UniProtKB - Q7L1W4 (LRC8D_HUMAN)

BLAST

>sp|Q7L1W4|LRC8D_HUMAN Volume-regulated anion channel subunit LRRC8D OS=Homo sapiens OX=9606 GN=LRRC8D PE=1 SV=1
MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPS
PVNSKAHTPPGNAEVTTNIPKMEAATNQDQDGRTTNDISFGTSAVTPDIPLRATYPRTDF
ALPNQEAKKEKKDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSS
NFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVST
SSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVED
SDLIYKLYVVQTVIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLIGYEVFECTHNMAY
MLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLL
HMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHISRNAQDKQELHLFMLS
GVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLR
CLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLT
KVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNL
QELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLES
LPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTL
NLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDHLFDTLPL
EVKEALNQDINIPFANGI

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Format
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History
Entry version 141 (07 Nov 2018)
Sequence version 1 (05 Jul 2004)
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Protein

Volume-regulated anion channel subunit LRRC8D

Gene

LRRC8D

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24782309, PubMed:24790029, PubMed:26824658, PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Mediates the import of the antibiotic blasticidin-S into the cell (PubMed:24782309).5 Publications

GO - Molecular functionⁱ

volume-sensitive anion channel activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26824658

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anion transmembrane transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24790029
aspartate transmembrane transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28193731
cellular response to osmotic stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28193731
cell volume homeostasis Source: InterPro
taurine transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28193731
transmembrane transport Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel
Biological process	Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5223345 Miscellaneous transport and binding events

Reactomeⁱ

R-HSA-5223345 Miscellaneous transport and binding events

Protein family/group databases

TCDBⁱ	1.A.25.3.1 the gap junction-forming innexin (innexin) family

TCDBⁱ

1.A.25.3.1 the gap junction-forming innexin (innexin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Volume-regulated anion channel subunit LRRC8D Alternative name(s): Leucine-rich repeat-containing protein 5 Leucine-rich repeat-containing protein 8D
Gene namesⁱ	Name:LRRC8D Synonyms:LRRC5 ORF Names:UNQ213/PRO239
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000171492.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16992 LRRC8D
MIMⁱ	612890 gene
neXtProtⁱ	NX_Q7L1W4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 22	CytoplasmicSequence analysisAdd BLAST	22
Transmembraneⁱ	23 – 43	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	44 – 163	ExtracellularSequence analysisAdd BLAST	120
Transmembraneⁱ	164 – 184	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	185 – 318	CytoplasmicSequence analysisAdd BLAST	134
Transmembraneⁱ	319 – 339	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	340 – 364	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	365 – 385	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	386 – 858	CytoplasmicSequence analysisAdd BLAST	473

Keywords - Cellular componentⁱ

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	44	T → C: Alters channel anion selectivity. 1 Publication		1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000171492
PharmGKBⁱ	PA30464

Polymorphism and mutation databases

BioMutaⁱ	LRRC8D
DMDMⁱ	51701663

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000084493	1 – 858	Volume-regulated anion channel subunit LRRC8DAdd BLAST		858

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	54 ↔ 354	By similarity
Modified residueⁱ	241	PhosphoserineCombined sources	1
Modified residueⁱ	242	PhosphoserineCombined sources	1
Modified residueⁱ	246	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

EPDⁱ	Q7L1W4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q7L1W4
PaxDbⁱ	Q7L1W4
PeptideAtlas More...PeptideAtlasⁱ	Q7L1W4
PRIDEⁱ	Q7L1W4
ProteomicsDBⁱ	68752
TopDownProteomicsⁱ	Q7L1W4

PTM databases

iPTMnetⁱ	Q7L1W4
PhosphoSitePlusⁱ	Q7L1W4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000171492 Expressed in 235 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_LRRC8D
ExpressionAtlasⁱ	Q7L1W4 baseline and differential
Genevisibleⁱ	Q7L1W4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014745

HPAⁱ

HPA014745

Interactionⁱ

Subunit structureⁱ

Heterohexamer (Probable). Oligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8E) to form a heterohexamer (PubMed:24782309, PubMed:26530471, PubMed:28193731, PubMed:26824658). In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist (Probable).Curated5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LRRC8A	Q8IWT6	2	EBI-861997,EBI-10970086

With

Entry

#Exp.

