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UniProtKB - Q7L2R6 (ZN765_HUMAN)

Entry version 147 (25 May 2022)
Sequence version 2 (22 Jul 2008)
Previous versions | rss
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Protein

Zinc finger protein 765

Gene

ZNF765

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri215 – 237C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 432C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7L2R6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q7L2R6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 765
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF765
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25092, ZNF765

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7L2R6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000196417

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		91661

Open Targets

More...OpenTargetsi		ENSG00000196417
ENSG00000204604

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162410312

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7L2R6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF765

Domain mapping of disease mutations (DMDM)

More...DMDMi		205639967

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003442171 – 523Zinc finger protein 765Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7L2R6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7L2R6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7L2R6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7L2R6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7L2R6

PeptideAtlas

More...PeptideAtlasi		Q7L2R6

PRoteomics IDEntifications database

More...PRIDEi		Q7L2R6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68766 [Q7L2R6-1]
68767 [Q7L2R6-2]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		Q7L2R6-2 [Q7L2R6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7L2R6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7L2R6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196417, Expressed in anatomical system and 212 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7L2R6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7L2R6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196417, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124860, 25 interactors

Protein interaction database and analysis system

More...IntActi		Q7L2R6, 16 interactors

Molecular INTeraction database

More...MINTi		Q7L2R6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000379689

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7L2R6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q7L2R6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7L2R6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 81KRABPROSITE-ProRule annotationAdd BLAST74

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 237C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 432C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154397

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002678_69_15_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7L2R6

Identification of Orthologs from Complete Genome Data

More...OMAi		FTCHHRV

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7L2R6

TreeFam database of animal gene trees

More...TreeFami		TF341892

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 11 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7L2R6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS 
        60         70         80         90        100
SKCMMKEFSS TAQGNREVFH AGTSQRHESH HNGDFCFQDI DKDIHDIEFQ 
       110        120        130        140        150
WQEDERNGHE ALMTKIKKLT GSTERYDQNY AGNKPVKYQL GFSFHSHLPE 
       160        170        180        190        200
LHIFHTEEKI DNQVVKSIHD ASLVSTAQRI SCRPETHISN DYGNNFLNSS 
       210        220        230        240        250
LFTQKQEVHM REKSFQCNDS GKAYNCSSLL RKHQLIHLGE KQYKCDICGK 
       260        270        280        290        300
VFNSKRYVAR HRRCHTGEKP YKCNECGKTF SQTYYLTCHR RLHTGEKPYK 
       310        320        330        340        350
CEECDKAFHF KSKLQIHRRI HTGEKPYKCN ECGKTFSQKS YLTCHRRLHT 
       360        370        380        390        400
GEKPYKCNEC GKTFSRKSHF TCHHRVHTGE KPYKCNECSK TFSHKSSLTY 
       410        420        430        440        450
HRRLHTEEKP YKCNECGKTF NQQLTLNICR LHSGEKPYKC EECDKAYSFK 
       460        470        480        490        500
SNLEIHQKIH TEENPYKCNE CGKTFSRTSS LTYHHRLHTG QKPYKCEDCD 
       510        520 
EAFSFKSNLE RHRRIYTGEK LHV
Length:523
Mass (Da):61,633
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF353F9210751258
GO
Isoform 2 (identifier: Q7L2R6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-60: DISSKCMMKEFSS → ELSGECPLAAPAS
     61-523: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:60
Mass (Da):6,801
Checksum:i1A9DD9902280C334
GO
Isoform 3 (identifier: Q7L2R6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-127: DISSKCMMKE...KLTGSTERYD → EFWSVIPAKV...KSSHWRILFP
     128-523: Missing.

Show »
Length:127
Mass (Da):15,272
Checksum:i38AA41DD8D149944
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RF03D6RF03_HUMAN
Zinc finger protein 765
ZNF765
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PDE6E9PDE6_HUMAN
Zinc finger protein 765
ZNF765
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti61T → A in BAG57279 (PubMed:14702039).Curated1
Sequence conflicti100Q → R in BAG57279 (PubMed:14702039).Curated1
Sequence conflicti241K → N in BAG57279 (PubMed:14702039).Curated1
Sequence conflicti297K → E in BAG57279 (PubMed:14702039).Curated1
Sequence conflicti382P → L in BAG57279 (PubMed:14702039).Curated1
Sequence conflicti494Y → N in BAH14671 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_045598389S → G2 PublicationsCorresponds to variant dbSNP:rs10425136Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05562948 – 127DISSK…TERYD → EFWSVIPAKVQWCHLRSLQP PLPRFKQFSCLSLPSTWDYR YLFQMHVEDVVVNRARQYRS DPHRDIAQTSKSSHWRILFP in isoform 3. CuratedAdd BLAST80
Alternative sequenceiVSP_03474648 – 60DISSK…KEFSS → ELSGECPLAAPAS in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_03474761 – 523Missing in isoform 2. 1 PublicationAdd BLAST463
Alternative sequenceiVSP_055630128 – 523Missing in isoform 3. CuratedAdd BLAST396

