UniProtKB - Q7KZI7 (MARK2_HUMAN)
Serine/threonine-protein kinase MARK2
MARK2
Functioni
Serine/threonine-protein kinase (PubMed:23666762).
Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762).
Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
11 PublicationsCatalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 82 | ATPPROSITE-ProRule annotationBy similarity | 1 | |
Active sitei | 175 | Proton acceptorPROSITE-ProRule annotationBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 59 – 67 | ATPPROSITE-ProRule annotationBy similarity | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- cadherin binding Source: BHF-UCL
- lipid binding Source: UniProtKB-KW
- magnesium ion binding Source: UniProtKB
- protein kinase activator activity Source: ParkinsonsUK-UCL
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- RNA binding Source: UniProtKB
- tau protein binding Source: ARUK-UCL
- tau-protein kinase activity Source: UniProtKB
GO - Biological processi
- activation of protein kinase activity Source: ParkinsonsUK-UCL
- autophagy of mitochondrion Source: ParkinsonsUK-UCL
- axon development Source: ARUK-UCL
- establishment of cell polarity Source: UniProtKB
- establishment or maintenance of cell polarity regulating cell shape Source: ARUK-UCL
- establishment or maintenance of epithelial cell apical/basal polarity Source: UniProtKB
- intracellular signal transduction Source: UniProtKB
- microtubule cytoskeleton organization Source: GO_Central
- mitochondrion localization Source: ParkinsonsUK-UCL
- neuron migration Source: UniProtKB
- peptidyl-serine phosphorylation Source: ARUK-UCL
- peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of neuron projection development Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of axonogenesis Source: UniProtKB
- regulation of cytoskeleton organization Source: UniProtKB
- regulation of microtubule binding Source: ARUK-UCL
- regulation of microtubule cytoskeleton organization Source: ARUK-UCL
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Differentiation, Wnt signaling pathway |
Ligand | ATP-binding, Lipid-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q7KZI7 |
SignaLinki | Q7KZI7 |
SIGNORi | Q7KZI7 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3332, MARK2 |
MIMi | 600526, gene |
neXtProti | NX_Q7KZI7 |
VEuPathDBi | HostDB:ENSG00000072518 |
Subcellular locationi
Cytoplasm and Cytosol
Plasma membrane
Cytoskeleton
Other locations
- dendrite 1 Publication
Note: Phosphorylation at Thr-596 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm.
Cytoskeleton
- actin filament Source: UniProtKB
- microtubule bundle Source: UniProtKB
Mitochondrion
- mitochondrion Source: ParkinsonsUK-UCL
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- lateral plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 208 | T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication | 1 | |
Mutagenesisi | 596 | T → A: Loss of membrane dissociation and binding to YWHAZ. 2 Publications | 1 |
Organism-specific databases
DisGeNETi | 2011 |
OpenTargetsi | ENSG00000072518 |
PharmGKBi | PA35047 |
Miscellaneous databases
Pharosi | Q7KZI7, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3831 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q7KZI7 |
Genetic variation databases
BioMutai | MARK2 |
DMDMi | 62510922 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086301 | 1 – 788 | Serine/threonine-protein kinase MARK2Add BLAST | 788 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 40 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 58 | Phosphothreonine; by autocatalysisBy similarity | 1 | ||
Modified residuei | 91 | Phosphoserine; by CaMK1By similarity | 1 | ||
Modified residuei | 92 | Phosphoserine; by CaMK1By similarity | 1 | ||
Modified residuei | 93 | Phosphoserine; by CaMK1By similarity | 1 | ||
Modified residuei | 208 | Phosphothreonine; by LKB1 and TAOK1Combined sources1 Publication | 1 | ||
Modified residuei | 212 | Phosphoserine; by GSK3-betaBy similarity | 1 | ||
Modified residuei | 274 | Phosphoserine; by autocatalysisBy similarity | 1 | ||
Modified residuei | 275 | Phosphothreonine; by autocatalysisBy similarity | 1 | ||
