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Entry version 141 (29 Sep 2021)
Sequence version 1 (30 Aug 2005)
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Protein

Cytochrome b5 reductase 4

Gene

CYB5R4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD1 Publication

Redox potential

E0 is -108 mV.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=25 mM for O2

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi89Iron (heme axial ligand)1
Metal bindingi112Iron (heme axial ligand)1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi365 – 380FADBy similarityAdd BLAST16
Nucleotide bindingi392 – 424FADBy similarityAdd BLAST33

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, Heme, Iron, Metal-binding, NAD

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.6.2.2, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7L1T6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1237044, Erythrocytes take up carbon dioxide and release oxygen

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome b5 reductase 4 (EC:1.6.2.2)
Alternative name(s):
Flavohemoprotein b5/b5R
Short name:
b5+b5R
N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
cb5/cb5R
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYB5R4
Synonyms:NCB5OR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20147, CYB5R4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608343, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7L1T6

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000065615

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endoplasmic reticulum

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
51167

Open Targets

More...
OpenTargetsi
ENSG00000065615

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134904907

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7L1T6, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CYB5R4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002875561 – 521Cytochrome b5 reductase 4Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7L1T6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7L1T6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7L1T6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7L1T6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7L1T6

PeptideAtlas

More...
PeptideAtlasi
Q7L1T6

PRoteomics IDEntifications database

More...
PRIDEi
Q7L1T6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
68750

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q7L1T6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7L1T6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7L1T6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000065615, Expressed in leukocyte and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7L1T6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7L1T6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000065615, Tissue enhanced (blood)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119347, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q7L1T6, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358695

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7L1T6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1521
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7L1T6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7L1T6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 130Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST77
Domaini165 – 256CSPROSITE-ProRule annotationAdd BLAST92
Domaini273 – 385FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 21Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0534, Eukaryota
KOG0536, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155536

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003827_0_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7L1T6

Identification of Orthologs from Complete Genome Data

More...
OMAi
KCALKPG

Database of Orthologous Groups

More...
OrthoDBi
1311668at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7L1T6

TreeFam database of animal gene trees

More...
TreeFami
TF313874

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06490, p23_NCB5OR, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.790, 1 hit
3.10.120.10, 1 hit
3.40.50.80, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001834, CBR-like
IPR008333, Cbr1-like_FAD-bd_dom
IPR007052, CS_dom
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR018506, Cyt_B5_heme-BS
IPR017927, FAD-bd_FR_type
IPR039261, FNR_nucleotide-bd
IPR008978, HSP20-like_chaperone
IPR001433, OxRdtase_FAD/NAD-bd
IPR037908, p23_NCB5OR
IPR017938, Riboflavin_synthase-like_b-brl

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04969, CS, 1 hit
PF00173, Cyt-b5, 1 hit
PF00970, FAD_binding_6, 1 hit
PF00175, NAD_binding_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00406, CYTB5RDTASE
PR00363, CYTOCHROMEB5

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01117, Cyt-b5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49764, SSF49764, 1 hit
SSF52343, SSF52343, 1 hit
SSF55856, SSF55856, 1 hit
SSF63380, SSF63380, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51203, CS, 1 hit
PS00191, CYTOCHROME_B5_1, 1 hit
PS50255, CYTOCHROME_B5_2, 1 hit
PS51384, FAD_FR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7L1T6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNVPSQSFP APRSQQRVAS GGRSKVPLKQ GRSLMDWIRL TKSGKDLTGL
60 70 80 90 100
KGRLIEVTEE ELKKHNKKDD CWICIRGFVY NVSPYMEYHP GGEDELMRAA
110 120 130 140 150
GSDGTELFDQ VHRWVNYESM LKECLVGRMA IKPAVLKDYR EEEKKVLNGM
160 170 180 190 200
LPKSQVTDTL AKEGPSYPSY DWFQTDSLVT IAIYTKQKDI NLDSIIVDHQ
210 220 230 240 250
NDSFRAETII KDCLYLIHIG LSHEVQEDFS VRVVESVGKI EIVLQKKENT
260 270 280 290 300
SWDFLGHPLK NHNSLIPRKD TGLYYRKCQL ISKEDVTHDT RLFCLMLPPS
310 320 330 340 350
THLQVPIGQH VYLKLPITGT EIVKPYTPVS GSLLSEFKEP VLPNNKYIYF
360 370 380 390 400
LIKIYPTGLF TPELDRLQIG DFVSVSSPEG NFKISKFQEL EDLFLLAAGT
410 420 430 440 450
GFTPMVKILN YALTDIPSLR KVKLMFFNKT EDDIIWRSQL EKLAFKDKRL
460 470 480 490 500
DVEFVLSAPI SEWNGKQGHI SPALLSEFLK RNLDKSKVLV CICGPVPFTE
510 520
QGVRLLHDLN FSKNEIHSFT A
Length:521
Mass (Da):59,474
Last modified:August 30, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D83BAB387E3B0F4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRM6A0A0A0MRM6_HUMAN
Cytochrome b5 reductase 4
CYB5R4
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF04812 differs from that shown. Reason: Erroneous initiation.Curated

