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UniProtKB - Q7L2R6 (ZN765_HUMAN)

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Protein

Zinc finger protein 765

Gene

ZNF765

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 237C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 432C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 765
Gene namesi
Name:ZNF765
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000196417.12
HGNCiHGNC:25092 ZNF765
neXtProtiNX_Q7L2R6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi91661
OpenTargetsiENSG00000196417
ENSG00000204604
PharmGKBiPA162410312

Polymorphism and mutation databases

BioMutaiZNF765
DMDMi205639967

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003442171 – 523Zinc finger protein 765Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki205Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ7L2R6
PaxDbiQ7L2R6
PeptideAtlasiQ7L2R6
PRIDEiQ7L2R6
ProteomicsDBi68766
68767 [Q7L2R6-2]
TopDownProteomicsiQ7L2R6-2 [Q7L2R6-2]

PTM databases

iPTMnetiQ7L2R6
PhosphoSitePlusiQ7L2R6

Expressioni

Gene expression databases

BgeeiENSG00000196417
CleanExiHS_ZNF765
ExpressionAtlasiQ7L2R6 baseline and differential
GenevisibleiQ7L2R6 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124860, 3 interactors
IntActiQ7L2R6, 14 interactors
MINTiQ7L2R6
STRINGi9606.ENSP00000379689

Structurei

3D structure databases

ProteinModelPortaliQ7L2R6
SMRiQ7L2R6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 81KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri215 – 237C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri243 – 265C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri271 – 293C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 321C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri327 – 349C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri355 – 377C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri383 – 405C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri411 – 432C2H2-type 8; atypicalPROSITE-ProRule annotationAdd BLAST22
Zinc fingeri438 – 460C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149028
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ7L2R6
KOiK09228
OMAiRKRDLAC
OrthoDBiEOG091G02KC
PhylomeDBiQ7L2R6
TreeFamiTF341892

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7L2R6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALPQGLLTF RDVAIEFSQE EWKCLDPAQR TLYRDVMLEN YRNLVSLDIS 
        60         70         80         90        100
SKCMMKEFSS TAQGNREVFH AGTSQRHESH HNGDFCFQDI DKDIHDIEFQ 
       110        120        130        140        150
WQEDERNGHE ALMTKIKKLT GSTERYDQNY AGNKPVKYQL GFSFHSHLPE 
       160        170        180        190        200
LHIFHTEEKI DNQVVKSIHD ASLVSTAQRI SCRPETHISN DYGNNFLNSS 
       210        220        230        240        250
LFTQKQEVHM REKSFQCNDS GKAYNCSSLL RKHQLIHLGE KQYKCDICGK 
       260        270        280        290        300
VFNSKRYVAR HRRCHTGEKP YKCNECGKTF SQTYYLTCHR RLHTGEKPYK 
       310        320        330        340        350
CEECDKAFHF KSKLQIHRRI HTGEKPYKCN ECGKTFSQKS YLTCHRRLHT 
       360        370        380        390        400
GEKPYKCNEC GKTFSRKSHF TCHHRVHTGE KPYKCNECSK TFSHKSSLTY 
       410        420        430        440        450
HRRLHTEEKP YKCNECGKTF NQQLTLNICR LHSGEKPYKC EECDKAYSFK 
       460        470        480        490        500
SNLEIHQKIH TEENPYKCNE CGKTFSRTSS LTYHHRLHTG QKPYKCEDCD 
       510        520 
EAFSFKSNLE RHRRIYTGEK LHV
Length:523
Mass (Da):61,633
Last modified:July 22, 2008 - v2
Checksum:iAF353F9210751258
GO
Isoform 2 (identifier: Q7L2R6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-60: DISSKCMMKEFSS → ELSGECPLAAPAS
     61-523: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Gene prediction based on EST data.
Show »
Length:60
Mass (Da):6,801
Checksum:i1A9DD9902280C334
GO
Isoform 3 (identifier: Q7L2R6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-127: DISSKCMMKE...KLTGSTERYD → EFWSVIPAKV...KSSHWRILFP
     128-523: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):15,272
Checksum:i38AA41DD8D149944
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61T → A in BAG57279 (PubMed:14702039).Curated1
Sequence conflicti100Q → R in BAG57279 (PubMed:14702039).Curated1
Sequence conflicti241K → N in BAG57279 (PubMed:14702039).Curated1
Sequence conflicti297K → E in BAG57279 (PubMed:14702039).Curated1
Sequence conflicti382P → L in BAG57279 (PubMed:14702039).Curated1
Sequence conflicti494Y → N in BAH14671 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045598389S → G2 PublicationsCorresponds to variant dbSNP:rs10425136Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05562948 – 127DISSK…TERYD → EFWSVIPAKVQWCHLRSLQP PLPRFKQFSCLSLPSTWDYR YLFQMHVEDVVVNRARQYRS DPHRDIAQTSKSSHWRILFP in isoform 3. CuratedAdd BLAST80
Alternative sequenceiVSP_03474648 – 60DISSK…KEFSS → ELSGECPLAAPAS in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_03474761 – 523Missing in isoform 2. 1 PublicationAdd BLAST463
Alternative sequenceiVSP_055630128 – 523Missing in isoform 3. CuratedAdd BLAST396

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK293890 mRNA Translation: BAG57279.1
AK316300 mRNA Translation: BAH14671.1
AC022137 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72134.1
BC001610 mRNA No translation available.
BC017357 mRNA No translation available.
BC140724 mRNA Translation: AAI40725.1
CCDSiCCDS46171.1 [Q7L2R6-1]
RefSeqiNP_001035275.1, NM_001040185.1 [Q7L2R6-1]
UniGeneiHs.657821
Hs.685640

Genome annotation databases

EnsembliENST00000396408; ENSP00000379689; ENSG00000196417 [Q7L2R6-1]
ENST00000504235; ENSP00000424395; ENSG00000196417 [Q7L2R6-2]
ENST00000594030; ENSP00000470468; ENSG00000196417 [Q7L2R6-2]
GeneIDi91661
KEGGihsa:91661
UCSCiuc002qbm.4 human [Q7L2R6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN765_HUMAN
AccessioniPrimary (citable) accession number: Q7L2R6
Secondary accession number(s): A8MYG0
, B4DF18, B7ZAI5, B9EIL1, Q9BV49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 18, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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