Modified residuei | 294 | Phosphothreonine; by CaMK1By similarity | 1 | ||
Modified residuei | 409 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 456 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 467 | PhosphothreonineCombined sources | 1 | ||
Modified residuei | 486 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 493 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 569 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 571 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 592 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 596 | Phosphothreonine; by PKC/PRKCZCombined sources2 Publications | 1 | ||
Modified residuei | 619 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 722 | PhosphoserineCombined sources | 1 | ||
Isoform 13 (identifier: Q7KZI7-13) | |||||
Modified residuei | 376 | PhosphoserineCombined sources | 1 | ||
Isoform 14 (identifier: Q7KZI7-14) | |||||
Modified residuei | 376 | PhosphoserineCombined sources | 1 | ||
Isoform 15 (identifier: Q7KZI7-15) | |||||
Modified residuei | 409 | PhosphoserineCombined sources | 1 | ||
Isoform 16 (identifier: Q7KZI7-16) | |||||
Modified residuei | 409 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q7KZI7 |
jPOSTi | Q7KZI7 |
MassIVEi | Q7KZI7 |
MaxQBi | Q7KZI7 |
PaxDbi | Q7KZI7 |
PeptideAtlasi | Q7KZI7 |
PRIDEi | Q7KZI7 |
ProteomicsDBi | 68707 [Q7KZI7-1] 68708 [Q7KZI7-10] 68709 [Q7KZI7-11] 68710 [Q7KZI7-12] 68711 [Q7KZI7-13] 68712 [Q7KZI7-14] 68713 [Q7KZI7-15] 68714 [Q7KZI7-16] 68715 [Q7KZI7-2] 68716 [Q7KZI7-3] 68717 [Q7KZI7-4] 68718 [Q7KZI7-5] 68719 [Q7KZI7-6] 68720 [Q7KZI7-7] 68721 [Q7KZI7-8] 68722 [Q7KZI7-9] |
PTM databases
GlyGeni | Q7KZI7, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q7KZI7 |
PhosphoSitePlusi | Q7KZI7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000072518, Expressed in esophagus mucosa and 161 other tissues |
ExpressionAtlasi | Q7KZI7, baseline and differential |
Genevisiblei | Q7KZI7, HS |
Organism-specific databases
HPAi | ENSG00000072518, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer.
Interacts with PAK5; leading to inhibit the protein kinase activity (By similarity).
Interacts with MAPT/TAU (PubMed:23666762).
Interacts with MTCL1 isoform 1; the interaction is direct and increases MARK2 microtubule-binding ability (PubMed:23902687).
Interacts (when phosphorylated at Thr-596) with YWHAZ (PubMed:15324659).
Interacts with YWHAB, YWHAG and YWHAQ (PubMed:16959763).
By similarity4 Publications(Microbial infection) In case of infection, interacts with H.pylori CagA, leading to inhibit kinase activity and junctional and polarity defects.
2 PublicationsBinary interactionsi
Q7KZI7
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- tau protein binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 108326, 192 interactors |
CORUMi | Q7KZI7 |
DIPi | DIP-31321N |
IntActi | Q7KZI7, 91 interactors |
MINTi | Q7KZI7 |
STRINGi | 9606.ENSP00000385751 |
Chemistry databases
BindingDBi | Q7KZI7 |
Miscellaneous databases
RNActi | Q7KZI7, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q7KZI7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q7KZI7 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 304 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 252 | |
Domaini | 323 – 362 | UBAPROSITE-ProRule annotationAdd BLAST | 40 | |
Domaini | 739 – 788 | KA1PROSITE-ProRule annotationAdd BLAST | 50 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 46 | DisorderedSequence analysisAdd BLAST | 46 | |
Regioni | 373 – 632 | DisorderedSequence analysisAdd BLAST | 260 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 378 – 407 | Polar residuesSequence analysisAdd BLAST | 30 | |
Compositional biasi | 414 – 430 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 431 – 447 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 465 – 632 | Polar residuesSequence analysisAdd BLAST | 168 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0586, Eukaryota |
GeneTreei | ENSGT00940000155031 |
HOGENOMi | CLU_000288_157_5_1 |
InParanoidi | Q7KZI7 |
OMAi | LHEPESK |
OrthoDBi | 1127668at2759 |
PhylomeDBi | Q7KZI7 |
TreeFami | TF315213 |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
s (16+)i Sequence
Sequence statusi: Complete.
