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Protein

Synaptic vesicle glycoprotein 2A

Gene

SV2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).By similarity
(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.1 Publication1 Publication

Miscellaneous

Identified as the brain binding-site for the antiepileptic drug levetiracetam/lev.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250968 Toxicity of botulinum toxin type A (BoNT/A)
R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F)
R-HSA-5250992 Toxicity of botulinum toxin type E (BoNT/E)

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle glycoprotein 2A
Gene namesi
Name:SV2A
Synonyms:KIAA0736
ORF Names:PSEC0174
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000159164.9
HGNCiHGNC:20566 SV2A
MIMi185860 gene
neXtProtiNX_Q7L0J3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 169CytoplasmicSequence analysisAdd BLAST169
Transmembranei170 – 190HelicalSequence analysisAdd BLAST21
Topological domaini191 – 205ExtracellularSequence analysisAdd BLAST15
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 233CytoplasmicSequence analysis7
Transmembranei234 – 254HelicalSequence analysisAdd BLAST21
Topological domaini255 – 262ExtracellularSequence analysis8
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21
Topological domaini284 – 294CytoplasmicSequence analysisAdd BLAST11
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 334ExtracellularSequence analysisAdd BLAST19
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21
Topological domaini356 – 447CytoplasmicSequence analysisAdd BLAST92
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Topological domaini469 – 598ExtracellularSequence analysisAdd BLAST130
Transmembranei599 – 619HelicalSequence analysisAdd BLAST21
Topological domaini620 – 626CytoplasmicSequence analysis7
Transmembranei627 – 647HelicalSequence analysisAdd BLAST21
Topological domaini648 – 651ExtracellularSequence analysis4
Transmembranei652 – 672HelicalSequence analysisAdd BLAST21
Topological domaini673 – 685CytoplasmicSequence analysisAdd BLAST13
Transmembranei686 – 708HelicalSequence analysisAdd BLAST23
Topological domaini709 – 712ExtracellularSequence analysis4
Transmembranei713 – 731HelicalSequence analysisAdd BLAST19
Topological domaini732 – 742CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi9900
OpenTargetsiENSG00000159164
PharmGKBiPA128394564

Chemistry databases

ChEMBLiCHEMBL1998
DrugBankiDB01202 Levetiracetam

Polymorphism and mutation databases

DMDMi74749878

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002397641 – 742Synaptic vesicle glycoprotein 2AAdd BLAST742

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei84PhosphothreonineCombined sources1
Modified residuei127PhosphoserineBy similarity1
Modified residuei393PhosphoserineBy similarity1
Modified residuei480PhosphotyrosineBy similarity1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi548N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi573N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ7L0J3
MaxQBiQ7L0J3
PaxDbiQ7L0J3
PeptideAtlasiQ7L0J3
PRIDEiQ7L0J3
ProteomicsDBi68731
68732 [Q7L0J3-2]

PTM databases

iPTMnetiQ7L0J3
PhosphoSitePlusiQ7L0J3

Expressioni

Gene expression databases

BgeeiENSG00000159164 Expressed in 176 organ(s), highest expression level in Brodmann (1909) area 10
CleanExiHS_SV2A
GenevisibleiQ7L0J3 HS

Organism-specific databases

HPAiCAB002226
HPA007863

Interactioni

Subunit structurei

Interacts with SYT1/synaptotagmin-1 in a calcium-dependent manner. Binds the adapter protein complex AP-2 (By similarity).By similarity
(Microbial infection) Interacts with C.botulinum neurotoxin type A2 (BoNT/A, botA) (PubMed:29649119). Interaction is improved by glycosylation of SV2 (PubMed:29649119).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115229, 7 interactors
IntActiQ7L0J3, 4 interactors
STRINGi9606.ENSP00000358142

Structurei

3D structure databases

ProteinModelPortaliQ7L0J3
SMRiQ7L0J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 57Interaction with SYT1By similarityAdd BLAST57

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRID Eukaryota
ENOG410YQME LUCA
GeneTreeiENSGT00550000074384
HOVERGENiHBG053967
InParanoidiQ7L0J3
KOiK06258
OMAiMMMAVWF
OrthoDBiEOG091G02NC
PhylomeDBiQ7L0J3
TreeFamiTF324824