IntAct

Notes

LRRC8A

Q8IWT6

EBI-861997,EBI-10970086

Protein-protein interaction databases

BioGridⁱ	120447, 9 interactors
CORUMⁱ	Q7L1W4
Database of interacting proteins More...DIPⁱ	DIP-31280N
IntActⁱ	Q7L1W4, 2 interactors
STRINGⁱ	9606.ENSP00000338887

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q7L1W4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	514 – 534	LRR 1Add BLAST	21
Repeatⁱ	538 – 559	LRR 2Add BLAST	22
Repeatⁱ	561 – 582	LRR 3Add BLAST	22
Repeatⁱ	589 – 609	LRR 4Add BLAST	21
Repeatⁱ	612 – 632	LRR 5Add BLAST	21
Repeatⁱ	636 – 657	LRR 6Add BLAST	22
Repeatⁱ	659 – 680	LRR 7Add BLAST	22
Repeatⁱ	684 – 705	LRR 8Add BLAST	22
Repeatⁱ	707 – 728	LRR 9Add BLAST	22
Repeatⁱ	730 – 751	LRR 10Add BLAST	22
Repeatⁱ	753 – 774	LRR 11Add BLAST	22
Repeatⁱ	776 – 797	LRR 12Add BLAST	22
Repeatⁱ	799 – 820	LRR 13Add BLAST	22

Sequence similaritiesⁱ

Belongs to the LRRC8 family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0619 Eukaryota COG4886 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150868
HOGENOMⁱ	HOG000231806
HOVERGENⁱ	HBG052360
InParanoidⁱ	Q7L1W4
KEGG Orthology (KO) More...KOⁱ	K22038
OMAⁱ	QLFKCVK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01ER
PhylomeDBⁱ	Q7L1W4
TreeFamⁱ	TF331443

Family and domain databases

Gene3Dⁱ	3.80.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR038960 LRRC8 IPR021040 LRRC8_Pannexin-like
PANTHERⁱ	PTHR43945 PTHR43945, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855 LRR_8, 2 hits PF12534 Pannexin_like, 1 hit
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 7 hits
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 9 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show all Align All

Q7L1W4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MFTLAEVASL NDIQPTYRIL KPWWDVFMDY LAVVMLMVAI FAGTMQLTKD 
        60         70         80         90        100
QVVCLPVLPS PVNSKAHTPP GNAEVTTNIP KMEAATNQDQ DGRTTNDISF 
       110        120        130        140        150
GTSAVTPDIP LRATYPRTDF ALPNQEAKKE KKDPTGRKTN LDFQQYVFIN 
       160        170        180        190        200
QMCYHLALPW YSKYFPYLAL IHTIILMVSS NFWFKYPKTC SKVEHFVSIL 
       210        220        230        240        250
GKCFESPWTT KALSETACED SEENKQRITG AQTLPKHVST SSDEGSPSAS 
       260        270        280        290        300
TPMINKTGFK FSAEKPVIEV PSMTILDKKD GEQAKALFEK VRKFRAHVED 
       310        320        330        340        350
SDLIYKLYVV QTVIKTAKFI FILCYTANFV NAISFEHVCK PKVEHLIGYE 
       360        370        380        390        400
VFECTHNMAY MLKKLLISYI SIICVYGFIC LYTLFWLFRI PLKEYSFEKV 
       410        420        430        440        450
REESSFSDIP DVKNDFAFLL HMVDQYDQLY SKRFGVFLSE VSENKLREIS 
       460        470        480        490        500
LNHEWTFEKL RQHISRNAQD KQELHLFMLS GVPDAVFDLT DLDVLKLELI 
       510        520        530        540        550
PEAKIPAKIS QMTNLQELHL CHCPAKVEQT AFSFLRDHLR CLHVKFTDVA 
       560        570        580        590        600
EIPAWVYLLK NLRELYLIGN LNSENNKMIG LESLRELRHL KILHVKSNLT 
       610        620        630        640        650
KVPSNITDVA PHLTKLVIHN DGTKLLVLNS LKKMMNVAEL ELQNCELERI 
       660        670        680        690        700
PHAIFSLSNL QELDLKSNNI RTIEEIISFQ HLKRLTCLKL WHNKIVTIPP 
       710        720        730        740        750
SITHVKNLES LYFSNNKLES LPVAVFSLQK LRCLDVSYNN ISMIPIEIGL 
       760        770        780        790        800
LQNLQHLHIT GNKVDILPKQ LFKCIKLRTL NLGQNCITSL PEKVGQLSQL 
       810        820        830        840        850
TQLELKGNCL DRLPAQLGQC RMLKKSGLVV EDHLFDTLPL EVKEALNQDI 

