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Entry version 141 (08 May 2019)
Sequence version 3 (25 Nov 2008)
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Protein

Butyrophilin subfamily 2 member A1

Gene

BTN2A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8851680 Butyrophilin (BTN) family interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Butyrophilin subfamily 2 member A1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BTN2A1
Synonyms:BT2.1, BTF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1136 BTN2A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613590 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q7KYR7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 248ExtracellularSequence analysisAdd BLAST220
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei249 – 269HelicalSequence analysisAdd BLAST21
Topological domaini270 – 527CytoplasmicSequence analysisAdd BLAST258

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11120

Open Targets

More...
OpenTargetsi
ENSG00000112763

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25456

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
BTN2A1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
215274180

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001452929 – 527Butyrophilin subfamily 2 member A1Add BLAST499

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 125PROSITE-ProRule annotation
Glycosylationi114N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi120N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q7KYR7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q7KYR7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7KYR7

PeptideAtlas

More...
PeptideAtlasi
Q7KYR7

PRoteomics IDEntifications database

More...
PRIDEi
Q7KYR7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
68699
68700 [Q7KYR7-1]
68701 [Q7KYR7-3]
68702 [Q7KYR7-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7KYR7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q7KYR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in brain, bone marrow, small intestine, muscle, spleen and pancreas. Moderate expression was seen in lung, liver and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112763 Expressed in 226 organ(s), highest expression level in lymph node

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7KYR7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7KYR7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019208

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116295, 38 interactors

Protein interaction database and analysis system

More...
IntActi
Q7KYR7, 8 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000312158

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7KYR7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 141Ig-like V-typeAdd BLAST113
Domaini310 – 506B30.2/SPRYPROSITE-ProRule annotationAdd BLAST197

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJI4 Eukaryota
ENOG410YA6W LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163835

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230860

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7KYR7

KEGG Orthology (KO)

More...
KOi
K06712

Identification of Orthologs from Complete Genome Data

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OMAi
EMRGHED

Database of Orthologous Groups

More...
OrthoDBi
522383at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7KYR7

TreeFam database of animal gene trees

More...
TreeFami
TF331083

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15819 SPRY_PRY_BTN1_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR037958 SPRY/PRY_BTN1/2
IPR003877 SPRY_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01407 BUTYPHLNCDUF

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q7KYR7-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESAAALHFS RPASLLLLLL SLCALVSAQF IVVGPTDPIL ATVGENTTLR
60 70 80 90 100
CHLSPEKNAE DMEVRWFRSQ FSPAVFVYKG GRERTEEQME EYRGRTTFVS
110 120 130 140 150
KDISRGSVAL VIHNITAQEN GTYRCYFQEG RSYDEAILHL VVAGLGSKPL
160 170 180 190 200
ISMRGHEDGG IRLECISRGW YPKPLTVWRD PYGGVAPALK EVSMPDADGL
210 220 230 240 250
FMVTTAVIIR DKSVRNMSCS INNTLLGQKK ESVIFIPESF MPSVSPCAVA
260 270 280 290 300
LPIIVVILMI PIAVCIYWIN KLQKEKKILS GEKEFERETR EIALKELEKE
310 320 330 340 350
RVQKEEELQV KEKLQEELRW RRTFLHAVDV VLDPDTAHPD LFLSEDRRSV
360 370 380 390 400
RRCPFRHLGE SVPDNPERFD SQPCVLGRES FASGKHYWEV EVENVIEWTV
410 420 430 440 450
GVCRDSVERK GEVLLIPQNG FWTLEMHKGQ YRAVSSPDRI LPLKESLCRV
460 470 480 490 500
GVFLDYEAGD VSFYNMRDRS HIYTCPRSAF SVPVRPFFRL GCEDSPIFIC
510 520
PALTGANGVT VPEEGLTLHR VGTHQSL
Length:527
Mass (Da):59,633
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0EB0731062E02F6C
GO
Isoform 2 (identifier: Q7KYR7-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     247-262: CAVALPIIVVILMIPI → L
     482-527: VPVRPFFRLG...LHRVGTHQSL → GPDTSQSGDP...SFLLLTRLCF

Show »
Length:528
Mass (Da):60,004
Checksum:i22EAF9F31FA2343B
GO
Isoform 3 (identifier: Q7KYR7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-152: Missing.

