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Entry version 138 (17 Jun 2020)
Sequence version 1 (05 Jul 2004)
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Protein

BTB/POZ domain-containing protein KCTD9

Gene

KCTD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.Curated
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCTD9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000104756.15

Human Gene Nomenclature Database

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HGNCi
HGNC:22401 KCTD9

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7L273

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi125V → A: Impaired interaction with CUL3. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
54793

Open Targets

More...
OpenTargetsi
ENSG00000104756

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134869993

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7L273 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCTD9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50400921

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001912931 – 389BTB/POZ domain-containing protein KCTD9Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei11PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7L273

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7L273

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7L273

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7L273

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7L273

PeptideAtlas

More...
PeptideAtlasi
Q7L273

PRoteomics IDEntifications database

More...
PRIDEi
Q7L273

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
68757

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7L273

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7L273

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104756 Expressed in thoracic aorta and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7L273 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7L273 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000104756 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms pentamers.

Component of a complex composed of 5 subunits of KCTD9 and 5 CUL3.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q7L273
With#Exp.IntAct
ADAMTSL4 - isoform 3 [Q6UY14-3]3EBI-4397613,EBI-10173507
ANKS1A [Q49AR9]3EBI-4397613,EBI-11954519
AQP1 [P29972]3EBI-4397613,EBI-745213
ARID5A [Q03989]3EBI-4397613,EBI-948603
BANP - isoform 2 [Q8N9N5-2]3EBI-4397613,EBI-11524452
BLZF1 [Q9H2G9]3EBI-4397613,EBI-2548012
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-4397613,EBI-11976299
C7orf31 [Q8N865]3EBI-4397613,EBI-10174456
CARD9 [Q9H257]3EBI-4397613,EBI-751319
CBX8 [Q9HC52]6EBI-4397613,EBI-712912
CDC37 [Q16543]3EBI-4397613,EBI-295634
CDPF1 [Q6NVV7]3EBI-4397613,EBI-2802782
CFP [P27918]3EBI-4397613,EBI-9038570
CRADD [P78560]3EBI-4397613,EBI-520375
CUL3 [Q13618]10EBI-4397613,EBI-456129
DDIT4L [Q96D03]3EBI-4397613,EBI-742054
DEUP1 [Q05D60]3EBI-4397613,EBI-748597
EHHADH [Q08426]4EBI-4397613,EBI-2339219
EPM2AIP1 [Q7L775]3EBI-4397613,EBI-6255981
