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UniProtKB - Q7KW39 (MMSA_DROME)
Protein
Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Gene
CG17896
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity).
By similarityCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 303 | NucleophilePROSITE-ProRule annotationBy similarity | 1 | |
Binding sitei | 403 | NADSequence analysis | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 195 – 199 | NADSequence analysis | 5 | |
Nucleotide bindingi | 247 – 252 | NADSequence analysis | 6 |
GO - Molecular functioni
- fatty-acyl-CoA binding Source: UniProtKB
- malonate-semialdehyde dehydrogenase (acetylating, NAD+) activity Source: RHEA
- malonate-semialdehyde dehydrogenase (acetylating) activity Source: UniProtKB
- methylmalonate-semialdehyde dehydrogenase (acylating) activity Source: UniProtKB
GO - Biological processi
- pyrimidine nucleobase metabolic process Source: FlyBase
- thymine catabolic process Source: GO_Central
- thymine metabolic process Source: UniProtKB
- valine catabolic process Source: GO_Central
- valine metabolic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
Reactomei | R-DME-70895, Branched-chain amino acid catabolism |
Protein family/group databases
MEROPSi | M14.A20 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:CG17896 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0023537, CG17896 |
VEuPathDBi | VectorBase:FBgn0023537 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: FlyBase
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – ? | MitochondrionSequence analysis | ||
ChainiPRO_0000043373 | ? – 520 | Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial |
Proteomic databases
PaxDbi | Q7KW39 |
Expressioni
Gene expression databases
Bgeei | FBgn0023537, Expressed in adult Malpighian tubule (Drosophila) and 40 other tissues |
ExpressionAtlasi | Q7KW39, baseline and differential |
Genevisiblei | Q7KW39, DM |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
BioGRIDi | 57566, 3 interactors |
IntActi | Q7KW39, 2 interactors |
STRINGi | 7227.FBpp0070087 |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Sequence analysis
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2449, Eukaryota |
GeneTreei | ENSGT00940000156110 |
InParanoidi | Q7KW39 |
OMAi | DRAGKHI |
PhylomeDBi | Q7KW39 |
Family and domain databases
CDDi | cd07085, ALDH_F6_MMSDH, 1 hit |
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR010061, MeMal-semiAld_DH |
PANTHERi | PTHR43866, PTHR43866, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01722, MMSDH, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform B1 Publication (identifier: Q7KW39-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLVRLIGAE ARHLAKRSYS SAAPTTKLFI DGKFVESKTN EWIDVHDPAT
60 70 80 90 100
NQVVTRVPKA TQAEMQAALE SNKKAFRSWS NQSILTRQQV MFKLQALIKE
110 120 130 140 150
NMGELAKNIT KEQGKTLADA EGDVLRGLQV VEHCCSIPSL QMGETVANVA
160 170 180 190 200
RDMDTYSLVL PLGVTAGVAP FNFPAMIPLW MFPVAITTGN TMLLKPSERV
210 220 230 240 250
PGATMLLMEL LNEAGCPPGV VNVIHGQHDA VNFICDAPEI KAVSFVGSDQ
260 270 280 290 300
AGKYIYERAG KNGKRVQSNM GAKNHGIILG DANKENTLNQ LAGAAFGAAG
310 320 330 340 350
QRCMALSTAV FVGDAQAWIP DLVERAQKLK VNAGHVPGTD VGPVISAASR
360 370 380 390 400
QRINDLIESG VKEGAKLILD GRKITVPGYE DGYFVGPTIL SDVTPSMKCY
410 420 430 440 450
TEEIFGPVLV ILKADTLDDA IGIVNANPYG NGTAVFTTNG AAARKFVNEI
460 470 480 490 500
DAGQVGVNVP IPVPLPMFSF TGTRGSFRGD HHFYGKQGIK FYTQTKTVTQ
510 520
LWRKTDVTHT QAAVAMPTMK
Sequence cautioni
The sequence CAA15632 differs from that shown. Reason: Erroneous gene model prediction.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_051919 | 2 – 10 | Missing in isoform A. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF45510.2 AE014298 Genomic DNA Translation: AAF45511.1 AL009147 Genomic DNA Translation: CAA15632.1 Sequence problems. AL009147 Genomic DNA Translation: CAB41309.1 AY069284 mRNA Translation: AAL39429.2 |
PIRi | T13418 |
RefSeqi | NP_569845.2, NM_130489.3 [Q7KW39-1] NP_726672.1, NM_166844.1 [Q7KW39-2] |
Genome annotation databases
EnsemblMetazoai | FBtr0070092; FBpp0070087; FBgn0023537 [Q7KW39-1] FBtr0070093; FBpp0070088; FBgn0023537 [Q7KW39-2] |
GeneIDi | 30995 |
KEGGi | dme:Dmel_CG17896 |
UCSCi | CG17896-RA, d. melanogaster [Q7KW39-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF45510.2 AE014298 Genomic DNA Translation: AAF45511.1 AL009147 Genomic DNA Translation: CAA15632.1 Sequence problems. AL009147 Genomic DNA Translation: CAB41309.1 AY069284 mRNA Translation: AAL39429.2 |
PIRi | T13418 |
RefSeqi | NP_569845.2, NM_130489.3 [Q7KW39-1] NP_726672.1, NM_166844.1 [Q7KW39-2] |
3D structure databases
SMRi | Q7KW39 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 57566, 3 interactors |
IntActi | Q7KW39, 2 interactors |
STRINGi | 7227.FBpp0070087 |
Protein family/group databases
MEROPSi | M14.A20 |
Proteomic databases
PaxDbi | Q7KW39 |
Protocols and materials databases
DNASUi | 30995 |
Genome annotation databases
EnsemblMetazoai | FBtr0070092; FBpp0070087; FBgn0023537 [Q7KW39-1] FBtr0070093; FBpp0070088; FBgn0023537 [Q7KW39-2] |
GeneIDi | 30995 |
KEGGi | dme:Dmel_CG17896 |
UCSCi | CG17896-RA, d. melanogaster [Q7KW39-1] |
Organism-specific databases
FlyBasei | FBgn0023537, CG17896 |
VEuPathDBi | VectorBase:FBgn0023537 |
Phylogenomic databases
eggNOGi | KOG2449, Eukaryota |
GeneTreei | ENSGT00940000156110 |
InParanoidi | Q7KW39 |
OMAi | DRAGKHI |
PhylomeDBi | Q7KW39 |
Enzyme and pathway databases
Reactomei | R-DME-70895, Branched-chain amino acid catabolism |
Miscellaneous databases
BioGRID-ORCSi | 30995, 0 hits in 1 CRISPR screen |
ChiTaRSi | CG17896, fly |
GenomeRNAii | 30995 |
PROi | PR:Q7KW39 |
Gene expression databases
Bgeei | FBgn0023537, Expressed in adult Malpighian tubule (Drosophila) and 40 other tissues |
ExpressionAtlasi | Q7KW39, baseline and differential |
Genevisiblei | Q7KW39, DM |
Family and domain databases
CDDi | cd07085, ALDH_F6_MMSDH, 1 hit |
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR010061, MeMal-semiAld_DH |
PANTHERi | PTHR43866, PTHR43866, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01722, MMSDH, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MMSA_DROME | |
Accessioni | Q7KW39Primary (citable) accession number: Q7KW39 Secondary accession number(s): O46056, Q8T9I0, Q9V408 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | September 29, 2021 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families