UniProtKB - Q7L1I2 (SV2B_HUMAN)
Synaptic vesicle glycoprotein 2B
SV2B
Functioni
Probably plays a role in the control of regulated secretion in neural and endocrine cells.
By similarity(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119).
Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.
1 Publication1 PublicationGO - Molecular functioni
- transmembrane transporter activity Source: InterPro
GO - Biological processi
- chemical synaptic transmission Source: InterPro
- neurotransmitter transport Source: UniProtKB-KW
Keywordsi
Biological process | Neurotransmitter transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q7L1I2 |
Reactomei | R-HSA-5250955, Toxicity of botulinum toxin type D (botD) R-HSA-5250968, Toxicity of botulinum toxin type A (botA) R-HSA-5250981, Toxicity of botulinum toxin type F (botF) R-HSA-5250992, Toxicity of botulinum toxin type E (botE) |
SignaLinki | Q7L1I2 |
Protein family/group databases
TCDBi | 2.A.1.22.7, the major facilitator superfamily (mfs) |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptic vesicle glycoprotein 2B |
Gene namesi | Name:SV2B Synonyms:KIAA0735 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16874, SV2B |
MIMi | 185861, gene |
neXtProti | NX_Q7L1I2 |
VEuPathDBi | HostDB:ENSG00000185518 |
Subcellular locationi
Other locations
- synaptic vesicle membrane By similarity; Multi-pass membrane protein Sequence analysis
- acrosome By similarity
Note: Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas (By similarity). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity).By similarity
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- acrosomal vesicle Source: UniProtKB-SubCell
- integral component of membrane Source: GO_Central
- membrane Source: ParkinsonsUK-UCL
- neuron projection Source: GO_Central
- synaptic vesicle Source: ParkinsonsUK-UCL
- synaptic vesicle membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 108 | CytoplasmicSequence analysisAdd BLAST | 108 | |
Transmembranei | 109 – 129 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 130 – 148 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 182 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 183 – 203 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 204 – 205 | ExtracellularSequence analysis | 2 | |
Transmembranei | 206 – 226 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 227 – 237 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 238 – 258 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 259 – 277 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 278 – 298 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 299 – 390 | CytoplasmicSequence analysisAdd BLAST | 92 | |
Transmembranei | 391 – 411 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 412 – 535 | ExtracellularSequence analysisAdd BLAST | 124 | |
Transmembranei | 536 – 556 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 557 – 565 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 566 – 586 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 587 – 592 | ExtracellularSequence analysis | 6 | |
Transmembranei | 593 – 613 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 614 – 626 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 627 – 649 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 650 – 653 | ExtracellularSequence analysis | 4 | |
Transmembranei | 654 – 672 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 673 – 683 | CytoplasmicSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 9899 |
OpenTargetsi | ENSG00000185518 |
PharmGKBi | PA134930999 |
Miscellaneous databases
Pharosi | Q7L1I2, Tbio |
Genetic variation databases
BioMutai | SV2B |
DMDMi | 74738530 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000239768 | 1 – 683 | Synaptic vesicle glycoprotein 2BAdd BLAST | 683 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 33 | PhosphoserineBy similarity | 1 | |
Modified residuei | 36 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 423 | PhosphotyrosineBy similarity | 1 | |
Glycosylationi | 441 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 491 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 516 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | Q7L1I2 |
PaxDbi | Q7L1I2 |
PeptideAtlasi | Q7L1I2 |
PRIDEi | Q7L1I2 |
ProteomicsDBi | 4186 68743 [Q7L1I2-1] |
PTM databases
GlyGeni | Q7L1I2, 3 sites |
iPTMneti | Q7L1I2 |
PhosphoSitePlusi | Q7L1I2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000185518, Expressed in middle temporal gyrus and 175 other tissues |
Genevisiblei | Q7L1I2, HS |
Organism-specific databases
HPAi | ENSG00000185518, Group enriched (brain, retina) |
Interactioni
Subunit structurei
Interacts with SYT1 in a calcium-independent manner.
Forms a complex with SYT1, syntaxin-1 and SNAP25 (By similarity).