Note: No experimental confirmation available.
Show »
Length:375
Mass (Da):42,770
Checksum:iFB6932C0E209A02B
GO
Isoform 4 (identifier: Q7KYR7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-334: VDVVLDP → ELQFFSN
     335-527: Missing.

Note: No experimental confirmation available.
Show »
Length:334
Mass (Da):37,853
Checksum:i3BF0FE990D1F8095
GO
Isoform 5 (identifier: Q7KYR7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-61: Missing.

Show »
Length:466
Mass (Da):53,204
Checksum:i854139B0C8D0E3F4
GO
Isoform 6 (identifier: Q7KYR7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-330: VDV → GPV
     331-527: Missing.

Note: No experimental confirmation available.
Show »
Length:330
Mass (Da):37,240
Checksum:iC91FC3F56606AF92
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BYC3H7BYC3_HUMAN
Butyrophilin subfamily 2 member A1
BTN2A1
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C542H7C542_HUMAN
Butyrophilin subfamily 2 member A1
BTN2A1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JNC3C9JNC3_HUMAN
Butyrophilin subfamily 2 member A1
BTN2A1
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD93014 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti29Q → H in AAC02650 (PubMed:9382921).Curated1
Sequence conflicti29Q → H in AAC02653 (PubMed:9382921).Curated1
Sequence conflicti119E → G in AAC02650 (PubMed:9382921).Curated1
Sequence conflicti119E → G in AAC02653 (PubMed:9382921).Curated1
Sequence conflicti144G → ER in AAC02650 (PubMed:9382921).Curated1
Sequence conflicti144G → ER in AAC02653 (PubMed:9382921).Curated1
Sequence conflicti208I → V in CAD97989 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049825124R → C. Corresponds to variant dbSNP:rs3734539Ensembl.1
Natural variantiVAR_061303178W → C. Corresponds to variant dbSNP:rs13195402Ensembl.1
Natural variantiVAR_061304178W → L. Corresponds to variant dbSNP:rs13195401Ensembl.1
Natural variantiVAR_049826207V → M. Corresponds to variant dbSNP:rs13195509Ensembl.1
Natural variantiVAR_049827378R → Q. Corresponds to variant dbSNP:rs3734542Ensembl.1
Natural variantiVAR_049828451G → A. Corresponds to variant dbSNP:rs3734543Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0127081 – 152Missing in isoform 3. 1 PublicationAdd BLAST152
Alternative sequenceiVSP_0442491 – 61Missing in isoform 5. 1 PublicationAdd BLAST61
Alternative sequenceiVSP_035843247 – 262CAVAL…LMIPI → L in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_043165328 – 334VDVVLDP → ELQFFSN in isoform 4. 1 Publication7
Alternative sequenceiVSP_045005328 – 330VDV → GPV in isoform 6. 1 Publication3
Alternative sequenceiVSP_045006331 – 527Missing in isoform 6. 1 PublicationAdd BLAST197
Alternative sequenceiVSP_043166335 – 527Missing in isoform 4. 1 PublicationAdd BLAST193
Alternative sequenceiVSP_035844482 – 527VPVRP…THQSL → GPDTSQSGDPPEPIESIPWS HSHVDKPWSFQQPPHNTHLP AASFTPTTDLSPSFLLLTRL CF in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U90142 mRNA Translation: AAC02650.1
U97496, U97495 Genomic DNA Translation: AAC02653.1
U97497 Genomic DNA Translation: AAC02654.1
U90543 mRNA Translation: AAB53421.1
BX538050 mRNA Translation: CAD97989.1
AK297098 mRNA Translation: BAG59611.1
AB209777 mRNA Translation: BAD93014.1 Different initiation.
AL050330 Genomic DNA No translation available.
AL121936 Genomic DNA No translation available.
BC016661 mRNA Translation: AAH16661.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4613.1 [Q7KYR7-2]
CCDS47390.1 [Q7KYR7-4]
CCDS56404.1 [Q7KYR7-6]
CCDS56405.1 [Q7KYR7-5]

NCBI Reference Sequences

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RefSeqi
NP_001184162.1, NM_001197233.2 [Q7KYR7-5]
NP_001184163.1, NM_001197234.2 [Q7KYR7-6]
NP_008980.1, NM_007049.4 [Q7KYR7-2]
NP_510961.1, NM_078476.3 [Q7KYR7-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000312541; ENSP00000312158; ENSG00000112763 [Q7KYR7-2]
ENST00000429381; ENSP00000416945; ENSG00000112763 [Q7KYR7-4]
ENST00000469185; ENSP00000419043; ENSG00000112763 [Q7KYR7-6]
ENST00000541522; ENSP00000443909; ENSG00000112763 [Q7KYR7-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11120

