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Entry version 142 (16 Oct 2019)
Sequence version 2 (20 Jan 2009)
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Protein

tRNA methyltransferase 10 homolog C

Gene

TRMT10C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial tRNA N1-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N1-methylguanine and N1-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N1-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N1-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N1-methyltransferase by mediating methylation of adenosine residues at the N1 position of MT-ND5 mRNA (PubMed:29072297).6 Publications

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated
The identity of the enzyme catalyzing mitochondrial mRNA N1-methyltransferase is unclear. According to a report, mitochondrial mRNA N1-methyltransferase activity is catalyzed by TRMT61B (AC Q9BVS5) (PubMed:29107537). According to a second report, it is mediated by TRMT10C (PubMed:29072297). As both reports only tested one protein (either TRMT61B or TRMT10C), it is possible that both proteins have this activity.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6785470 tRNA processing in the mitochondrion
R-HSA-6787450 tRNA modification in the mitochondrion
R-HSA-8868766 rRNA processing in the mitochondrion

Protein family/group databases

MoonProt database of moonlighting proteins

More...
MoonProti
Q7L0Y3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA methyltransferase 10 homolog CCurated
Alternative name(s):
HBV pre-S2 trans-regulated protein 21 Publication
Mitochondrial ribonuclease P protein 11 Publication
Short name:
Mitochondrial RNase P protein 11 Publication
RNA (guanine-9-)-methyltransferase domain-containing protein 1
Renal carcinoma antigen NY-REN-491 Publication
mRNA methyladenosine-N(1)-methyltransferase1 Publication (EC:2.1.1.-1 Publication)
tRNA (adenine(9)-N(1))-methyltransferase (EC:2.1.1.2181 Publication)
tRNA (guanine(9)-N(1))-methyltransferase (EC:2.1.1.2211 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRMT10CImported
Synonyms:MRPP11 Publication, RG9MTD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26022 TRMT10C

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615423 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7L0Y3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion, Mitochondrion nucleoid

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Combined oxidative phosphorylation deficiency 30 (COXPD30)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, severe mitochondrial disease characterized by lactic acidosis, hypotonia, feeding difficulties, deafness, and respiratory failure with fatal issue. Patient skeletal muscle cells show decreased activities of mitochondrial complexes I, III and IV.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_076993181R → L in COXPD30; decreased protein abundance; impaired mitochondrial tRNA processing; has no effect on steady-state mitochondrial-mRNA and mitochondrial-tRNA levels but indirectly impairs mitochondrial translation. 1 PublicationCorresponds to variant dbSNP:rs199730889EnsemblClinVar.1
Natural variantiVAR_076994272T → A in COXPD30; decreased protein abundance; impaired mitochondrial tRNA processing; has no effect on steady-state mitochondrial-mRNA and mitochondrial-tRNA levels but indirectly impairs mitochondrial translation. 1 PublicationCorresponds to variant dbSNP:rs875989831EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi314D → N: Abolished mitochondrial tRNA methylation. Does not affect mitochondrial tRNA 5'-end processing. 1 Publication1

Keywords - Diseasei

Disease mutation, Primary mitochondrial disease

Organism-specific databases

DisGeNET

More...
DisGeNETi
54931

MalaCards human disease database

More...
MalaCardsi
TRMT10C
MIMi616974 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000174173

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
478042 Combined oxidative phosphorylation defect type 30

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134988378

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q7L0Y3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRMT10C

Domain mapping of disease mutations (DMDM)

More...
DMDMi
221222465

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 39MitochondrionSequence analysisAdd BLAST39
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031130940 – 403tRNA methyltransferase 10 homolog CAdd BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei84PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q7L0Y3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q7L0Y3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q7L0Y3

MaxQB - The MaxQuant DataBase

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MaxQBi
Q7L0Y3

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q7L0Y3

PeptideAtlas

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PeptideAtlasi
Q7L0Y3

PRoteomics IDEntifications database

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PRIDEi
Q7L0Y3

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
68741

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q7L0Y3

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q7L0Y3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q7L0Y3

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q7L0Y3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000174173 Expressed in 202 organ(s), highest expression level in quadriceps femoris

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q7L0Y3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q7L0Y3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036671

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3.(PubMed:18984158).

