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Protein

TLR4 interactor with leucine rich repeats

Gene

TRIL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the TLR4 signaling complex. Mediate the innate immune response to bacterial lipopolysaccharide (LPS) leading to cytokine secretion.1 Publication

GO - Molecular functioni

  • lipopolysaccharide binding Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processImmunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
TLR4 interactor with leucine rich repeats
Alternative name(s):
Leucine-rich repeat-containing protein KIAA0644
Gene namesi
Name:TRIL
Synonyms:KIAA0644
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000255690.2
HGNCiHGNC:22200 TRIL
MIMi613356 gene
neXtProtiNX_Q7L0X0

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 696ExtracellularSequence analysisAdd BLAST671
Transmembranei697 – 717HelicalSequence analysisAdd BLAST21
Topological domaini718 – 811CytoplasmicSequence analysisAdd BLAST94

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000255690

Polymorphism and mutation databases

BioMutaiTRIL
DMDMi311033514

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000034925526 – 811TLR4 interactor with leucine rich repeatsAdd BLAST786

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi589N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei798PhosphoserineBy similarity1

Post-translational modificationi

N-glycolysaled.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PeptideAtlasiQ7L0X0
PRIDEiQ7L0X0
ProteomicsDBi68737

PTM databases

iPTMnetiQ7L0X0
PhosphoSitePlusiQ7L0X0

Expressioni

Tissue specificityi

Highly expressed in the brain, ovary, small intestine and spleen.1 Publication

Inductioni

By bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiENSG00000255690 Expressed in 189 organ(s), highest expression level in brain
GenevisibleiQ7L0X0 HS

Interactioni

Subunit structurei

Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. Interacts with TLR4; this interaction is greatly enhanced by LPS stimulation. Interacts with LPS.1 Publication

Protein-protein interaction databases

IntActiQ7L0X0, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ7L0X0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 57LRRNTAdd BLAST32
Repeati61 – 81LRR 1Add BLAST21
Repeati84 – 105LRR 2Add BLAST22
Repeati108 – 129LRR 3Add BLAST22
Repeati132 – 153LRR 4Add BLAST22
Repeati156 – 177LRR 5Add BLAST22
Repeati180 – 201LRR 6Add BLAST22
Repeati204 – 223LRR 7Add BLAST20
Repeati230 – 251LRR 8Add BLAST22
Repeati254 – 275LRR 9Add BLAST22
Repeati278 – 299LRR 10Add BLAST22
Repeati302 – 323LRR 11Add BLAST22
Repeati326 – 347LRR 12Add BLAST22
Domaini359 – 416LRRCTAdd BLAST58

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00920000148957
HOVERGENiHBG066060
InParanoidiQ7L0X0
OMAiEFPCDRF
OrthoDBiEOG091G02AN
PhylomeDBiQ7L0X0

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 11 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 13 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7L0X0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAARALRLL LVVCGCLALP PLAEPVCPER CDCQHPQHLL CTNRGLRVVP
60 70 80 90 100
KTSSLPSPHD VLTYSLGGNF ITNITAFDFH RLGQLRRLDL QYNQIRSLHP
110 120 130 140 150
KTFEKLSRLE ELYLGNNLLQ ALAPGTLAPL RKLRILYANG NEISRLSRGS
160 170 180 190 200
FEGLESLVKL RLDGNALGAL PDAVFAPLGN LLYLHLESNR IRFLGKNAFA
210 220 230 240 250
QLGKLRFLNL SANELQPSLR HAATFAPLRS LSSLILSANN LQHLGPRIFQ
260 270 280 290 300
HLPRLGLLSL RGNQLTHLAP EAFWGLEALR ELRLEGNRLS QLPTALLEPL
310 320 330 340 350
HSLEALDLSG NELSALHPAT FGHLGRLREL SLRNNALSAL SGDIFAASPA
360 370 380 390 400
LYRLDLDGNG WTCDCRLRGL KRWMGDWHSQ GRLLTVFVQC RHPPALRGKY
410 420 430 440 450
LDYLDDQQLQ NGSCADPSPS ASLTADRRRQ PLPTAAGEEM TPPAGLAEEL
460 470 480 490 500
PPQPQLQQQG RFLAGVAWDG AARELVGNRS ALRLSRRGPG LQQPSPSVAA
510 520 530 540 550
AAGPAPQSLD LHKKPQRGRP TRADPALAEP TPTASPGSAP SPAGDPWQRA
560 570 580 590 600
TKHRLGTEHQ ERAAQSDGGA GLPPLVSDPC DFNKFILCNL TVEAVGADSA
610 620 630 640 650
SVRWAVREHR SPRPLGGARF RLLFDRFGQQ PKFHRFVYLP ESSDSATLRE
660 670 680 690 700
LRGDTPYLVC VEGVLGGRVC PVAPRDHCAG LVTLPEAGSR GGVDYQLLTL
710 720 730 740 750
ALLTVNALLV LLALAAWASR WLRRKLRARR KGGAPVHVRH MYSTRRPLRS
760 770 780 790 800
MGTGVSADFS GFQSHRPRTT VCALSEADLI EFPCDRFMDS AGGGAGGSLR
810
REDRLLQRFA D
Length:811
Mass (Da):88,723
Last modified:November 2, 2010 - v2
Checksum:i5272376356F1A686
GO

