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Protein

Isoaspartyl peptidase/L-asparaginase

Gene

ASRGL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Glycine accelerates autocleavage into an alpha and beta chain.1 Publication

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=3.4 mM for L-asparagine (L-Asn)1 Publication
  2. KM=0.4 mM for L-aspartic acid beta-methyl ester1 Publication
  3. KM=0.4 mM for L-Asp-L-Phe1 Publication
  4. KM=1.0 mM for L-Asp-L-Ala1 Publication
  5. KM=0.1 mM for L-aspartic acid beta-hydroxamate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei168Nucleophile2 Publications1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • asparaginase activity Source: UniProtKB
    • beta-aspartyl-peptidase activity Source: UniProtKB
    • hydrolase activity Source: GO_Central

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase, Protease

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    MetaCyc:HS08648-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.4.19.5 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-71182 Phenylalanine and tyrosine catabolism

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Isoaspartyl peptidase/L-asparaginase (EC:3.4.19.51 Publication, EC:3.5.1.13 Publications)
    Alternative name(s):
    Asparaginase-like protein 11 Publication
    Beta-aspartyl-peptidase1 Publication
    Isoaspartyl dipeptidase
    L-asparagine amidohydrolase
    Cleaved into the following 2 chains:
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:ASRGL1
    Synonyms:ALP, CRASH
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000162174.12

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:16448 ASRGL1

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    609212 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q7L266

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi168T → A or C: Abolishes activation by autocleavage. Abolishes enzyme activity. 2 Publications1
    Mutagenesisi168T → S: Strongly reduced enzyme activity. 2 Publications1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    80150

    Open Targets

    More...
    OpenTargetsi
    ENSG00000162174

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA25059

    Chemistry databases

    Drug and drug target database

    More...
    DrugBanki
    DB00174 L-Asparagine
    DB00128 L-Aspartic Acid

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    ASRGL1

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    158706477

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003052041 – 167Isoaspartyl peptidase/L-asparaginase alpha chainAdd BLAST167
    ChainiPRO_0000420556168 – 308Isoaspartyl peptidase/L-asparaginase beta chainAdd BLAST141

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Cleaved into an alpha and beta chain by autocatalysis; this activates the enzyme. The N-terminal residue of the beta subunit is responsible for the nucleophile hydrolase activity.2 Publications

    Keywords - PTMi

    Acetylation, Autocatalytic cleavage

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q7L266

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q7L266

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q7L266

    PeptideAtlas

    More...
    PeptideAtlasi
    Q7L266

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q7L266

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    68755
    68756 [Q7L266-2]

    2D gel databases

    University College Dublin 2-DE Proteome Database

    More...
    UCD-2DPAGEi
    Q7L266

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q7L266

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q7L266

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in brain, kidney, testis and tissues of the gastrointestinal tract. Present in sperm (at protein level). Over-expressed in uterine, mammary, prostatic and ovarian carcinoma.2 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    By 5-alpha-di-hydrotestosterone and progesterone.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000162174 Expressed in 205 organ(s), highest expression level in endometrium

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_ASRGL1

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q7L266 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q7L266 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB070192
    HPA029725
    HPA055572

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Heterodimer of an alpha and beta chain produced by autocleavage. This heterodimer may then dimerize in turn, giving rise to a heterotetramer.2 Publications

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    123142, 7 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q7L266, 4 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q7L266

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000301776

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1308
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q7L266

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q7L266

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni196 – 199Substrate binding4
    Regioni219 – 222Substrate binding4

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the Ntn-hydrolase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1592 Eukaryota
    COG1446 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155304

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000174613

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG101662

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q7L266

    KEGG Orthology (KO)

    More...
    KOi
    K13051

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GITGKWP

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0CKQ

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q7L266

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF323960

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd04702 ASRGL1_like, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR033844 ASRGL1_meta
    IPR029055 Ntn_hydrolases_N
    IPR000246 Peptidase_T2

