UniProtKB - Q7L3S4 (ZN771_HUMAN)

BLAST

>sp|Q7L3S4|ZN771_HUMAN Zinc finger protein 771 OS=Homo sapiens OX=9606 GN=ZNF771 PE=1 SV=1
MPGEQQAEEEEEEEMQEEMVLLVKGEEDEGEEKYEVVKLKIPMDNKEVPGEAPAPSADPA
RPHACPDCGRAFARRSTLAKHARTHTGERPFGCTECGRRFSQKSALTKHGRTHTGERPYE
CPECDKRFSAASNLRQHRRRHTGEKPYACAHCGRRFAQSSNYAQHLRVHTGEKPYACPDC
GRAFGGSSCLARHRRTHTGERPYACADCGTRFAQSSALAKHRRVHTGEKPHRCAVCGRRF
GHRSNLAEHARTHTGERPYPCAECGRRFRLSSHFIRHRRAHMRRRLYICAGCGRDFKLPP
GATAATATERCPECEGS

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History
Entry version 135 (07 Nov 2018)
Sequence version 1 (05 Jul 2004)
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Protein

Zinc finger protein 771

Gene

ZNF771

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	63 – 85	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	91 – 113	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	119 – 141	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	147 – 169	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	175 – 197	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	203 – 225	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	231 – 253	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	259 – 281	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to DNA damage stimulus
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 771 Alternative name(s): Mesenchymal stem cell protein DSC43
Gene namesⁱ	Name:ZNF771
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 16

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179965.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29653 ZNF771
neXtProtⁱ	NX_Q7L3S4

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA162410347

PharmGKBⁱ

PA162410347

Polymorphism and mutation databases

BioMutaⁱ	ZNF771
DMDMⁱ	74759003

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000280439	1 – 317	Zinc finger protein 771Add BLAST		317

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	33	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q7L3S4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7L3S4
PaxDbⁱ	Q7L3S4
PeptideAtlas More...PeptideAtlasⁱ	Q7L3S4
PRIDEⁱ	Q7L3S4
ProteomicsDBⁱ	68771

PTM databases

iPTMnetⁱ	Q7L3S4
PhosphoSitePlusⁱ	Q7L3S4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000179965 Expressed in 106 organ(s), highest expression level in prefrontal cortex
CleanExⁱ	HS_ZNF771
ExpressionAtlasⁱ	Q7L3S4 baseline and differential
Genevisibleⁱ	Q7L3S4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030730 HPA046672 HPA059398

HPAⁱ

HPA030730
HPA046672
HPA059398

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	119480, 17 interactors
IntActⁱ	Q7L3S4, 1 interactor
STRINGⁱ	9606.ENSP00000323945

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7L3S4
SMRⁱ	Q7L3S4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	4 – 35	Glu-richAdd BLAST		32

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	63 – 85	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	91 – 113	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	119 – 141	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	147 – 169	C2H2-type 4PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	175 – 197	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	203 – 225	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	231 – 253	C2H2-type 7PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	259 – 281	C2H2-type 8PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150877
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q7L3S4
OMAⁱ	TYERSYQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q7L3S4
TreeFamⁱ	TF337055

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 8 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 8 hits
SUPFAMⁱ	SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 8 hits PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q7L3S4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPGEQQAEEE EEEEMQEEMV LLVKGEEDEG EEKYEVVKLK IPMDNKEVPG 
        60         70         80         90        100
EAPAPSADPA RPHACPDCGR AFARRSTLAK HARTHTGERP FGCTECGRRF 
       110        120        130        140        150
SQKSALTKHG RTHTGERPYE CPECDKRFSA ASNLRQHRRR HTGEKPYACA 
       160        170        180        190        200
HCGRRFAQSS NYAQHLRVHT GEKPYACPDC GRAFGGSSCL ARHRRTHTGE 
       210        220        230        240        250
RPYACADCGT RFAQSSALAK HRRVHTGEKP HRCAVCGRRF GHRSNLAEHA 
       260        270        280        290        300
RTHTGERPYP CAECGRRFRL SSHFIRHRRA HMRRRLYICA GCGRDFKLPP 
       310 
GATAATATER CPECEGS

Length:317

Mass (Da):35,702

Last modified:July 5, 2004 - v1

Checksum:ⁱBF752DE568010B88

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

I3L3L5	I3L3L5_HUMAN	Zinc finger protein 771 Zinc finger protein 771	ZNF771	52	Annotation score:
H3BRY2	H3BRY2_HUMAN	Zinc finger protein 771 Zinc finger protein 771	ZNF771	62	Annotation score:

Sequence cautionⁱ

The sequence AAF65445 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_031150	207	D → N1 PublicationCorresponds to variant dbSNP:rs17852362Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC011870 mRNA Translation: AAH11870.2 BC026192 mRNA Translation: AAH26192.2 AF242768 mRNA Translation: AAF65445.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS45460.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001135777.1, NM_001142305.1 NP_057727.2, NM_016643.3
UniGeneⁱ	Hs.148584

