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Protein

Centromere protein Q

Gene

CENPQ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579).2 Publications

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein Q
Short name:
CENP-Q
Gene namesi
Name:CENPQ
Synonyms:C6orf139
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000031691.6
HGNCiHGNC:21347 CENPQ
MIMi611506 gene
neXtProtiNX_Q7L2Z9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi50S → A: Abolishes the recruitment CENPE to kinetochores but has no effect on recruitment of PLK1 to knetochores. 1 Publication1
Mutagenesisi50S → D: No loss of the recruitment CENPE to kinetochores. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000031691
PharmGKBiPA134973276

Polymorphism and mutation databases

BioMutaiCENPQ
DMDMi68565184

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000895341 – 268Centromere protein QAdd BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1 Publication1
Modified residuei249PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Ser-50 is essential for CENPE recruitment to kinetochores and orderly chromosome congression.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7L2Z9
MaxQBiQ7L2Z9
PaxDbiQ7L2Z9
PeptideAtlasiQ7L2Z9
PRIDEiQ7L2Z9
ProteomicsDBi68768

PTM databases

iPTMnetiQ7L2Z9
PhosphoSitePlusiQ7L2Z9

Expressioni

Gene expression databases

BgeeiENSG00000031691 Expressed in 163 organ(s), highest expression level in heart
CleanExiHS_CENPQ
GenevisibleiQ7L2Z9 HS

Organism-specific databases

HPAiHPA029043
HPA046634
HPA054965

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU.2 Publications

Protein-protein interaction databases

BioGridi120466, 37 interactors
CORUMiQ7L2Z9
IntActiQ7L2Z9, 39 interactors
MINTiQ7L2Z9
STRINGi9606.ENSP00000337289

Structurei

3D structure databases

ProteinModelPortaliQ7L2Z9
SMRiQ7L2Z9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili170 – 206Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the CENP-Q/OKP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IXIS Eukaryota
ENOG410YTSN LUCA
GeneTreeiENSGT00390000005599
HOGENOMiHOG000111544
HOVERGENiHBG081088
InParanoidiQ7L2Z9
KOiK11509
OMAiNMLTFIE
OrthoDBiEOG091G0LBV
PhylomeDBiQ7L2Z9
TreeFamiTF336238

Family and domain databases

InterProiView protein in InterPro
IPR025212 CAD_CENP-Q
PfamiView protein in Pfam
PF13094 CENP-Q, 1 hit

Sequencei

Sequence statusi: Complete.

Q7L2Z9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGKANASKK NAQQLKRNPK RKKDNEEVVL SENKVRNTVK KNKNHLKDLS
60 70 80 90 100
SEGQTKHTNL KHGKTAASKR KTWQPLSKST RDHLQTMMES VIMTILSNSI
110 120 130 140 150
KEKEEIQYHL NFLKKRLLQQ CETLKVPPKK MEDLTNVSSL LNMERARDKA
160 170 180 190 200
NEEGLALLQE EIDKMVETTE LMTGNIQSLK NKIQILASEV EEEEERVKQM
210 220 230 240 250
HQINSSGVLS LPELSQKTLK APTLQKEILA LIPNQNALLK DLDILHNSSQ
260
MKSMSTFIEE AYKKLDAS
Length:268
Mass (Da):30,595
Last modified:July 5, 2004 - v1
Checksum:i5B3735279287B3E8
GO

Sequence cautioni

The sequence BAA91672 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02285763G → R. Corresponds to variant dbSNP:rs4267943Ensembl.1
Natural variantiVAR_024303266D → G. Corresponds to variant dbSNP:rs2501968Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001407 mRNA Translation: BAA91672.1 Different initiation.
AK293016 mRNA Translation: BAF85705.1
AL590244 Genomic DNA No translation available.
AL590668 Genomic DNA No translation available.
BC016279 mRNA Translation: AAH16279.2
CCDSiCCDS4925.1
RefSeqiNP_060602.2, NM_018132.3
XP_005249262.1, XM_005249205.1
UniGeneiHs.88663

Genome annotation databases

EnsembliENST00000335783; ENSP00000337289; ENSG00000031691
GeneIDi55166
KEGGihsa:55166
UCSCiuc003ozh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001407 mRNA Translation: BAA91672.1 Different initiation.
AK293016 mRNA Translation: BAF85705.1
AL590244 Genomic DNA No translation available.
AL590668 Genomic DNA No translation available.
BC016279 mRNA Translation: AAH16279.2
CCDSiCCDS4925.1
RefSeqiNP_060602.2, NM_018132.3
XP_005249262.1, XM_005249205.1
UniGeneiHs.88663

3D structure databases

ProteinModelPortaliQ7L2Z9
SMRiQ7L2Z9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120466, 37 interactors
CORUMiQ7L2Z9
IntActiQ7L2Z9, 39 interactors
MINTiQ7L2Z9
STRINGi9606.ENSP00000337289

PTM databases

iPTMnetiQ7L2Z9
PhosphoSitePlusiQ7L2Z9

Polymorphism and mutation databases

BioMutaiCENPQ
DMDMi68565184

Proteomic databases

EPDiQ7L2Z9
MaxQBiQ7L2Z9
PaxDbiQ7L2Z9
PeptideAtlasiQ7L2Z9
PRIDEiQ7L2Z9
ProteomicsDBi68768

Protocols and materials databases

DNASUi55166
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335783; ENSP00000337289; ENSG00000031691
GeneIDi55166
KEGGihsa:55166
UCSCiuc003ozh.2 human

Organism-specific databases

CTDi55166
EuPathDBiHostDB:ENSG00000031691.6
GeneCardsiCENPQ
HGNCiHGNC:21347 CENPQ
HPAiHPA029043
HPA046634
HPA054965
MIMi611506 gene
neXtProtiNX_Q7L2Z9
OpenTargetsiENSG00000031691
PharmGKBiPA134973276
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXIS Eukaryota
ENOG410YTSN LUCA
GeneTreeiENSGT00390000005599
HOGENOMiHOG000111544
HOVERGENiHBG081088
InParanoidiQ7L2Z9
KOiK11509
OMAiNMLTFIE
OrthoDBiEOG091G0LBV
PhylomeDBiQ7L2Z9
TreeFamiTF336238

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Miscellaneous databases

ChiTaRSiCENPQ human
GenomeRNAii55166
PROiPR:Q7L2Z9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000031691 Expressed in 163 organ(s), highest expression level in heart
CleanExiHS_CENPQ
GenevisibleiQ7L2Z9 HS

Family and domain databases

InterProiView protein in InterPro
IPR025212 CAD_CENP-Q
PfamiView protein in Pfam
PF13094 CENP-Q, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCENPQ_HUMAN
AccessioniPrimary (citable) accession number: Q7L2Z9
Secondary accession number(s): A8KAF1, Q6IN61, Q9NVS5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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