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Protein

Tubulin epsilon and delta complex protein 2

Gene

TEDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin epsilon and delta complex protein 2Curated
Gene namesi
Name:TEDC2Imported
Synonyms:C16orf59Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000162062.14
HGNCiHGNC:25849 TEDC2
neXtProtiNX_Q7L2K0

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162062
PharmGKBiPA143485396

Polymorphism and mutation databases

BioMutaiC16orf59
DMDMi121944421

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865571 – 433Tubulin epsilon and delta complex protein 2Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei159PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7L2K0
MaxQBiQ7L2K0
PaxDbiQ7L2K0
PeptideAtlasiQ7L2K0
PRIDEiQ7L2K0
ProteomicsDBi68763
68764 [Q7L2K0-2]
68765 [Q7L2K0-3]

PTM databases

iPTMnetiQ7L2K0
PhosphoSitePlusiQ7L2K0

Expressioni

Gene expression databases

BgeeiENSG00000162062 Expressed in 86 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_C16orf59
ExpressionAtlasiQ7L2K0 baseline and differential
GenevisibleiQ7L2K0 HS

Organism-specific databases

HPAiHPA051394
HPA055389

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123160, 11 interactors
IntActiQ7L2K0, 7 interactors
MINTiQ7L2K0
STRINGi9606.ENSP00000355022

Structurei

3D structure databases

SMRiQ7L2K0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IVDJ Eukaryota
ENOG410YP0K LUCA
GeneTreeiENSGT00390000011149
HOGENOMiHOG000057283
HOVERGENiHBG107747
InParanoidiQ7L2K0
OMAiLLQAWEP
OrthoDBiEOG091G0BFP
PhylomeDBiQ7L2K0
TreeFamiTF337397

Family and domain databases

InterProiView protein in InterPro
IPR031518 DUF4693
PANTHERiPTHR14870 PTHR14870, 1 hit
PfamiView protein in Pfam
PF15764 DUF4693, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q7L2K0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPAGCSRRL VAELQGALDA CAQRQLQLEQ SLRVCRRLLH AWEPTGTRAL
60 70 80 90 100
KPPPGPETNG EDPLPACTPS PQDLKELEFL TQALEKAVRV RRGITKAGER
110 120 130 140 150
DKAPSLKSRS IVTSSGTTAS APPHSPGQAG GHASDTRPTK GLRQTTVPAK
160 170 180 190 200
GHPERRLLSV GDGTRVGMGA RTPRPGAGLR DQQMAPSAAP QAPEAFTLKE
210 220 230 240 250
KGHLLRLPAA FRKAASQNSS LWAQLSSTQT SDSTDAAAAK TQFLQNMQTA
260 270 280 290 300
SGGPQPRLSA VEVEAEAGRL RKACSLLRLR MREELSAAPM DWMQEYRCLL
310 320 330 340 350
TLEGLQAMVG QCLHRLQELR AAVAEQPPRP CPVGRPPGAS PSCGGRAEPA
360 370 380 390 400
WSPQLLVYSS TQELQTLAAL KLRVAVLDQQ IHLEKVLMAE LLPLVSAAQP
410 420 430
QGPPWLALCR AVHSLLCEGG ARVLTILRDE PAV
Length:433
Mass (Da):46,402
Last modified:October 17, 2006 - v1
Checksum:i2B3C8B18D497D728
GO
Isoform 2 (identifier: Q7L2K0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.

Show »
Length:266
Mass (Da):28,645
Checksum:i204F4C994BFAC84E
GO
Isoform 3 (identifier: Q7L2K0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-167: Missing.
     323-362: VAEQPPRPCP...PQLLVYSSTQ → PRSCRPWRPS...RWGCNRGPQP
     363-433: Missing.

