Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q7L3V2 (BOP_HUMAN)

Entry version 107 (17 Jun 2020)
Sequence version 1 (24 May 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Protein Bop

Gene

RTL10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation RTL10/BOP intrinsic apoptotic signaling activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein Bop1 Publication
Alternative name(s):
BH3-only protein
Retrotransposon Gag-like protein 10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RTL10Imported
Synonyms:BOP, C22orf29
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000215012.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:26112 RTL10

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7L3V2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi118L → A: Reduces the pro-apoptotic activity and interaction with VDAC1. 1 Publication1
Mutagenesisi120Q → A: No effect on interaction with VDAC1. 1 Publication1
Mutagenesisi122G → A: No effect on interaction with VDAC1. 1 Publication1
Mutagenesisi123D → A: Reduces the pro-apoptotic activity, no effect on interaction with VDAC1. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		79680

Open Targets

More...OpenTargetsi		ENSG00000215012

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA145149415

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7L3V2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RTL10

Domain mapping of disease mutations (DMDM)

More...DMDMi		74739166

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002959101 – 364Protein BopAdd BLAST364

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7L3V2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7L3V2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7L3V2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7L3V2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7L3V2

PeptideAtlas

More...PeptideAtlasi		Q7L3V2

PRoteomics IDEntifications database

More...PRIDEi		Q7L3V2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68773

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7L3V2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7L3V2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000215012 Expressed in decidua and 170 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7L3V2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7L3V2 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000215012 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via BH3 domain) with VDAC1.

Interacts with pro-survival Bcl-2 family members, BCL2, BCL2L1 isoform Bcl-X(L), MCL1, BCL2A1 and BCL2L2.

Interacts with BAX and BAK.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122804, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q7L3V2, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000384924

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7L3V2 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi114 – 128BH3Add BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi265 – 324Pro-richAdd BLAST60

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The BH3 motif is required for pro-apoptotic activity and for interaction with pro-survival Bcl-2 family members.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410JAJ3 Eukaryota
ENOG41117AG LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000166811

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_801582_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7L3V2

Identification of Orthologs from Complete Genome Data

More...OMAi		LSRVCEI

Database of Orthologous Groups

More...OrthoDBi		998632at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7L3V2

TreeFam database of animal gene trees

More...TreeFami		TF342426

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031298 Bop
IPR032549 DUF4939
IPR032567 LDOC1-rel

The PANTHER Classification System

More...PANTHERi		PTHR15503 PTHR15503, 1 hit
PTHR15503:SF4 PTHR15503:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16297 DUF4939, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7L3V2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRGRCRQQG PRIPIWAAAN YANAHPWQQM DKASPGVAYT PLVDPWIERP 
        60         70         80         90        100
CCGDTVCVRT TMEQKSTASG TCGGKPAERG PLAGHMPSSR PHRVDFCWVP 
       110        120        130        140        150
GSDPGTFDGS PWLLDRFLAQ LGDYMSFHFE HYQDNISRVC EILRRLTGRA 
       160        170        180        190        200
QAWAAPYLDG DLPLPDDYEL FCQDLKEVVQ DPNSFAEYHA VVTCPLPLAS 
       210        220        230        240        250
SQLPVAPQLP VVRQYLARFL EGLALDMGTA PRSLPAAMAT PAVSGSNSVS 
       260        270        280        290        300
RSALFEQQLT KESTPGPKEP PVLPSSTCSS KPGPVEPASS QPEEAAPTPV 
       310        320        330        340        350
PRLSESANPP AQRPDPAHPG GPKPQKTEEE VLETEGDQEV SLGTPQEVVE 
       360 
APETPGEPPL SPGF
Length:364
Mass (Da):39,299
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28FD406757BE082A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0V4C9J0V4_HUMAN
Protein Bop
RTL10
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14998 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti124Y → H in BAF83951 (PubMed:14702039).Curated1
Sequence conflicti206A → V in CAE45984 (PubMed:17974005).Curated1
Sequence conflicti206A → V in CAE46001 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034590116R → H. Corresponds to variant dbSNP:rs17745302Ensembl.1
Natural variantiVAR_034591123D → Y1 PublicationCorresponds to variant dbSNP:rs34027839Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK291262 mRNA Translation: BAF83951.1
BX640785 mRNA Translation: CAE45875.1
BX640969 mRNA Translation: CAE45984.1
BX640998 mRNA Translation: CAE46001.1
AC000076 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03018.1
CH471176 Genomic DNA Translation: EAX03019.1
BC011679 mRNA Translation: AAH11679.2
AK024778 mRNA Translation: BAB14998.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13769.1

