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Protein

Staphylococcal nuclease domain-containing protein 1

Gene

SND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs (PubMed:28546213, PubMed:18453631). As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition (PubMed:28546213). Functions as a bridging factor between STAT6 and the basal transcription factor (PubMed:12234934). Plays a role in PIM1 regulation of MYB activity (PubMed:9809063). Functions as a transcriptional coactivator for STAT5 (By similarity).By similarity4 Publications
(Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).1 Publication

Catalytic activityi

Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products.2 Publications

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • endonuclease activity Source: UniProtKB
  • endoribonuclease activity Source: UniProtKB
  • nuclease activity Source: GO_Central
  • RISC complex binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • transcription coregulator activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processHost-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

BRENDAi3.1.31.1 2681
ReactomeiR-HSA-6802952 Signaling by BRAF and RAF fusions

Names & Taxonomyi

Protein namesi
Recommended name:
Staphylococcal nuclease domain-containing protein 1 (EC:3.1.31.12 Publications)
Alternative name(s):
100 kDa coactivator
EBNA2 coactivator p100
Tudor domain-containing protein 11
p100 co-activator
Gene namesi
Name:SND1
Synonyms:TDRD11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000197157.10
HGNCiHGNC:30646 SND1
MIMi602181 gene
neXtProtiNX_Q7KZF4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27044
OpenTargetsiENSG00000197157
PharmGKBiPA162404053

Chemistry databases

ChEMBLiCHEMBL3879865

Polymorphism and mutation databases

BioMutaiSND1
DMDMi60415926

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001831802 – 910Staphylococcal nuclease domain-containing protein 1Add BLAST909

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei103PhosphothreonineCombined sources1
Modified residuei193N6-acetyllysineCombined sources1
Modified residuei240PhosphothreonineCombined sources1
Modified residuei426PhosphoserineCombined sources1
Cross-linki513Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei641N6-acetyllysineCombined sources1
Modified residuei645PhosphoserineCombined sources1
Modified residuei779PhosphothreonineCombined sources1
Modified residuei781PhosphoserineCombined sources1
Modified residuei785PhosphoserineCombined sources1
Modified residuei909PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by PIM1 in vitro.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7KZF4
MaxQBiQ7KZF4
PaxDbiQ7KZF4
PeptideAtlasiQ7KZF4
PRIDEiQ7KZF4
ProteomicsDBi68706

2D gel databases

REPRODUCTION-2DPAGEiIPI00140420

PTM databases

iPTMnetiQ7KZF4
PhosphoSitePlusiQ7KZF4
SwissPalmiQ7KZF4

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000197157 Expressed in 233 organ(s), highest expression level in body of pancreas
CleanExiHS_SND1
ExpressionAtlasiQ7KZF4 baseline and differential
GenevisibleiQ7KZF4 HS

Organism-specific databases

HPAiCAB019323
HPA002529
HPA002632

Interactioni

Subunit structurei

Forms a ternary complex with STAT6 and POLR2A (PubMed:12234934). Associates with the RNA-induced silencing complex (RISC) (PubMed:14508492, PubMed:28546213). Interacts with the RISC components AGO2, FMR1 and TNRC6A (PubMed:14508492, PubMed:28546213). Interacts with GTF2E1 and GTF2E2 (PubMed:7651391). Interacts with PIM1 (PubMed:9809063). Interacts with STAT5 (By similarity).By similarity5 Publications
(Microbial infection) Interacts with EAV NSP1 (PubMed:12917451). Binds to acidic transactivation domain of EBNA2 (PubMed:7651391).2 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi117974, 128 interactors
CORUMiQ7KZF4
DIPiDIP-29613N
ELMiQ7KZF4
IntActiQ7KZF4, 34 interactors
MINTiQ7KZF4
STRINGi9606.ENSP00000346762

Structurei

Secondary structure

1910
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ7KZF4
SMRiQ7KZF4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7KZF4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 166TNase-like 1PROSITE-ProRule annotationAdd BLAST149
Domaini193 – 328TNase-like 2PROSITE-ProRule annotationAdd BLAST136
Domaini341 – 496TNase-like 3PROSITE-ProRule annotationAdd BLAST156
Domaini525 – 660TNase-like 4PROSITE-ProRule annotationAdd BLAST136
Domaini729 – 787TudorPROSITE-ProRule annotationAdd BLAST59

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi321 – 325Nuclear localization signalSequence analysis5
Motifi388 – 392Nuclear localization signalSequence analysis5

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2039 Eukaryota
COG1525 LUCA
GeneTreeiENSGT00510000047270
HOVERGENiHBG057234
InParanoidiQ7KZF4
KOiK15979
OMAiTDDLHFY
OrthoDBiEOG091G027G
PhylomeDBiQ7KZF4
TreeFamiTF300615

Family and domain databases

Gene3Di2.40.50.90, 6 hits
InterProiView protein in InterPro
IPR016685 Silence_cplx_Nase-comp_TudorSN
IPR035437 SNase_OB-fold_sf
IPR016071 Staphylococal_nuclease_OB-fold
IPR002071 Thermonucl_AS
IPR002999 Tudor
PfamiView protein in Pfam
PF00565 SNase, 5 hits
PF00567 TUDOR, 1 hit
PIRSFiPIRSF017179 RISC-Tudor-SN, 1 hit
SMARTiView protein in SMART
SM00318 SNc, 4 hits
SM00333 TUDOR, 1 hit
PROSITEiView protein in PROSITE
PS01284 TNASE_2, 1 hit
PS50830 TNASE_3, 4 hits
PS50304 TUDOR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q7KZF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSAQSGGS SGGPAVPTVQ RGIIKMVLSG CAIIVRGQPR GGPPPERQIN
60 70 80 90 100
LSNIRAGNLA RRAAATQPDA KDTPDEPWAF PAREFLRKKL IGKEVCFTIE
110 120 130 140 150
NKTPQGREYG MIYLGKDTNG ENIAESLVAE GLATRREGMR ANNPEQNRLS
160 170 180 190 200
ECEEQAKAAK KGMWSEGNGS HTIRDLKYTI ENPRHFVDSH HQKPVNAIIE
210 220 230 240 250
HVRDGSVVRA LLLPDYYLVT VMLSGIKCPT FRREADGSET PEPFAAEAKF
260 270 280 290 300
FTESRLLQRD VQIILESCHN QNILGTILHP NGNITELLLK EGFARCVDWS
310 320 330 340 350
IAVYTRGAEK LRAAERFAKE RRLRIWRDYV APTANLDQKD KQFVAKVMQV
360 370 380 390 400
LNADAIVVKL NSGDYKTIHL SSIRPPRLEG ENTQDKNKKL RPLYDIPYMF
410 420 430 440 450
EAREFLRKKL IGKKVNVTVD YIRPASPATE TVPAFSERTC ATVTIGGINI
460 470 480 490 500
AEALVSKGLA TVIRYRQDDD QRSSHYDELL AAEARAIKNG KGLHSKKEVP
510 520 530 540 550
IHRVADISGD TQKAKQFLPF LQRAGRSEAV VEYVFSGSRL KLYLPKETCL
560 570 580 590 600
ITFLLAGIEC PRGARNLPGL VQEGEPFSEE ATLFTKELVL QREVEVEVES
610 620 630 640 650
MDKAGNFIGW LHIDGANLSV LLVEHALSKV HFTAERSSYY KSLLSAEEAA
660 670 680 690 700
KQKKEKVWAH YEEQPVEEVM PVLEEKERSA SYKPVFVTEI TDDLHFYVQD
710 720 730 740 750
VETGTQLEKL MENMRNDIAS HPPVEGSYAP RRGEFCIAKF VDGEWYRARV
760 770 780 790 800
EKVESPAKIH VFYIDYGNRE VLPSTRLGTL SPAFSTRVLP AQATEYAFAF
810 820 830 840 850
IQVPQDDDAR TDAVDSVVRD IQNTQCLLNV EHLSAGCPHV TLQFADSKGD
860 870 880 890 900
VGLGLVKEGL VMVEVRKEKQ FQKVITEYLN AQESAKSARL NLWRYGDFRA
910
DDADEFGYSR
Length:910
Mass (Da):101,997
Last modified:July 5, 2004 - v1
Checksum:iD58BF200F3F3D628
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C597H7C597_HUMAN
Staphylococcal nuclease domain-cont...
SND1
231Annotation score:

Sequence cautioni

The sequence AAA80488 differs from that shown. Reason: Frameshift at position 5. The frameshift leads to wrong initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti274L → V in AAA80488 (PubMed:7651391).Curated1
Sequence conflicti707 – 708LE → FQ in AAA80488 (PubMed:7651391).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22055 mRNA Translation: AAA80488.1 Sequence problems.
BT009785 mRNA Translation: AAP88787.1
BC017180 mRNA Translation: AAH17180.3
CCDSiCCDS34747.1
PIRiI38968
RefSeqiNP_055205.2, NM_014390.3
UniGeneiHs.122523

Genome annotation databases

EnsembliENST00000354725; ENSP00000346762; ENSG00000197157
GeneIDi27044
KEGGihsa:27044
UCSCiuc003vmi.4 human

Similar proteinsi

Entry informationi

Entry nameiSND1_HUMAN
AccessioniPrimary (citable) accession number: Q7KZF4
Secondary accession number(s): Q13122, Q96AG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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