Interacts with HSD17B10/MRPP2; forming the MRPP1-MRPP2 subcomplex of the mitochondrial ribonuclease P complex (PubMed:23042678, PubMed:29040705).

Interacts with GRSF1 (PubMed:23473034).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q997145EBI-2107046,EBI-79964

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
120271, 54 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q7L0Y3

Protein interaction database and analysis system

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IntActi
Q7L0Y3, 52 interactors

Molecular INTeraction database

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MINTi
Q7L0Y3

STRING: functional protein association networks

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STRINGi
9606.ENSP00000312356

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7L0Y3

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini191 – 383SAM-dependent MTase TRM10-typePROSITE-ProRule annotationAdd BLAST193

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili138 – 169Sequence analysisAdd BLAST32

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2967 Eukaryota
ENOG4111JE4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063169

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000088648

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7L0Y3

KEGG Orthology (KO)

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KOi
K17654

Identification of Orthologs from Complete Genome Data

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OMAi
KYLYVKE

Database of Orthologous Groups

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OrthoDBi
1569668at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q7L0Y3

TreeFam database of animal gene trees

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TreeFami
TF319795

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.1280.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR028564 MT_TRM10-typ
IPR038459 MT_TRM10-typ_sf
IPR025812 TRM10C
IPR007356 tRNA_m1G_MeTrfase_euk
IPR016009 tRNA_MeTrfase_TRMD/TRM10

The PANTHER Classification System

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PANTHERi
PTHR13563 PTHR13563, 1 hit
PTHR13563:SF5 PTHR13563:SF5, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01746 tRNA_m1G_MT, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51675 SAM_MT_TRM10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7L0Y3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAFLKMSVS VNFFRPFTRF LVPFTLHRKR NNLTILQRYM SSKIPAVTYP
60 70 80 90 100
KNESTPPSEE LELDKWKTTM KSSVQEECVS TISSSKDEDP LAATREFIEM
110 120 130 140 150
WRLLGREVPE HITEEELKTL MECVSNTAKK KYLKYLYTKE KVKKARQIKK
160 170 180 190 200
EMKAAAREEA KNIKLLETTE EDKQKNFLFL RLWDRNMDIA MGWKGAQAMQ
210 220 230 240 250
FGQPLVFDMA YENYMKRKEL QNTVSQLLES EGWNRRNVDP FHIYFCNLKI
260 270 280 290 300
DGALHRELVK RYQEKWDKLL LTSTEKSHVD LFPKDSIIYL TADSPNVMTT
310 320 330 340 350
FRHDKVYVIG SFVDKSMQPG TSLAKAKRLN LATECLPLDK YLQWEIGNKN
360 370 380 390 400
LTLDQMIRIL LCLKNNGNWQ EALQFVPKRK HTGFLEISQH SQEFINRLKK

AKT
Length:403
Mass (Da):47,347
Last modified:January 20, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i28CBD97B4114819F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JVB6C9JVB6_HUMAN
tRNA methyltransferase 10 homolog C
TRMT10C
312Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD42877 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAH35967 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA91166 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05735556P → R1 PublicationCorresponds to variant dbSNP:rs3762735Ensembl.1
Natural variantiVAR_057356164K → N. Corresponds to variant dbSNP:rs16844031EnsemblClinVar.1
Natural variantiVAR_076993181R → L in COXPD30; decreased protein abundance; impaired mitochondrial tRNA processing; has no effect on steady-state mitochondrial-mRNA and mitochondrial-tRNA levels but indirectly impairs mitochondrial translation. 1 PublicationCorresponds to variant dbSNP:rs199730889EnsemblClinVar.1
Natural variantiVAR_076994272T → A in COXPD30; decreased protein abundance; impaired mitochondrial tRNA processing; has no effect on steady-state mitochondrial-mRNA and mitochondrial-tRNA levels but indirectly impairs mitochondrial translation. 1 PublicationCorresponds to variant dbSNP:rs875989831EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF226052 mRNA Translation: AAF86952.1
AK000439 mRNA Translation: BAA91166.1 Frameshift.
CH471052 Genomic DNA Translation: EAW79795.1
BC035967 mRNA Translation: AAH35967.2 Different initiation.
AF155111 mRNA Translation: AAD42877.1 Different initiation.
AY561707 mRNA Translation: AAS66980.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43122.1

