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Entry version 147 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Synaptic vesicle glycoprotein 2B

Gene

SV2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably plays a role in the control of regulated secretion in neural and endocrine cells.By similarity
(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q7L1I2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5250955, Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250968, Toxicity of botulinum toxin type A (BoNT/A)
R-HSA-5250981, Toxicity of botulinum toxin type F (BoNT/F)
R-HSA-5250992, Toxicity of botulinum toxin type E (BoNT/E)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SV2B
Synonyms:KIAA0735
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185518.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16874, SV2B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
185861, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7L1I2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 108CytoplasmicSequence analysisAdd BLAST108
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 148ExtracellularSequence analysisAdd BLAST19
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Topological domaini170 – 182CytoplasmicSequence analysisAdd BLAST13
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 205ExtracellularSequence analysis2
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 237CytoplasmicSequence analysisAdd BLAST11
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Topological domaini259 – 277ExtracellularSequence analysisAdd BLAST19
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 390CytoplasmicSequence analysisAdd BLAST92
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 535ExtracellularSequence analysisAdd BLAST124
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Topological domaini557 – 565CytoplasmicSequence analysis9
Transmembranei566 – 586HelicalSequence analysisAdd BLAST21
Topological domaini587 – 592ExtracellularSequence analysis6
Transmembranei593 – 613HelicalSequence analysisAdd BLAST21
Topological domaini614 – 626CytoplasmicSequence analysisAdd BLAST13
Transmembranei627 – 649HelicalSequence analysisAdd BLAST23
Topological domaini650 – 653ExtracellularSequence analysis4
Transmembranei654 – 672HelicalSequence analysisAdd BLAST19
Topological domaini673 – 683CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9899

Open Targets

More...
OpenTargetsi
ENSG00000185518

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134930999

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7L1I2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SV2B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74738530

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002397681 – 683Synaptic vesicle glycoprotein 2BAdd BLAST683

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei33PhosphoserineBy similarity1
Modified residuei36PhosphothreonineBy similarity1
Modified residuei423PhosphotyrosineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi441N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi516N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity
The N-terminal cytoplasmic domain is phosphorylated by CK1.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q7L1I2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7L1I2

PeptideAtlas

More...
PeptideAtlasi
Q7L1I2

PRoteomics IDEntifications database

More...
PRIDEi
Q7L1I2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
4186
68743 [Q7L1I2-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q7L1I2, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7L1I2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7L1I2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185518, Expressed in middle temporal gyrus and 175 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7L1I2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000185518, Tissue enriched (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SYT1 in a calcium-independent manner.

Forms a complex with SYT1, syntaxin-1 and SNAP25 (By similarity).

By similarity

(Microbial infection) Interacts with C.botulinum neurotoxin type A2 (BoNT/A, botA) (PubMed:29649119). Interaction is improved by glycosylation of SV2 (PubMed:29649119).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
115228, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q7L1I2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377779

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q7L1I2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7L1I2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0255, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182940

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001265_46_15_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7L1I2

KEGG Orthology (KO)

More...
KOi
K06258

Identification of Orthologs from Complete Genome Data

More...
OMAi
GLTFMPE

Database of Orthologous Groups

More...
OrthoDBi
724235at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7L1I2

