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UniProtKB - Q7KZI7 (MARK2_HUMAN)

Entry version 178 (23 Feb 2022)
Sequence version 2 (12 Apr 2005)
Previous versions | rss
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Protein

Serine/threonine-protein kinase MARK2

Gene

MARK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase (PubMed:23666762).

Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762).

Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.

11 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by PAK5; inhibition is independent of the kinase activity of PAK5 (By similarity). Activated by phosphorylation on Thr-208. Inhibited by phosphorylation at Ser-212 and Thr-596. Inhibited by hymenialdisine. Specifically inhibited by the H.pylori CagA peptide FPLKRHDKVDDLSK that mimics host substrates and binds to the kinase substrate-binding site.By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei82ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei175Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi59 – 67ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processDifferentiation, Wnt signaling pathway
LigandATP-binding, Lipid-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q7KZI7

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q7KZI7

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q7KZI7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase MARK2 (EC:2.7.11.1, EC:2.7.11.26)
Alternative name(s):
ELKL motif kinase 1
Short name:
EMK-1
MAP/microtubule affinity-regulating kinase 2
PAR1 homolog
PAR1 homolog b
Short name:
Par-1b
Short name:
Par1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MARK2Imported
Synonyms:EMK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3332, MARK2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600526, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q7KZI7

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000072518

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi208T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication1
Mutagenesisi596T → A: Loss of membrane dissociation and binding to YWHAZ. 2 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		2011

Open Targets

More...OpenTargetsi		ENSG00000072518

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35047

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q7KZI7, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3831

Drug and drug target database

More...DrugBanki		DB12010, Fostamatinib

DrugCentral

More...DrugCentrali		Q7KZI7

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MARK2

Domain mapping of disease mutations (DMDM)

More...DMDMi		62510922

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000863011 – 788Serine/threonine-protein kinase MARK2Add BLAST788

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40PhosphoserineCombined sources1
Modified residuei58Phosphothreonine; by autocatalysisBy similarity1
Modified residuei91Phosphoserine; by CaMK1By similarity1
Modified residuei92Phosphoserine; by CaMK1By similarity1
Modified residuei93Phosphoserine; by CaMK1By similarity1
Modified residuei208Phosphothreonine; by LKB1 and TAOK1Combined sources1 Publication1
Modified residuei212Phosphoserine; by GSK3-betaBy similarity1
Modified residuei274Phosphoserine; by autocatalysisBy similarity1
Modified residuei275Phosphothreonine; by autocatalysisBy similarity1
Modified residuei294Phosphothreonine; by CaMK1By similarity1
Modified residuei409PhosphoserineCombined sources1
Modified residuei456PhosphoserineCombined sources1
Modified residuei467PhosphothreonineCombined sources1
Modified residuei486PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei569PhosphoserineCombined sources1
Modified residuei571PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1
Modified residuei596Phosphothreonine; by PKC/PRKCZCombined sources2 Publications1
Modified residuei619PhosphoserineCombined sources1
Modified residuei722PhosphoserineCombined sources1
Isoform 13 (identifier: Q7KZI7-13)
Modified residuei376PhosphoserineCombined sources1
Isoform 14 (identifier: Q7KZI7-14)
Modified residuei376PhosphoserineCombined sources1
Isoform 15 (identifier: Q7KZI7-15)
Modified residuei409PhosphoserineCombined sources1
Isoform 16 (identifier: Q7KZI7-16)
Modified residuei409PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autophosphorylated. Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-208 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-212 by GSK3-beta (GSK3B) inhibits the kinase activity. Phosphorylation by CaMK1 promotes activity and is required to promote neurite outgrowth. Phosphorylation at Thr-596 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity and promotes binding to 14-3-3 protein YWHAZ, leading to relocation from cell membrane to cytoplasm.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q7KZI7

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q7KZI7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q7KZI7

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q7KZI7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q7KZI7

PeptideAtlas

More...PeptideAtlasi		Q7KZI7

PRoteomics IDEntifications database

More...PRIDEi		Q7KZI7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		68707 [Q7KZI7-1]
68708 [Q7KZI7-10]
68709 [Q7KZI7-11]
68710 [Q7KZI7-12]
68711 [Q7KZI7-13]
68712 [Q7KZI7-14]
68713 [Q7KZI7-15]
68714 [Q7KZI7-16]
68715 [Q7KZI7-2]
68716 [Q7KZI7-3]
68717 [Q7KZI7-4]
68718 [Q7KZI7-5]
68719 [Q7KZI7-6]
68720 [Q7KZI7-7]
68721 [Q7KZI7-8]
68722 [Q7KZI7-9]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q7KZI7, 3 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q7KZI7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q7KZI7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels of expression in heart, brain, skeletal muscle and pancreas, lower levels observed in lung, liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000072518, Expressed in esophagus mucosa and 161 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q7KZI7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q7KZI7, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000072518, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with PAK5; leading to inhibit the protein kinase activity (By similarity).

