM_001184873.1 [Q7L513-6]
NP_116127.3, NM_032738.3 [Q7L513-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000236938; ENSP00000236938; ENSG00000132185 [Q7L513-1]
ENST00000294796; ENSP00000294796; ENSG00000132185 [Q7L513-4]
ENST00000309691; ENSP00000309596; ENSG00000132185 [Q7L513-3]
ENST00000349527; ENSP00000294798; ENSG00000132185 [Q7L513-8]
ENST00000350710; ENSP00000344808; ENSG00000132185 [Q7L513-15]
ENST00000367949; ENSP00000356926; ENSG00000132185 [Q7L513-13]
ENST00000367953; ENSP00000356930; ENSG00000132185 [Q7L513-2]
ENST00000367957; ENSP00000356934; ENSG00000132185 [Q7L513-5]
ENST00000367959; ENSP00000356936; ENSG00000132185 [Q7L513-10]
ENST00000540521; ENSP00000442870; ENSG00000132185 [Q7L513-11]
ENST00000546024; ENSP00000439838; ENSG00000132185 [Q7L513-12]
ENST00000674251; ENSP00000501389; ENSG00000132185 [Q7L513-14]
ENST00000674323; ENSP00000501449; ENSG00000132185 [Q7L513-9]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84824

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84824

UCSC genome browser

More...UCSCi		uc001gbd.4, human [Q7L513-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF329489 mRNA Translation: AAL23899.1
AF329491 mRNA Translation: AAL23901.1
AF329493 mRNA Translation: AAL23903.1
AF329494 mRNA Translation: AAL23904.1
AF329495 mRNA Translation: AAL23905.1
AF390036 mRNA Translation: AAL27307.1
AF426461 mRNA Translation: AAL58111.1
AF531423 mRNA Translation: AAM97591.1
AY091642 mRNA Translation: AAM13980.2
EF064729 Genomic DNA Translation: ABK41912.1
AY358348 mRNA Translation: AAQ88714.1
AL359541 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW90683.1
CH471067 Genomic DNA Translation: EAW90684.1
CH471067 Genomic DNA Translation: EAW90685.1
BC006521 mRNA Translation: AAH06521.2
CCDSiCCDS30926.1 [Q7L513-1]
CCDS53415.1 [Q7L513-2]
CCDS53416.1 [Q7L513-4]
CCDS53417.1 [Q7L513-3]
CCDS53418.1 [Q7L513-6]
CCDS53419.1 [Q7L513-5]
CCDS53420.1 [Q7L513-7]
RefSeqiNP_001171795.1, NM_001184866.1 [Q7L513-2]
NP_001171796.1, NM_001184867.1 [Q7L513-3]
NP_001171799.1, NM_001184870.1 [Q7L513-4]
NP_001171800.1, NM_001184871.1 [Q7L513-7]
NP_001171801.1, NM_001184872.1 [Q7L513-5]
NP_001171802.1, NM_001184873.1 [Q7L513-6]
NP_116127.3, NM_032738.3 [Q7L513-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HWNX-ray2.01A169-264[»]
SMRiQ7L513
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124282, 2 interactors
IntActiQ7L513, 4 interactors
STRINGi9606.ENSP00000356936

PTM databases

iPTMnetiQ7L513
PhosphoSitePlusiQ7L513

Genetic variation databases

BioMutaiFCRLA
DMDMi90101291

Proteomic databases

MassIVEiQ7L513
MaxQBiQ7L513
PaxDbiQ7L513
PeptideAtlasiQ7L513
PRIDEiQ7L513
ProteomicsDBi1444
27358
29885
32350
65585
68782 [Q7L513-1]
68783 [Q7L513-2]
68784 [Q7L513-3]
68785 [Q7L513-4]
68786 [Q7L513-5]
68787 [Q7L513-6]
68788 [Q7L513-7]
68789 [Q7L513-8]
68790 [Q7L513-9]
793

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		34314, 110 antibodies

The DNASU plasmid repository

More...DNASUi		84824

Genome annotation databases

EnsembliENST00000236938; ENSP00000236938; ENSG00000132185 [Q7L513-1]
ENST00000294796; ENSP00000294796; ENSG00000132185 [Q7L513-4]
ENST00000309691; ENSP00000309596; ENSG00000132185 [Q7L513-3]
ENST00000349527; ENSP00000294798; ENSG00000132185 [Q7L513-8]
ENST00000350710; ENSP00000344808; ENSG00000132185 [Q7L513-15]
ENST00000367949; ENSP00000356926; ENSG00000132185 [Q7L513-13]
ENST00000367953; ENSP00000356930; ENSG00000132185 [Q7L513-2]
ENST00000367957; ENSP00000356934; ENSG00000132185 [Q7L513-5]
ENST00000367959; ENSP00000356936; ENSG00000132185 [Q7L513-10]
ENST00000540521; ENSP00000442870; ENSG00000132185 [Q7L513-11]
ENST00000546024; ENSP00000439838; ENSG00000132185 [Q7L513-12]
ENST00000674251; ENSP00000501389; ENSG00000132185 [Q7L513-14]
ENST00000674323; ENSP00000501449; ENSG00000132185 [Q7L513-9]
GeneIDi84824
KEGGihsa:84824
UCSCiuc001gbd.4, human [Q7L513-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84824
DisGeNETi84824

GeneCards: human genes, protein and diseases

More...GeneCardsi		FCRLA
HGNCiHGNC:18504, FCRLA
HPAiENSG00000132185, Group enriched (blood, lymphoid tissue)
MIMi606891, gene
neXtProtiNX_Q7L513
OpenTargetsiENSG00000132185
PharmGKBiPA162388180
VEuPathDBiHostDB:ENSG00000132185.16

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502T149, Eukaryota
GeneTreeiENSGT01000000214497
HOGENOMiCLU_1824654_0_0_1
InParanoidiQ7L513
OMAiAHSGSYW
PhylomeDBiQ7L513
TreeFamiTF335097

Enzyme and pathway databases

PathwayCommonsiQ7L513

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		84824, 5 hits in 867 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FCRLA, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FCRLA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84824
PharosiQ7L513, Tbio

Protein Ontology

More...PROi		PR:Q7L513
RNActiQ7L513, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132185, Expressed in tonsil and 125 other tissues
ExpressionAtlasiQ7L513, baseline and differential
GenevisibleiQ7L513, HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
PfamiView protein in Pfam
PF13895, Ig_2, 2 hits
SMARTiView protein in SMART
SM00409, IG, 2 hits
SUPFAMiSSF48726, SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCRLA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L513
Secondary accession number(s): A0N0M1
, A6NC03, A6NL20, F5H720, F8W743, G3V1J2, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXA4, Q5VXB0, Q5VXB1, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 21, 2006
Last modified: February 10, 2021
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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