UniProtKB - Q7KTC7 (Q7KTC7_DROME)
Protein
Submitted name:
Multidrug-Resistance like protein 1, isoform C
Gene
MRP
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 681 – 688 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1343 – 1350 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: UniProtKB-EC
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-UniRule
GO - Biological processi
- renal tubular secretion Source: FlyBase
- response to toxic substance Source: FlyBase
- transmembrane transport Source: GO_Central
Keywordsi
Molecular function | HydrolaseImported |
Ligand | ATP-bindingPROSITE-ProRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:MRPImported Synonyms:ABCC1Imported, Dmel\CG6214Imported, dMRPImported, dmrpImported, dMRP1Imported, lincRNA.123Imported, MrpImported, MRP1Imported, Mrp1Imported ORF Names:CG6214Imported, Dmel_CG6214Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0032456 MRP |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: FlyBase
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 39 – 58 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 78 – 96 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 111 – 128 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 135 – 154 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 186 – 208 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 324 – 342 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 373 – 395 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 449 – 468 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 474 – 492 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 560 – 579 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 591 – 611 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 1115 – 1145 | HelicalSequence analysisAdd BLAST | 31 | |
Transmembranei | 1215 – 1237 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | FBgn0032456 Expressed in 31 organ(s), highest expression level in larva |
ExpressionAtlasi | Q7KTC7 baseline and differential |
Genevisiblei | Q7KTC7 DM |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 334 – 617 | ABC transmembrane type-1InterPro annotationAdd BLAST | 284 | |
Domaini | 649 – 871 | ABC transporterInterPro annotationAdd BLAST | 223 | |
Domaini | 992 – 1271 | ABC transmembrane type-1InterPro annotationAdd BLAST | 280 | |
Domaini | 1309 – 1543 | ABC transporterInterPro annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 927 – 953 | DisorderedSequence analysisAdd BLAST | 27 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 869 – 889 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 935 – 953 | PolyampholyteSequence analysisAdd BLAST | 19 |
Keywords - Domaini
Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG0054 Eukaryota COG1132 LUCA |
GeneTreei | ENSGT00940000165791 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR005292 Multidrug-R_assoc IPR027417 P-loop_NTPase |
Pfami | View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382 AAA, 2 hits |
SUPFAMi | SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits |
TIGRFAMsi | TIGR00957 MRP_assoc_pro, 1 hit |
PROSITEi | View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
Q7KTC7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADDTSSPMD RFCGSTFWNA TETWYTNDPD FTPCFEQTAL VWTPCAFYWA
60 70 80 90 100
FVIFDFYYLK ASLDRNIPWN KLNVSKALVN LGLLVITALD LIMALVKKGG
110 120 130 140 150
DSELPLYDLD VWGPIIKFAT FLLLFIFIPL NRKYGVQTTG CQFIFWFLLT
160 170 180 190 200
VLSIPRCRTE VRLDAERQKI LNSQQPSEQD FSWEEYQFVS FFIFFTFTSI
210 220 230 240 250
MLILNCFADG MPRQTKYQRG ENEIPELSAS FLSRITYQWF DKMALKGYRN
260 270 280 290 300
PLEEKDLWDL RPQDSCSEVM PIFAHHWNQN VRKNYKNKAR VEPKAQFSNG
310 320 330 340 350
NVTFENPHGE KNGRKKGMAS IMPPIYKSFG GVFLFGALMK LFTDTLTFAQ
360 370 380 390 400
PQVLSLIISF VEAQDAEPEW KGILYAVLLF VLAAAQTFIL GQYFHRMFIV
410 420 430 440 450
GLRIRTALIN AIYRKALRIS NSTKKESTVG EIVNLMAVDA QRFMELTTYL
460 470 480 490 500
NMIWSAPLQI GLALYFLWQQ LGPSVLAGLA VMIILIPVNG VIASRIKTYQ
510 520 530 540 550
IRQMKYKDER VKLMNEVLSG IKVLKLYAWE PSFEKQVLDI RDKEIATLRS
560 570 580 590 600
TAYLNAGTSF LWSCAPFLVS LVTFATYVLT SEANQLSVEK VLVSIALFDL
610 620 630 640 650
MKLPLTILPM LSVDIAETQV SVNRINKFLN SEELDPNSVL HDSSKPHPMS
660 670 680 690 700
IENGEFSWGD EITLRNINIE VKKGSLVALV GTVGSGKSSV VQAFLGEMEK
710 720 730 740 750
LAGVVNTVGK LAYVPQQAWI QNATVRDNIL FGQTYDRKRY NKVIDACALR
760 770 780 790 800
ADIDILSAGD LTEIGEKGIN LSGGQKQRIS LARAVYSDAD LYLLDDPLSA
