The new UniProt website is here!
Take me to UniProt BETA
UniProtKB - Q7L2R6 (ZN765_HUMAN)
Protein
Zinc finger protein 765
Gene
ZNF765
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 215 – 237 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 432 | C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 438 – 460 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 466 – 488 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 494 – 516 | C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q7L2R6 |
SignaLinki | Q7L2R6 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 765 |
Gene namesi | Name:ZNF765 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25092, ZNF765 |
neXtProti | NX_Q7L2R6 |
VEuPathDBi | HostDB:ENSG00000196417 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 91661 |
OpenTargetsi | ENSG00000196417 ENSG00000204604 |
PharmGKBi | PA162410312 |
Miscellaneous databases
Pharosi | Q7L2R6, Tdark |
Genetic variation databases
BioMutai | ZNF765 |
DMDMi | 205639967 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000344217 | 1 – 523 | Zinc finger protein 765Add BLAST | 523 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 205 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q7L2R6 |
jPOSTi | Q7L2R6 |
MassIVEi | Q7L2R6 |
MaxQBi | Q7L2R6 |
PaxDbi | Q7L2R6 |
PeptideAtlasi | Q7L2R6 |
PRIDEi | Q7L2R6 |
ProteomicsDBi | 68766 [Q7L2R6-1] 68767 [Q7L2R6-2] |
TopDownProteomicsi | Q7L2R6-2 [Q7L2R6-2] |
PTM databases
iPTMneti | Q7L2R6 |
PhosphoSitePlusi | Q7L2R6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196417, Expressed in anatomical system and 212 other tissues |
ExpressionAtlasi | Q7L2R6, baseline and differential |
Genevisiblei | Q7L2R6, HS |
Organism-specific databases
HPAi | ENSG00000196417, Low tissue specificity |
Interactioni
Binary interactionsi
Q7L2R6
With | #Exp. | IntAct |
---|---|---|
DZIP3 [Q86Y13] | 3 | EBI-9676069,EBI-948630 |
REL [Q04864] | 3 | EBI-9676069,EBI-307352 |
USHBP1 [Q8N6Y0] | 3 | EBI-9676069,EBI-739895 |
Isoform 2 [Q7L2R6-2]
Protein-protein interaction databases
BioGRIDi | 124860, 25 interactors |
IntActi | Q7L2R6, 16 interactors |
MINTi | Q7L2R6 |
STRINGi | 9606.ENSP00000379689 |
Miscellaneous databases
RNActi | Q7L2R6, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 81 | KRABPROSITE-ProRule annotationAdd BLAST | 74 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 215 – 237 | C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 243 – 265 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 271 – 293 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 299 – 321 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 327 – 349 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 355 – 377 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 383 – 405 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 411 – 432 | C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 438 – 460 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 466 – 488 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 494 – 516 | C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154397 |
HOGENOMi | CLU_002678_69_15_1 |
InParanoidi | Q7L2R6 |
OMAi | FTCHHRV |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q7L2R6 |
TreeFami | TF341892 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q7L2R6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS
60 70 80 90 100
SKCMMKEFSS TAQGNREVFH AGTSQRHESH HNGDFCFQDI DKDIHDIEFQ
110 120 130 140 150
WQEDERNGHE ALMTKIKKLT GSTERYDQNY AGNKPVKYQL GFSFHSHLPE
160 170 180 190 200
LHIFHTEEKI DNQVVKSIHD ASLVSTAQRI SCRPETHISN DYGNNFLNSS
210 220 230 240 250
LFTQKQEVHM REKSFQCNDS GKAYNCSSLL RKHQLIHLGE KQYKCDICGK
260 270 280 290 300
VFNSKRYVAR HRRCHTGEKP YKCNECGKTF SQTYYLTCHR RLHTGEKPYK
310 320 330 340 350
CEECDKAFHF KSKLQIHRRI HTGEKPYKCN ECGKTFSQKS YLTCHRRLHT
360 370 380 390 400
GEKPYKCNEC GKTFSRKSHF TCHHRVHTGE KPYKCNECSK TFSHKSSLTY
410 420 430 440 450
HRRLHTEEKP YKCNECGKTF NQQLTLNICR LHSGEKPYKC EECDKAYSFK
460 470 480 490 500
SNLEIHQKIH TEENPYKCNE CGKTFSRTSS LTYHHRLHTG QKPYKCEDCD
510 520
EAFSFKSNLE RHRRIYTGEK LHV
Isoform 2 (identifier: Q7L2R6-2) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
48-60: DISSKCMMKEFSS → ELSGECPLAAPAS
61-523: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RF03 | D6RF03_HUMAN | Zinc finger protein 765 | ZNF765 | 128 | Annotation score: | ||
