UniProtKB - Q7KZA3 (Q7KZA3_HUMAN)
Protein
Ferrochelatase
Gene
DKFZp686P18130
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the ferrous insertion into protoporphyrin IX.UniRule annotation
Catalytic activityi
- EC:4.99.1.1UniRule annotation
: protoheme biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes protoheme from protoporphyrin-IX.UniRule annotationProteins known to be involved in this subpathway in this organism are:
- Ferrochelatase (DKFZp686P18130), Ferrochelatase, Ferrochelatase, Ferrochelatase, Ferrochelatase (FECH), Ferrochelatase, mitochondrial (FECH), Ferrochelatase (FECH)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes protoheme from protoporphyrin-IX, the pathway protoheme biosynthesis and in Porphyrin-containing compound metabolism.
GO - Molecular functioni
- ferrochelatase activity Source: UniProtKB-EC
GO - Biological processi
- heme biosynthetic process Source: UniProtKB-KW
Keywordsi
Molecular function | LyaseUniRule annotation |
Biological process | Heme biosynthesisUniRule annotation, Porphyrin biosynthesisUniRule annotation |
Ligand | IronUniRule annotation |
Enzyme and pathway databases
UniPathwayi | UPA00252;UER00325 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DKFZp686P18130Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Pathology & Biotechi
Organism-specific databases
PharmGKBi | PA28087 |
Chemistry databases
DrugBanki | DB02659 Cholic Acid |
Family & Domainsi
Sequence similaritiesi
Belongs to the ferrochelatase family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG1321 Eukaryota COG0276 LUCA |
KOi | K01772 |
OrthoDBi | 1003638at2759 |
Family and domain databases
CDDi | cd00419 Ferrochelatase_C, 1 hit cd03411 Ferrochelatase_N, 1 hit |
HAMAPi | MF_00323 Ferrochelatase, 1 hit |
InterProi | View protein in InterPro IPR001015 Ferrochelatase IPR019772 Ferrochelatase_AS IPR033644 Ferrochelatase_C IPR033659 Ferrochelatase_N |
PANTHERi | PTHR11108 PTHR11108, 1 hit |
Pfami | View protein in Pfam PF00762 Ferrochelatase, 1 hit |
TIGRFAMsi | TIGR00109 hemH, 1 hit |
PROSITEi | View protein in PROSITE PS00534 FERROCHELATASE, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7KZA3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAALRAAGV LLRDPLASSS WRVCQPWRWK SGAAAAAVTT ETAQHAQGAK
60 70 80 90 100
PQVQPQKRKP KTGILMLNMG GPETLGDVHD FLLRLFLDRD LMTLPIQNKL
110 120 130 140 150
APFIAKRRTP KIQEQYRRIG GGSPIKIWTS KQGEGMVKLL DELSPNTAPH
160 170 180 190 200
KYYIGFRYVH PLTEEAIEEM ERDGLERAIA FTQYPQYSCS TTGSSLNAIY
210 220 230 240 250
RYYNQVGRKP TMKWSTIDRW PTHHLLIQCF ADHILKELDH FPLEKRSEVV
260 270 280 290 300
ILFSAHSLPM SVVNRGDPYP QEVSATVQKV MERLEYCNPY RLVWQSKVGP
310 320 330 340 350
MPWLGPQTDE SIKGLCERGR KNILLVPIAF TSDHIETLYE LDIEYSQVLA
360 370 380 390 400
KECGVENIRR AESLNGNPLF SKALADLVHS HIQSNELCSK QLTLSCPLCV
410
NPVCRETKSF FTSQQL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571744 mRNA Translation: CAE11869.1 |
RefSeqi | NP_000131.2, NM_000140.3 NP_001012533.1, NM_001012515.2 |
Genome annotation databases
GeneIDi | 2235 |
KEGGi | hsa:2235 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX571744 mRNA Translation: CAE11869.1 |
RefSeqi | NP_000131.2, NM_000140.3 NP_001012533.1, NM_001012515.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Chemistry databases
DrugBanki | DB02659 Cholic Acid |
Proteomic databases
PRIDEi | Q7KZA3 |
Protocols and materials databases
DNASUi | 2235 |
Genome annotation databases
GeneIDi | 2235 |
KEGGi | hsa:2235 |
Organism-specific databases
CTDi | 2235 |
PharmGKBi | PA28087 |
Phylogenomic databases
eggNOGi | KOG1321 Eukaryota COG0276 LUCA |
KOi | K01772 |
OrthoDBi | 1003638at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00252;UER00325 |
Miscellaneous databases
EvolutionaryTracei | Q7KZA3 |
GenomeRNAii | 2235 |
Gene expression databases
Genevisiblei | Q7KZA3 HS |
Family and domain databases
CDDi | cd00419 Ferrochelatase_C, 1 hit cd03411 Ferrochelatase_N, 1 hit |
HAMAPi | MF_00323 Ferrochelatase, 1 hit |
InterProi | View protein in InterPro IPR001015 Ferrochelatase IPR019772 Ferrochelatase_AS IPR033644 Ferrochelatase_C IPR033659 Ferrochelatase_N |
PANTHERi | PTHR11108 PTHR11108, 1 hit |
Pfami | View protein in Pfam PF00762 Ferrochelatase, 1 hit |
TIGRFAMsi | TIGR00109 hemH, 1 hit |
PROSITEi | View protein in PROSITE PS00534 FERROCHELATASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7KZA3_HUMAN | |
Accessioni | Q7KZA3Primary (citable) accession number: Q7KZA3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 8, 2019 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |