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Entry version 162 (13 Feb 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Staphylococcal nuclease domain-containing protein 1

Gene

SND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:28546213, PubMed:18453631). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity).By similarity4 Publications
(Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • endonuclease activity Source: UniProtKB
  • endoribonuclease activity Source: UniProtKB
  • nuclease activity Source: GO_Central
  • RISC complex binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • transcription coregulator activity Source: ProtInc

GO - Biological processi

  • gene silencing by RNA Source: InterPro
  • miRNA catabolic process Source: UniProtKB
  • osteoblast differentiation Source: UniProtKB
  • regulation of cell cycle process Source: UniProtKB
  • RNA catabolic process Source: GO_Central
  • viral process Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.31.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6802952 Signaling by BRAF and RAF fusions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Staphylococcal nuclease domain-containing protein 1 (EC:3.1.31.12 Publications)
Alternative name(s):
100 kDa coactivator
EBNA2 coactivator p100
Tudor domain-containing protein 11
p100 co-activator
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SND1
Synonyms:TDRD11
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197157.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30646 SND1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602181 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7KZF4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
27044

Open Targets

More...
OpenTargetsi
ENSG00000197157

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162404053

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3879865

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SND1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
60415926

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001831802 – 910Staphylococcal nuclease domain-containing protein 1Add BLAST909

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei103PhosphothreonineCombined sources1
Modified residuei193N6-acetyllysineCombined sources1
Modified residuei240PhosphothreonineCombined sources1
Modified residuei426PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki513Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei641N6-acetyllysineCombined sources1
Modified residuei645PhosphoserineCombined sources1
Modified residuei779PhosphothreonineCombined sources1
Modified residuei781PhosphoserineCombined sources1
Modified residuei785PhosphoserineCombined sources1
Modified residuei909PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by PIM1 in vitro.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7KZF4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7KZF4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q7KZF4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7KZF4

PeptideAtlas

More...
PeptideAtlasi
Q7KZF4

PRoteomics IDEntifications database

More...
PRIDEi
Q7KZF4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68706

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
IPI00140420

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7KZF4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7KZF4

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7KZF4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197157 Expressed in 233 organ(s), highest expression level in body of pancreas

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7KZF4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7KZF4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB019323
HPA002529
HPA002632

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a ternary complex with STAT6 and POLR2A (PubMed:12234934). Associates with the RNA-induced silencing complex (RISC) (PubMed:14508492, PubMed:28546213). Interacts with the RISC components AGO2, FMR1 and TNRC6A (PubMed:14508492, PubMed:28546213). Interacts with GTF2E1 and GTF2E2 (PubMed:7651391). Interacts with PIM1 (PubMed:9809063). Interacts with STAT5 (By similarity).By similarity5 Publications
(Microbial infection) Interacts with EAV NSP1 (PubMed:12917451). Binds to acidic transactivation domain of EBNA2 (PubMed:7651391).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117974, 132 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q7KZF4

Database of interacting proteins

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DIPi
DIP-29613N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q7KZF4

Protein interaction database and analysis system

More...
IntActi
Q7KZF4, 37 interactors

Molecular INTeraction database

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MINTi
Q7KZF4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000346762

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1910
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E6NNMR-A704-800[»]
2HQEX-ray2.00A/B665-910[»]
2HQXX-ray1.42A/B665-910[»]
2O4XX-ray2.00A679-895[»]
B705-795[»]
3BDLX-ray1.90A340-888[»]
3OMCX-ray1.77A/B650-910[»]
3OMGX-ray1.85A/B650-910[»]
4QMGX-ray2.70A/B/C/D/E16-339[»]
5M9OX-ray1.45A677-900[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q7KZF4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7KZF4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q7KZF4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 166TNase-like 1PROSITE-ProRule annotationAdd BLAST149
Domaini193 – 328TNase-like 2PROSITE-ProRule annotationAdd BLAST136
Domaini341 – 496TNase-like 3PROSITE-ProRule annotationAdd BLAST156
Domaini525 – 660TNase-like 4PROSITE-ProRule annotationAdd BLAST136
Domaini729 – 787TudorPROSITE-ProRule annotationAdd BLAST59

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi321 – 325Nuclear localization signalSequence analysis5
Motifi388 – 392Nuclear localization signalSequence analysis5

