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Entry version 164 (18 Sep 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Protein lap4

Gene

scrib

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for polarization of the embryonic, imaginal disk and follicular epithelia. Specifically restricts apical membrane determinants to the apical cell surface; acts to exclude crb from the basolateral domain and define adherens junction position. Regulates cellular growth and differentiation; acts as a tumor suppressor. Essential for odor guided behavior.4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis, Olfaction, Sensory transduction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-DME-6798695 Neutrophil degranulation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q7KRY7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein lap4
Alternative name(s):
Protein scribble
Protein smell-impaired
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:scribImported
Synonyms:smi1 Publication, vartImported
ORF Names:CG5462
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0263289 scrib

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Tight junction

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies exhibit aberrant cell shape and loss of the monolayer organization of embryonic epithelia creating a corrugated cuticular surface that is riddled with holes hence the gene name scribble. Misdistribution of apical proteins and adherens junctions to the basolateral cell surface is also exhibited.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001883071 – 1851Protein lap4Add BLAST1851

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei433Phosphoserine1 Publication1
Modified residuei435Phosphoserine1 Publication1
Modified residuei700Phosphoserine1 Publication1
Modified residuei702Phosphoserine1 Publication1
Modified residuei705Phosphoserine1 Publication1
Modified residuei834Phosphoserine1 Publication1
Modified residuei837Phosphoserine1 Publication1
Modified residuei1031Phosphoserine1 Publication1
Modified residuei1041Phosphoserine1 Publication1
Modified residuei1475Phosphoserine1 Publication1
Modified residuei1477Phosphoserine1 Publication1
Modified residuei1478Phosphoserine1 Publication1
Modified residuei1599Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7KRY7

PeptideAtlas

More...
PeptideAtlasi
Q7KRY7

PRoteomics IDEntifications database

More...
PRIDEi
Q7KRY7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7KRY7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q7KRY7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

During germ band extension, expression of isoform A occurs predominantly in neuroblasts derived from the neuro-ectoderm and later is restricted to CNS neurons and pole cells. Isoform C is strongly expressed in PNS and a subset of CNS neurons. In the adult, expressed in third antennal segment and maxillary palps, major olfactory organs and in Johnstons organ in the second antennal segment. Expression is also observed in cortical regions of the brain. Isoforms expressed in epithelia are coexpressed with dlg1 throughout development.3 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both zygotically and maternally in embryos. Isoform A and isoform C have high expression throughout embryonic development and very low expression in later developmental stages. In adults, isoform A is a male-specific isoform and isoform C a female specific.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0263289 Expressed in 45 organ(s), highest expression level in embryo

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q7KRY7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7KRY7 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
gukhQ4AB302EBI-419788,EBI-8282973

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
69066, 51 interactors

Protein interaction database and analysis system

More...
IntActi
Q7KRY7, 3 interactors

Molecular INTeraction database

More...
MINTi
Q7KRY7

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0300852

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11851
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7KRY7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati38 – 59LRR 1Add BLAST22
Repeati61 – 82LRR 2Add BLAST22
Repeati84 – 105LRR 3Add BLAST22
Repeati107 – 128LRR 4Add BLAST22
Repeati130 – 152LRR 5Add BLAST23
Repeati153 – 174LRR 6Add BLAST22
Repeati176 – 197LRR 7Add BLAST22
Repeati199 – 220LRR 8Add BLAST22
Repeati222 – 243LRR 9Add BLAST22
Repeati245 – 267LRR 10Add BLAST23
Repeati268 – 289LRR 11Add BLAST22
Repeati291 – 312LRR 12Add BLAST22
Repeati314 – 335LRR 13Add BLAST22
Repeati337 – 358LRR 14Add BLAST22
Repeati360 – 382LRR 15Add BLAST23
Repeati383 – 403LRR 16Add BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini731 – 818PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini929 – 1019PDZ 2PROSITE-ProRule annotationAdd BLAST91
Domaini1239 – 1329PDZ 3PROSITE-ProRule annotationAdd BLAST91
Domaini1336 – 1428PDZ 4PROSITE-ProRule annotationAdd BLAST93