Sequence cautioni

The sequence BAA31619 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence EAL24209 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046307240N → S3 PublicationsCorresponds to variant dbSNP:rs740250Ensembl.1
Natural variantiVAR_046308347A → T. Corresponds to variant dbSNP:rs3735561Ensembl.1
Natural variantiVAR_046309369G → D. Corresponds to variant dbSNP:rs3735562Ensembl.1
Natural variantiVAR_075695666G → R1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014544 mRNA Translation: BAA31619.2 Different initiation.
AC005013 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24208.1
CH236948 Genomic DNA Translation: EAL24209.1 Sequence problems.
CH471073 Genomic DNA Translation: EAW93913.1
BC036337 mRNA Translation: AAH36337.1
CCDSiCCDS75573.1
RefSeqiNP_055632.2, NM_014817.3
UniGeneiHs.744120

Genome annotation databases

EnsembliENST00000539664; ENSP00000479256; ENSG00000255690
GeneIDi9865
KEGGihsa:9865
UCSCiuc032zip.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014544 mRNA Translation: BAA31619.2 Different initiation.
AC005013 Genomic DNA No translation available.
CH236948 Genomic DNA Translation: EAL24208.1
CH236948 Genomic DNA Translation: EAL24209.1 Sequence problems.
CH471073 Genomic DNA Translation: EAW93913.1
BC036337 mRNA Translation: AAH36337.1
CCDSiCCDS75573.1
RefSeqiNP_055632.2, NM_014817.3
UniGeneiHs.744120

3D structure databases

ProteinModelPortaliQ7L0X0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7L0X0, 1 interactor

PTM databases

iPTMnetiQ7L0X0
PhosphoSitePlusiQ7L0X0

Polymorphism and mutation databases

BioMutaiTRIL
DMDMi311033514

Proteomic databases

PeptideAtlasiQ7L0X0
PRIDEiQ7L0X0
ProteomicsDBi68737

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000539664; ENSP00000479256; ENSG00000255690
GeneIDi9865
KEGGihsa:9865
UCSCiuc032zip.2 human

Organism-specific databases

CTDi9865
EuPathDBiHostDB:ENSG00000255690.2
GeneCardsiTRIL
HGNCiHGNC:22200 TRIL
MIMi613356 gene
neXtProtiNX_Q7L0X0
OpenTargetsiENSG00000255690
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00920000148957
HOVERGENiHBG066060
InParanoidiQ7L0X0
OMAiEFPCDRF
OrthoDBiEOG091G02AN
PhylomeDBiQ7L0X0

Miscellaneous databases

GeneWikiiKIAA0644
GenomeRNAii9865
PROiPR:Q7L0X0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000255690 Expressed in 189 organ(s), highest expression level in brain
GenevisibleiQ7L0X0 HS

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR003961 FN3_dom
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 4 hits
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 11 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTRIL_HUMAN
AccessioniPrimary (citable) accession number: Q7L0X0
Secondary accession number(s): A4D1A6, O75139
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: November 2, 2010
Last modified: September 12, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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