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UniProtKB - Q7L3V2 (BOP_HUMAN)
Protein
Protein Bop
Gene
RTL10
Organism
Homo sapiens (Human)
Status
Functioni
Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.
1 PublicationGO - Biological processi
- mitochondrial outer membrane permeabilization Source: UniProtKB
- regulation of mitochondrial membrane potential Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q7L3V2 |
SignaLinki | Q7L3V2 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein Bop1 PublicationAlternative name(s): BH3-only protein Retrotransposon Gag-like protein 10Imported |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26112, RTL10 |
neXtProti | NX_Q7L3V2 |
VEuPathDBi | HostDB:ENSG00000215012 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Mitochondrion
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 118 | L → A: Reduces the pro-apoptotic activity and interaction with VDAC1. 1 Publication | 1 | |
Mutagenesisi | 120 | Q → A: No effect on interaction with VDAC1. 1 Publication | 1 | |
Mutagenesisi | 122 | G → A: No effect on interaction with VDAC1. 1 Publication | 1 | |
Mutagenesisi | 123 | D → A: Reduces the pro-apoptotic activity, no effect on interaction with VDAC1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 79680 |
OpenTargetsi | ENSG00000215012 |
PharmGKBi | PA145149415 |
Miscellaneous databases
Pharosi | Q7L3V2, Tbio |
Genetic variation databases
BioMutai | RTL10 |
DMDMi | 74739166 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000295910 | 1 – 364 | Protein BopAdd BLAST | 364 |
Proteomic databases
EPDi | Q7L3V2 |
MassIVEi | Q7L3V2 |
MaxQBi | Q7L3V2 |
PaxDbi | Q7L3V2 |
PeptideAtlasi | Q7L3V2 |
PRIDEi | Q7L3V2 |
ProteomicsDBi | 68773 |
PTM databases
iPTMneti | Q7L3V2 |
PhosphoSitePlusi | Q7L3V2 |
Expressioni
Tissue specificityi
Ubiquitously expressed.1 Publication
Gene expression databases
Bgeei | ENSG00000215012, Expressed in decidua and 192 other tissues |
ExpressionAtlasi | Q7L3V2, baseline and differential |
Genevisiblei | Q7L3V2, HS |
Organism-specific databases
HPAi | ENSG00000215012, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via BH3 domain) with VDAC1.
Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2.
Interacts with BAX and BAK1.
1 PublicationBinary interactionsi
Q7L3V2
Protein-protein interaction databases
BioGRIDi | 122804, 12 interactors |
IntActi | Q7L3V2, 9 interactors |
STRINGi | 9606.ENSP00000384924 |
Miscellaneous databases
RNActi | Q7L3V2, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 66 – 88 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 258 – 364 | DisorderedSequence analysisAdd BLAST | 107 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 114 – 128 | BH3Add BLAST | 15 |
Domaini
The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.1 Publication
Phylogenomic databases
eggNOGi | ENOG502TE0G, Eukaryota |
GeneTreei | ENSGT00940000166811 |
HOGENOMi | CLU_801582_0_0_1 |
InParanoidi | Q7L3V2 |
OMAi | LSRVCEI |
OrthoDBi | 998632at2759 |
PhylomeDBi | Q7L3V2 |
TreeFami | TF342426 |
Family and domain databases
InterProi | View protein in InterPro IPR031298, Bop IPR032549, DUF4939 IPR032567, LDOC1-rel |
PANTHERi | PTHR15503, PTHR15503, 1 hit PTHR15503:SF4, PTHR15503:SF4, 1 hit |
Pfami | View protein in Pfam PF16297, DUF4939, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7L3V2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPRGRCRQQG PRIPIWAAAN YANAHPWQQM DKASPGVAYT PLVDPWIERP
60 70 80 90 100
CCGDTVCVRT TMEQKSTASG TCGGKPAERG PLAGHMPSSR PHRVDFCWVP
110 120 130 140 150
GSDPGTFDGS PWLLDRFLAQ LGDYMSFHFE HYQDNISRVC EILRRLTGRA
160 170 180 190 200
QAWAAPYLDG DLPLPDDYEL FCQDLKEVVQ DPNSFAEYHA VVTCPLPLAS
210 220 230 240 250
SQLPVAPQLP VVRQYLARFL EGLALDMGTA PRSLPAAMAT PAVSGSNSVS
260 270 280 290 300
RSALFEQQLT KESTPGPKEP PVLPSSTCSS KPGPVEPASS QPEEAAPTPV
310 320 330 340 350
PRLSESANPP AQRPDPAHPG GPKPQKTEEE VLETEGDQEV SLGTPQEVVE
360
APETPGEPPL SPGF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J0V4 | C9J0V4_HUMAN | Protein Bop | RTL10 | 91 | Annotation score: |
Sequence cautioni