810 820 830 840 850
VDAHVGKHIF EEVIGPKGIL ARKSRVLVTH GVTFLPQVDS IYVIKMGEIS
860 870 880 890 900
ESGTFDQLVK NKGAFADFII QHLQEGNEEE EELNQIKRQI SSTADVPELL
910 920 930 940 950
GTVEKAIKLA RTESLSDSIS VTSADSLMGG GGSLRRRTKR QDSHDSVASA
960 970 980 990 1000
ASLKKKQEVE GKLIETEKSQ TGGVEFAVYK HYIKSVGIFL SVATLVLNFV
1010 1020 1030 1040 1050
FQAFQIGSNL WLTQWANDQN VANDTGLRDM YLGVYGAFGF GQVLSKYLSG
1060 1070 1080 1090 1100
LALAIGGLHC SMNVFNKLLN TGLKWPMELF DTTPLGRILS RYSKDVDTVD
1110 1120 1130 1140 1150
SVLPAITVQL LNTCFGVLAT IVVISLSTPI FLAVIVPIAF LYYFAQRFYV
1160 1170 1180 1190 1200
ATSRQLMRLE SVSRSPIYSH FSETVTGAST IRAYNVGDRF IEESDAKVDK
1210 1220 1230 1240 1250
NQVCKYPSVI ANRWLAIRLE MVGNLIILFA SLFAVLGGQT NPGLVGLSVS
1260 1270 1280 1290 1300
YALQVTQTLN WLVRMSSDIE TNIVSVERIK EYGETKQEAP WELEQDKNKP
1310 1320 1330 1340 1350
KNWPQEGRVE FQNFQVRYRE GLDLVLRGVS FNIQGGEKVG IVGRTGAGKS
1360 1370 1380 1390 1400
SLTLALFRII EAAGGRISID GVDIASMGLH MLRSRLTIIP QDPVLFSGSL
1410 1420 1430 1440 1450
RINLDPFEIK TDDEIWKALE LSHLKSFVKS LAAGLNHEIA EGGENLSVGQ
1460 1470 1480 1490 1500
RQLVCLARAL LRKTKVLVLD EATAAVDLET DDLIQKTIRT EFKECTVLTI
1510 1520 1530 1540
AHRLNTILDS DKVIVLDKGQ IIEFASPTEL LDNPKSAFYS MAKDANLV
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9I7N0 | Q9I7N0_DROME | FI23224p1 | MRP ABCC1, Dmel\CG6214, dMRP, dmrp, dMRP1 | 1,548 | Annotation score: | ||
Q7KTC0 | Q7KTC0_DROME | Multidrug-Resistance like protein 1... | MRP ABCC1, Dmel\CG6214, dMRP, dmrp, dMRP1 | 1,549 | Annotation score: | ||
Q9VK56 | Q9VK56_DROME | Multidrug-Resistance like protein 1... | MRP ABCC1, Dmel\CG6214, dMRP, dmrp, dMRP1 | 1,549 | Annotation score: | ||
Q7KTC4 | Q7KTC4_DROME | Multidrug-Resistance like protein 1... | MRP ABCC1, Dmel\CG6214, dMRP, dmrp, dMRP1 | 1,548 | Annotation score: | ||
Q7KTC9 | Q7KTC9_DROME | Multidrug-Resistance like protein 1... | MRP ABCC1, Dmel\CG6214, dMRP, dmrp, dMRP1 | 1,548 | Annotation score: | ||
Q7KTD0 | Q7KTD0_DROME | Multidrug-Resistance like protein 1... | MRP ABCC1, Dmel\CG6214, dMRP, dmrp, dMRP1 | 1,548 | Annotation score: | ||
Q7KTB7 | Q7KTB7_DROME | Multidrug-Resistance like protein 1... | MRP ABCC1, Dmel\CG6214, dMRP, dmrp, dMRP1 | 1,548 | Annotation score: | ||
Q7KTB8 | Q7KTB8_DROME | Multidrug-Resistance like protein 1... | MRP ABCC1, Dmel\CG6214, dMRP, dmrp, dMRP1 | 1,548 | Annotation score: | ||
Q7KTC1 | Q7KTC1_DROME | Multidrug-Resistance like protein 1... | MRP ABCC1, Dmel\CG6214, dMRP, dmrp, dMRP1 | 1,548 | Annotation score: | ||
Q7KTC2 | Q7KTC2_DROME | Multidrug-Resistance like protein 1... | MRP ABCC1, Dmel\CG6214, dMRP, dmrp, dMRP1 | 1,548 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAS64688.1 |
RefSeqi | NP_995699.1, NM_205977.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0090015; FBpp0089058; FBgn0032456 |
GeneIDi | 34686 |
UCSCi | CG6214-RC d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014134 Genomic DNA Translation: AAS64688.1 |
RefSeqi | NP_995699.1, NM_205977.2 |
3D structure databases
SMRi | Q7KTC7 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q7KTC7 |
Genome annotation databases
EnsemblMetazoai | FBtr0090015; FBpp0089058; FBgn0032456 |
GeneIDi | 34686 |
UCSCi | CG6214-RC d. melanogaster |
Organism-specific databases
CTDi | 34686 |
FlyBasei | FBgn0032456 MRP |
Phylogenomic databases
eggNOGi | KOG0054 Eukaryota COG1132 LUCA |
GeneTreei | ENSGT00940000165791 |
Miscellaneous databases
ChiTaRSi | Mhc fly |
GenomeRNAii | 34686 |
Gene expression databases
Bgeei | FBgn0032456 Expressed in 31 organ(s), highest expression level in larva |
ExpressionAtlasi | Q7KTC7 baseline and differential |
Genevisiblei | Q7KTC7 DM |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR011527 ABC1_TM_dom IPR036640 ABC1_TM_sf IPR003439 ABC_transporter-like IPR017871 ABC_transporter_CS IPR005292 Multidrug-R_assoc IPR027417 P-loop_NTPase |
Pfami | View protein in Pfam PF00664 ABC_membrane, 2 hits PF00005 ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382 AAA, 2 hits |
SUPFAMi | SSF52540 SSF52540, 2 hits SSF90123 SSF90123, 2 hits |
TIGRFAMsi | TIGR00957 MRP_assoc_pro, 1 hit |
PROSITEi | View protein in PROSITE PS50929 ABC_TM1F, 2 hits PS00211 ABC_TRANSPORTER_1, 2 hits PS50893 ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q7KTC7_DROME | |
Accessioni | Q7KTC7Primary (citable) accession number: Q7KTC7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | October 16, 2019 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |