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Protein

Zinc finger protein 771

Gene

ZNF771

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 85C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri91 – 113C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri119 – 141C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri147 – 169C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri175 – 197C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: GO_Central

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 771
Alternative name(s):
Mesenchymal stem cell protein DSC43
Gene namesi
Name:ZNF771
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000179965.11
HGNCiHGNC:29653 ZNF771
neXtProtiNX_Q7L3S4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410347

Polymorphism and mutation databases

BioMutaiZNF771
DMDMi74759003

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804391 – 317Zinc finger protein 771Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki33Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ7L3S4
MaxQBiQ7L3S4
PaxDbiQ7L3S4
PeptideAtlasiQ7L3S4
PRIDEiQ7L3S4
ProteomicsDBi68771

PTM databases

iPTMnetiQ7L3S4
PhosphoSitePlusiQ7L3S4

Expressioni

Gene expression databases

BgeeiENSG00000179965 Expressed in 106 organ(s), highest expression level in prefrontal cortex
CleanExiHS_ZNF771
ExpressionAtlasiQ7L3S4 baseline and differential
GenevisibleiQ7L3S4 HS

Organism-specific databases

HPAiHPA030730
HPA046672
HPA059398

Interactioni

Protein-protein interaction databases

BioGridi119480, 17 interactors
IntActiQ7L3S4, 1 interactor
STRINGi9606.ENSP00000323945

Structurei

3D structure databases

ProteinModelPortaliQ7L3S4
SMRiQ7L3S4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 35Glu-richAdd BLAST32

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 85C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri91 – 113C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri119 – 141C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri147 – 169C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri175 – 197C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri203 – 225C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri231 – 253C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri259 – 281C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150877
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ7L3S4
OMAiTYERSYQ
OrthoDBiEOG091G02KC
PhylomeDBiQ7L3S4
TreeFamiTF337055

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q7L3S4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGEQQAEEE EEEEMQEEMV LLVKGEEDEG EEKYEVVKLK IPMDNKEVPG
60 70 80 90 100
EAPAPSADPA RPHACPDCGR AFARRSTLAK HARTHTGERP FGCTECGRRF
110 120 130 140 150
SQKSALTKHG RTHTGERPYE CPECDKRFSA ASNLRQHRRR HTGEKPYACA
160 170 180 190 200
HCGRRFAQSS NYAQHLRVHT GEKPYACPDC GRAFGGSSCL ARHRRTHTGE
210 220 230 240 250
RPYACADCGT RFAQSSALAK HRRVHTGEKP HRCAVCGRRF GHRSNLAEHA
260 270 280 290 300
RTHTGERPYP CAECGRRFRL SSHFIRHRRA HMRRRLYICA GCGRDFKLPP
310
GATAATATER CPECEGS
Length:317
Mass (Da):35,702
Last modified:July 5, 2004 - v1
Checksum:iBF752DE568010B88
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3L5I3L3L5_HUMAN
Zinc finger protein 771
ZNF771
52Annotation score:
H3BRY2H3BRY2_HUMAN
Zinc finger protein 771
ZNF771
62Annotation score:

Sequence cautioni

The sequence AAF65445 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031150207D → N1 PublicationCorresponds to variant dbSNP:rs17852362Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011870 mRNA Translation: AAH11870.2
BC026192 mRNA Translation: AAH26192.2
AF242768 mRNA Translation: AAF65445.1 Different initiation.
CCDSiCCDS45460.1
RefSeqiNP_001135777.1, NM_001142305.1
NP_057727.2, NM_016643.3
UniGeneiHs.148584

Genome annotation databases

EnsembliENST00000319296; ENSP00000323945; ENSG00000179965
ENST00000434417; ENSP00000416197; ENSG00000179965
GeneIDi51333
KEGGihsa:51333
UCSCiuc002dyd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011870 mRNA Translation: AAH11870.2
BC026192 mRNA Translation: AAH26192.2
AF242768 mRNA Translation: AAF65445.1 Different initiation.
CCDSiCCDS45460.1
RefSeqiNP_001135777.1, NM_001142305.1
NP_057727.2, NM_016643.3
UniGeneiHs.148584

3D structure databases

ProteinModelPortaliQ7L3S4
SMRiQ7L3S4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119480, 17 interactors
IntActiQ7L3S4, 1 interactor
STRINGi9606.ENSP00000323945

PTM databases

iPTMnetiQ7L3S4
PhosphoSitePlusiQ7L3S4

Polymorphism and mutation databases

BioMutaiZNF771
DMDMi74759003

Proteomic databases

EPDiQ7L3S4
MaxQBiQ7L3S4
PaxDbiQ7L3S4
PeptideAtlasiQ7L3S4
PRIDEiQ7L3S4
ProteomicsDBi68771

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319296; ENSP00000323945; ENSG00000179965
ENST00000434417; ENSP00000416197; ENSG00000179965
GeneIDi51333
KEGGihsa:51333
UCSCiuc002dyd.4 human

Organism-specific databases

CTDi51333
EuPathDBiHostDB:ENSG00000179965.11
GeneCardsiZNF771
HGNCiHGNC:29653 ZNF771
HPAiHPA030730
HPA046672
HPA059398
neXtProtiNX_Q7L3S4
PharmGKBiPA162410347
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150877
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ7L3S4
OMAiTYERSYQ
OrthoDBiEOG091G02KC
PhylomeDBiQ7L3S4
TreeFamiTF337055

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF771 human
GenomeRNAii51333
PROiPR:Q7L3S4

Gene expression databases

BgeeiENSG00000179965 Expressed in 106 organ(s), highest expression level in prefrontal cortex
CleanExiHS_ZNF771
ExpressionAtlasiQ7L3S4 baseline and differential
GenevisibleiQ7L3S4 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN771_HUMAN
AccessioniPrimary (citable) accession number: Q7L3S4
Secondary accession number(s): Q8TAQ7, Q9NYI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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