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Protein

Arginine/serine-rich coiled-coil protein 2

Gene

RSRC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine/serine-rich coiled-coil protein 2
Gene namesi
Name:RSRC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111011.17
HGNCiHGNC:30559 RSRC2
neXtProtiNX_Q7L4I2

Pathology & Biotechi

Organism-specific databases

DisGeNETi65117
OpenTargetsiENSG00000111011
PharmGKBiPA162402249

Polymorphism and mutation databases

BioMutaiRSRC2
DMDMi74739167

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003149372 – 434Arginine/serine-rich coiled-coil protein 2Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei4PhosphoserineCombined sources1
Modified residuei6PhosphothreonineCombined sources1
Modified residuei16PhosphothreonineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Modified residuei30PhosphoserineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei104PhosphoserineCombined sources1
Cross-linki375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki375Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei376PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7L4I2
MaxQBiQ7L4I2
PaxDbiQ7L4I2
PeptideAtlasiQ7L4I2
PRIDEiQ7L4I2
ProteomicsDBi68777
68778 [Q7L4I2-2]

PTM databases

iPTMnetiQ7L4I2
PhosphoSitePlusiQ7L4I2

Expressioni

Gene expression databases

BgeeiENSG00000111011
CleanExiHS_RSRC2
ExpressionAtlasiQ7L4I2 baseline and differential
GenevisibleiQ7L4I2 HS

Organism-specific databases

HPAiHPA040070
HPA048183

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122398, 25 interactors
IntActiQ7L4I2, 23 interactors
MINTiQ7L4I2
STRINGi9606.ENSP00000330188

Structurei

3D structure databases

ProteinModelPortaliQ7L4I2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili230 – 270Sequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi27 – 200Ser-richAdd BLAST174

Sequence similaritiesi

Belongs to the RSRC2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIT5 Eukaryota
ENOG4111VFY LUCA
GeneTreeiENSGT00730000111142
HOGENOMiHOG000154211
HOVERGENiHBG061992
InParanoidiQ7L4I2
OMAiPRSSKHH
OrthoDBiEOG091G0YUO
PhylomeDBiQ7L4I2
TreeFamiTF325523

Family and domain databases

InterProiView protein in InterPro
IPR028124 SMAP_dom
PfamiView protein in Pfam
PF15477 SMAP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L4I2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAASDTERDG LAPEKTSPDR DKKKEQSEVS VSPRASKHHY SRSRSRSRER
60 70 80 90 100
KRKSDNEGRK HRSRSRSKEG RRHESKDKSS KKHKSEEHND KEHSSDKGRE
110 120 130 140 150
RLNSSENGED RHKRKERKSS RGRSHSRSRS RERRHRSRSR ERKKSRSRSR
160 170 180 190 200
ERKKSRSRSR ERKKSRSRSR ERKRRIRSRS RSRSRHRHRT RSRSRTRSRS
210 220 230 240 250
RDRKKRIEKP RRFSRSLSRT PSPPPFRGRN TAMDAQEALA RRLERAKKLQ
260 270 280 290 300
EQREKEMVEK QKQQEIAAAA ATGGSVLNVA ALLASGTQVT PQIAMAAQMA
310 320 330 340 350
ALQAKALAET GIAVPSYYNP AAVNPMKFAE QEKKRKMLWQ GKKEGDKSQS
360 370 380 390 400
AEIWEKLNFG NKDQNVKFRK LMGIKSEDEA GCSSVDEESY KTLKQQEEVF
410 420 430
RNLDAQYEMA RSQTHTQRGM GLGFTSSMRG MDAV
Length:434
Mass (Da):50,560
Last modified:May 24, 2005 - v1
Checksum:iD744ADEFF395E888
GO
Isoform 2 (identifier: Q7L4I2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: MAASDTERDG...KHRSRSRSKE → MKEENTGAGAEAKRTNFFLKQ

Show »
Length:386
Mass (Da):44,879
Checksum:iACEEDC35C56029E2
GO

Sequence cautioni

The sequence BAB14755 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW98327 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti224P → R in AAH67773 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03813388H → R. Corresponds to variant dbSNP:rs17886684Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0304401 – 69MAASD…SRSKE → MKEENTGAGAEAKRTNFFLK Q in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB212664 mRNA Translation: BAE93762.1
BX640711 mRNA Translation: CAE45830.1
CH471054 Genomic DNA Translation: EAW98327.1 Sequence problems.
CH471054 Genomic DNA Translation: EAW98330.1
BC008684 mRNA Translation: AAH08684.2
BC067773 mRNA Translation: AAH67773.1
AK023985 mRNA Translation: BAB14755.1 Different initiation.
CCDSiCCDS31920.1 [Q7L4I2-1]
RefSeqiNP_075388.2, NM_023012.5 [Q7L4I2-1]
XP_016875322.1, XM_017019833.1
UniGeneiHs.432996

Genome annotation databases

EnsembliENST00000331738; ENSP00000330188; ENSG00000111011 [Q7L4I2-1]
GeneIDi65117
KEGGihsa:65117
UCSCiuc001ucr.4 human [Q7L4I2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRSRC2_HUMAN
AccessioniPrimary (citable) accession number: Q7L4I2
Secondary accession number(s): Q6N040, Q6NW16, Q9H864
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 24, 2005
Last modified: July 18, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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