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10188 PTHR10188, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01112 Asparaginase_2, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF56235 SSF56235, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q7L266-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MNPIVVVHGG GAGPISKDRK ERVHQGMVRA ATVGYGILRE GGSAVDAVEG
    60 70 80 90 100
    AVVALEDDPE FNAGCGSVLN TNGEVEMDAS IMDGKDLSAG AVSAVQCIAN
    110 120 130 140 150
    PIKLARLVME KTPHCFLTDQ GAAQFAAAMG VPEIPGEKLV TERNKKRLEK
    160 170 180 190 200
    EKHEKGAQKT DCQKNLGTVG AVALDCKGNV AYATSTGGIV NKMVGRVGDS
    210 220 230 240 250
    PCLGAGGYAD NDIGAVSTTG HGESILKVNL ARLTLFHIEQ GKTVEEAADL
    260 270 280 290 300
    SLGYMKSRVK GLGGLIVVSK TGDWVAKWTS TSMPWAAAKD GKLHFGIDPD

    DTTITDLP
    Length:308
    Mass (Da):32,055
    Last modified:April 3, 2007 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84E3D6C2D1555B32
    GO
    Isoform 2 (identifier: Q7L266-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-128: Missing.

    Note: No experimental confirmation available.
    Show »
    Length:180
    Mass (Da):18,981
    Checksum:iE21C4620A2261D0C
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    E9PJK6E9PJK6_HUMAN
    Isoaspartyl peptidase/L-asparaginas...
    ASRGL1
    70Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087WZI5A0A087WZI5_HUMAN
    Isoaspartyl peptidase/L-asparaginas...
    ASRGL1
    133Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087WUG3A0A087WUG3_HUMAN
    Isoaspartyl peptidase/L-asparaginas...
    ASRGL1
    164Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A087X1T8A0A087X1T8_HUMAN
    Isoaspartyl peptidase/L-asparaginas...
    ASRGL1
    56Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAB15302 differs from that shown. Contaminating sequence.Curated
    The sequence BAB15302 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti181A → T in AAM28434 (PubMed:11984834).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_081118178G → R Found in a large family with early-onset recessive retinal degeneration; abolishes autocleavage resulting in loss of enzymatic activity; increased protein aggregation; changes protein localization that becomes perinuclear, does not change ligand affinity for L-aspartic acid beta-hydroxamate. 1 Publication1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0282871 – 128Missing in isoform 2. 1 PublicationAdd BLAST128

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF411076 mRNA Translation: AAM28434.1
    AK025969 mRNA Translation: BAB15302.1 Different initiation.
    AK091894 mRNA Translation: BAG52437.1
    AK313069 mRNA Translation: BAG35897.1
    CH471076 Genomic DNA Translation: EAW74012.1
    BC021295 mRNA Translation: AAH21295.3
    BC064963 mRNA Translation: AAH64963.1
    BC093070 mRNA Translation: AAH93070.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS8019.1 [Q7L266-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001077395.1, NM_001083926.1 [Q7L266-1]
    NP_079356.3, NM_025080.3 [Q7L266-1]
    XP_005274362.1, XM_005274305.3 [Q7L266-2]
    XP_005274363.1, XM_005274306.2 [Q7L266-2]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.535326

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000301776; ENSP00000301776; ENSG00000162174 [Q7L266-1]
    ENST00000415229; ENSP00000400057; ENSG00000162174 [Q7L266-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    80150

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:80150

    UCSC genome browser

    More...
    UCSCi
    uc001nte.5 human [Q7L266-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF411076 mRNA Translation: AAM28434.1
    AK025969 mRNA Translation: BAB15302.1 Different initiation.
    AK091894 mRNA Translation: BAG52437.1
    AK313069 mRNA Translation: BAG35897.1
    CH471076 Genomic DNA Translation: EAW74012.1
    BC021295 mRNA Translation: AAH21295.3
    BC064963 mRNA Translation: AAH64963.1
    BC093070 mRNA Translation: AAH93070.1
    CCDSiCCDS8019.1 [Q7L266-1]
    RefSeqiNP_001077395.1, NM_001083926.1 [Q7L266-1]
    NP_079356.3, NM_025080.3 [Q7L266-1]
    XP_005274362.1, XM_005274305.3 [Q7L266-2]
    XP_005274363.1, XM_005274306.2 [Q7L266-2]
    UniGeneiHs.535326