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2039 Eukaryota
COG1525 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047270

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG057234

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q7KZF4

KEGG Orthology (KO)

More...
KOi
K15979

Identification of Orthologs from Complete Genome Data

More...
OMAi
QDEDART

Database of Orthologous Groups

More...
OrthoDBi
227839at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7KZF4

TreeFam database of animal gene trees

More...
TreeFami
TF300615

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.90, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016685 Silence_cplx_Nase-comp_TudorSN
IPR035437 SNase_OB-fold_sf
IPR016071 Staphylococal_nuclease_OB-fold
IPR002071 Thermonucl_AS
IPR002999 Tudor

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00565 SNase, 5 hits
PF00567 TUDOR, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF017179 RISC-Tudor-SN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00318 SNc, 4 hits
SM00333 TUDOR, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01284 TNASE_2, 1 hit
PS50830 TNASE_3, 4 hits
PS50304 TUDOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7KZF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSAQSGGS SGGPAVPTVQ RGIIKMVLSG CAIIVRGQPR GGPPPERQIN
60 70 80 90 100
LSNIRAGNLA RRAAATQPDA KDTPDEPWAF PAREFLRKKL IGKEVCFTIE
110 120 130 140 150
NKTPQGREYG MIYLGKDTNG ENIAESLVAE GLATRREGMR ANNPEQNRLS
160 170 180 190 200
ECEEQAKAAK KGMWSEGNGS HTIRDLKYTI ENPRHFVDSH HQKPVNAIIE
210 220 230 240 250
HVRDGSVVRA LLLPDYYLVT VMLSGIKCPT FRREADGSET PEPFAAEAKF
260 270 280 290 300
FTESRLLQRD VQIILESCHN QNILGTILHP NGNITELLLK EGFARCVDWS
310 320 330 340 350
IAVYTRGAEK LRAAERFAKE RRLRIWRDYV APTANLDQKD KQFVAKVMQV
360 370 380 390 400
LNADAIVVKL NSGDYKTIHL SSIRPPRLEG ENTQDKNKKL RPLYDIPYMF
410 420 430 440 450
EAREFLRKKL IGKKVNVTVD YIRPASPATE TVPAFSERTC ATVTIGGINI
460 470 480 490 500
AEALVSKGLA TVIRYRQDDD QRSSHYDELL AAEARAIKNG KGLHSKKEVP
510 520 530 540 550
IHRVADISGD TQKAKQFLPF LQRAGRSEAV VEYVFSGSRL KLYLPKETCL
560 570 580 590 600
ITFLLAGIEC PRGARNLPGL VQEGEPFSEE ATLFTKELVL QREVEVEVES
610 620 630 640 650
MDKAGNFIGW LHIDGANLSV LLVEHALSKV HFTAERSSYY KSLLSAEEAA
660 670 680 690 700
KQKKEKVWAH YEEQPVEEVM PVLEEKERSA SYKPVFVTEI TDDLHFYVQD
710 720 730 740 750
VETGTQLEKL MENMRNDIAS HPPVEGSYAP RRGEFCIAKF VDGEWYRARV
760 770 780 790 800
EKVESPAKIH VFYIDYGNRE VLPSTRLGTL SPAFSTRVLP AQATEYAFAF
810 820 830 840 850
IQVPQDDDAR TDAVDSVVRD IQNTQCLLNV EHLSAGCPHV TLQFADSKGD
860 870 880 890 900
VGLGLVKEGL VMVEVRKEKQ FQKVITEYLN AQESAKSARL NLWRYGDFRA
910
DDADEFGYSR
Length:910
Mass (Da):101,997
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD58BF200F3F3D628
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C597H7C597_HUMAN
Staphylococcal nuclease domain-cont...
SND1
231Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA80488 differs from that shown. Reason: Frameshift at position 5. The frameshift leads to wrong initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti274L → V in AAA80488 (PubMed:7651391).Curated1
Sequence conflicti707 – 708LE → FQ in AAA80488 (PubMed:7651391).Curated2

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U22055 mRNA Translation: AAA80488.1 Sequence problems.
BT009785 mRNA Translation: AAP88787.1
BC017180 mRNA Translation: AAH17180.3

The Consensus CDS (CCDS) project

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CCDSi
CCDS34747.1

Protein sequence database of the Protein Information Resource

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PIRi
I38968

NCBI Reference Sequences

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RefSeqi
NP_055205.2, NM_014390.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.122523

