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Entry version 150 (02 Jun 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Chromodomain-helicase-DNA-binding protein 1

Gene

Chd1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin remodeling, but also required to maintain a specific chromatin configuration across the genome (By similarity).

Involved in assembly of active chromatin. Required for maintaining open chromatin and pluripotency in embryonic stem cells and is important for wing development and fertility. Is essential for the incorporation of histone H3.3 and assembly of paternal chromatin. Required for replication-independent nucleosome assembly in the decondensing male pronucleus.

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi553 – 560ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, DNA-binding, Helicase, Hydrolase
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromodomain-helicase-DNA-binding protein 1 (EC:3.6.4.12)
Short name:
CHD-1
Alternative name(s):
ATP-dependent helicase Chd1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Chd1
ORF Names:CG3733
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0250786, Chd1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003887731 – 1883Chromodomain-helicase-DNA-binding protein 1Add BLAST1883

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7KU24

PRoteomics IDEntifications database

More...
PRIDEi
Q7KU24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0250786, Expressed in embryo and 38 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7KU24, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7KU24, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the SAGA complex (By similarity).

Interacts with SSRP1.

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
59725, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q7KU24, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0297122

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7KU24

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini318 – 414Chromo 1PROSITE-ProRule annotationAdd BLAST97
Domaini439 – 501Chromo 2PROSITE-ProRule annotationAdd BLAST63
Domaini540 – 710Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST171
Domaini840 – 991Helicase C-terminalPROSITE-ProRule annotationAdd BLAST152

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 293DisorderedSequence analysisAdd BLAST293
Regioni1074 – 1185DisorderedSequence analysisAdd BLAST112
Regioni1246 – 1265DisorderedSequence analysisAdd BLAST20
Regioni1390 – 1491DisorderedSequence analysisAdd BLAST102
Regioni1599 – 1829DisorderedSequence analysisAdd BLAST231
Regioni1848 – 1883DisorderedSequence analysisAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi661 – 664DEAH box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi27 – 56Polar residuesSequence analysisAdd BLAST30
Compositional biasi78 – 130Polar residuesSequence analysisAdd BLAST53
Compositional biasi143 – 171Polar residuesSequence analysisAdd BLAST29
Compositional biasi174 – 196Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi231 – 251Polar residuesSequence analysisAdd BLAST21
Compositional biasi252 – 271Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1101 – 1126Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi1142 – 1156Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi1166 – 1185Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1246 – 1264Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1390 – 1405Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1435 – 1455Polar residuesSequence analysisAdd BLAST21
Compositional biasi1599 – 1614Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1624 – 1654Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi1704 – 1723Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi1735 – 1756Polar residuesSequence analysisAdd BLAST22
Compositional biasi1775 – 1795Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi1803 – 1819Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi1869 – 1883Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0384, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000315_8_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7KU24