Interacts with MAPT/TAU (PubMed:23666762).

Interacts with MTCL1 isoform 1; the interaction is direct and increases MARK2 microtubule-binding ability (PubMed:23902687).

Interacts (when phosphorylated at Thr-596) with YWHAZ (PubMed:15324659).

Interacts with YWHAB, YWHAG and YWHAQ (PubMed:16959763).

By similarity4 Publications

(Microbial infection) In case of infection, interacts with H.pylori CagA, leading to inhibit kinase activity and junctional and polarity defects.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108326, 192 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q7KZI7

Database of interacting proteins

More...DIPi		DIP-31321N

Protein interaction database and analysis system

More...IntActi		Q7KZI7, 91 interactors

Molecular INTeraction database

More...MINTi		Q7KZI7

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000385751

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q7KZI7

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q7KZI7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1788
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7KZI7

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q7KZI7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 304Protein kinasePROSITE-ProRule annotationAdd BLAST252
Domaini323 – 362UBAPROSITE-ProRule annotationAdd BLAST40
Domaini739 – 788KA1PROSITE-ProRule annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 46DisorderedSequence analysisAdd BLAST46
Regioni373 – 632DisorderedSequence analysisAdd BLAST260

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi378 – 407Polar residuesSequence analysisAdd BLAST30
Compositional biasi414 – 430Polar residuesSequence analysisAdd BLAST17
Compositional biasi431 – 447Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi465 – 632Polar residuesSequence analysisAdd BLAST168

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The UBA domain does not seem to bind ubiquitin and ubiquitin-like and might play a role in regulating the enzyme conformation and localization. Activation of the kinase activity following phosphorylation at Thr-208 is accompanied by a conformational change that alters the orientation of the UBA domain with respect to the catalytic domain.1 Publication
The KA1 domain mediates binding to phospholipids and targeting to membranes.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0586, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155031

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_157_5_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q7KZI7

Identification of Orthologs from Complete Genome Data

More...OMAi		LHEPESK

Database of Orthologous Groups

More...OrthoDBi		1127668at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q7KZI7

TreeFam database of animal gene trees

More...TreeFami		TF315213

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028375, KA1/Ssp2_C
IPR001772, KA1_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR015940, UBA

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02149, KA1, 1 hit
PF00069, Pkinase, 1 hit
PF00627, UBA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit
SM00165, UBA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103243, SSF103243, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50032, KA1, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS50030, UBA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (16+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 16 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 16 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q7KZI7-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI 
        60         70         80         90        100
GNYRLLKTIG KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE 
       110        120        130        140        150
VRIMKVLNHP NIVKLFEVIE TEKTLYLVME YASGGEVFDY LVAHGRMKEK 
       160        170        180        190        200
EARAKFRQIV SAVQYCHQKF IVHRDLKAEN LLLDADMNIK IADFGFSNEF 
       210        220        230        240        250
TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF 
       260        270        280        290        300
DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK 
       310        320        330        340        350
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR 
       360        370        380        390        400
YNEVMATYLL LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS 
       410        420        430        440        450
ANPKQRRFSD QAAGPAIPTS NSYSKKTQSN NAENKRPEED RESGRKASST 
       460        470        480        490        500
AKVPASPLPG LERKKTTPTP STNSVLSTST NRSRNSPLLE RASLGQASIQ 
       510        520        530        540        550
NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP NKASGLPPTE 
       560        570        580        590        600
SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG 
       610        620        630        640        650
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR 
       660        670        680        690        700
FARRNLNEPE SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK 
       710        720        730        740        750
TTSSMEPNEM MREIRKVLDA NSCQSELHEK YMLLCMHGTP GHEDFVQWEM 
       760        770        780 
EVCKLPRLSL NGVRFKRISG TSMAFKNIAS KIANELKL
Note: Produced by alternative promoter usage.
Length:788
Mass (Da):87,911
Last modified:April 12, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF307BF4DDB543A70
GO
Isoform 21 Publication (identifier: Q7KZI7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     505-558: Missing.

Note: Produced by alternative splicing of isoform 6.1 Publication
Show »
Length:701
Mass (Da):78,851
Checksum:i3D68318CFDCA31EE
GO
Isoform 31 Publication (identifier: Q7KZI7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     644-652: Missing.

Note: Produced by alternative splicing of isoform 6.1 Publication
Show »
Length:746
Mass (Da):83,184
Checksum:i58F2BBE10943C90F
GO
Isoform 41 Publication (identifier: Q7KZI7-4) [UniParc]FASTAAdd to basket
Also known as: Par-1Balpha1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     505-558: Missing.
     644-652: Missing.

Note: Produced by alternative splicing of isoform 1.1 Publication
Show »
Length:725
Mass (Da):81,280
Checksum:iD676331938A84716
GO
Isoform 5 (identifier: Q7KZI7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-558: Missing.
     654-668: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:719
Mass (Da):80,647
Checksum:iEC39154CF73E9858
GO
Isoform 6Curated (identifier: Q7KZI7-6) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.

Note: Produced by alternative promoter usage.Curated
Show »
Length:755
Mass (Da):84,333
Checksum:i493CD8C6DC3A4C06
GO
Isoform 7Curated (identifier: Q7KZI7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     505-558: Missing.
     644-652: Missing.

Note: Produced by alternative splicing of isoform 6.Curated
Show »
Length:692
Mass (Da):77,702
Checksum:i4BD9AA1F872638A6
GO
Isoform 8Curated (identifier: Q7KZI7-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     644-652: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:779
Mass (Da):86,762
Checksum:i5AF7014EB5639857
GO
Isoform 9Curated (identifier: Q7KZI7-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-558: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:734
Mass (Da):82,429
Checksum:i60D126D3C8967186
GO
Isoform 10Curated (identifier: Q7KZI7-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     505-558: Missing.
     654-668: Missing.

Note: Produced by alternative splicing of isoform 6.Curated
Show »
Length:686
Mass (Da):77,069
Checksum:i9389E28076FDDAF8
GO
Isoform 11Curated (identifier: Q7KZI7-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     654-668: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:773
Mass (Da):86,129
Checksum:i0378FF0433C4D901
GO
Isoform 12Curated (identifier: Q7KZI7-12) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     654-668: Missing.

Note: Produced by alternative splicing of isoform 6.Curated
Show »
Length:740
Mass (Da):82,551
Checksum:i6220FC8C1A308548
GO
Isoform 13 (identifier: Q7KZI7-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     412-412: Missing.
     505-558: Missing.
     644-652: Missing.

Note: Produced by alternative splicing of isoform 6.Curated
Show »
Length:691
Mass (Da):77,631
Checksum:i2216B4AE7BCF31BE
GO
Isoform 14 (identifier: Q7KZI7-14) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     412-412: Missing.
     644-652: Missing.

Note: Produced by alternative splicing of isoform 6.Curated
Show »
Length:745
Mass (Da):83,113
Checksum:i54CA1DAF4B6E02CF
GO
Isoform 15 (identifier: Q7KZI7-15) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     412-412: Missing.
     505-558: Missing.
     645-668: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:709
Mass (Da):79,427
Checksum:iF30B3AB6B60B3621
GO
Isoform 16 (identifier: Q7KZI7-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     412-412: Missing.
     505-558: Missing.
     644-652: Missing.