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK293890 mRNA Translation: BAG57279.1
AK316300 mRNA Translation: BAH14671.1
AC022137 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72134.1
BC001610 mRNA No translation available.
BC017357 mRNA No translation available.
BC140724 mRNA Translation: AAI40725.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS46171.1 [Q7L2R6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001035275.1, NM_001040185.1 [Q7L2R6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000396408.8; ENSP00000379689.3; ENSG00000196417.13
ENST00000504235.5; ENSP00000424395.1; ENSG00000196417.13 [Q7L2R6-2]
ENST00000594030.2; ENSP00000470468.1; ENSG00000196417.13 [Q7L2R6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		91661

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:91661

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000396408.8; ENSP00000379689.3; NM_001040185.3; NP_001035275.1

UCSC genome browser

More...UCSCi		uc002qbm.4, human [Q7L2R6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293890 mRNA Translation: BAG57279.1
AK316300 mRNA Translation: BAH14671.1
AC022137 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72134.1
BC001610 mRNA No translation available.
BC017357 mRNA No translation available.
BC140724 mRNA Translation: AAI40725.1
CCDSiCCDS46171.1 [Q7L2R6-1]
RefSeqiNP_001035275.1, NM_001040185.1 [Q7L2R6-1]

3D structure databases

AlphaFoldDBiQ7L2R6
SMRiQ7L2R6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124860, 25 interactors
IntActiQ7L2R6, 16 interactors
MINTiQ7L2R6
STRINGi9606.ENSP00000379689

PTM databases

iPTMnetiQ7L2R6
PhosphoSitePlusiQ7L2R6

Genetic variation databases

BioMutaiZNF765
DMDMi205639967

Proteomic databases

EPDiQ7L2R6
jPOSTiQ7L2R6
MassIVEiQ7L2R6
MaxQBiQ7L2R6
PaxDbiQ7L2R6
PeptideAtlasiQ7L2R6
PRIDEiQ7L2R6
ProteomicsDBi68766 [Q7L2R6-1]
68767 [Q7L2R6-2]
TopDownProteomicsiQ7L2R6-2 [Q7L2R6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32701, 73 antibodies from 13 providers

The DNASU plasmid repository

More...DNASUi		91661

Genome annotation databases

EnsembliENST00000396408.8; ENSP00000379689.3; ENSG00000196417.13
ENST00000504235.5; ENSP00000424395.1; ENSG00000196417.13 [Q7L2R6-2]
ENST00000594030.2; ENSP00000470468.1; ENSG00000196417.13 [Q7L2R6-2]
GeneIDi91661
KEGGihsa:91661
MANE-SelectiENST00000396408.8; ENSP00000379689.3; NM_001040185.3; NP_001035275.1
UCSCiuc002qbm.4, human [Q7L2R6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		91661
DisGeNETi91661

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF765
HGNCiHGNC:25092, ZNF765
HPAiENSG00000196417, Low tissue specificity
neXtProtiNX_Q7L2R6
OpenTargetsiENSG00000196417
ENSG00000204604
PharmGKBiPA162410312
VEuPathDBiHostDB:ENSG00000196417

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000154397
HOGENOMiCLU_002678_69_15_1
InParanoidiQ7L2R6
OMAiFTCHHRV
OrthoDBi1318335at2759
PhylomeDBiQ7L2R6
TreeFamiTF341892

Enzyme and pathway databases

PathwayCommonsiQ7L2R6
SignaLinkiQ7L2R6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		91661, 11 hits in 1028 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		91661
PharosiQ7L2R6, Tdark

Protein Ontology

More...PROi		PR:Q7L2R6
RNActiQ7L2R6, protein

Gene expression databases

BgeeiENSG00000196417, Expressed in anatomical system and 212 other tissues
ExpressionAtlasiQ7L2R6, baseline and differential
GenevisibleiQ7L2R6, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 9 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 11 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 8 hits
PS50157, ZINC_FINGER_C2H2_2, 11 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN765_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L2R6
Secondary accession number(s): A8MYG0
, B4DF18, B7ZAI5, B9EIL1, Q9BV49
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: May 25, 2022
This is version 147 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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