This entry describes 16 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 16 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI
60 70 80 90 100
GNYRLLKTIG KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE
110 120 130 140 150
VRIMKVLNHP NIVKLFEVIE TEKTLYLVME YASGGEVFDY LVAHGRMKEK
160 170 180 190 200
EARAKFRQIV SAVQYCHQKF IVHRDLKAEN LLLDADMNIK IADFGFSNEF
210 220 230 240 250
TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF
260 270 280 290 300
DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
310 320 330 340 350
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR
360 370 380 390 400
YNEVMATYLL LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS
410 420 430 440 450
ANPKQRRFSD QAAGPAIPTS NSYSKKTQSN NAENKRPEED RESGRKASST
460 470 480 490 500
AKVPASPLPG LERKKTTPTP STNSVLSTST NRSRNSPLLE RASLGQASIQ
510 520 530 540 550
NGKDSLTMPG SRASTASASA AVSAARPRQH QKSMSASVHP NKASGLPPTE
560 570 580 590 600
SNCEVPRPST APQRVPVASP SAHNISSSGG APDRTNFPRG VSSRSTFHAG
610 620 630 640 650
QLRQVRDQQN LPYGVTPASP SGHSQGRRGA SGSIFSKFTS KFVRRNLSFR
660 670 680 690 700
FARRNLNEPE SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK
710 720 730 740 750
TTSSMEPNEM MREIRKVLDA NSCQSELHEK YMLLCMHGTP GHEDFVQWEM
760 770 780
EVCKLPRLSL NGVRFKRISG TSMAFKNIAS KIANELKL
The sequence of this isoform differs from the canonical sequence as follows:
1-33: Missing.
505-558: Missing.
654-668: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
654-668: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-33: Missing.
654-668: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-33: Missing.
412-412: Missing.
505-558: Missing.
644-652: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
1-33: Missing.
412-412: Missing.
644-652: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
412-412: Missing.
505-558: Missing.
645-668: Missing.
The sequence of this isoform differs from the canonical sequence as follows:
412-412: Missing.
505-558: Missing.
644-652: Missing.
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PC69 | E9PC69_HUMAN | Non-specific serine/threonine prote... | MARK2 | 778 | Annotation score: | ||
E7ETY4 | E7ETY4_HUMAN | Non-specific serine/threonine prote... | MARK2 | 763 | Annotation score: | ||
A0A0A0MRU9 | A0A0A0MRU9_HUMAN | Non-specific serine/threonine prote... | MARK2 | 732 | Annotation score: | ||
A0A7I2YQR3 | A0A7I2YQR3_HUMAN | Non-specific serine/threonine prote... | MARK2 | 718 | Annotation score: | ||
A0A7I2V3R3 | A0A7I2V3R3_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 561 | Annotation score: | ||
F5H4F6 | F5H4F6_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 161 | Annotation score: | ||
F5H6N2 | F5H6N2_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 111 | Annotation score: | ||
F5H4J8 | F5H4J8_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 91 | Annotation score: | ||
A0A1B0GXH6 | A0A1B0GXH6_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 60 | Annotation score: | ||
A0A7I2YQF3 | A0A7I2YQF3_HUMAN | Serine/threonine-protein kinase MAR... | MARK2 | 128 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 192 | A → G in CAA80914 (PubMed:8274451).Curated | 1 | |
Sequence conflicti | 236 | L → C in CAA80914 (PubMed:8274451).Curated | 1 | |
Sequence conflicti | 389 – 390 | PS → QF in CAA66229 (PubMed:9730619).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_051705 | 1 – 33 | Missing in isoform 2, isoform 3, isoform 6, isoform 7, isoform 10, isoform 12, isoform 13 and isoform 14. 2 PublicationsAdd BLAST | 33 | |