Note: No experimental confirmation available.
Show »
Length:195
Mass (Da):21,869
Checksum:i38D31C22146EEDC8
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BND0H3BND0_HUMAN
Tubulin epsilon and delta complex p...
TEDC2
405Annotation score:
H3BPH1H3BPH1_HUMAN
Tubulin epsilon and delta complex p...
TEDC2
99Annotation score:
H3BTF6H3BTF6_HUMAN
Tubulin epsilon and delta complex p...
TEDC2
285Annotation score:
H3BU38H3BU38_HUMAN
Tubulin epsilon and delta complex p...
TEDC2
171Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032115346R → K. Corresponds to variant dbSNP:rs34948268Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0250861 – 167Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST167
Alternative sequenceiVSP_025087323 – 362VAEQP…YSSTQ → PRSCRPWRPSSCEWLCWTSR STWKRCFWKRRWGCNRGPQP in isoform 3. 1 PublicationAdd BLAST40
Alternative sequenceiVSP_025088363 – 433Missing in isoform 3. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023971 mRNA Translation: BAB14745.1
AK301929 mRNA Translation: BAG63349.1
CR457319 mRNA Translation: CAG33600.1
CH471112 Genomic DNA Translation: EAW85507.1
BC008882 mRNA Translation: AAH08882.1
BC018719 mRNA Translation: AAH18719.2
CCDSiCCDS10468.2 [Q7L2K0-1]
RefSeqiNP_079384.2, NM_025108.2 [Q7L2K0-1]
UniGeneiHs.534491

Genome annotation databases

EnsembliENST00000361837; ENSP00000355022; ENSG00000162062 [Q7L2K0-1]
ENST00000483320; ENSP00000456478; ENSG00000162062 [Q7L2K0-2]
GeneIDi80178
KEGGihsa:80178
UCSCiuc002cqh.4 human [Q7L2K0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023971 mRNA Translation: BAB14745.1
AK301929 mRNA Translation: BAG63349.1
CR457319 mRNA Translation: CAG33600.1
CH471112 Genomic DNA Translation: EAW85507.1
BC008882 mRNA Translation: AAH08882.1
BC018719 mRNA Translation: AAH18719.2
CCDSiCCDS10468.2 [Q7L2K0-1]
RefSeqiNP_079384.2, NM_025108.2 [Q7L2K0-1]
UniGeneiHs.534491

3D structure databases

SMRiQ7L2K0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123160, 11 interactors
IntActiQ7L2K0, 7 interactors
MINTiQ7L2K0
STRINGi9606.ENSP00000355022

PTM databases

iPTMnetiQ7L2K0
PhosphoSitePlusiQ7L2K0

Polymorphism and mutation databases

BioMutaiC16orf59
DMDMi121944421

Proteomic databases

EPDiQ7L2K0
MaxQBiQ7L2K0
PaxDbiQ7L2K0
PeptideAtlasiQ7L2K0
PRIDEiQ7L2K0
ProteomicsDBi68763
68764 [Q7L2K0-2]
68765 [Q7L2K0-3]

Protocols and materials databases

DNASUi80178
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361837; ENSP00000355022; ENSG00000162062 [Q7L2K0-1]
ENST00000483320; ENSP00000456478; ENSG00000162062 [Q7L2K0-2]
GeneIDi80178
KEGGihsa:80178
UCSCiuc002cqh.4 human [Q7L2K0-1]

Organism-specific databases

CTDi80178
EuPathDBiHostDB:ENSG00000162062.14
GeneCardsiTEDC2
HGNCiHGNC:25849 TEDC2
HPAiHPA051394
HPA055389
neXtProtiNX_Q7L2K0
OpenTargetsiENSG00000162062
PharmGKBiPA143485396
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVDJ Eukaryota
ENOG410YP0K LUCA
GeneTreeiENSGT00390000011149
HOGENOMiHOG000057283
HOVERGENiHBG107747
InParanoidiQ7L2K0
OMAiLLQAWEP
OrthoDBiEOG091G0BFP
PhylomeDBiQ7L2K0
TreeFamiTF337397

Miscellaneous databases

GenomeRNAii80178
PROiPR:Q7L2K0

Gene expression databases

BgeeiENSG00000162062 Expressed in 86 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_C16orf59
ExpressionAtlasiQ7L2K0 baseline and differential
GenevisibleiQ7L2K0 HS

Family and domain databases

InterProiView protein in InterPro
IPR031518 DUF4693
PANTHERiPTHR14870 PTHR14870, 1 hit
PfamiView protein in Pfam
PF15764 DUF4693, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTEDC2_HUMAN
AccessioniPrimary (citable) accession number: Q7L2K0
Secondary accession number(s): B4DXD7, Q96H61, Q9H872
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 17, 2006
Last modified: September 12, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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