Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 142 (11 Dec 2019)
Sequence version 1 (11 Oct 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Protein ABHD13

Gene

ABHD13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei193Charge relay systemBy similarity1
Active sitei268Charge relay systemBy similarity1
Active sitei298Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-ABHD13 ABHD13-BEM46

MEROPS protease database

More...
MEROPSi
S09.051

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein ABHD13Curated (EC:3.-.-.-)
Alternative name(s):
Alpha/beta hydrolase domain-containing protein 13Curated
Short name:
Abhydrolase domain-containing protein 13Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABHD13Imported
Synonyms:C13orf6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000139826.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20293 ABHD13

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7L211

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei37 – 57Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000139826

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134862303

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7L211 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ABHD13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749881

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002810761 – 337Protein ABHD13Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7L211

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7L211

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7L211

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7L211

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7L211

PeptideAtlas

More...
PeptideAtlasi
Q7L211

PRoteomics IDEntifications database

More...
PRIDEi
Q7L211

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68754

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7L211

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7L211

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139826 Expressed in 166 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7L211 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7L211 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA032143
HPA032144

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q7L211, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365063

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7L211 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7L211

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the serine esterase family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4391 Eukaryota
COG1073 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158114

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000007143

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7L211

KEGG Orthology (KO)

More...
KOi
K06889

Identification of Orthologs from Complete Genome Data

More...
OMAi
FPEGTHN

Database of Orthologous Groups

More...
OrthoDBi
1036130at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7L211

TreeFam database of animal gene trees

More...
TreeFami
TF315122

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR022742 Hydrolase_4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12146 Hydrolase_4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7L211-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKSWMLWNF VERWLIALAS WSWALCRISL LPLIVTFHLY GGIILLLLIF
60 70 80 90 100
ISIAGILYKF QDVLLYFPEQ PSSSRLYVPM PTGIPHENIF IRTKDGIRLN
110 120 130 140 150
LILIRYTGDN SPYSPTIIYF HGNAGNIGHR LPNALLMLVN LKVNLLLVDY
160 170 180 190 200
RGYGKSEGEA SEEGLYLDSE AVLDYVMTRP DLDKTKIFLF GRSLGGAVAI
210 220 230 240 250
HLASENSHRI SAIMVENTFL SIPHMASTLF SFFPMRYLPL WCYKNKFLSY
260 270 280 290 300
RKISQCRMPS LFISGLSDQL IPPVMMKQLY ELSPSRTKRL AIFPDGTHND
310 320 330
TWQCQGYFTA LEQFIKEVVK SHSPEEMAKT SSNVTII
Length:337
Mass (Da):38,548
Last modified:October 11, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8298BF81784827F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH70226 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AK075195 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAB55387 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti43I → V in AK075195 (PubMed:16303743).Curated1
Sequence conflicti80M → I in AK075195 (PubMed:16303743).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027812 mRNA Translation: BAB55387.1 Different initiation.
AK124864 mRNA Translation: BAG54109.1
AK075195 mRNA No translation available.
AL157762 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09097.1
BC022566 mRNA Translation: AAH22566.2
BC070226 mRNA Translation: AAH70226.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32007.1

NCBI Reference Sequences

More...
RefSeqi
NP_116248.2, NM_032859.2
XP_011519430.1, XM_011521128.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375898; ENSP00000365063; ENSG00000139826

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84945

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84945

UCSC genome browser

More...
UCSCi
uc001vqq.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027812 mRNA Translation: BAB55387.1 Different initiation.
AK124864 mRNA Translation: BAG54109.1
AK075195 mRNA No translation available.
AL157762 Genomic DNA No translation available.
CH471085 Genomic DNA Translation: EAX09097.1
BC022566 mRNA Translation: AAH22566.2
BC070226 mRNA Translation: AAH70226.1 Different initiation.
CCDSiCCDS32007.1
RefSeqiNP_116248.2, NM_032859.2
XP_011519430.1, XM_011521128.2

3D structure databases

SMRiQ7L211
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ7L211, 1 interactor
STRINGi9606.ENSP00000365063

Protein family/group databases

ESTHERihuman-ABHD13 ABHD13-BEM46
MEROPSiS09.051

PTM databases

iPTMnetiQ7L211
PhosphoSitePlusiQ7L211

Polymorphism and mutation databases

BioMutaiABHD13
DMDMi74749881

Proteomic databases

EPDiQ7L211
jPOSTiQ7L211
MassIVEiQ7L211
MaxQBiQ7L211
PaxDbiQ7L211
PeptideAtlasiQ7L211
PRIDEiQ7L211
ProteomicsDBi68754

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84945

Genome annotation databases

EnsembliENST00000375898; ENSP00000365063; ENSG00000139826
GeneIDi84945
KEGGihsa:84945
UCSCiuc001vqq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84945
EuPathDBiHostDB:ENSG00000139826.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ABHD13
HGNCiHGNC:20293 ABHD13
HPAiHPA032143
HPA032144
neXtProtiNX_Q7L211
OpenTargetsiENSG00000139826
PharmGKBiPA134862303

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4391 Eukaryota
COG1073 LUCA
GeneTreeiENSGT00940000158114
HOGENOMiHOG000007143
InParanoidiQ7L211
KOiK06889
OMAiFPEGTHN
OrthoDBi1036130at2759
PhylomeDBiQ7L211
TreeFamiTF315122

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84945
PharosiQ7L211 Tdark

Protein Ontology

More...
PROi
PR:Q7L211
RNActiQ7L211 protein

Gene expression databases

BgeeiENSG00000139826 Expressed in 166 organ(s), highest expression level in leukocyte
ExpressionAtlasiQ7L211 baseline and differential
GenevisibleiQ7L211 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR022742 Hydrolase_4
PfamiView protein in Pfam
PF12146 Hydrolase_4, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABHDD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L211
Secondary accession number(s): B3KWE7, Q8NBW1, Q96JX9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 11, 2004
Last modified: December 11, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again