Genome annotation databases

Ensemblⁱ	ENST00000319296; ENSP00000323945; ENSG00000179965 ENST00000434417; ENSP00000416197; ENSG00000179965
GeneIDⁱ	51333
KEGGⁱ	hsa:51333
UCSC genome browser More...UCSCⁱ	uc002dyd.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7L3S4	ZNF771 isoform 2		PANTR		317	UniRef100_Q7L3S4
cDNA, FLJ94570, Homo sapiens mesenchymal stem cell protein DSC43 (LOC51333), mRNA		HUMAN		275

Protein	Similar proteins		Species	Score	Length	Source
Q7L3S4	ZNF771 isoform 2		PANTR		317	UniRef90_Q7L3S4
cDNA, FLJ94570, Homo sapiens mesenchymal stem cell protein DSC43 (LOC51333), mRNA		HUMAN		275
zinc finger protein 771		ODORO		321
zinc finger protein 771		Enhydra lutris kenyoni		318
Uncharacterized protein		MANLE		317
+46

Protein	Similar proteins		Species	Score	Length	Source
Q7L3S4	Zinc finger protein 771		MOUSE		317	UniRef50_Q7L3S4
ZNF771 isoform 2		PANTR		317
cDNA, FLJ94570, Homo sapiens mesenchymal stem cell protein DSC43 (LOC51333), mRNA		HUMAN		275
zinc finger protein 771		ODORO		321
zinc finger protein 771		Enhydra lutris kenyoni		318
+110

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC011870 mRNA Translation: AAH11870.2 BC026192 mRNA Translation: AAH26192.2 AF242768 mRNA Translation: AAF65445.1 Different initiation.
CCDSⁱ	CCDS45460.1
RefSeqⁱ	NP_001135777.1, NM_001142305.1 NP_057727.2, NM_016643.3
UniGeneⁱ	Hs.148584

3D structure databases

ProteinModelPortalⁱ	Q7L3S4
SMRⁱ	Q7L3S4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119480, 17 interactors
IntActⁱ	Q7L3S4, 1 interactor
STRINGⁱ	9606.ENSP00000323945

PTM databases

iPTMnetⁱ	Q7L3S4
PhosphoSitePlusⁱ	Q7L3S4

Polymorphism and mutation databases

BioMutaⁱ	ZNF771
DMDMⁱ	74759003

Proteomic databases

EPDⁱ	Q7L3S4
MaxQBⁱ	Q7L3S4
PaxDbⁱ	Q7L3S4
PeptideAtlasⁱ	Q7L3S4
PRIDEⁱ	Q7L3S4
ProteomicsDBⁱ	68771

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000319296; ENSP00000323945; ENSG00000179965 ENST00000434417; ENSP00000416197; ENSG00000179965
GeneIDⁱ	51333
KEGGⁱ	hsa:51333
UCSCⁱ	uc002dyd.4 human

Organism-specific databases

CTDⁱ	51333
EuPathDBⁱ	HostDB:ENSG00000179965.11
GeneCardsⁱ	ZNF771
HGNCⁱ	HGNC:29653 ZNF771
HPAⁱ	HPA030730 HPA046672 HPA059398
neXtProtⁱ	NX_Q7L3S4
PharmGKBⁱ	PA162410347
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00930000150877
HOGENOMⁱ	HOG000234617
HOVERGENⁱ	HBG018163
InParanoidⁱ	Q7L3S4
OMAⁱ	TYERSYQ
OrthoDBⁱ	EOG091G02KC
PhylomeDBⁱ	Q7L3S4
TreeFamⁱ	TF337055

Enzyme and pathway databases

Reactomeⁱ	R-HSA-212436 Generic Transcription Pathway

Reactomeⁱ

R-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSⁱ	ZNF771 human
GenomeRNAiⁱ	51333
Protein Ontology More...PROⁱ	PR:Q7L3S4

Gene expression databases

Bgeeⁱ	ENSG00000179965 Expressed in 106 organ(s), highest expression level in prefrontal cortex
CleanExⁱ	HS_ZNF771
ExpressionAtlasⁱ	Q7L3S4 baseline and differential
Genevisibleⁱ	Q7L3S4 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 8 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 8 hits
SUPFAMⁱ	SSF57667 SSF57667, 5 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 8 hits PS50157 ZINC_FINGER_C2H2_2, 8 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN771_HUMAN
Accessionⁱ	Q7L3S4Primary (citable) accession number: Q7L3S4 Secondary accession number(s): Q8TAQ7, Q9NYI6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7L3S4 (ZN771_HUMAN)

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Zinc finger protein 771

ZNF771

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