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili471 – 492Sequence analysisAdd BLAST22
Coiled coili677 – 693Sequence analysisAdd BLAST17
Coiled coili1753 – 1790Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi128 – 397Leu-richAdd BLAST270
Compositional biasi868 – 882Gln-richAdd BLAST15

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.Sequence analysis

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7KRY7

KEGG Orthology (KO)

More...
KOi
K16175

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7KRY7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 3 hits
PF00595 PDZ, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 13 hits
SM00228 PDZ, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156 SSF50156, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 15 hits
PS50106 PDZ, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (11+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 11 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 11 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform D1 Publication (identifier: Q7KRY7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFKCIPIFKG CNRQVEFVDK RHCSLPQVPE EILRYSRTLE ELFLDANHIR
60 70 80 90 100
DLPKNFFRLH RLRKLGLSDN EIGRLPPDIQ NFENLVELDV SRNDIPDIPD
110 120 130 140 150
DIKHLQSLQV ADFSSNPIPK LPSGFSQLKN LTVLGLNDMS LTTLPADFGS
160 170 180 190 200
LTQLESLELR ENLLKHLPET ISQLTKLKRL DLGDNEIEDL PPYLGYLPGL
210 220 230 240 250
HELWLDHNQL QRLPPELGLL TKLTYLDVSE NRLEELPNEI SGLVSLTDLD
260 270 280 290 300
LAQNLLEALP DGIAKLSRLT ILKLDQNRLQ RLNDTLGNCE NMQELILTEN
310 320 330 340 350
FLSELPASIG QMTKLNNLNV DRNALEYLPL EIGQCANLGV LSLRDNKLKK
360 370 380 390 400
LPPELGNCTV LHVLDVSGNQ LLYLPYSLVN LQLKAVWLSE NQSQPLLTFQ
410 420 430 440 450
PDTDAETGEQ VLSCYLLPQQ EYQPITPARD LESDSEPFEE REPSRTVVKF
460 470 480 490 500
SEEATQEKET PFVRQNTPHP KDLKAKAQKL KVERSRNEEH ANLVTLPEEN
510 520 530 540 550
GTKLAETPTE TRTIANNHQQ QPHPVQQPIV GVNSKQPVVV GVVTPTTTTV
560 570 580 590 600
APTGVQGGSE GASSTANNVK AATAAVVAEL AATVGGSDEV QDDDEQEDEF
610 620 630 640 650
ESDRRVGFQV EGEDDDFYKR PPKLHRRDTP HHLKNKRVQH LTDKQASEIL
660 670 680 690 700
ANALASQERN DTTPQHSLSG KVTSPIEEEE QLEVEQEQQQ QQQQHPFDSS
710 720 730 740 750
LSPISAGKTA EASTDPDNLD GVTELRLEQY EIHIERTAAG LGLSIAGGKG
760 770 780 790 800
STPFKGDDDG IFISRVTEAG PADLAGLKVG DKVIKVNGIV VVDADHYQAV
810 820 830 840 850
QVLKACGAVL VLVVQREVTR LIGHPVFSED GSVSQISVET RPLVADAPPA
860 870 880 890 900
ASISHERYIP APIEIVPQQQ HLQQQQQQPI QQVAPTHSYS GNVFATPTAA
910 920 930 940 950
QTVQPAVSAA PNGLLLNGRE APLSYIQLHT TLIRDQIGQG LGFSIAGGKG
960 970 980 990 1000
SPPFKDDCDG IFISRITEGG LAYRDGKIMV GDRVMAINGN DMTEAHHDAA
1010 1020 1030 1040 1050
VACLTEPQRF VRLVLQREYR GPLEPPTSPR SPAVLNSLSP SGYLANRPAN
1060 1070 1080 1090 1100
FSRSVVEVEQ PYKYNTLATT TPTPKPTVPA SISNNNNTLP SSKTNGFATA
1110 1120 1130 1140 1150
AAATIDSSTG QPVPAPRRTN SVPMGDGDIG AGSTTSGDSG EAQPSSLRPL
1160 1170 1180 1190 1200
TSDDFQAMIP AHFLSGGSQH QVHVARPNEV GVSAVTVNVN KPQPDLPMFP
1210 1220 1230 1240 1250
AAPTELGRVT ETITKSTFTE TVMTRITDNQ LAEPLISEEV VLPKNQGSLG
1260 1270 1280 1290 1300
FSIIGGTDHS CVPFGTREPG IFISHIVPGG IASKCGKLRM GDRILKVNEA
1310 1320 1330 1340 1350
DVSKATHQDA VLELLKPGDE IKLTIQHDPL PPGFQEVLLS KAEGERLGMH
1360 1370 1380 1390 1400
IKGGLNGQRG NPADPSDEGV FVSKINSVGA ARRDGRLKVG MRLLEVNGHS
1410 1420 1430 1440 1450
LLGASHQDAV NVLRNAGNEI QLVVCKGYDK SNLIHSIGQA GGMSTGFNSS
1460 1470 1480 1490 1500
ASCSGGSRQG SRASETGSEL SQSQSVSSLD HEEDERLRQD FDVFASQKPD
1510 1520 1530 1540 1550
AQQPTGPSVL AAAAAMVHGA SSPTPPAATS NITPLPTAAA VASADLTAPD
1560 1570 1580 1590 1600
TPATQTVALI HAEQQAHQQQ QQTQLAPLGQ EKSTQEKVLE IVRAADAFTT
1610 1620 1630 1640 1650
VPPKSPSEHH EQDKIQKTTT VVISKHTLDT NPTTPTTPAA PLSIAGAESA
1660 1670 1680 1690 1700
NSAGAPSPAV PASTPGSAPV LPAVAVQTQT QTTSTEKDEE EESQLQSTPA
1710 1720 1730 1740 1750
SRDGAEEQQE EVRAKPTPTK VPKSVSDKKR FFESAMEDQH KPTQKTDKVF
1760 1770 1780 1790 1800
SFLSKDEVEK LRQEEERKIA TLRRDKNSRL LDAANDNIDK DAAQQRTKSN
1810 1820 1830 1840 1850
SNSSSGDDND DSDQEEGIAR GDSVDNAALG HFDDAEDMRN PLDEIEAVFR