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Variants Arg-187 and Arg-223 do not influence the pathogenesis of non-autoimmune diabetes.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047967140R → H1 PublicationCorresponds to variant dbSNP:rs61762820Ensembl.1
Natural variantiVAR_032323187Q → R1 PublicationCorresponds to variant dbSNP:rs143478181Ensembl.1
Natural variantiVAR_032324223H → R1 PublicationCorresponds to variant dbSNP:rs141290525Ensembl.1
Natural variantiVAR_047968267P → A1 PublicationCorresponds to variant dbSNP:rs61382555EnsemblClinVar.1
Natural variantiVAR_032325282S → P. Corresponds to variant dbSNP:rs10080628Ensembl.1
Natural variantiVAR_047969316P → S1 PublicationCorresponds to variant dbSNP:rs10080628Ensembl.1
Natural variantiVAR_036240371D → Y in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_036241390L → M in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU448291 Genomic DNA Translation: ACA06109.1
AL034347 Genomic DNA No translation available.
AL139232 Genomic DNA No translation available.
BC025380 mRNA Translation: AAH25380.2
AF169803 mRNA Translation: AAF04812.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5000.2

NCBI Reference Sequences

More...
RefSeqi
NP_057314.2, NM_016230.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369681; ENSP00000358695; ENSG00000065615

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51167

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51167

UCSC genome browser

More...
UCSCi
uc003pkf.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU448291 Genomic DNA Translation: ACA06109.1
AL034347 Genomic DNA No translation available.
AL139232 Genomic DNA No translation available.
BC025380 mRNA Translation: AAH25380.2
AF169803 mRNA Translation: AAF04812.1 Different initiation.
CCDSiCCDS5000.2
RefSeqiNP_057314.2, NM_016230.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LF5X-ray1.25A/B51-137[»]
6MV1X-ray2.15A164-521[»]
6MV2X-ray2.05A164-521[»]
SMRiQ7L1T6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119347, 2 interactors
IntActiQ7L1T6, 1 interactor
STRINGi9606.ENSP00000358695

PTM databases

iPTMnetiQ7L1T6
PhosphoSitePlusiQ7L1T6

Genetic variation databases

BioMutaiCYB5R4

Proteomic databases

EPDiQ7L1T6
jPOSTiQ7L1T6
MassIVEiQ7L1T6
MaxQBiQ7L1T6
PaxDbiQ7L1T6
PeptideAtlasiQ7L1T6
PRIDEiQ7L1T6
ProteomicsDBi68750
TopDownProteomicsiQ7L1T6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
18533, 154 antibodies

The DNASU plasmid repository

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DNASUi
51167

Genome annotation databases

EnsembliENST00000369681; ENSP00000358695; ENSG00000065615
GeneIDi51167
KEGGihsa:51167
UCSCiuc003pkf.4, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51167
DisGeNETi51167

GeneCards: human genes, protein and diseases

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GeneCardsi
CYB5R4
HGNCiHGNC:20147, CYB5R4
HPAiENSG00000065615, Tissue enhanced (blood)
MIMi608343, gene
neXtProtiNX_Q7L1T6
OpenTargetsiENSG00000065615
PharmGKBiPA134904907
VEuPathDBiHostDB:ENSG00000065615

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0534, Eukaryota
KOG0536, Eukaryota
GeneTreeiENSGT00940000155536
HOGENOMiCLU_003827_0_2_1
InParanoidiQ7L1T6
OMAiKCALKPG
OrthoDBi1311668at2759
PhylomeDBiQ7L1T6
TreeFamiTF313874

Enzyme and pathway databases

BRENDAi1.6.2.2, 2681
PathwayCommonsiQ7L1T6
ReactomeiR-HSA-1237044, Erythrocytes take up carbon dioxide and release oxygen

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51167, 202 hits in 1020 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CYB5R4, human
EvolutionaryTraceiQ7L1T6

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CYB5R4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51167
PharosiQ7L1T6, Tbio

Protein Ontology

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PROi
PR:Q7L1T6
RNActiQ7L1T6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000065615, Expressed in leukocyte and 213 other tissues
ExpressionAtlasiQ7L1T6, baseline and differential
GenevisibleiQ7L1T6, HS

Family and domain databases

CDDicd06490, p23_NCB5OR, 1 hit
Gene3Di2.60.40.790, 1 hit
3.10.120.10, 1 hit
3.40.50.80, 1 hit
InterProiView protein in InterPro
IPR001834, CBR-like
IPR008333, Cbr1-like_FAD-bd_dom
IPR007052, CS_dom
IPR001199, Cyt_B5-like_heme/steroid-bd
IPR036400, Cyt_B5-like_heme/steroid_sf
IPR018506, Cyt_B5_heme-BS
IPR017927, FAD-bd_FR_type
IPR039261, FNR_nucleotide-bd
IPR008978, HSP20-like_chaperone
IPR001433, OxRdtase_FAD/NAD-bd
IPR037908, p23_NCB5OR
IPR017938, Riboflavin_synthase-like_b-brl
PfamiView protein in Pfam
PF04969, CS, 1 hit
PF00173, Cyt-b5, 1 hit
PF00970, FAD_binding_6, 1 hit
PF00175, NAD_binding_1, 1 hit
PRINTSiPR00406, CYTB5RDTASE
PR00363, CYTOCHROMEB5
SMARTiView protein in SMART
SM01117, Cyt-b5, 1 hit
SUPFAMiSSF49764, SSF49764, 1 hit
SSF52343, SSF52343, 1 hit
SSF55856, SSF55856, 1 hit
SSF63380, SSF63380, 1 hit
PROSITEiView protein in PROSITE
PS51203, CS, 1 hit
PS00191, CYTOCHROME_B5_1, 1 hit
PS50255, CYTOCHROME_B5_2, 1 hit
PS51384, FAD_FR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNB5R4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L1T6
Secondary accession number(s): B1AEM2
, Q5TGI9, Q9NUE4, Q9UHI9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: August 30, 2005
Last modified: September 29, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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