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Entry version 75 (02 Jun 2021)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Pi3K21B, isoform B

Gene

Pi3K21B

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-109704, PI3K Cascade
R-DME-112399, IRS-mediated signalling
R-DME-114604, GPVI-mediated activation cascade
R-DME-1250342, PI3K events in ERBB4 signaling
R-DME-1257604, PIP3 activates AKT signaling
R-DME-1433557, Signaling by SCF-KIT
R-DME-1660499, Synthesis of PIPs at the plasma membrane
R-DME-180292, GAB1 signalosome
R-DME-194840, Rho GTPase cycle
R-DME-1963642, PI3K events in ERBB2 signaling
R-DME-198203, PI3K/AKT activation
R-DME-210993, Tie2 Signaling
R-DME-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-DME-416476, G alpha (q) signalling events
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-5654689, PI-3K cascade:FGFR1
R-DME-5654695, PI-3K cascade:FGFR2
R-DME-5654710, PI-3K cascade:FGFR3
R-DME-5654720, PI-3K cascade:FGFR4
R-DME-5673001, RAF/MAP kinase cascade
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-912631, Regulation of signaling by CBL
R-DME-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Pi3K21B, isoform BImported
Submitted name:
Pi3K21B, isoform EImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pi3K21BImported
Synonyms:deltap60Imported, Dmel\CG2699Imported, Dp60Imported, dP60Imported, dp60Imported, dPI3KImported, droPIK57Imported, P60Imported, p60Imported, p85Imported, PI(3)KImported, PI3KImported, PI3K-p60Imported, PI3K21BImported, Pi3k21BImported, Pi3K21B|p60Imported, Pi3Kp60Imported, PI[[3]]KImported
ORF Names:CG2699Imported, Dmel_CG2699Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0020622, Pi3K21B

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q7KTZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0020622, Expressed in digestive system element and 41 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7KTZ2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0303635

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7KTZ2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 116SH2InterPro annotationAdd BLAST95
Domaini327 – 420SH2InterPro annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni450 – 496DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili145 – 169Sequence analysisAdd BLAST25
Coiled coili221 – 245Sequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3K p85 subunit family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH2 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4637, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169711

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041839_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
IEMDQPP

Database of Orthologous Groups

More...
OrthoDBi
737926at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09930, SH2_cSH2_p85_like, 1 hit
cd09942, SH2_nSH2_p85_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.505.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032498, PI3K_P85_iSH2
IPR035020, PI3kinase_P85_cSH2
IPR035022, PI3kinase_P85_nSH2
IPR000980, SH2
IPR036860, SH2_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16454, PI3K_P85_iSH2, 1 hit
PF00017, SH2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00401, SH2DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00252, SH2, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55550, SSF55550, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50001, SH2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q7KTZ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPQAPGSLV DPNEDELRMA PWYWGRISRE EAKSILHGKP DGSFLVRDAL
60 70 80 90 100
SMKGEYTLTL MKDGCEKLIK ICHMDRKYGF IETDLFNSVV EMINYYKENS
110 120 130 140 150
LSMYNKTLDI TLSNPIVRAR EDEESQPHGD LCLLSNEFIR TCQLLQNLEQ
160 170 180 190 200
NLENKRNSFN AIREELQEKK LHQSVFGNTE KIFRNQIKLN ESFMKAPADA
210 220 230 240 250
PSTEAGGAGD GANAAASAAA NANARRSLQE HKQTLLNLLD ALQAKGQVLN
260 270 280 290 300
HYMENKKKEE LLLERQINAL KPELQILQLR KDKYIERLKG FNLKDDDLKM
310 320 330 340 350
ILQMGFDKWQ QLYETVSNQP HSNEALWLLK DAKRRNAEEM LKGAPSGTFL
360 370 380 390 400
IRARDAGHYA LSIACKNIVQ HCLIYETSTG FGFAAPYNIY ATLKSLVEHY
410 420 430 440 450
ANNSLEEHND TLTTTLRWPV LYWKNNPLQV QMIQLQEEMD LEYEQAATLR
460 470 480 490
PPPMMGSSAP IPTSRSREHD VVDGTGSLEA EAAPASISPS NFSTSQ
Length:496
Mass (Da):56,286
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBF3C715AEA8E8460
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PAY7M9PAY7_DROME
Pi3K21B, isoform C
Pi3K21B deltap60, Dmel\CG2699, Dp60, dP60, dp60
197Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51510.3
AE014134 Genomic DNA Translation: AGB92354.1