S
Length:1,851
Mass (Da):200,440
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB744F9BA3827742C
GO
Isoform A1 Publication (identifier: Q7KRY7-2) [UniParc]FASTAAdd to basket
Also known as: B1 Publication, Scrib11 Publication, Vartul-1Imported

The sequence of this isoform differs from the canonical sequence as follows:
     1144-1238: Missing.

Show »
Length:1,756
Mass (Da):190,190
Checksum:i2174864916E87491
GO
Isoform C1 Publication (identifier: Q7KRY7-3) [UniParc]FASTAAdd to basket
Also known as: Scrib21 Publication, Vartul-2Imported

The sequence of this isoform differs from the canonical sequence as follows:
     1239-1247: EVVLPKNQG → VTISTSRIH
     1248-1851: Missing.

Show »
Length:1,247
Mass (Da):136,425
Checksum:i2B4EE65563C67833
GO
Isoform E1 Publication (identifier: Q7KRY7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     99-137: Missing.
     446-1051: Missing.
     1238-1238: Missing.

Show »
Length:1,205
Mass (Da):130,771
Checksum:iEEC544F7EA0484BB
GO
Isoform F1 Publication (identifier: Q7KRY7-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1468-1471: Missing.
     1697-1711: STPASRDGAEEQQEE → VCTHLTVDARLLSWL
     1712-1851: Missing.

Show »
Length:1,707
Mass (Da):184,321
Checksum:iA8289BED88E84A93
GO
Isoform G1 Publication (identifier: Q7KRY7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-137: Missing.
     446-1051: Missing.
     1468-1471: Missing.

Show »
Length:1,200
Mass (Da):130,256
Checksum:iA357F96B2E7C38E9
GO
Isoform H (identifier: Q7KRY7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-716: P → PANQAMFNVK...RDYERQRQHY
     1238-1238: Missing.