Family and domain databases

CDDicd06174 MFS, 2 hits
InterProiView protein in InterPro
IPR001646 5peptide_repeat
IPR011701 MFS
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
IPR022308 SV2
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PF13599 Pentapeptide_4, 1 hit
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR01299 synapt_SV2, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q7L0J3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEGFRDRAA FIRGAKDIAK EVKKHAAKKV VKGLDRVQDE YSRRSYSRFE
60 70 80 90 100
EEDDDDDFPA PSDGYYRGEG TQDEEEGGAS SDATEGHDED DEIYEGEYQG
110 120 130 140 150
IPRAESGGKG ERMADGAPLA GVRGGLSDGE GPPGGRGEAQ RRKEREELAQ
160 170 180 190 200
QYEAILRECG HGRFQWTLYF VLGLALMADG VEVFVVGFVL PSAEKDMCLS
210 220 230 240 250
DSNKGMLGLI VYLGMMVGAF LWGGLADRLG RRQCLLISLS VNSVFAFFSS
260 270 280 290 300
FVQGYGTFLF CRLLSGVGIG GSIPIVFSYF SEFLAQEKRG EHLSWLCMFW
310 320 330 340 350
MIGGVYAAAM AWAIIPHYGW SFQMGSAYQF HSWRVFVLVC AFPSVFAIGA
360 370 380 390 400
LTTQPESPRF FLENGKHDEA WMVLKQVHDT NMRAKGHPER VFSVTHIKTI
410 420 430 440 450
HQEDELIEIQ SDTGTWYQRW GVRALSLGGQ VWGNFLSCFG PEYRRITLMM
460 470 480 490 500
MGVWFTMSFS YYGLTVWFPD MIRHLQAVDY ASRTKVFPGE RVEHVTFNFT
510 520 530 540 550
LENQIHRGGQ YFNDKFIGLR LKSVSFEDSL FEECYFEDVT SSNTFFRNCT
560 570 580 590 600
FINTVFYNTD LFEYKFVNSR LINSTFLHNK EGCPLDVTGT GEGAYMVYFV
610 620 630 640 650
SFLGTLAVLP GNIVSALLMD KIGRLRMLAG SSVMSCVSCF FLSFGNSESA
660 670 680 690 700
MIALLCLFGG VSIASWNALD VLTVELYPSD KRTTAFGFLN ALCKLAAVLG
710 720 730 740
ISIFTSFVGI TKAAPILFAS AALALGSSLA LKLPETRGQV LQ
Length:742
Mass (Da):82,695
Last modified:July 5, 2004 - v1
Checksum:i913E216D5CFC2FB2
GO
Isoform 2 (identifier: Q7L0J3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     683-742: Missing.

Note: No experimental confirmation available.
Show »
Length:682
Mass (Da):76,619
Checksum:i926FD8E2F5EAF88F
GO

Sequence cautioni

The sequence BAA34456 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAI12573 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100G → D in CAD97824 (PubMed:17974005).Curated1
Sequence conflicti404D → G in BAC11645 (PubMed:16303743).Curated1
Sequence conflicti493E → G in CAD97824 (PubMed:17974005).Curated1
Sequence conflicti524V → A in BAC11645 (PubMed:16303743).Curated1
Sequence conflicti544T → A in BAC11645 (PubMed:16303743).Curated1
Sequence conflicti582G → D in BAC11645 (PubMed:16303743).Curated1
Sequence conflicti611G → R in BAC11645 (PubMed:16303743).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019265683 – 742Missing in isoform 2. 1 PublicationAdd BLAST60

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018279 mRNA Translation: BAA34456.2 Different initiation.
AK075480 mRNA Translation: BAC11645.1
BX537754 mRNA Translation: CAD97824.1
AL591493 Genomic DNA Translation: CAI12572.1
AL591493 Genomic DNA Translation: CAI12573.1 Sequence problems.
CH471121 Genomic DNA Translation: EAW53596.1
CH471121 Genomic DNA Translation: EAW53598.1
BC000776 mRNA Translation: AAH00776.2
BC045111 mRNA Translation: AAH45111.1
CCDSiCCDS940.1 [Q7L0J3-1]
RefSeqiNP_001265648.1, NM_001278719.1
NP_001315603.1, NM_001328674.1 [Q7L0J3-1]
NP_001315604.1, NM_001328675.1 [Q7L0J3-1]
NP_055664.3, NM_014849.4 [Q7L0J3-1]
UniGeneiHs.516153

