Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 130 (18 Sep 2019)
Sequence version 1 (30 Aug 2005)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Cytochrome b5 reductase 4

Gene

CYB5R4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD1 Publication

Redox potential

E0 is -108 mV.

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=25 mM for O2

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi89Iron (heme axial ligand)1
    Metal bindingi112Iron (heme axial ligand)1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi365 – 380FADBy similarityAdd BLAST16
    Nucleotide bindingi392 – 424FADBy similarityAdd BLAST33

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionOxidoreductase
    LigandFAD, Flavoprotein, Heme, Iron, Metal-binding, NAD

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    1.6.2.2 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cytochrome b5 reductase 4 (EC:1.6.2.2)
    Alternative name(s):
    Flavohemoprotein b5/b5R
    Short name:
    b5+b5R
    N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
    cb5/cb5R
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CYB5R4
    Synonyms:NCB5OR
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:20147 CYB5R4

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    608343 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q7L1T6

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Endoplasmic reticulum

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    51167

    Open Targets

    More...
    OpenTargetsi
    ENSG00000065615

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134904907

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CYB5R4

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002875561 – 521Cytochrome b5 reductase 4Add BLAST521

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q7L1T6

    jPOST - Japan Proteome Standard Repository/Database

    More...
    jPOSTi
    Q7L1T6

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q7L1T6

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q7L1T6

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q7L1T6

    PeptideAtlas

    More...
    PeptideAtlasi
    Q7L1T6

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q7L1T6

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    68750

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q7L1T6

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q7L1T6

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q7L1T6

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000065615 Expressed in 199 organ(s), highest expression level in leukocyte

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q7L1T6 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q7L1T6 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA018992

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    119347, 1 interactor

    Protein interaction database and analysis system

    More...
    IntActi
    Q7L1T6, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000358695

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1521
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q7L1T6

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q7L1T6

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 130Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST77
    Domaini165 – 256CSPROSITE-ProRule annotationAdd BLAST92
    Domaini273 – 385FAD-binding FR-typePROSITE-ProRule annotationAdd BLAST113

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0534 Eukaryota
    KOG0536 Eukaryota
    COG0543 LUCA
    COG5274 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155536

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000230826

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q7L1T6

    KEGG Orthology (KO)

    More...
    KOi
    K00326

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    KCALKPG

    Database of Orthologous Groups

    More...
    OrthoDBi
    1311668at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q7L1T6

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313874

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd06490 p23_NCB5OR, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.40.790, 1 hit
    3.10.120.10, 1 hit
    3.40.50.80, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001834 CBR-like
    IPR008333 Cbr1-like_FAD-bd_dom
    IPR007052 CS_dom
    IPR001199 Cyt_B5-like_heme/steroid-bd
    IPR036400 Cyt_B5-like_heme/steroid_sf
    IPR018506 Cyt_B5_heme-BS
    IPR017927 FAD-bd_FR_type
    IPR039261 FNR_nucleotide-bd
    IPR008978 HSP20-like_chaperone
    IPR001433 OxRdtase_FAD/NAD-bd
    IPR037908 p23_NCB5OR
    IPR017938 Riboflavin_synthase-like_b-brl

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF04969 CS, 1 hit
    PF00173 Cyt-b5, 1 hit
    PF00970 FAD_binding_6, 1 hit
    PF00175 NAD_binding_1, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00406 CYTB5RDTASE
    PR00363 CYTOCHROMEB5