Note: No experimental confirmation available.
Show »
Length:1,939
Mass (Da):210,185
Checksum:iAD9E5B62D2B093CC
GO
Isoform I (identifier: Q7KRY7-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1697-1711: STPASRDGAEEQQEE → VCTHLTVDARLLSWL
     1712-1851: Missing.

Note: No experimental confirmation available.
Show »
Length:1,711
Mass (Da):184,737
Checksum:i67BAAD73F7AC6C25
GO
Isoform J (identifier: Q7KRY7-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1238-1238: Missing.

Show »
Length:1,850
Mass (Da):200,311
Checksum:iDFF69A064BACF2ED
GO
Isoform K (identifier: Q7KRY7-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1144-1238: Missing.
     1839-1851: RNPLDEIEAVFRS → SAEKRASWRA...NKNKRKGKKK

Note: No experimental confirmation available.
Show »
Length:2,331
Mass (Da):253,060
Checksum:iE7B806DCFC1B761A
GO
Isoform PImported (identifier: Q7KRY7-11) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-427: P → PDYPPMTLYRSSEKFDSTEFFSYQQK
     1697-1704: STPASRDG → LTAEQRIA
     1705-1851: Missing.

Note: No experimental confirmation available.
Show »
Length:1,729
Mass (Da):186,988
Checksum:i28C8766BC47CB617
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JIZ0E1JIZ0_DROME
Scribble, isoform L
scrib 0424, 05, CG31082, CG42614, CG5462
2,585Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JIZ1E1JIZ1_DROME
Scribble, isoform J
scrib 0424, 05, CG31082, CG42614, CG5462
2,426Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JIZ2E1JIZ2_DROME
Scribble, isoform M
scrib 0424, 05, CG31082, CG42614, CG5462
2,490Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K784A0A0B4K784_DROME
Scribble, isoform R
scrib 0424, 05, CG31082, CG42614, CG5462
1,951Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6M4A0A0B4K6M4_DROME
Scribble, isoform O
scrib 0424, 05, CG31082, CG42614, CG5462
2,515Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KHN3A0A0B4KHN3_DROME
Scribble, isoform S
scrib 0424, 05, CG31082, CG42614, CG5462
1,859Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7W1A0A0B4K7W1_DROME
Scribble, isoform Q
scrib 0424, 05, CG31082, CG42614, CG5462
2,577Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6I1A0A0B4K6I1_DROME
Scribble, isoform N
scrib 0424, 05, CG31082, CG42614, CG5462
2,554Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KHY2A0A0B4KHY2_DROME
Scribble, isoform U
scrib 0424, 05, CG31082, CG42614, CG5462
1,766Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4KI37A0A0B4KI37_DROME
Scribble, isoform T
scrib 0424, 05, CG31082, CG42614, CG5462
2,444Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL25508 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti19D → N in CAB70601 (PubMed:11578873).Curated1
Sequence conflicti19D → N in CAB71137 (PubMed:11578873).Curated1
Sequence conflicti19D → N in AAO32791 (PubMed:12930751).Curated1
Sequence conflicti19D → N in AAO32792 (PubMed:12930751).Curated1
Sequence conflicti19D → N in AAO32794 (PubMed:12930751).Curated1
Sequence conflicti40E → K in CAB70601 (PubMed:11578873).Curated1
Sequence conflicti40E → K in CAB71137 (PubMed:11578873).Curated1
Sequence conflicti40E → K in AAO32791 (PubMed:12930751).Curated1
Sequence conflicti40E → K in AAO32792 (PubMed:12930751).Curated1
Sequence conflicti40E → K in AAO32794 (PubMed:12930751).Curated1
Sequence conflicti262G → D in AAT94469 (Ref. 6) Curated1
Sequence conflicti313T → I in AAT94469 (Ref. 6) Curated1