NIPFANGI

Length:858

Mass (Da):98,201

Last modified:July 5, 2004 - v1

Checksum:ⁱ52A8B6EEF6F0FE2B

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PMF9	E9PMF9_HUMAN	Volume-regulated anion channel subu... Volume-regulated anion channel subunit LRRC8D	LRRC8D	274	Annotation score:
E9PL08	E9PL08_HUMAN	Volume-regulated anion channel subu... Volume-regulated anion channel subunit LRRC8D	LRRC8D	186	Annotation score:
E9PJS7	E9PJS7_HUMAN	Volume-regulated anion channel subu... Volume-regulated anion channel subunit LRRC8D	LRRC8D	121	Annotation score:
Q5VWA0	Q5VWA0_HUMAN	Volume-regulated anion channel subu... Volume-regulated anion channel subunit LRRC8D	LRRC8D	116	Annotation score:
E9PJ89	E9PJ89_HUMAN	Volume-regulated anion channel subu... Volume-regulated anion channel subunit LRRC8D	LRRC8D	30	Annotation score:

Sequence cautionⁱ

The sequence AAQ89233 differs from that shown. Reason: Erroneous initiation.Curated

The sequence BAA91631 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_051132	371	S → Y. Corresponds to variant dbSNP:rs11552246Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL391497 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW73130.1 CH471097 Genomic DNA Translation: EAW73131.1 CH471097 Genomic DNA Translation: EAW73132.1 BC024159 mRNA Translation: AAH24159.2 AK001332 mRNA Translation: BAA91631.1 Different initiation. AY358874 mRNA Translation: AAQ89233.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS726.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001127951.1, NM_001134479.1 NP_060573.2, NM_018103.4 XP_011539991.1, XM_011541689.1 XP_016857088.1, XM_017001599.1 XP_016857089.1, XM_017001600.1 XP_016857090.1, XM_017001601.1 XP_016857091.1, XM_017001602.1
UniGeneⁱ	Hs.482087

Genome annotation databases

Ensemblⁱ	ENST00000337338; ENSP00000338887; ENSG00000171492 ENST00000394593; ENSP00000378093; ENSG00000171492
GeneIDⁱ	55144
KEGGⁱ	hsa:55144
UCSC genome browser More...UCSCⁱ	uc001dnm.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q7L1W4	Uncharacterized protein DKFZp547I0910 (Fragment)		HUMAN		819	UniRef100_Q7L1W4
Uncharacterized protein DKFZp666L2010 (Fragment)		HUMAN		805
Volume-regulated anion channel subunit LRRC8D (Fragment)		HUMAN		274
Volume-regulated anion channel subunit LRRC8D (Fragment)		HUMAN		121
Volume-regulated anion channel subunit LRRC8D (Fragment)		HUMAN		116
+1

Protein	Similar proteins		Species	Score	Length	Source
Q7L1W4	Volume-regulated anion channel subunit LRRC8D		MOUSE		859	UniRef90_Q7L1W4
Volume-regulated anion channel subunit LRRC8D		RAT		858
Uncharacterized protein DKFZp547I0910 (Fragment)		HUMAN		819
Leucine rich repeat containing 8 VRAC subunit D		MUSPF		912
Uncharacterized protein		CALJA		911
+140

Protein	Similar proteins		Species	Score	Length	Source
Q7L1W4	Volume-regulated anion channel subunit LRRC8D		MOUSE		859	UniRef50_Q7L1W4
Volume-regulated anion channel subunit LRRC8D		RAT		858
Uncharacterized protein DKFZp547I0910 (Fragment)		HUMAN		819
Leucine rich repeat containing 8 VRAC subunit D		MUSPF		912
Uncharacterized protein		CALJA		911
+537