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7KU24

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040793, CDH1_2_SANT_HL1
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR023779, Chromodomain_CS
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR025260, DUF4208
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18375, CDH1_2_SANT_HL1, 1 hit
PF00385, Chromo, 2 hits
PF13907, DUF4208, 1 hit
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM01176, DUF4208, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00598, CHROMO_1, 1 hit
PS50013, CHROMO_2, 2 hits
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q7KU24-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQALNESAN SIGSDEQDDT REEANGTDHS GSGSGSGSSG SDSDSDSSSG
60 70 80 90 100
NSSDGRSSPE PEDKSLSVAG FPPTAAAAQA DSKTNGFTDD QEDSSSDGSS
110 120 130 140 150
GSDSDSDAEG PSDQRNQSIN NANTSSSLPK PEQNEEEDNE TEAGQQQPAS
160 170 180 190 200
DASADESSDS SANVSPTSSS SSSEEEEEDY RPKRTRQARK PPTAAEKSKK
210 220 230 240 250
APAPKNKKKT WDSDESDESE DSDDEVSTAQ KRKPAATTSR SKLAQQQQRR
260 270 280 290 300
RVKPFSSEDS DDDDASKRCA TRRKGAAVSY KEASEDEATD SEDLLEFEYD
310 320 330 340 350
ESQAATTAAT AEEEEKCETI ERILAQRAGK RGCTGNQTTI YAIEENGFDP
360 370 380 390 400
HAGFDEKQTP DAETEAQFLI KWKGWSYIHN TWESEATLRD MKAKGMKKLD
410 420 430 440 450
NFIKKEKEQA YWRRYAGPED IDYFECQLEL QHELLKSYNN VDRIIAKGSK
460 470 480 490 500
PDDGTEEYLC KWQSLPYAES TWEDAALVLR KWQRCAEQFN DRESSKCTPS
510 520 530 540 550
RHCRVIKYRP KFSRIKNQPE FLSSGLTLRD YQMDGLNWLL HSWCKENSVI
560 570 580 590 600
LADEMGLGKT IQTICFLYSL FKIHHLYGPF LCVVPLSTMT AWQREFDLWA
610 620 630 640 650
PDMNVVTYLG DIKSRELIQQ YEWQFESSKR LKFNCILTTY EIVLKDKQFL
660 670 680 690 700
GTLQWAALLV DEAHRLKNDD SLLYKSLKEF DTNHRLLITG TPLQNSLKEL
710 720 730 740 750
WALLHFIMPD KFDTWENFEV QHGNAEDKGY TRLHQQLEPY ILRRVKKDVE
760 770 780 790 800
KSLPAKVEQI LRVEMTSLQK QYYKWILTKN FDALRKGKRG STSTFLNIVI
810 820 830 840 850
ELKKCCNHAA LIRPSEFELM GLQQDEALQT LLKGSGKLVL LDKLLCRLKE
860 870 880 890 900
TGHRVLIFSQ MVRMLDVLAD YLQKRHFPFQ RLDGSIKGEM RRQALDHFNA
910 920 930 940 950
EGSQDFCFLL STRAGGLGIN LATADTVIIF DSDWNPQNDL QAQARAHRIG
960 970 980 990 1000
QKNQVNIYRL VTARSVEEQI VERAKQKMVL DHLVIQRMDT TGRTVLDKSG
1010 1020 1030 1040 1050
NGHSSNSNPF NKDDLSAILK FGAEELFKDE QEHDDDLVCD IDEILRRAET
1060 1070 1080 1090 1100
RNEDPEMPAD DLLSAFKVAS IAAFEEEPSD SVSKQDQNAA GEEDDSKDWD
1110 1120 1130 1140 1150
DIIPEGFRKA IDDQERAKEM EDLYLPPRRK TAANQNEGKR GAGKGGKGKQ
1160 1170 1180 1190 1200
QADDSGGDSD YELGSDGSGD DGRPRKRGRP TMKEKITGFT DAELRRFIRS
1210 1220 1230 1240 1250
YKKFPAPLHR MEAIACDAEL QEKPLAELKR LGEMLHDRCV QFLHEHKEEE
1260 1270 1280 1290 1300
SKTAATDETP GAKQRRARAT FSVKLGGVSF NAKKLLACEQ ELQPLNEIMP
1310 1320 1330 1340 1350
SMPEERQQWS FNIKTRAPVF DVDWGIEEDT KLLCGIYQYG IGSWEQMKLD
1360 1370 1380 1390 1400
PTLKLTDKIL LNDTRKPQAK QLQTRAEYLL KIIKKNVELT KGGQRRQRRP
1410 1420 1430 1440 1450
RASRANDAKA ASQSASSTID AKPHDGEDAA GDARTVAESS NSQVDPSTAS
1460 1470 1480 1490 1500
PHNAPATEQH GDPAKKAKKS KARSKKTSAS DNNGNKPMHF TANNEPRALE
1510 1520 1530 1540 1550
VLGDLDPSIF NECKEKMRPV KKALKALDQP DVSLSDQDQL QHTRDCLLQI
1560 1570 1580 1590 1600
GKQIDVCLNP YAETEKKEWR SNLWYFVSKF TELDAKRLFK IYKHALKQKA
1610 1620 1630 1640 1650
GGDGEAKGKD KGSSGSPAKS KPNGVTTEEK EKERDRSGGK KKKKDKDKER
1660 1670 1680 1690 1700
SGQARYPETG IPTSGRYADP PLKRKRDEND ADASSGLAGA PGGGIGDNLK
1710 1720 1730 1740 1750
SMSFKRLNMD RHEDRKKHHR GPDYYGGSGP PMGSGSYEGG SNSRRQGPTS
1760 1770 1780 1790 1800
PSTPRTGRGG YDPPPAPSGY TPEMERWQSR DRYSQDYKRD RYDGYGRSGG
1810 1820 1830 1840 1850
GQGSYHRERD RRPEKRRYPS GLPPHPYSSH YLPPNYYGLP NGAVPGLPPP
1860 1870 1880
SSVYRSDPRG YPVMPRDYPA DYRRSDYERR TQT
Length:1,883
Mass (Da):211,828
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i226F2CA8996F6F17
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PEB2M9PEB2_DROME
DNA helicase
Chd1 2, CHD-1, CHD1, chd1, dCHD1
1,881Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9ND16M9ND16_DROME
DNA helicase
Chd1 2, CHD-1, CHD1, chd1, dCHD1
1,900Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti730Y → H in AAC37264 (PubMed:8692958).Curated1
Sequence conflicti1448T → N in AAC37264 (PubMed:8692958).Curated1
Sequence conflicti1745R → S in AAC37264 (PubMed:8692958).Curated1
Sequence conflicti1804S → I in AAC37264 (PubMed:8692958).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L77907 mRNA Translation: AAC37264.1
AE014134 Genomic DNA Translation: AAF51170.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T13944