Sequence conflicti1108S → T in CAB70601 (PubMed:11578873).Curated1
Sequence conflicti1108S → T in CAB71137 (PubMed:11578873).Curated1
Sequence conflicti1108S → T in AAO32791 (PubMed:12930751).Curated1
Sequence conflicti1108S → T in AAO32792 (PubMed:12930751).Curated1
Sequence conflicti1108S → T in AAO32793 (PubMed:12930751).Curated1
Sequence conflicti1108S → T in AAO32794 (PubMed:12930751).Curated1
Sequence conflicti1239Missing in AAO32791 (PubMed:12930751).Curated1
Sequence conflicti1239Missing in AAO32792 (PubMed:12930751).Curated1
Sequence conflicti1326Q → P in CAB70601 (PubMed:11578873).Curated1
Sequence conflicti1326Q → P in AAO32791 (PubMed:12930751).Curated1
Sequence conflicti1326Q → P in AAO32792 (PubMed:12930751).Curated1
Sequence conflicti1326Q → P in AAO32793 (PubMed:12930751).Curated1
Sequence conflicti1326Q → P in AAO32794 (PubMed:12930751).Curated1
Sequence conflicti1340S → N in CAB70601 (PubMed:11578873).Curated1
Sequence conflicti1340S → N in AAO32791 (PubMed:12930751).Curated1
Sequence conflicti1340S → N in AAO32792 (PubMed:12930751).Curated1
Sequence conflicti1340S → N in AAO32793 (PubMed:12930751).Curated1
Sequence conflicti1340S → N in AAO32794 (PubMed:12930751).Curated1
Sequence conflicti1361N → Y in CAB70601 (PubMed:11578873).Curated1
Sequence conflicti1361N → Y in AAO32791 (PubMed:12930751).Curated1
Sequence conflicti1361N → Y in AAO32792 (PubMed:12930751).Curated1
Sequence conflicti1361N → Y in AAO32793 (PubMed:12930751).Curated1
Sequence conflicti1361N → Y in AAO32794 (PubMed:12930751).Curated1
Sequence conflicti1388K → Q in AAF26357 (PubMed:10688207).Curated1
Sequence conflicti1540A → P in CAB70601 (PubMed:11578873).Curated1
Sequence conflicti1540A → P in AAO32791 (PubMed:12930751).Curated1
Sequence conflicti1540A → P in AAO32792 (PubMed:12930751).Curated1
Sequence conflicti1540A → P in AAO32793 (PubMed:12930751).Curated1
Sequence conflicti1540A → P in AAO32794 (PubMed:12930751).Curated1
Sequence conflicti1688D → Y in CAB70601 (PubMed:11578873).Curated1
Sequence conflicti1688D → Y in AAO32791 (PubMed:12930751).Curated1
Sequence conflicti1688D → Y in AAO32792 (PubMed:12930751).Curated1
Sequence conflicti1688D → Y in AAO32793 (PubMed:12930751).Curated1
Sequence conflicti1688D → Y in AAO32794 (PubMed:12930751).Curated1
Sequence conflicti1700A → S in AAL25508 (PubMed:12537569).Curated1
Sequence conflicti1741K → R in CAB70601 (PubMed:11578873).Curated1
Sequence conflicti1741K → R in AAO32791 (PubMed:12930751).Curated1
Sequence conflicti1741K → R in AAO32792 (PubMed:12930751).Curated1
Sequence conflicti1741K → R in AAO32794 (PubMed:12930751).Curated1
Sequence conflicti1769I → F in CAB70601 (PubMed:11578873).Curated1
Sequence conflicti1769I → F in AAO32791 (PubMed:12930751).Curated1
Sequence conflicti1769I → F in AAO32792 (PubMed:12930751).Curated1
Sequence conflicti1769I → F in AAO32794 (PubMed:12930751).Curated1
Sequence conflicti1833D → V in AAL39806 (Ref. 6) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05087697 – 137Missing in isoform G. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_05087799 – 137Missing in isoform E. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_058487427P → PDYPPMTLYRSSEKFDSTEF FSYQQK in isoform P. Curated1
Alternative sequenceiVSP_050878446 – 1051Missing in isoform E and isoform G. 1 PublicationAdd BLAST606