Genome annotation databases

EnsembliENST00000369145; ENSP00000358141; ENSG00000159164 [Q7L0J3-2]
ENST00000369146; ENSP00000358142; ENSG00000159164 [Q7L0J3-1]
GeneIDi9900
KEGGihsa:9900
UCSCiuc001etg.4 human [Q7L0J3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018279 mRNA Translation: BAA34456.2 Different initiation.
AK075480 mRNA Translation: BAC11645.1
BX537754 mRNA Translation: CAD97824.1
AL591493 Genomic DNA Translation: CAI12572.1
AL591493 Genomic DNA Translation: CAI12573.1 Sequence problems.
CH471121 Genomic DNA Translation: EAW53596.1
CH471121 Genomic DNA Translation: EAW53598.1
BC000776 mRNA Translation: AAH00776.2
BC045111 mRNA Translation: AAH45111.1
CCDSiCCDS940.1 [Q7L0J3-1]
RefSeqiNP_001265648.1, NM_001278719.1
NP_001315603.1, NM_001328674.1 [Q7L0J3-1]
NP_001315604.1, NM_001328675.1 [Q7L0J3-1]
NP_055664.3, NM_014849.4 [Q7L0J3-1]
UniGeneiHs.516153

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V11X-ray1.95B81-90[»]
ProteinModelPortaliQ7L0J3
SMRiQ7L0J3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115229, 7 interactors
IntActiQ7L0J3, 4 interactors
STRINGi9606.ENSP00000358142

Chemistry databases

ChEMBLiCHEMBL1998
DrugBankiDB01202 Levetiracetam

PTM databases

iPTMnetiQ7L0J3
PhosphoSitePlusiQ7L0J3

Polymorphism and mutation databases

DMDMi74749878

Proteomic databases

EPDiQ7L0J3
MaxQBiQ7L0J3
PaxDbiQ7L0J3
PeptideAtlasiQ7L0J3
PRIDEiQ7L0J3
ProteomicsDBi68731
68732 [Q7L0J3-2]

Protocols and materials databases

DNASUi9900
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369145; ENSP00000358141; ENSG00000159164 [Q7L0J3-2]
ENST00000369146; ENSP00000358142; ENSG00000159164 [Q7L0J3-1]
GeneIDi9900
KEGGihsa:9900
UCSCiuc001etg.4 human [Q7L0J3-1]

Organism-specific databases

CTDi9900
DisGeNETi9900
EuPathDBiHostDB:ENSG00000159164.9
GeneCardsiSV2A
HGNCiHGNC:20566 SV2A
HPAiCAB002226
HPA007863
MIMi185860 gene
neXtProtiNX_Q7L0J3
OpenTargetsiENSG00000159164
PharmGKBiPA128394564
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRID Eukaryota
ENOG410YQME LUCA
GeneTreeiENSGT00550000074384
HOVERGENiHBG053967
InParanoidiQ7L0J3
KOiK06258
OMAiMMMAVWF
OrthoDBiEOG091G02NC
PhylomeDBiQ7L0J3
TreeFamiTF324824

Enzyme and pathway databases

ReactomeiR-HSA-5250955 Toxicity of botulinum toxin type D (BoNT/D)
R-HSA-5250968 Toxicity of botulinum toxin type A (BoNT/A)
R-HSA-5250981 Toxicity of botulinum toxin type F (BoNT/F)
R-HSA-5250992 Toxicity of botulinum toxin type E (BoNT/E)

Miscellaneous databases

ChiTaRSiSV2A human
GeneWikiiSV2A
GenomeRNAii9900
PROiPR:Q7L0J3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159164 Expressed in 176 organ(s), highest expression level in Brodmann (1909) area 10
CleanExiHS_SV2A
GenevisibleiQ7L0J3 HS

Family and domain databases

CDDicd06174 MFS, 2 hits
InterProiView protein in InterPro
IPR001646 5peptide_repeat
IPR011701 MFS
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
IPR022308 SV2
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
PF13599 Pentapeptide_4, 1 hit
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR01299 synapt_SV2, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSV2A_HUMAN
AccessioniPrimary (citable) accession number: Q7L0J3
Secondary accession number(s): D3DUZ7
, O94841, Q5QNX8, Q7Z3L6, Q8NBJ6, Q9BVZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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