E9PDE6 | E9PDE6_HUMAN | Zinc finger protein 765 | ZNF765 | 85 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 61 | T → A in BAG57279 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 100 | Q → R in BAG57279 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 241 | K → N in BAG57279 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 297 | K → E in BAG57279 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 382 | P → L in BAG57279 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 494 | Y → N in BAH14671 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_045598 | 389 | S → G2 PublicationsCorresponds to variant dbSNP:rs10425136Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055629 | 48 – 127 | DISSK…TERYD → EFWSVIPAKVQWCHLRSLQP PLPRFKQFSCLSLPSTWDYR YLFQMHVEDVVVNRARQYRS DPHRDIAQTSKSSHWRILFP in isoform 3. CuratedAdd BLAST | 80 | |
Alternative sequenceiVSP_034746 | 48 – 60 | DISSK…KEFSS → ELSGECPLAAPAS in isoform 2. 1 PublicationAdd BLAST | 13 | |
Alternative sequenceiVSP_034747 | 61 – 523 | Missing in isoform 2. 1 PublicationAdd BLAST | 463 | |
Alternative sequenceiVSP_055630 | 128 – 523 | Missing in isoform 3. CuratedAdd BLAST | 396 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293890 mRNA Translation: BAG57279.1 AK316300 mRNA Translation: BAH14671.1 AC022137 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72134.1 BC001610 mRNA No translation available. BC017357 mRNA No translation available. BC140724 mRNA Translation: AAI40725.1 |
CCDSi | CCDS46171.1 [Q7L2R6-1] |
RefSeqi | NP_001035275.1, NM_001040185.1 [Q7L2R6-1] |
Genome annotation databases
Ensembli | ENST00000396408.8; ENSP00000379689.3; ENSG00000196417.13 ENST00000504235.5; ENSP00000424395.1; ENSG00000196417.13 [Q7L2R6-2] ENST00000594030.2; ENSP00000470468.1; ENSG00000196417.13 [Q7L2R6-2] |
GeneIDi | 91661 |
KEGGi | hsa:91661 |
MANE-Selecti | ENST00000396408.8; ENSP00000379689.3; NM_001040185.3; NP_001035275.1 |
UCSCi | uc002qbm.4, human [Q7L2R6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK293890 mRNA Translation: BAG57279.1 AK316300 mRNA Translation: BAH14671.1 AC022137 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72134.1 BC001610 mRNA No translation available. BC017357 mRNA No translation available. BC140724 mRNA Translation: AAI40725.1 |
CCDSi | CCDS46171.1 [Q7L2R6-1] |
RefSeqi | NP_001035275.1, NM_001040185.1 [Q7L2R6-1] |
3D structure databases
AlphaFoldDBi | Q7L2R6 |
SMRi | Q7L2R6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 124860, 25 interactors |
IntActi | Q7L2R6, 16 interactors |
MINTi | Q7L2R6 |
STRINGi | 9606.ENSP00000379689 |
PTM databases
iPTMneti | Q7L2R6 |
PhosphoSitePlusi | Q7L2R6 |
Genetic variation databases
BioMutai | ZNF765 |
DMDMi | 205639967 |
Proteomic databases
EPDi | Q7L2R6 |
jPOSTi | Q7L2R6 |
MassIVEi | Q7L2R6 |
MaxQBi | Q7L2R6 |
PaxDbi | Q7L2R6 |
PeptideAtlasi | Q7L2R6 |
PRIDEi | Q7L2R6 |
ProteomicsDBi | 68766 [Q7L2R6-1] 68767 [Q7L2R6-2] |
TopDownProteomicsi | Q7L2R6-2 [Q7L2R6-2] |
Protocols and materials databases
Antibodypediai | 32701, 73 antibodies from 13 providers |
DNASUi | 91661 |
Genome annotation databases
Ensembli | ENST00000396408.8; ENSP00000379689.3; ENSG00000196417.13 ENST00000504235.5; ENSP00000424395.1; ENSG00000196417.13 [Q7L2R6-2] ENST00000594030.2; ENSP00000470468.1; ENSG00000196417.13 [Q7L2R6-2] |
GeneIDi | 91661 |
KEGGi | hsa:91661 |
MANE-Selecti | ENST00000396408.8; ENSP00000379689.3; NM_001040185.3; NP_001035275.1 |
UCSCi | uc002qbm.4, human [Q7L2R6-1] |
Organism-specific databases
CTDi | 91661 |
DisGeNETi | 91661 |
GeneCardsi | ZNF765 |
HGNCi | HGNC:25092, ZNF765 |
HPAi | ENSG00000196417, Low tissue specificity |
neXtProti | NX_Q7L2R6 |
OpenTargetsi | ENSG00000196417 ENSG00000204604 |
PharmGKBi | PA162410312 |
VEuPathDBi | HostDB:ENSG00000196417 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154397 |
HOGENOMi | CLU_002678_69_15_1 |
InParanoidi | Q7L2R6 |
OMAi | FTCHHRV |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q7L2R6 |
TreeFami | TF341892 |
Enzyme and pathway databases
PathwayCommonsi | Q7L2R6 |
SignaLinki | Q7L2R6 |
Miscellaneous databases
BioGRID-ORCSi | 91661, 11 hits in 1028 CRISPR screens |
GenomeRNAii | 91661 |
Pharosi | Q7L2R6, Tdark |
PROi | PR:Q7L2R6 |
RNActi | Q7L2R6, protein |
Gene expression databases
Bgeei | ENSG00000196417, Expressed in anatomical system and 212 other tissues |
ExpressionAtlasi | Q7L2R6, baseline and differential |
Genevisiblei | Q7L2R6, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 9 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 11 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 6 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 11 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN765_HUMAN | |
Accessioni | Q7L2R6Primary (citable) accession number: Q7L2R6 Secondary accession number(s): A8MYG0 Q9BV49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | July 22, 2008 | |
Last modified: | May 25, 2022 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families