Alternative sequenceiVSP_035210716P → PANQAMFNVKIKVKEGNNTL PRNGQRSNGNFSYSGAGSGR NSPAMSSLRSSLASSNRSPS GSLQRKGKRVRIVTSYDPID RDYERQRQHY in isoform H. Curated1
Alternative sequenceiVSP_0508791144 – 1238Missing in isoform A and isoform K. 4 PublicationsAdd BLAST95
Alternative sequenceiVSP_0185951238Missing in isoform E, isoform H and isoform J. 1 Publication1
Alternative sequenceiVSP_0508801239 – 1247EVVLPKNQG → VTISTSRIH in isoform C. 2 Publications9
Alternative sequenceiVSP_0508811248 – 1851Missing in isoform C. 2 PublicationsAdd BLAST604
Alternative sequenceiVSP_0508821468 – 1471Missing in isoform F and isoform G. 1 Publication4
Alternative sequenceiVSP_0508831697 – 1711STPAS…EQQEE → VCTHLTVDARLLSWL in isoform F and isoform I. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_0584881697 – 1704STPASRDG → LTAEQRIA in isoform P. Curated8
Alternative sequenceiVSP_0584891705 – 1851Missing in isoform P. CuratedAdd BLAST147
Alternative sequenceiVSP_0508841712 – 1851Missing in isoform F and isoform I. 1 PublicationAdd BLAST140
Alternative sequenceiVSP_0428671839 – 1851RNPLD…AVFRS → SAEKRASWRAARLRSLEQGA VEAQDVIKNMRKMTDDLITH ESRASEVETCKERIISLELQ VPETEDEGKLDDTQPPLELE ADDFQDDEDDDDDDDDEDDF EDEDEEEDTASIVTVQANNE KLFLRHDSDTYGPSSIESVA SGKVRIKPTPLSLHQTLAKE TTIVEVLNPVIGGDGSARTI HVSGGLPFDEDAFEQGAVAV LRSETFVLPGAAGGGRSELS LNAKMKTVLEELLENERVKL NLQKSLEGEEGEDDDDEDEN GSAYGDARDEEESAYGDAID DVVDFGSATVTSRAANDKDD VKNGNQQLLEELIKDSNRNT IIAKLAGQLSDDDEEDDDEE ESSDSSDDDSDDSDEEDNAQ QQLNVTYVQGAQVIENLNTL ATGGKLQKSQTYTAIKQAEE PKEEDTKLEEDPSAEKPCGA DTLAKLQAEQRALAEISKQL RKSVEDLLSADGETVVETQR TYTLPAPSDSSAVVTVTEVV KKQKKKKSETGEELFNRLLN AAESERQVFDRQQGETITTT TTTTEAVSSEDNEPSTSVVT TTRTVSNIVTSGIPRPETSK QNNRSSSSSNSNSSNNNRNK NKRKGKKK in isoform K. CuratedAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF190774 mRNA Translation: AAF26357.2
AJ252084 mRNA Translation: CAB70601.1
AJ271647 mRNA Translation: CAB71137.1
AY167903 mRNA Translation: AAO32791.1
AY167904 mRNA Translation: AAO32792.1
AY167905 mRNA Translation: AAO32793.1
AY167906 mRNA Translation: AAO32794.1
AE014297 Genomic DNA Translation: AAF56598.2
AE014297 Genomic DNA Translation: AAN14076.1
AE014297 Genomic DNA Translation: AAN14077.2
AE014297 Genomic DNA Translation: AAN14078.1
AE014297 Genomic DNA Translation: AAX52995.2
AE014297 Genomic DNA Translation: AAX52996.1
AE014297 Genomic DNA Translation: ABI31210.3
AE014297 Genomic DNA Translation: AFH06635.1
AY069661 mRNA Translation: AAL39806.2
BT015240 mRNA Translation: AAT94469.1
AY060469 mRNA Translation: AAL25508.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_001014669.1, NM_001014669.3 [Q7KRY7-8]
NP_001014670.2, NM_001014670.4 [Q7KRY7-7]
NP_001036761.3, NM_001043296.3 [Q7KRY7-2]
NP_001247318.1, NM_001260389.1 [Q7KRY7-10]
NP_524754.2, NM_080015.4 [Q7KRY7-1]
NP_733154.1, NM_170275.3 [Q7KRY7-2]
NP_733155.2, NM_170276.3 [Q7KRY7-11]
NP_733156.1, NM_170277.4 [Q7KRY7-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0308620; FBpp0300844; FBgn0263289 [Q7KRY7-2]
FBtr0308621; FBpp0300845; FBgn0263289 [Q7KRY7-2]
FBtr0308622; FBpp0300846; FBgn0263289 [Q7KRY7-7]
FBtr0308623; FBpp0300847; FBgn0263289 [Q7KRY7-8]
FBtr0308624; FBpp0300848; FBgn0263289 [Q7KRY7-3]
FBtr0308625; FBpp0300849; FBgn0263289 [Q7KRY7-1]
FBtr0308627; FBpp0300851; FBgn0263289 [Q7KRY7-10]
FBtr0308632; FBpp0300856; FBgn0263289 [Q7KRY7-11]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
44448