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000354725; ENSP00000346762; ENSG00000197157

Database of genes from NCBI RefSeq genomes

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GeneIDi
27044

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:27044

UCSC genome browser

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UCSCi
uc003vmi.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22055 mRNA Translation: AAA80488.1 Sequence problems.
BT009785 mRNA Translation: AAP88787.1
BC017180 mRNA Translation: AAH17180.3
CCDSiCCDS34747.1
PIRiI38968
RefSeqiNP_055205.2, NM_014390.3
UniGeneiHs.122523

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E6NNMR-A704-800[»]
2HQEX-ray2.00A/B665-910[»]
2HQXX-ray1.42A/B665-910[»]
2O4XX-ray2.00A679-895[»]
B705-795[»]
3BDLX-ray1.90A340-888[»]
3OMCX-ray1.77A/B650-910[»]
3OMGX-ray1.85A/B650-910[»]
4QMGX-ray2.70A/B/C/D/E16-339[»]
5M9OX-ray1.45A677-900[»]
ProteinModelPortaliQ7KZF4
SMRiQ7KZF4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117974, 132 interactors
CORUMiQ7KZF4
DIPiDIP-29613N
ELMiQ7KZF4
IntActiQ7KZF4, 37 interactors
MINTiQ7KZF4
STRINGi9606.ENSP00000346762

Chemistry databases

ChEMBLiCHEMBL3879865

PTM databases

iPTMnetiQ7KZF4
PhosphoSitePlusiQ7KZF4
SwissPalmiQ7KZF4

Polymorphism and mutation databases

BioMutaiSND1
DMDMi60415926

2D gel databases

REPRODUCTION-2DPAGEiIPI00140420

Proteomic databases

EPDiQ7KZF4
jPOSTiQ7KZF4
MaxQBiQ7KZF4
PaxDbiQ7KZF4
PeptideAtlasiQ7KZF4
PRIDEiQ7KZF4
ProteomicsDBi68706

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
27044
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354725; ENSP00000346762; ENSG00000197157
GeneIDi27044
KEGGihsa:27044
UCSCiuc003vmi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
27044
DisGeNETi27044
EuPathDBiHostDB:ENSG00000197157.10

GeneCards: human genes, protein and diseases

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GeneCardsi
SND1
HGNCiHGNC:30646 SND1
HPAiCAB019323
HPA002529
HPA002632
MIMi602181 gene
neXtProtiNX_Q7KZF4
OpenTargetsiENSG00000197157
PharmGKBiPA162404053

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2039 Eukaryota
COG1525 LUCA
GeneTreeiENSGT00510000047270
HOVERGENiHBG057234
InParanoidiQ7KZF4
KOiK15979
OMAiQDEDART
OrthoDBi227839at2759
PhylomeDBiQ7KZF4
TreeFamiTF300615

Enzyme and pathway databases

BRENDAi3.1.31.1 2681
ReactomeiR-HSA-6802952 Signaling by BRAF and RAF fusions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SND1 human
EvolutionaryTraceiQ7KZF4

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SND1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
27044

Protein Ontology

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PROi
PR:Q7KZF4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197157 Expressed in 233 organ(s), highest expression level in body of pancreas
ExpressionAtlasiQ7KZF4 baseline and differential
GenevisibleiQ7KZF4 HS

Family and domain databases

Gene3Di2.40.50.90, 5 hits
InterProiView protein in InterPro
IPR016685 Silence_cplx_Nase-comp_TudorSN
IPR035437 SNase_OB-fold_sf
IPR016071 Staphylococal_nuclease_OB-fold
IPR002071 Thermonucl_AS
IPR002999 Tudor
PfamiView protein in Pfam
PF00565 SNase, 5 hits
PF00567 TUDOR, 1 hit
PIRSFiPIRSF017179 RISC-Tudor-SN, 1 hit
SMARTiView protein in SMART
SM00318 SNc, 4 hits
SM00333 TUDOR, 1 hit
PROSITEiView protein in PROSITE
PS01284 TNASE_2, 1 hit
PS50830 TNASE_3, 4 hits
PS50304 TUDOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSND1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KZF4
Secondary accession number(s): Q13122, Q96AG0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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