Alternative sequenceiVSP_039872 | 412 | Missing in isoform 13, isoform 14, isoform 15 and isoform 16. Curated | 1 | |
Alternative sequenceiVSP_051706 | 505 – 558 | Missing in isoform 2, isoform 4, isoform 5, isoform 7, isoform 9, isoform 10, isoform 13, isoform 15 and isoform 16. 4 PublicationsAdd BLAST | 54 | |
Alternative sequenceiVSP_051707 | 644 – 652 | Missing in isoform 3, isoform 4, isoform 7, isoform 8, isoform 13, isoform 14 and isoform 16. 3 Publications | 9 | |
Alternative sequenceiVSP_041853 | 645 – 668 | Missing in isoform 15. CuratedAdd BLAST | 24 | |
Alternative sequenceiVSP_051708 | 654 – 668 | Missing in isoform 5, isoform 11, isoform 10 and isoform 12. 3 PublicationsAdd BLAST | 15 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97630 mRNA Translation: CAA66229.1 AB188493 mRNA Translation: BAD37141.1 BT007342 mRNA Translation: AAP36006.1 AP003780 Genomic DNA No translation available. BC008771 mRNA Translation: AAH08771.2 BC084540 mRNA Translation: AAH84540.1 AF387638 mRNA Translation: AAK82368.1 Different initiation. Z25427 mRNA Translation: CAA80914.1 |
CCDSi | CCDS41665.1 [Q7KZI7-14] CCDS53649.1 [Q7KZI7-1] CCDS53650.1 [Q7KZI7-5] CCDS53651.1 [Q7KZI7-15] CCDS8051.2 [Q7KZI7-16] |
PIRi | G01025 I38217 |
RefSeqi | NP_001034558.2, NM_001039469.2 [Q7KZI7-1] NP_001156768.1, NM_001163296.1 [Q7KZI7-5] NP_001156769.1, NM_001163297.1 [Q7KZI7-15] NP_004945.4, NM_004954.4 [Q7KZI7-16] NP_059672.2, NM_017490.3 [Q7KZI7-14] |
Genome annotation databases
Ensembli | ENST00000350490; ENSP00000294247; ENSG00000072518 [Q7KZI7-15] ENST00000361128; ENSP00000355091; ENSG00000072518 [Q7KZI7-5] ENST00000402010; ENSP00000385751; ENSG00000072518 ENST00000408948; ENSP00000386128; ENSG00000072518 [Q7KZI7-13] ENST00000508192; ENSP00000425765; ENSG00000072518 [Q7KZI7-16] ENST00000509502; ENSP00000423974; ENSG00000072518 [Q7KZI7-14] ENST00000513765; ENSP00000421075; ENSG00000072518 [Q7KZI7-8] |
GeneIDi | 2011 |
KEGGi | hsa:2011 |
MANE-Selecti | ENST00000402010.8; ENSP00000385751.2; NM_001039469.3; NP_001034558.2 |
UCSCi | uc001nxv.5, human [Q7KZI7-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97630 mRNA Translation: CAA66229.1 AB188493 mRNA Translation: BAD37141.1 BT007342 mRNA Translation: AAP36006.1 AP003780 Genomic DNA No translation available. BC008771 mRNA Translation: AAH08771.2 BC084540 mRNA Translation: AAH84540.1 AF387638 mRNA Translation: AAK82368.1 Different initiation. Z25427 mRNA Translation: CAA80914.1 |
CCDSi | CCDS41665.1 [Q7KZI7-14] CCDS53649.1 [Q7KZI7-1] CCDS53650.1 [Q7KZI7-5] CCDS53651.1 [Q7KZI7-15] CCDS8051.2 [Q7KZI7-16] |
PIRi | G01025 I38217 |
RefSeqi | NP_001034558.2, NM_001039469.2 [Q7KZI7-1] NP_001156768.1, NM_001163296.1 [Q7KZI7-5] NP_001156769.1, NM_001163297.1 [Q7KZI7-15] NP_004945.4, NM_004954.4 [Q7KZI7-16] NP_059672.2, NM_017490.3 [Q7KZI7-14] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3IEC | X-ray | 2.20 | A/B/C/D | 49-363 | [»] | |
5EAK | X-ray | 2.80 | A/B | 39-364 | [»] | |
5KZ7 | X-ray | 3.20 | A/B | 39-364 | [»] | |
5KZ8 | X-ray | 3.21 | A/B | 39-364 | [»] | |
SMRi | Q7KZI7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108326, 192 interactors |
CORUMi | Q7KZI7 |
DIPi | DIP-31321N |
IntActi | Q7KZI7, 91 interactors |
MINTi | Q7KZI7 |