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11120

UCSC genome browser

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UCSCi
uc003nib.4 human [Q7KYR7-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90142 mRNA Translation: AAC02650.1
U97496, U97495 Genomic DNA Translation: AAC02653.1
U97497 Genomic DNA Translation: AAC02654.1
U90543 mRNA Translation: AAB53421.1
BX538050 mRNA Translation: CAD97989.1
AK297098 mRNA Translation: BAG59611.1
AB209777 mRNA Translation: BAD93014.1 Different initiation.
AL050330 Genomic DNA No translation available.
AL121936 Genomic DNA No translation available.
BC016661 mRNA Translation: AAH16661.1
CCDSiCCDS4613.1 [Q7KYR7-2]
CCDS47390.1 [Q7KYR7-4]
CCDS56404.1 [Q7KYR7-6]
CCDS56405.1 [Q7KYR7-5]
RefSeqiNP_001184162.1, NM_001197233.2 [Q7KYR7-5]
NP_001184163.1, NM_001197234.2 [Q7KYR7-6]
NP_008980.1, NM_007049.4 [Q7KYR7-2]
NP_510961.1, NM_078476.3 [Q7KYR7-4]

3D structure databases

SMRiQ7KYR7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116295, 38 interactors
IntActiQ7KYR7, 8 interactors
STRINGi9606.ENSP00000312158

PTM databases

iPTMnetiQ7KYR7
PhosphoSitePlusiQ7KYR7

Polymorphism and mutation databases

BioMutaiBTN2A1
DMDMi215274180

Proteomic databases

EPDiQ7KYR7
jPOSTiQ7KYR7
PaxDbiQ7KYR7
PeptideAtlasiQ7KYR7
PRIDEiQ7KYR7
ProteomicsDBi68699
68700 [Q7KYR7-1]
68701 [Q7KYR7-3]
68702 [Q7KYR7-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
11120
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312541; ENSP00000312158; ENSG00000112763 [Q7KYR7-2]
ENST00000429381; ENSP00000416945; ENSG00000112763 [Q7KYR7-4]
ENST00000469185; ENSP00000419043; ENSG00000112763 [Q7KYR7-6]
ENST00000541522; ENSP00000443909; ENSG00000112763 [Q7KYR7-5]
GeneIDi11120
KEGGihsa:11120
UCSCiuc003nib.4 human [Q7KYR7-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11120
DisGeNETi11120

GeneCards: human genes, protein and diseases

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GeneCardsi
BTN2A1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0005650
HGNCiHGNC:1136 BTN2A1
HPAiHPA019208
MIMi613590 gene
neXtProtiNX_Q7KYR7
OpenTargetsiENSG00000112763
PharmGKBiPA25456

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJI4 Eukaryota
ENOG410YA6W LUCA
GeneTreeiENSGT00940000163835
HOGENOMiHOG000230860
InParanoidiQ7KYR7
KOiK06712
OMAiEMRGHED
OrthoDBi522383at2759
PhylomeDBiQ7KYR7
TreeFamiTF331083

Enzyme and pathway databases

ReactomeiR-HSA-8851680 Butyrophilin (BTN) family interactions

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
BTN2A1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11120

Protein Ontology

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PROi
PR:Q7KYR7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112763 Expressed in 226 organ(s), highest expression level in lymph node
ExpressionAtlasiQ7KYR7 baseline and differential
GenevisibleiQ7KYR7 HS

Family and domain databases

CDDicd15819 SPRY_PRY_BTN1_2, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR003879 Butyrophylin_SPRY
IPR013320 ConA-like_dom_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
IPR006574 PRY
IPR037958 SPRY/PRY_BTN1/2
IPR003877 SPRY_dom
PfamiView protein in Pfam
PF13765 PRY, 1 hit
PF00622 SPRY, 1 hit
PF07686 V-set, 1 hit
PRINTSiPR01407 BUTYPHLNCDUF
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SM00589 PRY, 1 hit
SM00449 SPRY, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50835 IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBT2A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KYR7
Secondary accession number(s): B4DLP9
, E9PGR4, O00475, P78408, Q59EN4, Q7KYQ7, Q7Z386, Q96AV7, Q9NU62
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 25, 2008
Last modified: May 8, 2019
This is version 141 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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