NCBI Reference Sequences

More...
RefSeqi
NP_001259817.1, NM_001272888.1
NP_477270.2, NM_057922.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0331205; FBpp0303632; FBgn0020622
FBtr0331208; FBpp0303635; FBgn0020622

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
33203

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: AAF51510.3
AE014134 Genomic DNA Translation: AGB92354.1
RefSeqiNP_001259817.1, NM_001272888.1
NP_477270.2, NM_057922.4

3D structure databases

SMRiQ7KTZ2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0303635

Proteomic databases

PRIDEiQ7KTZ2

Genome annotation databases

EnsemblMetazoaiFBtr0331205; FBpp0303632; FBgn0020622
FBtr0331208; FBpp0303635; FBgn0020622
GeneIDi33203

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
33203
FlyBaseiFBgn0020622, Pi3K21B

Phylogenomic databases

eggNOGiKOG4637, Eukaryota
GeneTreeiENSGT00940000169711
HOGENOMiCLU_041839_0_0_1
OMAiIEMDQPP
OrthoDBi737926at2759

Enzyme and pathway databases

ReactomeiR-DME-109704, PI3K Cascade
R-DME-112399, IRS-mediated signalling
R-DME-114604, GPVI-mediated activation cascade
R-DME-1250342, PI3K events in ERBB4 signaling
R-DME-1257604, PIP3 activates AKT signaling
R-DME-1433557, Signaling by SCF-KIT
R-DME-1660499, Synthesis of PIPs at the plasma membrane
R-DME-180292, GAB1 signalosome
R-DME-194840, Rho GTPase cycle
R-DME-1963642, PI3K events in ERBB2 signaling
R-DME-198203, PI3K/AKT activation
R-DME-210993, Tie2 Signaling
R-DME-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-DME-416476, G alpha (q) signalling events
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-5654689, PI-3K cascade:FGFR1
R-DME-5654695, PI-3K cascade:FGFR2
R-DME-5654710, PI-3K cascade:FGFR3
R-DME-5654720, PI-3K cascade:FGFR4
R-DME-5673001, RAF/MAP kinase cascade
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-912631, Regulation of signaling by CBL
R-DME-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
33203, 1 hit in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pi3K68D, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
33203

Gene expression databases

BgeeiFBgn0020622, Expressed in digestive system element and 41 other tissues
ExpressionAtlasiQ7KTZ2, baseline and differential

Family and domain databases

CDDicd09930, SH2_cSH2_p85_like, 1 hit
cd09942, SH2_nSH2_p85_like, 1 hit
Gene3Di3.30.505.10, 2 hits
InterProiView protein in InterPro
IPR032498, PI3K_P85_iSH2
IPR035020, PI3kinase_P85_cSH2
IPR035022, PI3kinase_P85_nSH2
IPR000980, SH2
IPR036860, SH2_dom_sf
PfamiView protein in Pfam
PF16454, PI3K_P85_iSH2, 1 hit
PF00017, SH2, 2 hits
PRINTSiPR00401, SH2DOMAIN
SMARTiView protein in SMART
SM00252, SH2, 2 hits
SUPFAMiSSF55550, SSF55550, 2 hits
PROSITEiView protein in PROSITE
PS50001, SH2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7KTZ2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KTZ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: June 2, 2021
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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