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UniProtKB - Q7L3S4 (ZN771_HUMAN)
Protein
Zinc finger protein 771
Gene
ZNF771
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 63 – 85 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 91 – 113 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 119 – 141 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 147 – 169 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 175 – 197 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 203 – 225 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 231 – 253 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 259 – 281 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q7L3S4 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q7L3S4 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 771Alternative name(s): Mesenchymal stem cell protein DSC43 |
Gene namesi | Name:ZNF771 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29653, ZNF771 |
neXtProti | NX_Q7L3S4 |
VEuPathDBi | HostDB:ENSG00000179965 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 51333 |
PharmGKBi | PA162410347 |
Miscellaneous databases
Pharosi | Q7L3S4, Tdark |
Genetic variation databases
BioMutai | ZNF771 |
DMDMi | 74759003 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000280439 | 1 – 317 | Zinc finger protein 771Add BLAST | 317 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 33 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q7L3S4 |
MassIVEi | Q7L3S4 |
MaxQBi | Q7L3S4 |
PaxDbi | Q7L3S4 |
PeptideAtlasi | Q7L3S4 |
PRIDEi | Q7L3S4 |
ProteomicsDBi | 68771 |
PTM databases
iPTMneti | Q7L3S4 |
PhosphoSitePlusi | Q7L3S4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000179965, Expressed in prefrontal cortex and 128 other tissues |
ExpressionAtlasi | Q7L3S4, baseline and differential |
Genevisiblei | Q7L3S4, HS |
Organism-specific databases
HPAi | ENSG00000179965, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 119480, 54 interactors |
IntActi | Q7L3S4, 15 interactors |
STRINGi | 9606.ENSP00000323945 |
Miscellaneous databases
RNActi | Q7L3S4, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 63 | DisorderedSequence analysisAdd BLAST | 63 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | Acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 18 – 45 | Basic and acidic residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 63 – 85 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 91 – 113 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 119 – 141 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 147 – 169 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 175 – 197 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 203 – 225 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 231 – 253 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 259 – 281 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162367 |
HOGENOMi | CLU_002678_2_6_1 |
InParanoidi | Q7L3S4 |
OMAi | ATPTERC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q7L3S4 |
TreeFami | TF337055 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q7L3S4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGEQQAEEE EEEEMQEEMV LLVKGEEDEG EEKYEVVKLK IPMDNKEVPG
60 70 80 90 100
EAPAPSADPA RPHACPDCGR AFARRSTLAK HARTHTGERP FGCTECGRRF
110 120 130 140 150
SQKSALTKHG RTHTGERPYE CPECDKRFSA ASNLRQHRRR HTGEKPYACA
160 170 180 190 200
HCGRRFAQSS NYAQHLRVHT GEKPYACPDC GRAFGGSSCL ARHRRTHTGE
210 220 230 240 250
RPYACADCGT RFAQSSALAK HRRVHTGEKP HRCAVCGRRF GHRSNLAEHA
260 270 280 290 300
RTHTGERPYP CAECGRRFRL SSHFIRHRRA HMRRRLYICA GCGRDFKLPP
310
GATAATATER CPECEGS
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BRY2 | H3BRY2_HUMAN | Zinc finger protein 771 | ZNF771 | 62 | Annotation score: | ||
I3L3L5 | I3L3L5_HUMAN | Zinc finger protein 771 | ZNF771 | 52 | Annotation score: |
Sequence cautioni
The sequence AAF65445 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_031150 | 207 | D → N1 PublicationCorresponds to variant dbSNP:rs17852362Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC011870 mRNA Translation: AAH11870.2 BC026192 mRNA Translation: AAH26192.2 AF242768 mRNA Translation: AAF65445.1 Different initiation. |
CCDSi | CCDS45460.1 |
RefSeqi | NP_001135777.1, NM_001142305.1 NP_057727.2, NM_016643.3 |
Genome annotation databases
Ensembli | ENST00000319296; ENSP00000323945; ENSG00000179965 ENST00000434417; ENSP00000416197; ENSG00000179965 |
GeneIDi | 51333 |
KEGGi | hsa:51333 |
MANE-Selecti | ENST00000319296.10; ENSP00000323945.5; NM_001142305.2; NP_001135777.1 |
UCSCi | uc002dyd.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC011870 mRNA Translation: AAH11870.2 BC026192 mRNA Translation: AAH26192.2 AF242768 mRNA Translation: AAF65445.1 Different initiation. |
CCDSi | CCDS45460.1 |
RefSeqi | NP_001135777.1, NM_001142305.1 NP_057727.2, NM_016643.3 |
3D structure databases
SMRi | Q7L3S4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119480, 54 interactors |
IntActi | Q7L3S4, 15 interactors |
STRINGi | 9606.ENSP00000323945 |
PTM databases
iPTMneti | Q7L3S4 |
PhosphoSitePlusi | Q7L3S4 |
Genetic variation databases
BioMutai | ZNF771 |
DMDMi | 74759003 |
Proteomic databases
EPDi | Q7L3S4 |
MassIVEi | Q7L3S4 |
MaxQBi | Q7L3S4 |
PaxDbi | Q7L3S4 |
PeptideAtlasi | Q7L3S4 |
PRIDEi | Q7L3S4 |
ProteomicsDBi | 68771 |
Protocols and materials databases
Antibodypediai | 27266, 81 antibodies from 19 providers |
DNASUi | 51333 |
Genome annotation databases
Ensembli | ENST00000319296; ENSP00000323945; ENSG00000179965 ENST00000434417; ENSP00000416197; ENSG00000179965 |
GeneIDi | 51333 |
KEGGi | hsa:51333 |
MANE-Selecti | ENST00000319296.10; ENSP00000323945.5; NM_001142305.2; NP_001135777.1 |
UCSCi | uc002dyd.4, human |
Organism-specific databases
CTDi | 51333 |
DisGeNETi | 51333 |
GeneCardsi | ZNF771 |
HGNCi | HGNC:29653, ZNF771 |
HPAi | ENSG00000179965, Low tissue specificity |
neXtProti | NX_Q7L3S4 |
PharmGKBi | PA162410347 |
VEuPathDBi | HostDB:ENSG00000179965 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000162367 |
HOGENOMi | CLU_002678_2_6_1 |
InParanoidi | Q7L3S4 |
OMAi | ATPTERC |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q7L3S4 |
TreeFami | TF337055 |
Enzyme and pathway databases
PathwayCommonsi | Q7L3S4 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
SignaLinki | Q7L3S4 |
Miscellaneous databases
BioGRID-ORCSi | 51333, 18 hits in 1067 CRISPR screens |
ChiTaRSi | ZNF771, human |
GenomeRNAii | 51333 |
Pharosi | Q7L3S4, Tdark |
PROi | PR:Q7L3S4 |
RNActi | Q7L3S4, protein |
Gene expression databases
Bgeei | ENSG00000179965, Expressed in prefrontal cortex and 128 other tissues |
ExpressionAtlasi | Q7L3S4, baseline and differential |
Genevisiblei | Q7L3S4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 8 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 8 hits |
SUPFAMi | SSF57667, SSF57667, 5 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 8 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN771_HUMAN | |
Accessioni | Q7L3S4Primary (citable) accession number: Q7L3S4 Secondary accession number(s): Q8TAQ7, Q9NYI6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 20, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 23, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families