STRINGi | 9606.ENSP00000385751 |
Chemistry databases
BindingDBi | Q7KZI7 |
ChEMBLi | CHEMBL3831 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q7KZI7 |
PTM databases
GlyGeni | Q7KZI7, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q7KZI7 |
PhosphoSitePlusi | Q7KZI7 |
Genetic variation databases
BioMutai | MARK2 |
DMDMi | 62510922 |
Proteomic databases
EPDi | Q7KZI7 |
jPOSTi | Q7KZI7 |
MassIVEi | Q7KZI7 |
MaxQBi | Q7KZI7 |
PaxDbi | Q7KZI7 |
PeptideAtlasi | Q7KZI7 |
PRIDEi | Q7KZI7 |
ProteomicsDBi | 68707 [Q7KZI7-1] 68708 [Q7KZI7-10] 68709 [Q7KZI7-11] 68710 [Q7KZI7-12] 68711 [Q7KZI7-13] 68712 [Q7KZI7-14] 68713 [Q7KZI7-15] 68714 [Q7KZI7-16] 68715 [Q7KZI7-2] 68716 [Q7KZI7-3] 68717 [Q7KZI7-4] 68718 [Q7KZI7-5] 68719 [Q7KZI7-6] 68720 [Q7KZI7-7] 68721 [Q7KZI7-8] 68722 [Q7KZI7-9] |
Protocols and materials databases
Antibodypediai | 15193, 479 antibodies from 41 providers |
DNASUi | 2011 |
Genome annotation databases
Ensembli | ENST00000350490; ENSP00000294247; ENSG00000072518 [Q7KZI7-15] ENST00000361128; ENSP00000355091; ENSG00000072518 [Q7KZI7-5] ENST00000402010; ENSP00000385751; ENSG00000072518 ENST00000408948; ENSP00000386128; ENSG00000072518 [Q7KZI7-13] ENST00000508192; ENSP00000425765; ENSG00000072518 [Q7KZI7-16] ENST00000509502; ENSP00000423974; ENSG00000072518 [Q7KZI7-14] ENST00000513765; ENSP00000421075; ENSG00000072518 [Q7KZI7-8] |
GeneIDi | 2011 |
KEGGi | hsa:2011 |
MANE-Selecti | ENST00000402010.8; ENSP00000385751.2; NM_001039469.3; NP_001034558.2 |
UCSCi | uc001nxv.5, human [Q7KZI7-1] |
Organism-specific databases
CTDi | 2011 |
DisGeNETi | 2011 |
GeneCardsi | MARK2 |
HGNCi | HGNC:3332, MARK2 |
HPAi | ENSG00000072518, Low tissue specificity |
MIMi | 600526, gene |
neXtProti | NX_Q7KZI7 |
OpenTargetsi | ENSG00000072518 |
PharmGKBi | PA35047 |
VEuPathDBi | HostDB:ENSG00000072518 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0586, Eukaryota |
GeneTreei | ENSGT00940000155031 |
HOGENOMi | CLU_000288_157_5_1 |
InParanoidi | Q7KZI7 |
OMAi | LHEPESK |
OrthoDBi | 1127668at2759 |
PhylomeDBi | Q7KZI7 |
TreeFami | TF315213 |
Enzyme and pathway databases
PathwayCommonsi | Q7KZI7 |
SignaLinki | Q7KZI7 |
SIGNORi | Q7KZI7 |
Miscellaneous databases
BioGRID-ORCSi | 2011, 134 hits in 1093 CRISPR screens |
ChiTaRSi | MARK2, human |
EvolutionaryTracei | Q7KZI7 |
GeneWikii | MARK2 |
GenomeRNAii | 2011 |
Pharosi | Q7KZI7, Tchem |
PROi | PR:Q7KZI7 |
RNActi | Q7KZI7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000072518, Expressed in esophagus mucosa and 161 other tissues |
ExpressionAtlasi | Q7KZI7, baseline and differential |
Genevisiblei | Q7KZI7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028375, KA1/Ssp2_C IPR001772, KA1_dom IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR015940, UBA |
Pfami | View protein in Pfam PF02149, KA1, 1 hit PF00069, Pkinase, 1 hit PF00627, UBA, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit SM00165, UBA, 1 hit |
SUPFAMi | SSF103243, SSF103243, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50032, KA1, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MARK2_HUMAN | |
Accessioni | Q7KZI7Primary (citable) accession number: Q7KZI7 Secondary accession number(s): Q15449 Q96RG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 12, 2005 |
Last sequence update: | April 12, 2005 | |
Last modified: | February 23, 2022 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families