Note: Produced by alternative splicing of isoform 1.Curated
Show »
Length:724
Mass (Da):81,209
Checksum:i9D8FB211F5B08149
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PC69E9PC69_HUMAN
Non-specific serine/threonine prote...
MARK2
778Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ETY4E7ETY4_HUMAN
Non-specific serine/threonine prote...
MARK2
763Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MRU9A0A0A0MRU9_HUMAN
Non-specific serine/threonine prote...
MARK2
732Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2YQR3A0A7I2YQR3_HUMAN
Non-specific serine/threonine prote...
MARK2
718Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2V3R3A0A7I2V3R3_HUMAN
Serine/threonine-protein kinase MAR...
MARK2
561Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4F6F5H4F6_HUMAN
Serine/threonine-protein kinase MAR...
MARK2
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H6N2F5H6N2_HUMAN
Serine/threonine-protein kinase MAR...
MARK2
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H4J8F5H4J8_HUMAN
Serine/threonine-protein kinase MAR...
MARK2
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GXH6A0A1B0GXH6_HUMAN
Serine/threonine-protein kinase MAR...
MARK2
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2YQF3A0A7I2YQF3_HUMAN
Serine/threonine-protein kinase MAR...
MARK2
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK82368 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti192A → G in CAA80914 (PubMed:8274451).Curated1
Sequence conflicti236L → C in CAA80914 (PubMed:8274451).Curated1
Sequence conflicti389 – 390PS → QF in CAA66229 (PubMed:9730619).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0517051 – 33Missing in isoform 2, isoform 3, isoform 6, isoform 7, isoform 10, isoform 12, isoform 13 and isoform 14. 2 PublicationsAdd BLAST33
Alternative sequenceiVSP_039872412Missing in isoform 13, isoform 14, isoform 15 and isoform 16. Curated1
Alternative sequenceiVSP_051706505 – 558Missing in isoform 2, isoform 4, isoform 5, isoform 7, isoform 9, isoform 10, isoform 13, isoform 15 and isoform 16. 4 PublicationsAdd BLAST54
Alternative sequenceiVSP_051707644 – 652Missing in isoform 3, isoform 4, isoform 7, isoform 8, isoform 13, isoform 14 and isoform 16. 3 Publications9
Alternative sequenceiVSP_041853645 – 668Missing in isoform 15. CuratedAdd BLAST24
Alternative sequenceiVSP_051708654 – 668Missing in isoform 5, isoform 11, isoform 10 and isoform 12. 3 PublicationsAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X97630 mRNA Translation: CAA66229.1
AB188493 mRNA Translation: BAD37141.1
BT007342 mRNA Translation: AAP36006.1
AP003780 Genomic DNA No translation available.
BC008771 mRNA Translation: AAH08771.2
BC084540 mRNA Translation: AAH84540.1
AF387638 mRNA Translation: AAK82368.1 Different initiation.
Z25427 mRNA Translation: CAA80914.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41665.1 [Q7KZI7-14]
CCDS53649.1 [Q7KZI7-1]
CCDS53650.1 [Q7KZI7-5]
CCDS53651.1 [Q7KZI7-15]
CCDS8051.2 [Q7KZI7-16]

Protein sequence database of the Protein Information Resource

More...PIRi		G01025
I38217

NCBI Reference Sequences

More...RefSeqi		NP_001034558.2, NM_001039469.2 [Q7KZI7-1]
NP_001156768.1, NM_001163296.1 [Q7KZI7-5]
NP_001156769.1, NM_001163297.1 [Q7KZI7-15]
NP_004945.4, NM_004954.4 [Q7KZI7-16]
NP_059672.2, NM_017490.3 [Q7KZI7-14]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000350490; ENSP00000294247; ENSG00000072518 [Q7KZI7-15]
ENST00000361128; ENSP00000355091; ENSG00000072518 [Q7KZI7-5]
ENST00000402010; ENSP00000385751; ENSG00000072518
ENST00000408948; ENSP00000386128; ENSG00000072518 [Q7KZI7-13]
ENST00000508192; ENSP00000425765; ENSG00000072518 [Q7KZI7-16]
ENST00000509502; ENSP00000423974; ENSG00000072518 [Q7KZI7-14]
ENST00000513765; ENSP00000421075; ENSG00000072518 [Q7KZI7-8]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2011

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2011

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000402010.8; ENSP00000385751.2; NM_001039469.3; NP_001034558.2

UCSC genome browser

More...UCSCi		uc001nxv.5, human [Q7KZI7-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97630 mRNA Translation: CAA66229.1
AB188493 mRNA Translation: BAD37141.1
BT007342 mRNA Translation: AAP36006.1
AP003780 Genomic DNA No translation available.
BC008771 mRNA Translation: AAH08771.2
BC084540 mRNA Translation: AAH84540.1
AF387638 mRNA Translation: AAK82368.1 Different initiation.
Z25427 mRNA Translation: CAA80914.1
CCDSiCCDS41665.1 [Q7KZI7-14]
CCDS53649.1 [Q7KZI7-1]
CCDS53650.1 [Q7KZI7-5]
CCDS53651.1 [Q7KZI7-15]
CCDS8051.2 [Q7KZI7-16]
PIRiG01025
I38217
RefSeqiNP_001034558.2, NM_001039469.2 [Q7KZI7-1]
NP_001156768.1, NM_001163296.1 [Q7KZI7-5]
NP_001156769.1, NM_001163297.1 [Q7KZI7-15]
NP_004945.4, NM_004954.4 [Q7KZI7-16]
NP_059672.2, NM_017490.3 [Q7KZI7-14]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IECX-ray2.20A/B/C/D49-363[»]
5EAKX-ray2.80A/B39-364[»]
5KZ7X-ray3.20A/B39-364[»]
5KZ8X-ray3.21A/B39-364[»]
SMRiQ7KZI7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108326, 192 interactors
CORUMiQ7KZI7
DIPiDIP-31321N
IntActiQ7KZI7, 91 interactors
MINTiQ7KZI7
STRINGi9606.ENSP00000385751