NCBI Reference Sequences

More...
RefSeqi
NP_477197.1, NM_057849.5

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077674; FBpp0077358; FBgn0250786

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33505

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3733

UCSC genome browser

More...
UCSCi
CG3733-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77907 mRNA Translation: AAC37264.1
AE014134 Genomic DNA Translation: AAF51170.1
PIRiT13944
RefSeqiNP_477197.1, NM_057849.5

3D structure databases

SMRiQ7KU24
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi59725, 8 interactors
IntActiQ7KU24, 5 interactors
STRINGi7227.FBpp0297122

Proteomic databases

PaxDbiQ7KU24
PRIDEiQ7KU24

Genome annotation databases

EnsemblMetazoaiFBtr0077674; FBpp0077358; FBgn0250786
GeneIDi33505
KEGGidme:Dmel_CG3733
UCSCiCG3733-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1105
FlyBaseiFBgn0250786, Chd1

Phylogenomic databases

eggNOGiKOG0384, Eukaryota
HOGENOMiCLU_000315_8_1_1
InParanoidiQ7KU24
PhylomeDBiQ7KU24

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
33505, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Chd1, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
33505

Protein Ontology

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PROi
PR:Q7KU24

Gene expression databases

BgeeiFBgn0250786, Expressed in embryo and 38 other tissues
ExpressionAtlasiQ7KU24, baseline and differential
GenevisibleiQ7KU24, DM

Family and domain databases

Gene3Di3.40.50.10810, 1 hit
InterProiView protein in InterPro
IPR040793, CDH1_2_SANT_HL1
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR023779, Chromodomain_CS
IPR002464, DNA/RNA_helicase_DEAH_CS
IPR025260, DUF4208
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
PfamiView protein in Pfam
PF18375, CDH1_2_SANT_HL1, 1 hit
PF00385, Chromo, 2 hits
PF13907, DUF4208, 1 hit
PF00271, Helicase_C, 1 hit
PF00176, SNF2_N, 1 hit
SMARTiView protein in SMART
SM00298, CHROMO, 2 hits
SM00487, DEXDc, 1 hit
SM01176, DUF4208, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
SSF54160, SSF54160, 2 hits
PROSITEiView protein in PROSITE
PS00598, CHROMO_1, 1 hit
PS50013, CHROMO_2, 2 hits
PS00690, DEAH_ATP_HELICASE, 1 hit
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHD1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KU24
Secondary accession number(s): Q24376, Q9VQJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: July 5, 2004
Last modified: June 2, 2021
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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