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM01117 Cyt-b5, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF49764 SSF49764, 1 hit
    SSF52343 SSF52343, 1 hit
    SSF55856 SSF55856, 1 hit
    SSF63380 SSF63380, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51203 CS, 1 hit
    PS00191 CYTOCHROME_B5_1, 1 hit
    PS50255 CYTOCHROME_B5_2, 1 hit
    PS51384 FAD_FR, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q7L1T6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MLNVPSQSFP APRSQQRVAS GGRSKVPLKQ GRSLMDWIRL TKSGKDLTGL
    60 70 80 90 100
    KGRLIEVTEE ELKKHNKKDD CWICIRGFVY NVSPYMEYHP GGEDELMRAA
    110 120 130 140 150
    GSDGTELFDQ VHRWVNYESM LKECLVGRMA IKPAVLKDYR EEEKKVLNGM
    160 170 180 190 200
    LPKSQVTDTL AKEGPSYPSY DWFQTDSLVT IAIYTKQKDI NLDSIIVDHQ
    210 220 230 240 250
    NDSFRAETII KDCLYLIHIG LSHEVQEDFS VRVVESVGKI EIVLQKKENT
    260 270 280 290 300
    SWDFLGHPLK NHNSLIPRKD TGLYYRKCQL ISKEDVTHDT RLFCLMLPPS
    310 320 330 340 350
    THLQVPIGQH VYLKLPITGT EIVKPYTPVS GSLLSEFKEP VLPNNKYIYF
    360 370 380 390 400
    LIKIYPTGLF TPELDRLQIG DFVSVSSPEG NFKISKFQEL EDLFLLAAGT
    410 420 430 440 450
    GFTPMVKILN YALTDIPSLR KVKLMFFNKT EDDIIWRSQL EKLAFKDKRL
    460 470 480 490 500
    DVEFVLSAPI SEWNGKQGHI SPALLSEFLK RNLDKSKVLV CICGPVPFTE
    510 520
    QGVRLLHDLN FSKNEIHSFT A
    Length:521
    Mass (Da):59,474
    Last modified:August 30, 2005 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D83BAB387E3B0F4
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A0A0MRM6A0A0A0MRM6_HUMAN
    Cytochrome b5 reductase 4
    CYB5R4
    109Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAF04812 differs from that shown. Reason: Erroneous initiation.Curated

    <p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

    Variants Arg-187 and Arg-223 do not influence the pathogenesis of non-autoimmune diabetes.1 Publication

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_047967140R → H1 PublicationCorresponds to variant dbSNP:rs61762820Ensembl.1
    Natural variantiVAR_032323187Q → R1 PublicationCorresponds to variant dbSNP:rs143478181Ensembl.1
    Natural variantiVAR_032324223H → R1 PublicationCorresponds to variant dbSNP:rs141290525Ensembl.1
    Natural variantiVAR_047968267P → A1 PublicationCorresponds to variant dbSNP:rs61382555Ensembl.1
    Natural variantiVAR_032325282S → P. Corresponds to variant dbSNP:rs10080628Ensembl.1
    Natural variantiVAR_047969316P → S1 PublicationCorresponds to variant dbSNP:rs10080628Ensembl.1
    Natural variantiVAR_036240371D → Y in a breast cancer sample; somatic mutation. 1 Publication1
    Natural variantiVAR_036241390L → M in a breast cancer sample; somatic mutation. 1 Publication1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    EU448291 Genomic DNA Translation: ACA06109.1
    AL034347 Genomic DNA No translation available.
    AL139232 Genomic DNA No translation available.
    BC025380 mRNA Translation: AAH25380.2
    AF169803 mRNA Translation: AAF04812.1 Different initiation.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS5000.2

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_057314.2, NM_016230.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000369681; ENSP00000358695; ENSG00000065615

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    51167

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:51167

    UCSC genome browser

    More...
    UCSCi
    uc003pkf.4 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    EU448291 Genomic DNA Translation: ACA06109.1
    AL034347 Genomic DNA No translation available.
    AL139232 Genomic DNA No translation available.
    BC025380 mRNA Translation: AAH25380.2
    AF169803 mRNA Translation: AAF04812.1 Different initiation.
    CCDSiCCDS5000.2
    RefSeqiNP_057314.2, NM_016230.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    3LF5X-ray1.25A/B51-137[»]
    6MV1X-ray2.15A164-521[»]
    6MV2X-ray2.05A164-521[»]
    SMRiQ7L1T6
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGridi119347, 1 interactor
    IntActiQ7L1T6, 1 interactor
    STRINGi9606.ENSP00000358695