TreeFam database of animal gene trees

More...
TreeFami
TF324824

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001646, 5peptide_repeat
IPR011701, MFS
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR005829, Sugar_transporter_CS
IPR022308, SV2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07690, MFS_1, 1 hit
PF13599, Pentapeptide_4, 1 hit
PF00083, Sugar_tr, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103473, SSF103473, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01299, synapt_SV2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50850, MFS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7L1I2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDDYKYQDNY GGYAPSDGYY RGNESNPEED AQSDVTEGHD EEDEIYEGEY
60 70 80 90 100
QGIPHPDDVK AKQAKMAPSR MDSLRGQTDL MAERLEDEEQ LAHQYETIMD
110 120 130 140 150
ECGHGRFQWI LFFVLGLALM ADGVEVFVVS FALPSAEKDM CLSSSKKGML
160 170 180 190 200
GMIVYLGMMA GAFILGGLAD KLGRKRVLSM SLAVNASFAS LSSFVQGYGA
210 220 230 240 250
FLFCRLISGI GIGGALPIVF AYFSEFLSRE KRGEHLSWLG IFWMTGGLYA
260 270 280 290 300
SAMAWSIIPH YGWGFSMGTN YHFHSWRVFV IVCALPCTVS MVALKFMPES
310 320 330 340 350
PRFLLEMGKH DEAWMILKQV HDTNMRAKGT PEKVFTVSNI KTPKQMDEFI
360 370 380 390 400
EIQSSTGTWY QRWLVRFKTI FKQVWDNALY CVMGPYRMNT LILAVVWFAM
410 420 430 440 450
AFSYYGLTVW FPDMIRYFQD EEYKSKMKVF FGEHVYGATI NFTMENQIHQ
460 470 480 490 500
HGKLVNDKFT RMYFKHVLFE DTFFDECYFE DVTSTDTYFK NCTIESTIFY
510 520 530 540 550
NTDLYEHKFI NCRFINSTFL EQKEGCHMDL EQDNDFLIYL VSFLGSLSVL
560 570 580 590 600
PGNIISALLM DRIGRLKMIG GSMLISAVCC FFLFFGNSES AMIGWQCLFC
610 620 630 640 650
GTSIAAWNAL DVITVELYPT NQRATAFGIL NGLCKFGAIL GNTIFASFVG
660 670 680
ITKVVPILLA AASLVGGGLI ALRLPETREQ VLM
Length:683
Mass (Da):77,444
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9818120898F09E2
GO
Isoform 2 (identifier: Q7L1I2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-151: Missing.

Show »
Length:532
Mass (Da):60,439
Checksum:i0079FA3304D1C038
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34455 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti683M → I in CAG33367 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0451941 – 151Missing in isoform 2. 1 PublicationAdd BLAST151

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018278 mRNA Translation: BAA34455.2 Different initiation.
CR457086 mRNA Translation: CAG33367.1
AK294902 mRNA Translation: BAG57991.1
FJ515843 Genomic DNA Translation: ACS13737.1
AC123784 Genomic DNA No translation available.
AC127520 Genomic DNA No translation available.
CH471101 Genomic DNA Translation: EAX02143.1
BC030011 mRNA Translation: AAH30011.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10370.1 [Q7L1I2-1]
CCDS53972.1 [Q7L1I2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001161052.1, NM_001167580.2 [Q7L1I2-2]
NP_001309960.1, NM_001323031.2 [Q7L1I2-1]
NP_001309961.1, NM_001323032.2 [Q7L1I2-1]
NP_001309966.1, NM_001323037.2 [Q7L1I2-1]
NP_001309967.1, NM_001323038.2 [Q7L1I2-1]
NP_001309968.1, NM_001323039.2 [Q7L1I2-1]
NP_001309969.1, NM_001323040.2 [Q7L1I2-2]
NP_055663.1, NM_014848.6 [Q7L1I2-1]
XP_005255055.1, XM_005254998.3 [Q7L1I2-1]
XP_016878250.1, XM_017022761.1 [Q7L1I2-1]
XP_016878251.1, XM_017022762.1 [Q7L1I2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330276; ENSP00000332818; ENSG00000185518 [Q7L1I2-1]
ENST00000394232; ENSP00000377779; ENSG00000185518 [Q7L1I2-1]
ENST00000545111; ENSP00000443243; ENSG00000185518 [Q7L1I2-2]
ENST00000557410; ENSP00000450992; ENSG00000185518 [Q7L1I2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9899