The sequence BAB14998 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 124 | Y → H in BAF83951 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 206 | A → V in CAE45984 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 206 | A → V in CAE46001 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034590 | 116 | R → H. Corresponds to variant dbSNP:rs17745302Ensembl. | 1 | |
Natural variantiVAR_034591 | 123 | D → Y1 PublicationCorresponds to variant dbSNP:rs34027839Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291262 mRNA Translation: BAF83951.1 BX640785 mRNA Translation: CAE45875.1 BX640969 mRNA Translation: CAE45984.1 BX640998 mRNA Translation: CAE46001.1 AC000076 Genomic DNA No translation available. CH471176 Genomic DNA Translation: EAX03018.1 CH471176 Genomic DNA Translation: EAX03019.1 BC011679 mRNA Translation: AAH11679.2 AK024778 mRNA Translation: BAB14998.1 Different initiation. |
CCDSi | CCDS13769.1 |
RefSeqi | NP_078903.3, NM_024627.5 |
Genome annotation databases
Ensembli | ENST00000328554; ENSP00000330596; ENSG00000215012 ENST00000405640; ENSP00000384924; ENSG00000215012 ENST00000407472; ENSP00000386111; ENSG00000215012 |
GeneIDi | 79680 |
KEGGi | hsa:79680 |
MANE-Selecti | ENST00000328554.9; ENSP00000330596.4; NM_024627.6; NP_078903.3 |
UCSCi | uc002zqg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291262 mRNA Translation: BAF83951.1 BX640785 mRNA Translation: CAE45875.1 BX640969 mRNA Translation: CAE45984.1 BX640998 mRNA Translation: CAE46001.1 AC000076 Genomic DNA No translation available. CH471176 Genomic DNA Translation: EAX03018.1 CH471176 Genomic DNA Translation: EAX03019.1 BC011679 mRNA Translation: AAH11679.2 AK024778 mRNA Translation: BAB14998.1 Different initiation. |
CCDSi | CCDS13769.1 |
RefSeqi | NP_078903.3, NM_024627.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122804, 12 interactors |
IntActi | Q7L3V2, 9 interactors |
STRINGi | 9606.ENSP00000384924 |
PTM databases
iPTMneti | Q7L3V2 |
PhosphoSitePlusi | Q7L3V2 |
Genetic variation databases
BioMutai | RTL10 |
DMDMi | 74739166 |
Proteomic databases
EPDi | Q7L3V2 |
MassIVEi | Q7L3V2 |
MaxQBi | Q7L3V2 |
PaxDbi | Q7L3V2 |
PeptideAtlasi | Q7L3V2 |
PRIDEi | Q7L3V2 |
ProteomicsDBi | 68773 |
Protocols and materials databases
Antibodypediai | 201, 22 antibodies from 9 providers |
DNASUi | 79680 |
Genome annotation databases
Ensembli | ENST00000328554; ENSP00000330596; ENSG00000215012 ENST00000405640; ENSP00000384924; ENSG00000215012 ENST00000407472; ENSP00000386111; ENSG00000215012 |
GeneIDi | 79680 |
KEGGi | hsa:79680 |
MANE-Selecti | ENST00000328554.9; ENSP00000330596.4; NM_024627.6; NP_078903.3 |
UCSCi | uc002zqg.4, human |
Organism-specific databases
CTDi | 79680 |
DisGeNETi | 79680 |
GeneCardsi | RTL10 |
HGNCi | HGNC:26112, RTL10 |
HPAi | ENSG00000215012, Low tissue specificity |
neXtProti | NX_Q7L3V2 |
OpenTargetsi | ENSG00000215012 |
PharmGKBi | PA145149415 |
VEuPathDBi | HostDB:ENSG00000215012 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502TE0G, Eukaryota |
GeneTreei | ENSGT00940000166811 |
HOGENOMi | CLU_801582_0_0_1 |
InParanoidi | Q7L3V2 |
OMAi | LSRVCEI |
OrthoDBi | 998632at2759 |
PhylomeDBi | Q7L3V2 |
TreeFami | TF342426 |
Enzyme and pathway databases
PathwayCommonsi | Q7L3V2 |
SignaLinki | Q7L3V2 |
Miscellaneous databases
BioGRID-ORCSi | 79680, 17 hits in 1024 CRISPR screens |
GenomeRNAii | 79680 |
Pharosi | Q7L3V2, Tbio |
PROi | PR:Q7L3V2 |
RNActi | Q7L3V2, protein |
Gene expression databases
Bgeei | ENSG00000215012, Expressed in decidua and 192 other tissues |
ExpressionAtlasi | Q7L3V2, baseline and differential |
Genevisiblei | Q7L3V2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR031298, Bop IPR032549, DUF4939 IPR032567, LDOC1-rel |
PANTHERi | PTHR15503, PTHR15503, 1 hit PTHR15503:SF4, PTHR15503:SF4, 1 hit |
Pfami | View protein in Pfam PF16297, DUF4939, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | BOP_HUMAN | |
Accessioni | Q7L3V2Primary (citable) accession number: Q7L3V2 Secondary accession number(s): A8K5E7 Q9H7A0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | May 24, 2005 | |
Last modified: | February 23, 2022 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports