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Protein

BEN domain-containing protein 5

Gene

BEND5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor (PubMed:23468431).1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
BEN domain-containing protein 5
Gene namesi
Name:BEND5
Synonyms:C1orf165
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162373.12
HGNCiHGNC:25668 BEND5
neXtProtiNX_Q7L4P6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162373
PharmGKBiPA164716542

Polymorphism and mutation databases

BioMutaiBEND5
DMDMi74738577

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002742791 – 421BEN domain-containing protein 5Add BLAST421

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei133N6-acetyllysineCombined sources1
Cross-linki258Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ7L4P6
MaxQBiQ7L4P6
PaxDbiQ7L4P6
PeptideAtlasiQ7L4P6
PRIDEiQ7L4P6
ProteomicsDBi68779
68780 [Q7L4P6-2]

PTM databases

iPTMnetiQ7L4P6
PhosphoSitePlusiQ7L4P6

Expressioni

Gene expression databases

BgeeiENSG00000162373
CleanExiHS_BEND5
ExpressionAtlasiQ7L4P6 baseline and differential
GenevisibleiQ7L4P6 HS

Organism-specific databases

HPAiHPA054347
HPA058007

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122782, 19 interactors
IntActiQ7L4P6, 27 interactors
STRINGi9606.ENSP00000360899

Structurei

3D structure databases

ProteinModelPortaliQ7L4P6
SMRiQ7L4P6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini302 – 408BENPROSITE-ProRule annotationAdd BLAST107

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili180 – 243Sequence analysisAdd BLAST64

Domaini

The BEN domain mediates DNA-binding.1 Publication

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II6Q Eukaryota
ENOG4110WSD LUCA
GeneTreeiENSGT00390000001724
HOGENOMiHOG000049159
HOVERGENiHBG095938
InParanoidiQ7L4P6
OMAiSEPMHDN
OrthoDBiEOG091G0U5K
PhylomeDBiQ7L4P6
TreeFamiTF331898

Family and domain databases

InterProiView protein in InterPro
IPR018379 BEN_domain
PfamiView protein in Pfam
PF10523 BEN, 1 hit
SMARTiView protein in SMART
SM01025 BEN, 1 hit
PROSITEiView protein in PROSITE
PS51457 BEN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L4P6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYAFVRFLED NVCYALPVSC VRDFSPRSRL DFDNQKVYAV YRGPEELGAG
60 70 80 90 100
PESPPRAPRD WGALLLHKAQ ILALAEDKSD LENSVMQKKI KIPKLSLNHV
110 120 130 140 150
EEDGEVKDYG EEDLQLRHIK RPEGRKPSEV AHKSIEAVVA RLEKQNGLSL
160 170 180 190 200
GHSTCPEEVF VEASPGTEDM DSLEDAVVPR ALYEELLRNY QQQQEEMRHL
210 220 230 240 250
QQELERTRRQ LVQQAKKLKE YGALVSEMKE LRDLNRRLQD VLLLRLGSGP
260 270 280 290 300
AIDLEKVKSE CLEPEPELRS TFSEEANTSS YYPAPAPVMD KYILDNGKVH
310 320 330 340 350
LGSGIWVDEE KWHQLQVTQG DSKYTKNLAV MIWGTDVLKN RSVTGVATKK
360 370 380 390 400
KKDAVPKPPL SPHKLSIVRE CLYDRIAQET VDETEIAQRL SKVNKYICEK
410 420
IMDINKSCKN EERREAKYNL Q
Length:421
Mass (Da):48,182
Last modified:July 5, 2004 - v1
Checksum:iC2C552B932F42AAC
GO
Isoform 2 (identifier: Q7L4P6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.

Show »
Length:252
Mass (Da):29,215
Checksum:i1305E13ECA76A7F3
GO

Sequence cautioni

The sequence AAH11804 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti363H → R in BAB13864 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0226951 – 169Missing in isoform 2. 1 PublicationAdd BLAST169

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021650 mRNA Translation: BAB13864.1
CH471059 Genomic DNA Translation: EAX06851.1
BC007932 mRNA Translation: AAH07932.2
BC011804 mRNA Translation: AAH11804.1 Different initiation.
CCDSiCCDS552.2 [Q7L4P6-1]
RefSeqiNP_001289011.1, NM_001302082.1 [Q7L4P6-2]
NP_078879.2, NM_024603.3 [Q7L4P6-1]
XP_011540444.1, XM_011542142.2 [Q7L4P6-2]
XP_016857823.1, XM_017002334.1
UniGeneiHs.475348

Genome annotation databases

EnsembliENST00000371833; ENSP00000360899; ENSG00000162373 [Q7L4P6-1]
GeneIDi79656
KEGGihsa:79656
UCSCiuc001crx.5 human [Q7L4P6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiBEND5_HUMAN
AccessioniPrimary (citable) accession number: Q7L4P6
Secondary accession number(s): D3DQ27, Q96A62, Q9HAI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: July 18, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM

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