    PTM databases

    iPTMnetiQ7L1T6
    PhosphoSitePlusiQ7L1T6

    Polymorphism and mutation databases

    BioMutaiCYB5R4

    Proteomic databases

    EPDiQ7L1T6
    jPOSTiQ7L1T6
    MassIVEiQ7L1T6
    MaxQBiQ7L1T6
    PaxDbiQ7L1T6
    PeptideAtlasiQ7L1T6
    PRIDEiQ7L1T6
    ProteomicsDBi68750
    TopDownProteomicsiQ7L1T6

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    51167
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000369681; ENSP00000358695; ENSG00000065615
    GeneIDi51167
    KEGGihsa:51167
    UCSCiuc003pkf.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    51167
    DisGeNETi51167

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    CYB5R4
    HGNCiHGNC:20147 CYB5R4
    HPAiHPA018992
    MIMi608343 gene
    neXtProtiNX_Q7L1T6
    OpenTargetsiENSG00000065615
    PharmGKBiPA134904907

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG0534 Eukaryota
    KOG0536 Eukaryota
    COG0543 LUCA
    COG5274 LUCA
    GeneTreeiENSGT00940000155536
    HOGENOMiHOG000230826
    InParanoidiQ7L1T6
    KOiK00326
    OMAiKCALKPG
    OrthoDBi1311668at2759
    PhylomeDBiQ7L1T6
    TreeFamiTF313874

    Enzyme and pathway databases

    BRENDAi1.6.2.2 2681
    ReactomeiR-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    CYB5R4 human
    EvolutionaryTraceiQ7L1T6

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    CYB5R4

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    51167

    Pharos

    More...
    Pharosi
    Q7L1T6

    Protein Ontology

    More...
    PROi
    PR:Q7L1T6

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000065615 Expressed in 199 organ(s), highest expression level in leukocyte
    ExpressionAtlasiQ7L1T6 baseline and differential
    GenevisibleiQ7L1T6 HS

    Family and domain databases

    CDDicd06490 p23_NCB5OR, 1 hit
    Gene3Di2.60.40.790, 1 hit
    3.10.120.10, 1 hit
    3.40.50.80, 1 hit
    InterProiView protein in InterPro
    IPR001834 CBR-like
    IPR008333 Cbr1-like_FAD-bd_dom
    IPR007052 CS_dom
    IPR001199 Cyt_B5-like_heme/steroid-bd
    IPR036400 Cyt_B5-like_heme/steroid_sf
    IPR018506 Cyt_B5_heme-BS
    IPR017927 FAD-bd_FR_type
    IPR039261 FNR_nucleotide-bd
    IPR008978 HSP20-like_chaperone
    IPR001433 OxRdtase_FAD/NAD-bd
    IPR037908 p23_NCB5OR
    IPR017938 Riboflavin_synthase-like_b-brl
    PfamiView protein in Pfam
    PF04969 CS, 1 hit
    PF00173 Cyt-b5, 1 hit
    PF00970 FAD_binding_6, 1 hit
    PF00175 NAD_binding_1, 1 hit
    PRINTSiPR00406 CYTB5RDTASE
    PR00363 CYTOCHROMEB5
    SMARTiView protein in SMART
    SM01117 Cyt-b5, 1 hit
    SUPFAMiSSF49764 SSF49764, 1 hit
    SSF52343 SSF52343, 1 hit
    SSF55856 SSF55856, 1 hit
    SSF63380 SSF63380, 1 hit
    PROSITEiView protein in PROSITE
    PS51203 CS, 1 hit
    PS00191 CYTOCHROME_B5_1, 1 hit
    PS50255 CYTOCHROME_B5_2, 1 hit
    PS51384 FAD_FR, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNB5R4_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L1T6
    Secondary accession number(s): B1AEM2
    , Q5TGI9, Q9NUE4, Q9UHI9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: August 30, 2005
    Last modified: September 18, 2019
    This is version 130 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

    We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

    Do not show this banner again