By similarityBinary interactionsi
Q7L1I2
With | #Exp. | IntAct |
---|---|---|
HSFY2 [Q96LI6] | 3 | EBI-10290607,EBI-3957665 |
Protein-protein interaction databases
BioGRIDi | 115228, 7 interactors |
IntActi | Q7L1I2, 1 interactor |
STRINGi | 9606.ENSP00000377779 |
Miscellaneous databases
RNActi | Q7L1I2, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q7L1I2 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 42 | DisorderedSequence analysisAdd BLAST | 42 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0255, Eukaryota |
GeneTreei | ENSGT00950000182940 |
HOGENOMi | CLU_001265_46_15_1 |
InParanoidi | Q7L1I2 |
OMAi | TNQVSDD |
OrthoDBi | 724235at2759 |
PhylomeDBi | Q7L1I2 |
TreeFami | TF324824 |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR001646, 5peptide_repeat IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS IPR022308, SV2 |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF13599, Pentapeptide_4, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 2 hits |
TIGRFAMsi | TIGR01299, synapt_SV2, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDDYKYQDNY GGYAPSDGYY RGNESNPEED AQSDVTEGHD EEDEIYEGEY
60 70 80 90 100
QGIPHPDDVK AKQAKMAPSR MDSLRGQTDL MAERLEDEEQ LAHQYETIMD
110 120 130 140 150
ECGHGRFQWI LFFVLGLALM ADGVEVFVVS FALPSAEKDM CLSSSKKGML
160 170 180 190 200
GMIVYLGMMA GAFILGGLAD KLGRKRVLSM SLAVNASFAS LSSFVQGYGA
210 220 230 240 250
FLFCRLISGI GIGGALPIVF AYFSEFLSRE KRGEHLSWLG IFWMTGGLYA
260 270 280 290 300
SAMAWSIIPH YGWGFSMGTN YHFHSWRVFV IVCALPCTVS MVALKFMPES
310 320 330 340 350
PRFLLEMGKH DEAWMILKQV HDTNMRAKGT PEKVFTVSNI KTPKQMDEFI
360 370 380 390 400
EIQSSTGTWY QRWLVRFKTI FKQVWDNALY CVMGPYRMNT LILAVVWFAM
410 420 430 440 450
AFSYYGLTVW FPDMIRYFQD EEYKSKMKVF FGEHVYGATI NFTMENQIHQ
460 470 480 490 500
HGKLVNDKFT RMYFKHVLFE DTFFDECYFE DVTSTDTYFK NCTIESTIFY
510 520 530 540 550
NTDLYEHKFI NCRFINSTFL EQKEGCHMDL EQDNDFLIYL VSFLGSLSVL
560 570 580 590 600
PGNIISALLM DRIGRLKMIG GSMLISAVCC FFLFFGNSES AMIGWQCLFC
610 620 630 640 650
GTSIAAWNAL DVITVELYPT NQRATAFGIL NGLCKFGAIL GNTIFASFVG
660 670 680
ITKVVPILLA AASLVGGGLI ALRLPETREQ VLM
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 683 | M → I in CAG33367 (Ref. 3) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045194 | 1 – 151 | Missing in isoform 2. 1 PublicationAdd BLAST | 151 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018278 mRNA Translation: BAA34455.2 Different initiation. CR457086 mRNA Translation: CAG33367.1 AK294902 mRNA Translation: BAG57991.1 FJ515843 Genomic DNA Translation: ACS13737.1 AC123784 Genomic DNA No translation available. AC127520 Genomic DNA No translation available. CH471101 Genomic DNA Translation: EAX02143.1 BC030011 mRNA Translation: AAH30011.1 |
CCDSi | CCDS10370.1 [Q7L1I2-1] CCDS53972.1 [Q7L1I2-2] |
RefSeqi | NP_001161052.1, NM_001167580.2 [Q7L1I2-2] NP_001309960.1, NM_001323031.2 [Q7L1I2-1] NP_001309961.1, NM_001323032.2 [Q7L1I2-1] NP_001309966.1, NM_001323037.2 [Q7L1I2-1] NP_001309967.1, NM_001323038.2 [Q7L1I2-1] NP_001309968.1, NM_001323039.2 [Q7L1I2-1] NP_001309969.1, NM_001323040.2 [Q7L1I2-2] NP_055663.1, NM_014848.6 [Q7L1I2-1] XP_005255055.1, XM_005254998.3 [Q7L1I2-1] XP_016878250.1, XM_017022761.1 [Q7L1I2-1] XP_016878251.1, XM_017022762.1 [Q7L1I2-1] |
Genome annotation databases
Ensembli | ENST00000330276.4; ENSP00000332818.4; ENSG00000185518.12 ENST00000394232.6; ENSP00000377779.1; ENSG00000185518.12 ENST00000545111.6; ENSP00000443243.2; ENSG00000185518.12 [Q7L1I2-2] ENST00000557410.5; ENSP00000450992.1; ENSG00000185518.12 |
GeneIDi | 9899 |
KEGGi | hsa:9899 |
MANE-Selecti | ENST00000394232.6; ENSP00000377779.1; NM_001323032.3; NP_001309961.1 |