FAM124B [Q9H5Z6]3EBI-4397613,EBI-741626
GEM [P55040]6EBI-4397613,EBI-744104
GOLGA6A [Q9NYA3]3EBI-4397613,EBI-11163335
GOLGA6L9 [A6NEM1]3EBI-4397613,EBI-5916454
GORASP2 [Q9H8Y8]7EBI-4397613,EBI-739467
GPANK1 [O95872]3EBI-4397613,EBI-751540
HOXA1 [P49639]5EBI-4397613,EBI-740785
HOXC8 [P31273]3EBI-4397613,EBI-1752118
IGFN1 - isoform 5 [Q86VF2-5]3EBI-4397613,EBI-11955401
IL16 - isoform 2 [Q14005-2]3EBI-4397613,EBI-17178971
INCA1 [Q0VD86]3EBI-4397613,EBI-6509505
itself4EBI-4397613,EBI-4397613
KIF9 [Q9HAQ2]3EBI-4397613,EBI-8472129
KLHL26 [Q53HC5]3EBI-4397613,EBI-724915
KRT31 [Q15323]3EBI-4397613,EBI-948001
KRT34 [O76011]3EBI-4397613,EBI-1047093
KRT35 [Q92764]3EBI-4397613,EBI-1058674
KRT40 [Q6A162]3EBI-4397613,EBI-10171697
KRTAP13-2 [Q52LG2]3EBI-4397613,EBI-11953846
KRTAP13-3 [Q3SY46]3EBI-4397613,EBI-10241252
LNX1 [Q8TBB1]6EBI-4397613,EBI-739832
LONRF1 [Q17RB8]6EBI-4397613,EBI-2341787
MAD2L2 [Q9UI95]3EBI-4397613,EBI-77889
MBD3L1 [Q8WWY6]3EBI-4397613,EBI-12516603
MEOX2 [Q6FHY5]3EBI-4397613,EBI-16439278
MIIP [Q5JXC2]3EBI-4397613,EBI-2801965
NDUFAB1 [O14561]3EBI-4397613,EBI-1246261
NIF3L1 [Q9GZT8]3EBI-4397613,EBI-740897
NUP35 [Q8NFH5]7EBI-4397613,EBI-9050429
PDZD4 [Q17RL8]3EBI-4397613,EBI-10239064
PFDN5 [Q99471]3EBI-4397613,EBI-357275
PICK1 [Q9NRD5]3EBI-4397613,EBI-79165
PLOD3 [O60568]3EBI-4397613,EBI-741582
PNKD [Q8N490]3EBI-4397613,EBI-746368
POF1B - isoform 1 [Q8WVV4-1]3EBI-4397613,EBI-11986735
PPP1R16B [Q96T49]3EBI-4397613,EBI-10293968
PPP1R18 [Q6NYC8]3EBI-4397613,EBI-2557469
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-4397613,EBI-12000762
PRDM6 [Q9NQX0]3EBI-4397613,EBI-11320284
PRKAA2 [P54646]3EBI-4397613,EBI-1383852
PSMA1 [P25786]6EBI-4397613,EBI-359352
PSMB2 [P49721]3EBI-4397613,EBI-359335
RBPMS [Q93062]3EBI-4397613,EBI-740322
RFX6 [Q8HWS3]3EBI-4397613,EBI-746118
RUSC1 [Q9BVN2]3EBI-4397613,EBI-6257312
SDCBP [O00560]6EBI-4397613,EBI-727004
SKP1 [P63208]3EBI-4397613,EBI-307486
SLAIN1 [Q8ND83]3EBI-4397613,EBI-10269374
SMRP1 [Q8NCR6]3EBI-4397613,EBI-10269322
SMUG1 - isoform 2 [Q53HV7-2]3EBI-4397613,EBI-12275818
SPATS1 [Q496A3]3EBI-4397613,EBI-3923692
SPG21 [Q9NZD8]3EBI-4397613,EBI-742688
STX11 [O75558]3EBI-4397613,EBI-714135
SYT6 - isoform 2 [Q5T7P8-2]6EBI-4397613,EBI-10246152
TASOR2 [Q5VWN6]3EBI-4397613,EBI-745958
TASOR2 - isoform 2 [Q5VWN6-2]3EBI-4397613,EBI-10172380
TEPSIN [Q96N21]3EBI-4397613,EBI-11139477
TEX37 [Q96LM6]3EBI-4397613,EBI-743976
TNS2 [Q63HR2]3EBI-4397613,EBI-949753
TRIM27 [P14373]6EBI-4397613,EBI-719493
TRIM32 [Q13049]6EBI-4397613,EBI-742790
TRIM42 [Q8IWZ5]6EBI-4397613,EBI-5235829
TRIP6 [Q15654]3EBI-4397613,EBI-742327
UNKL - isoform 5 [Q9H9P5-5]3EBI-4397613,EBI-12817837
USP21 [Q9UK80]3EBI-4397613,EBI-373242
USP54 - isoform 6 [Q70EL1-9]3EBI-4397613,EBI-11975223
WDR83 [Q9BRX9]3EBI-4397613,EBI-7705033
WDYHV1 [Q96HA8]3EBI-4397613,EBI-741158
ZBTB25 [P24278]3EBI-4397613,EBI-739899
ZBTB42 [B2RXF5]3EBI-4397613,EBI-12287587
ZNF408 [Q9H9D4]3EBI-4397613,EBI-347633
ZNF426 [Q9BUY5]3EBI-4397613,EBI-743265
ZNF620 [Q6ZNG0]3EBI-4397613,EBI-4395669
ZNF76 [P36508]3EBI-4397613,EBI-7254550

