UniProtKB - Q7KTS4 (Q7KTS4_DROME)
Protein
Histone deacetylase
Gene
HDAC3
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Catalytic activityi
- EC:3.5.1.98UniRule annotationARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 98 | SubstrateUniRule annotation | 1 | |
Active sitei | 140 | Proton acceptorUniRule annotation | 1 | |
Binding sitei | 148 | Substrate; via carbonyl oxygenUniRule annotation | 1 | |
Metal bindingi | 175 | Divalent metal cationUniRule annotation | 1 | |
Metal bindingi | 177 | Divalent metal cationUniRule annotation | 1 | |
Metal bindingi | 264 | Divalent metal cationUniRule annotation | 1 | |
Binding sitei | 303 | SubstrateUniRule annotation | 1 |
GO - Molecular functioni
- histone deacetylase activity Source: FlyBase
- metal ion binding Source: UniProtKB-KW
- NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
- protein domain specific binding Source: UniProtKB
GO - Biological processi
- chromatin silencing Source: FlyBase
- histone deacetylation Source: FlyBase
- histone H3 deacetylation Source: GO_Central
- histone H4 deacetylation Source: GO_Central
- negative regulation of apoptotic process Source: FlyBase
- positive regulation of cell growth Source: FlyBase
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transcription, DNA-templated Source: FlyBase
Keywordsi
Molecular function | Chromatin regulatorUniRule annotationARBA annotation, HydrolaseUniRule annotationImported, RepressorARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotation |
Ligand | Metal-bindingUniRule annotation |
Enzyme and pathway databases
Reactomei | R-DME-350054, Notch-HLH transcription pathway R-DME-400206, Regulation of lipid metabolism by PPARalpha R-DME-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
Names & Taxonomyi
Protein namesi | Recommended name: Histone deacetylaseUniRule annotationARBA annotation (EC:3.5.1.98UniRule annotationARBA annotation) |
Gene namesi | Name:HDAC3Imported Synonyms:DHDAC3Imported, dHDAC3Imported, Dmel\CG2128Imported, dmHDA402Imported, DmHDAC3Imported, HDACImported, Hdac 3Imported, Hdac3Imported, hdac3Imported ORF Names:CG2128Imported, Dmel_CG2128Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0025825, HDAC3 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- histone deacetylase complex Source: GO_Central
- nucleus Source: FlyBase
Other locations
- cytoplasm Source: FlyBase
Keywords - Cellular componenti
NucleusUniRule annotationInteractioni
GO - Molecular functioni
- protein domain specific binding Source: UniProtKB
Protein-protein interaction databases
IntActi | Q7KTS4, 1 interactor |
STRINGi | 7227.FBpp0078414 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 317 | Hist_deacetylInterPro annotationAdd BLAST | 295 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 417 – 438 | DisorderedSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1342, Eukaryota |
GeneTreei | ENSGT00940000165542 |
HOGENOMi | CLU_007727_7_6_1 |
OMAi | GWLRAFH |
Family and domain databases
Gene3Di | 3.40.800.20, 1 hit |
InterProi | View protein in InterPro IPR000286, His_deacetylse IPR003084, His_deacetylse_1 IPR023801, His_deacetylse_dom IPR037138, His_deacetylse_dom_sf IPR023696, Ureohydrolase_dom_sf |
Pfami | View protein in Pfam PF00850, Hist_deacetyl, 1 hit |
PIRSFi | PIRSF037913, His_deacetylse_1, 1 hit |
PRINTSi | PR01270, HDASUPER PR01271, HISDACETLASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
i Sequence
Sequence statusi: Complete.
Q7KTS4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDRRVSYFY NADVGNFHYG AGHPMKPQRL AVTHSLVMNY GLHKKMKIYR
60 70 80 90 100
PYKASAQDML RFHSDEYIAY LQQVTPQNIQ CNSVAYTKYL AHFSVGEDCP
110 120 130 140 150
VFDGLFDFCA MYTGASLEGA QKLNHNHSDI CINWSGGLHH AKKFEASGFC
160 170 180 190 200
YVNDIVIGIL ELLKYHPRVL YIDIDVHHGD GVQEAFYLTD RVMTASFHKY
210 220 230 240 250
GNYFFPGTGD MYEIGAESGR YYSVNVPLKE GIDDQSYFQV FKPIISAIMD
260 270 280 290 300
FYRPTAIVLQ CGADSLAGDR LGCFSLSTKG HGECVKFVKE LNVPTLVVGG
310 320 330 340 350
GGYTLRNVAR CWTHETSLLV DQDIENDLPA TEYYDFFAPD FTLHPEINSR
360 370 380 390 400
QDNANSKQYL ELIVKHVYEN LKMCQHSPSV QMVQTPPDVD LEELRSNREE
410 420 430
ASDPDVRISV ADEDKLVDAK NEFYDGDQDQ DKPDSAES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF52023.1 AY061321 mRNA Translation: AAL28869.1 JQ663528 Genomic DNA Translation: AFI26263.1 |
RefSeqi | NP_651978.2, NM_143721.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0078767; FBpp0078414; FBgn0025825 |
GeneIDi | 44446 |
KEGGi | dme:Dmel_CG2128 |
UCSCi | CG2128-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014297 Genomic DNA Translation: AAF52023.1 AY061321 mRNA Translation: AAL28869.1 JQ663528 Genomic DNA Translation: AFI26263.1 |
RefSeqi | NP_651978.2, NM_143721.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q7KTS4, 1 interactor |
STRINGi | 7227.FBpp0078414 |
Genome annotation databases
EnsemblMetazoai | FBtr0078767; FBpp0078414; FBgn0025825 |
GeneIDi | 44446 |
KEGGi | dme:Dmel_CG2128 |
UCSCi | CG2128-RA, d. melanogaster |
Organism-specific databases
CTDi | 8841 |
FlyBasei | FBgn0025825, HDAC3 |
Phylogenomic databases
eggNOGi | KOG1342, Eukaryota |
GeneTreei | ENSGT00940000165542 |
HOGENOMi | CLU_007727_7_6_1 |
OMAi | GWLRAFH |
Enzyme and pathway databases
Reactomei | R-DME-350054, Notch-HLH transcription pathway R-DME-400206, Regulation of lipid metabolism by PPARalpha R-DME-9029569, NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux |
Miscellaneous databases
BioGRID-ORCSi | 44446, 1 hit in 3 CRISPR screens |
GenomeRNAii | 44446 |
Gene expression databases
Bgeei | FBgn0025825, Expressed in embryo and 23 other tissues |
Family and domain databases
Gene3Di | 3.40.800.20, 1 hit |
InterProi | View protein in InterPro IPR000286, His_deacetylse IPR003084, His_deacetylse_1 IPR023801, His_deacetylse_dom IPR037138, His_deacetylse_dom_sf IPR023696, Ureohydrolase_dom_sf |
Pfami | View protein in Pfam PF00850, Hist_deacetyl, 1 hit |
PIRSFi | PIRSF037913, His_deacetylse_1, 1 hit |
PRINTSi | PR01270, HDASUPER PR01271, HISDACETLASE |
SUPFAMi | SSF52768, SSF52768, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7KTS4_DROME | |
Accessioni | Q7KTS4Primary (citable) accession number: Q7KTS4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | February 10, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |