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Protein

Hsp90 co-chaperone Cdc37-like 1

Gene

CDC37L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hsp90 co-chaperone Cdc37-like 1
Alternative name(s):
Hsp90-associating relative of Cdc37
Gene namesi
Name:CDC37L1
Synonyms:CDC37B, HARC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000106993.11
HGNCiHGNC:17179 CDC37L1
MIMi610346 gene
neXtProtiNX_Q7L3B6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000106993
PharmGKBiPA134982210

Polymorphism and mutation databases

BioMutaiCDC37L1
DMDMi182705252

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003185211 – 337Hsp90 co-chaperone Cdc37-like 1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7L3B6
MaxQBiQ7L3B6
PaxDbiQ7L3B6
PeptideAtlasiQ7L3B6
PRIDEiQ7L3B6
ProteomicsDBi68770

PTM databases

iPTMnetiQ7L3B6
PhosphoSitePlusiQ7L3B6

Expressioni

Tissue specificityi

Expressed in brain, heart, kidney, liver, placenta and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000106993
CleanExiHS_CDC37L1
ExpressionAtlasiQ7L3B6 baseline and differential
GenevisibleiQ7L3B6 HS

Organism-specific databases

HPAiHPA021175

Interactioni

Subunit structurei

Self-associates. Forms complexes with Hsp70 and Hsp90. Interacts with CDC37, FKBP4, PPID and STIP1.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120796, 28 interactors
IntActiQ7L3B6, 23 interactors
STRINGi9606.ENSP00000371278

Structurei

3D structure databases

ProteinModelPortaliQ7L3B6
SMRiQ7L3B6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 171Self-associationAdd BLAST170
Regioni147 – 277Self-association and interaction with Hsp90Add BLAST131
Regioni267 – 337Interaction with Hsp70Add BLAST71
Regioni278 – 337Required for interaction with STIP1Add BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili84 – 122Sequence analysisAdd BLAST39

Sequence similaritiesi

Belongs to the CDC37 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2260 Eukaryota
ENOG410XTCZ LUCA
GeneTreeiENSGT00390000013443
HOGENOMiHOG000018180
HOVERGENiHBG056343
InParanoidiQ7L3B6
OMAiWNMDAIS
OrthoDBiEOG091G0HL8
PhylomeDBiQ7L3B6
TreeFamiTF101059

Family and domain databases

Gene3Di1.20.58.610, 1 hit
InterProiView protein in InterPro
IPR004918 Cdc37
IPR013874 Cdc37_Hsp90-bd
IPR038189 Cdc37_Hsp90-bd_sf
PANTHERiPTHR12800 PTHR12800, 1 hit
PfamiView protein in Pfam
PF08565 CDC37_M, 1 hit
SMARTiView protein in SMART
SM01070 CDC37_M, 1 hit

Sequencei

Sequence statusi: Complete.

Q7L3B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQPWPPPGP WSLPRAEGEA EEESDFDVFP SSPRCPQLPG GGAQMYSHGI
60 70 80 90 100
ELACQKQKEF VKSSVACKWN LAEAQQKLGS LALHNSESLD QEHAKAQTAV
110 120 130 140 150
SELRQREEEW RQKEEALVQR EKMCLWSTDA ISKDVFNKSF INQDKRKDTE
160 170 180 190 200
DEDKSESFMQ KYEQKIRHFG MLSRWDDSQR FLSDHPYLVC EETAKYLILW
210 220 230 240 250
CFHLEAEKKG ALMEQIAHQA VVMQFIMEMA KNCNVDPRGC FRLFFQKAKA
260 270 280 290 300
EEEGYFEAFK NELEAFKSRV RLYSQSQSFQ PMTVQNHVPH SGVGSIGLLE
310 320 330
SLPQNPDYLQ YSISTALCSL NSVVHKEDDE PKMMDTV
Length:337
Mass (Da):38,835
Last modified:February 5, 2008 - v1
Checksum:i46ACDDCE5D07B587
GO

Sequence cautioni

The sequence BAA91206 differs from that shown. Reason: Erroneous termination at position 124. Translated as Cys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17E → G in BAA91304 (PubMed:14702039).Curated1
Sequence conflicti159M → V in BAA91206 (PubMed:14702039).Curated1
Sequence conflicti305N → S in BAA91304 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038755291S → F. Corresponds to variant dbSNP:rs7036014Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000497 mRNA Translation: BAA91206.1 Sequence problems.
AK000646 mRNA Translation: BAA91304.1
AL136231 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58782.1
BC014133 mRNA Translation: AAH14133.1
CCDSiCCDS6454.1
RefSeqiNP_060383.2, NM_017913.3
UniGeneiHs.666439

Genome annotation databases

EnsembliENST00000381854; ENSP00000371278; ENSG00000106993
GeneIDi55664
KEGGihsa:55664
UCSCiuc003zio.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCD37L_HUMAN
AccessioniPrimary (citable) accession number: Q7L3B6
Secondary accession number(s): B1AL70, Q9NWS3, Q9NX16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 5, 2008
Last modified: June 20, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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