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
120153, 41 interactors

Protein interaction database and analysis system

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IntActi
Q7L273, 98 interactors

Molecular INTeraction database

More...
MINTi
Q7L273

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000221200

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7L273 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1389
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7L273

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 82KHAPROSITE-ProRule annotationAdd BLAST80
Domaini89 – 161BTBPROSITE-ProRule annotationAdd BLAST73
Domaini224 – 256Pentapeptide repeat 1Sequence analysisAdd BLAST33
Domaini258 – 297Pentapeptide repeat 2Sequence analysisAdd BLAST40
Domaini338 – 376Pentapeptide repeat 3Sequence analysisAdd BLAST39

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1665 Eukaryota
COG1357 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154314

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_043894_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7L273

KEGG Orthology (KO)

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KOi
K21919

Identification of Orthologs from Complete Genome Data

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OMAi
HTLPRHP

Database of Orthologous Groups

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OrthoDBi
1041330at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7L273

TreeFam database of animal gene trees

More...
TreeFami
TF313754

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001646 5peptide_repeat
IPR000210 BTB/POZ_dom
IPR036572 Doublecortin_dom_sf
IPR021789 KHA_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02214 BTB_2, 1 hit
PF11834 KHA, 1 hit
PF00805 Pentapeptide, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00225 BTB, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54695 SSF54695, 1 hit
SSF89837 SSF89837, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50097 BTB, 1 hit
PS51490 KHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q7L273-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRVTLFLNG SPKNGKVVAV YGTLSDLLSV ASSKLGIKAT SVYNGKGGLI
60 70 80 90 100
DDIALIRDDD VLFVCEGEPF IDPQTDSKPP EGLLGFHTDW LTLNVGGRYF
110 120 130 140 150
TTTRSTLVNK EPDSMLAHMF KDKGVWGNKQ DHRGAFLIDR SPEYFEPILN
160 170 180 190 200
YLRHGQLIVN DGINLLGVLE EARFFGIDSL IEHLEVAIKN SQPPEDHSPI
210 220 230 240 250
SRKEFVRFLL ATPTKSELRC QGLNFSGADL SRLDLRYINF KMANLSRCNL
260 270 280 290 300
AHANLCCANL ERADLSGSVL DCANLQGVKM LCSNAEGASL KLCNFEDPSG
310 320 330 340 350
LKANLEGANL KGVDMEGSQM TGINLRVATL KNAKLKNCNL RGATLAGTDL
360 370 380
ENCDLSGCDL QEANLRGSNV KGAIFEEMLT PLHMSQSVR
Length:389
Mass (Da):42,567
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i43D4AE36F3B9618F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EQN1K7EQN1_HUMAN
BTB/POZ domain-containing protein K...
KCTD9
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENB5K7ENB5_HUMAN
BTB/POZ domain-containing protein K...
KCTD9
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA90904 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12P → R in AAH68518 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC021216 mRNA Translation: AAH21216.2
BC068518 mRNA Translation: AAH68518.1
AK000045 mRNA Translation: BAA90904.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS6048.1

NCBI Reference Sequences

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RefSeqi
NP_060104.2, NM_017634.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000221200; ENSP00000221200; ENSG00000104756

Database of genes from NCBI RefSeq genomes

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GeneIDi
54793

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54793

UCSC genome browser

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UCSCi
uc003xeo.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021216 mRNA Translation: AAH21216.2
BC068518 mRNA Translation: AAH68518.1
AK000045 mRNA Translation: BAA90904.1 Different initiation.
CCDSiCCDS6048.1
RefSeqiNP_060104.2, NM_017634.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5BXHX-ray2.76A/B/C/D/E89-191[»]
SMRiQ7L273
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120153, 41 interactors
IntActiQ7L273, 98 interactors
MINTiQ7L273
STRINGi9606.ENSP00000221200

PTM databases

iPTMnetiQ7L273
PhosphoSitePlusiQ7L273

Polymorphism and mutation databases

BioMutaiKCTD9
DMDMi50400921

Proteomic databases

EPDiQ7L273
jPOSTiQ7L273
MassIVEiQ7L273
MaxQBiQ7L273
PaxDbiQ7L273
PeptideAtlasiQ7L273
PRIDEiQ7L273
ProteomicsDBi68757

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
22883 221 antibodies

The DNASU plasmid repository

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DNASUi
54793

Genome annotation databases

EnsembliENST00000221200; ENSP00000221200; ENSG00000104756
GeneIDi54793
KEGGihsa:54793
UCSCiuc003xeo.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54793
DisGeNETi54793
EuPathDBiHostDB:ENSG00000104756.15

GeneCards: human genes, protein and diseases

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GeneCardsi
KCTD9
HGNCiHGNC:22401 KCTD9
HPAiENSG00000104756 Low tissue specificity
neXtProtiNX_Q7L273
OpenTargetsiENSG00000104756
PharmGKBiPA134869993

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1665 Eukaryota
COG1357 LUCA
GeneTreeiENSGT00940000154314
HOGENOMiCLU_043894_0_0_1
InParanoidiQ7L273
KOiK21919
OMAiHTLPRHP
OrthoDBi1041330at2759
PhylomeDBiQ7L273
TreeFamiTF313754

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
54793 54 hits in 777 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KCTD9 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54793
PharosiQ7L273 Tbio

Protein Ontology

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PROi
PR:Q7L273
RNActiQ7L273 protein

Gene expression databases

BgeeiENSG00000104756 Expressed in thoracic aorta and 227 other tissues
ExpressionAtlasiQ7L273 baseline and differential
GenevisibleiQ7L273 HS

Family and domain databases

InterProiView protein in InterPro
IPR001646 5peptide_repeat
IPR000210 BTB/POZ_dom
IPR036572 Doublecortin_dom_sf
IPR021789 KHA_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF11834 KHA, 1 hit
PF00805 Pentapeptide, 3 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
SSF89837 SSF89837, 1 hit
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS51490 KHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCTD9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L273
Secondary accession number(s): Q6NUM8, Q9NXV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 5, 2004
Last modified: June 17, 2020
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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