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9899

UCSC genome browser

More...
UCSCi
uc010uqv.3, human [Q7L1I2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018278 mRNA Translation: BAA34455.2 Different initiation.
CR457086 mRNA Translation: CAG33367.1
AK294902 mRNA Translation: BAG57991.1
FJ515843 Genomic DNA Translation: ACS13737.1
AC123784 Genomic DNA No translation available.
AC127520 Genomic DNA No translation available.
CH471101 Genomic DNA Translation: EAX02143.1
BC030011 mRNA Translation: AAH30011.1
CCDSiCCDS10370.1 [Q7L1I2-1]
CCDS53972.1 [Q7L1I2-2]
RefSeqiNP_001161052.1, NM_001167580.2 [Q7L1I2-2]
NP_001309960.1, NM_001323031.2 [Q7L1I2-1]
NP_001309961.1, NM_001323032.2 [Q7L1I2-1]
NP_001309966.1, NM_001323037.2 [Q7L1I2-1]
NP_001309967.1, NM_001323038.2 [Q7L1I2-1]
NP_001309968.1, NM_001323039.2 [Q7L1I2-1]
NP_001309969.1, NM_001323040.2 [Q7L1I2-2]
NP_055663.1, NM_014848.6 [Q7L1I2-1]
XP_005255055.1, XM_005254998.3 [Q7L1I2-1]
XP_016878250.1, XM_017022761.1 [Q7L1I2-1]
XP_016878251.1, XM_017022762.1 [Q7L1I2-1]

3D structure databases

SMRiQ7L1I2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115228, 5 interactors
IntActiQ7L1I2, 1 interactor
STRINGi9606.ENSP00000377779

PTM databases

GlyGeniQ7L1I2, 3 sites
iPTMnetiQ7L1I2
PhosphoSitePlusiQ7L1I2

Polymorphism and mutation databases

BioMutaiSV2B
DMDMi74738530

Proteomic databases

MassIVEiQ7L1I2
PaxDbiQ7L1I2
PeptideAtlasiQ7L1I2
PRIDEiQ7L1I2
ProteomicsDBi4186
68743 [Q7L1I2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
29003, 136 antibodies

The DNASU plasmid repository

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DNASUi
9899

Genome annotation databases

EnsembliENST00000330276; ENSP00000332818; ENSG00000185518 [Q7L1I2-1]
ENST00000394232; ENSP00000377779; ENSG00000185518 [Q7L1I2-1]
ENST00000545111; ENSP00000443243; ENSG00000185518 [Q7L1I2-2]
ENST00000557410; ENSP00000450992; ENSG00000185518 [Q7L1I2-1]
GeneIDi9899
KEGGihsa:9899
UCSCiuc010uqv.3, human [Q7L1I2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9899
DisGeNETi9899
EuPathDBiHostDB:ENSG00000185518.11

GeneCards: human genes, protein and diseases

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GeneCardsi
SV2B
HGNCiHGNC:16874, SV2B
HPAiENSG00000185518, Tissue enriched (brain)
MIMi185861, gene
neXtProtiNX_Q7L1I2
OpenTargetsiENSG00000185518
PharmGKBiPA134930999

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0255, Eukaryota
GeneTreeiENSGT00950000182940
HOGENOMiCLU_001265_46_15_1
InParanoidiQ7L1I2
KOiK06258
OMAiGLTFMPE
OrthoDBi724235at2759
PhylomeDBiQ7L1I2
TreeFamiTF324824

Enzyme and pathway databases

PathwayCommonsiQ7L1I2
ReactomeiR-HSA-5250955, Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250968, Toxicity of botulinum toxin type A (BoNT/A)
R-HSA-5250981, Toxicity of botulinum toxin type F (BoNT/F)
R-HSA-5250992, Toxicity of botulinum toxin type E (BoNT/E)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
9899, 3 hits in 872 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SV2B, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SV2B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9899
PharosiQ7L1I2, Tbio

Protein Ontology

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PROi
PR:Q7L1I2
RNActiQ7L1I2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185518, Expressed in middle temporal gyrus and 175 other tissues
GenevisibleiQ7L1I2, HS

Family and domain databases

InterProiView protein in InterPro
IPR001646, 5peptide_repeat
IPR011701, MFS
IPR020846, MFS_dom
IPR005828, MFS_sugar_transport-like
IPR036259, MFS_trans_sf
IPR005829, Sugar_transporter_CS
IPR022308, SV2
PfamiView protein in Pfam
PF07690, MFS_1, 1 hit
PF13599, Pentapeptide_4, 1 hit
PF00083, Sugar_tr, 1 hit
SUPFAMiSSF103473, SSF103473, 2 hits
TIGRFAMsiTIGR01299, synapt_SV2, 1 hit
PROSITEiView protein in PROSITE
PS50850, MFS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSV2B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L1I2
Secondary accession number(s): B4DH30
, C6G489, O94840, Q6IAR8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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