UCSCi | uc010uqv.3, human [Q7L1I2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018278 mRNA Translation: BAA34455.2 Different initiation. CR457086 mRNA Translation: CAG33367.1 AK294902 mRNA Translation: BAG57991.1 FJ515843 Genomic DNA Translation: ACS13737.1 AC123784 Genomic DNA No translation available. AC127520 Genomic DNA No translation available. CH471101 Genomic DNA Translation: EAX02143.1 BC030011 mRNA Translation: AAH30011.1 |
CCDSi | CCDS10370.1 [Q7L1I2-1] CCDS53972.1 [Q7L1I2-2] |
RefSeqi | NP_001161052.1, NM_001167580.2 [Q7L1I2-2] NP_001309960.1, NM_001323031.2 [Q7L1I2-1] NP_001309961.1, NM_001323032.2 [Q7L1I2-1] NP_001309966.1, NM_001323037.2 [Q7L1I2-1] NP_001309967.1, NM_001323038.2 [Q7L1I2-1] NP_001309968.1, NM_001323039.2 [Q7L1I2-1] NP_001309969.1, NM_001323040.2 [Q7L1I2-2] NP_055663.1, NM_014848.6 [Q7L1I2-1] XP_005255055.1, XM_005254998.3 [Q7L1I2-1] XP_016878250.1, XM_017022761.1 [Q7L1I2-1] XP_016878251.1, XM_017022762.1 [Q7L1I2-1] |
3D structure databases
AlphaFoldDBi | Q7L1I2 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 115228, 7 interactors |
IntActi | Q7L1I2, 1 interactor |
STRINGi | 9606.ENSP00000377779 |
Protein family/group databases
TCDBi | 2.A.1.22.7, the major facilitator superfamily (mfs) |
PTM databases
GlyGeni | Q7L1I2, 3 sites |
iPTMneti | Q7L1I2 |
PhosphoSitePlusi | Q7L1I2 |
Genetic variation databases
BioMutai | SV2B |
DMDMi | 74738530 |
Proteomic databases
MassIVEi | Q7L1I2 |
PaxDbi | Q7L1I2 |
PeptideAtlasi | Q7L1I2 |
PRIDEi | Q7L1I2 |
ProteomicsDBi | 4186 68743 [Q7L1I2-1] |
Protocols and materials databases
Antibodypediai | 29003, 146 antibodies from 26 providers |
DNASUi | 9899 |
Genome annotation databases
Ensembli | ENST00000330276.4; ENSP00000332818.4; ENSG00000185518.12 ENST00000394232.6; ENSP00000377779.1; ENSG00000185518.12 ENST00000545111.6; ENSP00000443243.2; ENSG00000185518.12 [Q7L1I2-2] ENST00000557410.5; ENSP00000450992.1; ENSG00000185518.12 |
GeneIDi | 9899 |
KEGGi | hsa:9899 |
MANE-Selecti | ENST00000394232.6; ENSP00000377779.1; NM_001323032.3; NP_001309961.1 |
UCSCi | uc010uqv.3, human [Q7L1I2-1] |
Organism-specific databases
CTDi | 9899 |
DisGeNETi | 9899 |
GeneCardsi | SV2B |
HGNCi | HGNC:16874, SV2B |
HPAi | ENSG00000185518, Group enriched (brain, retina) |
MIMi | 185861, gene |
neXtProti | NX_Q7L1I2 |
OpenTargetsi | ENSG00000185518 |
PharmGKBi | PA134930999 |
VEuPathDBi | HostDB:ENSG00000185518 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0255, Eukaryota |
GeneTreei | ENSGT00950000182940 |
HOGENOMi | CLU_001265_46_15_1 |
InParanoidi | Q7L1I2 |
OMAi | TNQVSDD |
OrthoDBi | 724235at2759 |
PhylomeDBi | Q7L1I2 |
TreeFami | TF324824 |
Enzyme and pathway databases
PathwayCommonsi | Q7L1I2 |
Reactomei | R-HSA-5250955, Toxicity of botulinum toxin type D (botD) R-HSA-5250968, Toxicity of botulinum toxin type A (botA) R-HSA-5250981, Toxicity of botulinum toxin type F (botF) R-HSA-5250992, Toxicity of botulinum toxin type E (botE) |
SignaLinki | Q7L1I2 |
Miscellaneous databases
BioGRID-ORCSi | 9899, 9 hits in 1070 CRISPR screens |
ChiTaRSi | SV2B, human |
GeneWikii | SV2B |
GenomeRNAii | 9899 |
Pharosi | Q7L1I2, Tbio |
PROi | PR:Q7L1I2 |
RNActi | Q7L1I2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185518, Expressed in middle temporal gyrus and 175 other tissues |
Genevisiblei | Q7L1I2, HS |
Family and domain databases
Gene3Di | 1.20.1250.20, 2 hits |
InterProi | View protein in InterPro IPR001646, 5peptide_repeat IPR011701, MFS IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR005829, Sugar_transporter_CS IPR022308, SV2 |
Pfami | View protein in Pfam PF07690, MFS_1, 1 hit PF13599, Pentapeptide_4, 1 hit PF00083, Sugar_tr, 1 hit |
SUPFAMi | SSF103473, SSF103473, 2 hits |
TIGRFAMsi | TIGR01299, synapt_SV2, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SV2B_HUMAN | |
Accessioni | Q7L1I2Primary (citable) accession number: Q7L1I2 Secondary accession number(s): B4DH30 Q6IAR8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 13, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families