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL391497 Genomic DNA No translation available. CH471097 Genomic DNA Translation: EAW73130.1 CH471097 Genomic DNA Translation: EAW73131.1 CH471097 Genomic DNA Translation: EAW73132.1 BC024159 mRNA Translation: AAH24159.2 AK001332 mRNA Translation: BAA91631.1 Different initiation. AY358874 mRNA Translation: AAQ89233.1 Different initiation.
CCDSⁱ	CCDS726.1
RefSeqⁱ	NP_001127951.1, NM_001134479.1 NP_060573.2, NM_018103.4 XP_011539991.1, XM_011541689.1 XP_016857088.1, XM_017001599.1 XP_016857089.1, XM_017001600.1 XP_016857090.1, XM_017001601.1 XP_016857091.1, XM_017001602.1
UniGeneⁱ	Hs.482087

3D structure databases

ProteinModelPortalⁱ	Q7L1W4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120447, 9 interactors
CORUMⁱ	Q7L1W4
DIPⁱ	DIP-31280N
IntActⁱ	Q7L1W4, 2 interactors
STRINGⁱ	9606.ENSP00000338887

Protein family/group databases

TCDBⁱ	1.A.25.3.1 the gap junction-forming innexin (innexin) family

TCDBⁱ

1.A.25.3.1 the gap junction-forming innexin (innexin) family

PTM databases

iPTMnetⁱ	Q7L1W4
PhosphoSitePlusⁱ	Q7L1W4

Polymorphism and mutation databases

BioMutaⁱ	LRRC8D
DMDMⁱ	51701663

Proteomic databases

EPDⁱ	Q7L1W4
MaxQBⁱ	Q7L1W4
PaxDbⁱ	Q7L1W4
PeptideAtlasⁱ	Q7L1W4
PRIDEⁱ	Q7L1W4
ProteomicsDBⁱ	68752
TopDownProteomicsⁱ	Q7L1W4

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55144
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000337338; ENSP00000338887; ENSG00000171492 ENST00000394593; ENSP00000378093; ENSG00000171492
GeneIDⁱ	55144
KEGGⁱ	hsa:55144
UCSCⁱ	uc001dnm.4 human

Organism-specific databases

CTDⁱ	55144
EuPathDBⁱ	HostDB:ENSG00000171492.14
GeneCardsⁱ	LRRC8D
HGNCⁱ	HGNC:16992 LRRC8D
HPAⁱ	HPA014745
MIMⁱ	612890 gene
neXtProtⁱ	NX_Q7L1W4
OpenTargetsⁱ	ENSG00000171492
PharmGKBⁱ	PA30464
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0619 Eukaryota COG4886 LUCA
GeneTreeⁱ	ENSGT00930000150868
HOGENOMⁱ	HOG000231806
HOVERGENⁱ	HBG052360
InParanoidⁱ	Q7L1W4
KOⁱ	K22038
OMAⁱ	QLFKCVK
OrthoDBⁱ	EOG091G01ER
PhylomeDBⁱ	Q7L1W4
TreeFamⁱ	TF331443

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5223345 Miscellaneous transport and binding events

Reactomeⁱ

R-HSA-5223345 Miscellaneous transport and binding events

Miscellaneous databases

ChiTaRSⁱ	LRRC8D human
GeneWikiⁱ	LRRC8D
GenomeRNAiⁱ	55144
Protein Ontology More...PROⁱ	PR:Q7L1W4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000171492 Expressed in 235 organ(s), highest expression level in corpus callosum
CleanExⁱ	HS_LRRC8D
ExpressionAtlasⁱ	Q7L1W4 baseline and differential
Genevisibleⁱ	Q7L1W4 HS

Family and domain databases

Gene3Dⁱ	3.80.10.10, 2 hits
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR038960 LRRC8 IPR021040 LRRC8_Pannexin-like
PANTHERⁱ	PTHR43945 PTHR43945, 1 hit
Pfamⁱ	View protein in Pfam PF13855 LRR_8, 2 hits PF12534 Pannexin_like, 1 hit
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 7 hits
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LRC8D_HUMAN
Accessionⁱ	Q7L1W4Primary (citable) accession number: Q7L1W4 Secondary accession number(s): D3DT29, Q6UWB2, Q9NVW3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7L1W4 (LRC8D_HUMAN)

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Volume-regulated anion channel subunit LRRC8D

LRRC8D

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