Chemistry databases

BindingDBiQ7KZI7
ChEMBLiCHEMBL3831
DrugBankiDB12010, Fostamatinib
DrugCentraliQ7KZI7

PTM databases

GlyGeniQ7KZI7, 3 sites, 1 O-linked glycan (1 site)
iPTMnetiQ7KZI7
PhosphoSitePlusiQ7KZI7

Genetic variation databases

BioMutaiMARK2
DMDMi62510922

Proteomic databases

EPDiQ7KZI7
jPOSTiQ7KZI7
MassIVEiQ7KZI7
MaxQBiQ7KZI7
PaxDbiQ7KZI7
PeptideAtlasiQ7KZI7
PRIDEiQ7KZI7
ProteomicsDBi68707 [Q7KZI7-1]
68708 [Q7KZI7-10]
68709 [Q7KZI7-11]
68710 [Q7KZI7-12]
68711 [Q7KZI7-13]
68712 [Q7KZI7-14]
68713 [Q7KZI7-15]
68714 [Q7KZI7-16]
68715 [Q7KZI7-2]
68716 [Q7KZI7-3]
68717 [Q7KZI7-4]
68718 [Q7KZI7-5]
68719 [Q7KZI7-6]
68720 [Q7KZI7-7]
68721 [Q7KZI7-8]
68722 [Q7KZI7-9]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15193, 479 antibodies from 41 providers

The DNASU plasmid repository

More...DNASUi		2011

Genome annotation databases

EnsembliENST00000350490; ENSP00000294247; ENSG00000072518 [Q7KZI7-15]
ENST00000361128; ENSP00000355091; ENSG00000072518 [Q7KZI7-5]
ENST00000402010; ENSP00000385751; ENSG00000072518
ENST00000408948; ENSP00000386128; ENSG00000072518 [Q7KZI7-13]
ENST00000508192; ENSP00000425765; ENSG00000072518 [Q7KZI7-16]
ENST00000509502; ENSP00000423974; ENSG00000072518 [Q7KZI7-14]
ENST00000513765; ENSP00000421075; ENSG00000072518 [Q7KZI7-8]
GeneIDi2011
KEGGihsa:2011
MANE-SelectiENST00000402010.8; ENSP00000385751.2; NM_001039469.3; NP_001034558.2
UCSCiuc001nxv.5, human [Q7KZI7-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2011
DisGeNETi2011

GeneCards: human genes, protein and diseases

More...GeneCardsi		MARK2
HGNCiHGNC:3332, MARK2
HPAiENSG00000072518, Low tissue specificity
MIMi600526, gene
neXtProtiNX_Q7KZI7
OpenTargetsiENSG00000072518
PharmGKBiPA35047
VEuPathDBiHostDB:ENSG00000072518

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0586, Eukaryota
GeneTreeiENSGT00940000155031
HOGENOMiCLU_000288_157_5_1
InParanoidiQ7KZI7
OMAiLHEPESK
OrthoDBi1127668at2759
PhylomeDBiQ7KZI7
TreeFamiTF315213

Enzyme and pathway databases

PathwayCommonsiQ7KZI7
SignaLinkiQ7KZI7
SIGNORiQ7KZI7

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2011, 134 hits in 1093 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MARK2, human
EvolutionaryTraceiQ7KZI7

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		MARK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2011
PharosiQ7KZI7, Tchem

Protein Ontology

More...PROi		PR:Q7KZI7
RNActiQ7KZI7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000072518, Expressed in esophagus mucosa and 161 other tissues
ExpressionAtlasiQ7KZI7, baseline and differential
GenevisibleiQ7KZI7, HS

Family and domain databases

InterProiView protein in InterPro
IPR028375, KA1/Ssp2_C
IPR001772, KA1_dom
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
IPR015940, UBA
PfamiView protein in Pfam
PF02149, KA1, 1 hit
PF00069, Pkinase, 1 hit
PF00627, UBA, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SM00165, UBA, 1 hit
SUPFAMiSSF103243, SSF103243, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50032, KA1, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit
PS50030, UBA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMARK2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KZI7
Secondary accession number(s): Q15449
, Q15524, Q5XGA3, Q68A18, Q96HB3, Q96RG0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: February 23, 2022
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
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