NCBI Reference Sequences

More...RefSeqi		NP_078903.3, NM_024627.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000328554; ENSP00000330596; ENSG00000215012
ENST00000405640; ENSP00000384924; ENSG00000215012
ENST00000407472; ENSP00000386111; ENSG00000215012

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79680

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79680

UCSC genome browser

More...UCSCi		uc002zqg.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK291262 mRNA Translation: BAF83951.1
BX640785 mRNA Translation: CAE45875.1
BX640969 mRNA Translation: CAE45984.1
BX640998 mRNA Translation: CAE46001.1
AC000076 Genomic DNA No translation available.
CH471176 Genomic DNA Translation: EAX03018.1
CH471176 Genomic DNA Translation: EAX03019.1
BC011679 mRNA Translation: AAH11679.2
AK024778 mRNA Translation: BAB14998.1 Different initiation.
CCDSiCCDS13769.1
RefSeqiNP_078903.3, NM_024627.5

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122804, 4 interactors
IntActiQ7L3V2, 10 interactors
STRINGi9606.ENSP00000384924

PTM databases

iPTMnetiQ7L3V2
PhosphoSitePlusiQ7L3V2

Polymorphism and mutation databases

BioMutaiRTL10
DMDMi74739166

Proteomic databases

EPDiQ7L3V2
jPOSTiQ7L3V2
MassIVEiQ7L3V2
MaxQBiQ7L3V2
PaxDbiQ7L3V2
PeptideAtlasiQ7L3V2
PRIDEiQ7L3V2
ProteomicsDBi68773

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		201 21 antibodies

The DNASU plasmid repository

More...DNASUi		79680

Genome annotation databases

EnsembliENST00000328554; ENSP00000330596; ENSG00000215012
ENST00000405640; ENSP00000384924; ENSG00000215012
ENST00000407472; ENSP00000386111; ENSG00000215012
GeneIDi79680
KEGGihsa:79680
UCSCiuc002zqg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79680
DisGeNETi79680
EuPathDBiHostDB:ENSG00000215012.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		RTL10
HGNCiHGNC:26112 RTL10
HPAiENSG00000215012 Low tissue specificity
neXtProtiNX_Q7L3V2
OpenTargetsiENSG00000215012
PharmGKBiPA145149415

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410JAJ3 Eukaryota
ENOG41117AG LUCA
GeneTreeiENSGT00940000166811
HOGENOMiCLU_801582_0_0_1
InParanoidiQ7L3V2
OMAiLSRVCEI
OrthoDBi998632at2759
PhylomeDBiQ7L3V2
TreeFamiTF342426

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		79680 8 hits in 780 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79680
PharosiQ7L3V2 Tbio

Protein Ontology

More...PROi		PR:Q7L3V2
RNActiQ7L3V2 protein

Gene expression databases

BgeeiENSG00000215012 Expressed in decidua and 170 other tissues
ExpressionAtlasiQ7L3V2 baseline and differential
GenevisibleiQ7L3V2 HS

Family and domain databases

InterProiView protein in InterPro
IPR031298 Bop
IPR032549 DUF4939
IPR032567 LDOC1-rel
PANTHERiPTHR15503 PTHR15503, 1 hit
PTHR15503:SF4 PTHR15503:SF4, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBOP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L3V2
Secondary accession number(s): A8K5E7
, D3DX21, Q6MZM8, Q6N000, Q9H7A0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 24, 2005
Last modified: June 17, 2020
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again