NCBI Reference Sequences

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RefSeqi
NP_060289.2, NM_017819.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000309922; ENSP00000312356; ENSG00000174173

Database of genes from NCBI RefSeq genomes

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GeneIDi
54931

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:54931

UCSC genome browser

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UCSCi
uc003duz.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226052 mRNA Translation: AAF86952.1
AK000439 mRNA Translation: BAA91166.1 Frameshift.
CH471052 Genomic DNA Translation: EAW79795.1
BC035967 mRNA Translation: AAH35967.2 Different initiation.
AF155111 mRNA Translation: AAD42877.1 Different initiation.
AY561707 mRNA Translation: AAS66980.1
CCDSiCCDS43122.1
RefSeqiNP_060289.2, NM_017819.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5NFJX-ray1.96A/B/C203-403[»]
SMRiQ7L0Y3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120271, 54 interactors
CORUMiQ7L0Y3
IntActiQ7L0Y3, 52 interactors
MINTiQ7L0Y3
STRINGi9606.ENSP00000312356

Protein family/group databases

MoonProtiQ7L0Y3

PTM databases

iPTMnetiQ7L0Y3
PhosphoSitePlusiQ7L0Y3
SwissPalmiQ7L0Y3

Polymorphism and mutation databases

BioMutaiTRMT10C
DMDMi221222465

Proteomic databases

EPDiQ7L0Y3
jPOSTiQ7L0Y3
MassIVEiQ7L0Y3
MaxQBiQ7L0Y3
PaxDbiQ7L0Y3
PeptideAtlasiQ7L0Y3
PRIDEiQ7L0Y3
ProteomicsDBi68741
TopDownProteomicsiQ7L0Y3

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
54931

Genome annotation databases

EnsembliENST00000309922; ENSP00000312356; ENSG00000174173
GeneIDi54931
KEGGihsa:54931
UCSCiuc003duz.5 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
54931
DisGeNETi54931

GeneCards: human genes, protein and diseases

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GeneCardsi
TRMT10C
HGNCiHGNC:26022 TRMT10C
HPAiHPA036671
MalaCardsiTRMT10C
MIMi615423 gene
616974 phenotype
neXtProtiNX_Q7L0Y3
OpenTargetsiENSG00000174173
Orphaneti478042 Combined oxidative phosphorylation defect type 30
PharmGKBiPA134988378

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2967 Eukaryota
ENOG4111JE4 LUCA
GeneTreeiENSGT00530000063169
HOGENOMiHOG000088648
InParanoidiQ7L0Y3
KOiK17654
OMAiKYLYVKE
OrthoDBi1569668at2759
PhylomeDBiQ7L0Y3
TreeFamiTF319795

Enzyme and pathway databases

ReactomeiR-HSA-6785470 tRNA processing in the mitochondrion
R-HSA-6787450 tRNA modification in the mitochondrion
R-HSA-8868766 rRNA processing in the mitochondrion

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRMT10C human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
54931
PharosiQ7L0Y3

Protein Ontology

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PROi
PR:Q7L0Y3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000174173 Expressed in 202 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ7L0Y3 baseline and differential
GenevisibleiQ7L0Y3 HS

Family and domain databases

Gene3Di3.40.1280.30, 1 hit
InterProiView protein in InterPro
IPR028564 MT_TRM10-typ
IPR038459 MT_TRM10-typ_sf
IPR025812 TRM10C
IPR007356 tRNA_m1G_MeTrfase_euk
IPR016009 tRNA_MeTrfase_TRMD/TRM10
PANTHERiPTHR13563 PTHR13563, 1 hit
PTHR13563:SF5 PTHR13563:SF5, 1 hit
PfamiView protein in Pfam
PF01746 tRNA_m1G_MT, 1 hit
PROSITEiView protein in PROSITE
PS51675 SAM_MT_TRM10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM10C_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7L0Y3
Secondary accession number(s): Q9NRG5, Q9NX54, Q9Y596
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: January 20, 2009
Last modified: October 16, 2019
This is version 142 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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