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3TKJX-ray2.30A/B2-308[»]
    4ET0X-ray3.30A/B2-308[»]
    4O0CX-ray1.50A/B1-308[»]
    4O0DX-ray1.95A/B1-308[»]
    4O0EX-ray1.71A/B1-308[»]
    4O0FX-ray1.92A/B1-308[»]
    4O0GX-ray2.10A/B1-308[»]
    4O0HX-ray1.97A/B1-308[»]
    4OSXX-ray1.95A/B1-308[»]
    4OSYX-ray1.91A/B1-308[»]
    4PVPX-ray1.85A/B1-308[»]
    4PVQX-ray2.13A/B1-308[»]
    4PVRX-ray1.75A/B1-308[»]
    4PVSX-ray1.84A/B1-308[»]
    4ZM9X-ray2.51A/B/C/D2-308[»]
    ProteinModelPortaliQ7L266
    SMRiQ7L266
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi123142, 7 interactors
    IntActiQ7L266, 4 interactors
    MINTiQ7L266
    STRINGi9606.ENSP00000301776

    Chemistry databases

    DrugBankiDB00174 L-Asparagine
    DB00128 L-Aspartic Acid

    PTM databases

    iPTMnetiQ7L266
    PhosphoSitePlusiQ7L266

    Polymorphism and mutation databases

    BioMutaiASRGL1
    DMDMi158706477

    2D gel databases

    UCD-2DPAGEiQ7L266

    Proteomic databases

    EPDiQ7L266
    MaxQBiQ7L266
    PaxDbiQ7L266
    PeptideAtlasiQ7L266
    PRIDEiQ7L266
    ProteomicsDBi68755
    68756 [Q7L266-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    80150
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000301776; ENSP00000301776; ENSG00000162174 [Q7L266-1]
    ENST00000415229; ENSP00000400057; ENSG00000162174 [Q7L266-1]
    GeneIDi80150
    KEGGihsa:80150
    UCSCiuc001nte.5 human [Q7L266-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    80150
    DisGeNETi80150
    EuPathDBiHostDB:ENSG00000162174.12

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    ASRGL1
    HGNCiHGNC:16448 ASRGL1
    HPAiCAB070192
    HPA029725
    HPA055572
    MIMi609212 gene
    neXtProtiNX_Q7L266
    OpenTargetsiENSG00000162174
    PharmGKBiPA25059

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG1592 Eukaryota
    COG1446 LUCA
    GeneTreeiENSGT00940000155304
    HOGENOMiHOG000174613
    HOVERGENiHBG101662
    InParanoidiQ7L266
    KOiK13051
    OMAiGITGKWP
    OrthoDBiEOG091G0CKQ
    PhylomeDBiQ7L266
    TreeFamiTF323960

    Enzyme and pathway databases

    BioCyciMetaCyc:HS08648-MONOMER
    BRENDAi3.4.19.5 2681
    ReactomeiR-HSA-71182 Phenylalanine and tyrosine catabolism

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    ASRGL1 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    ASRGL1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    80150

    Protein Ontology

    More...
    PROi
    PR:Q7L266

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000162174 Expressed in 205 organ(s), highest expression level in endometrium
    CleanExiHS_ASRGL1
    ExpressionAtlasiQ7L266 baseline and differential
    GenevisibleiQ7L266 HS

    Family and domain databases

    CDDicd04702 ASRGL1_like, 1 hit
    InterProiView protein in InterPro
    IPR033844 ASRGL1_meta
    IPR029055 Ntn_hydrolases_N
    IPR000246 Peptidase_T2
    PANTHERiPTHR10188 PTHR10188, 1 hit
    PfamiView protein in Pfam
    PF01112 Asparaginase_2, 1 hit
    SUPFAMiSSF56235 SSF56235, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASGL1_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L266
    Secondary accession number(s): B2R7Q0
    , Q567Q4, Q6P1P0, Q8NI34, Q9H6F7
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: April 3, 2007
    Last modified: December 5, 2018
    This is version 130 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    6. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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