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG43398

UCSC genome browser

More...
UCSCi
CG5462-RB d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190774 mRNA Translation: AAF26357.2
AJ252084 mRNA Translation: CAB70601.1
AJ271647 mRNA Translation: CAB71137.1
AY167903 mRNA Translation: AAO32791.1
AY167904 mRNA Translation: AAO32792.1
AY167905 mRNA Translation: AAO32793.1
AY167906 mRNA Translation: AAO32794.1
AE014297 Genomic DNA Translation: AAF56598.2
AE014297 Genomic DNA Translation: AAN14076.1
AE014297 Genomic DNA Translation: AAN14077.2
AE014297 Genomic DNA Translation: AAN14078.1
AE014297 Genomic DNA Translation: AAX52995.2
AE014297 Genomic DNA Translation: AAX52996.1
AE014297 Genomic DNA Translation: ABI31210.3
AE014297 Genomic DNA Translation: AFH06635.1
AY069661 mRNA Translation: AAL39806.2
BT015240 mRNA Translation: AAT94469.1
AY060469 mRNA Translation: AAL25508.1 Sequence problems.
RefSeqiNP_001014669.1, NM_001014669.3 [Q7KRY7-8]
NP_001014670.2, NM_001014670.4 [Q7KRY7-7]
NP_001036761.3, NM_001043296.3 [Q7KRY7-2]
NP_001247318.1, NM_001260389.1 [Q7KRY7-10]
NP_524754.2, NM_080015.4 [Q7KRY7-1]
NP_733154.1, NM_170275.3 [Q7KRY7-2]
NP_733155.2, NM_170276.3 [Q7KRY7-11]
NP_733156.1, NM_170277.4 [Q7KRY7-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WOUX-ray1.55A726-820[»]
SMRiQ7KRY7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi69066, 51 interactors
IntActiQ7KRY7, 3 interactors
MINTiQ7KRY7
STRINGi7227.FBpp0300852

PTM databases

iPTMnetiQ7KRY7
SwissPalmiQ7KRY7

Proteomic databases

PaxDbiQ7KRY7
PeptideAtlasiQ7KRY7
PRIDEiQ7KRY7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0308620; FBpp0300844; FBgn0263289 [Q7KRY7-2]
FBtr0308621; FBpp0300845; FBgn0263289 [Q7KRY7-2]
FBtr0308622; FBpp0300846; FBgn0263289 [Q7KRY7-7]
FBtr0308623; FBpp0300847; FBgn0263289 [Q7KRY7-8]
FBtr0308624; FBpp0300848; FBgn0263289 [Q7KRY7-3]
FBtr0308625; FBpp0300849; FBgn0263289 [Q7KRY7-1]
FBtr0308627; FBpp0300851; FBgn0263289 [Q7KRY7-10]
FBtr0308632; FBpp0300856; FBgn0263289 [Q7KRY7-11]
GeneIDi44448
KEGGidme:Dmel_CG43398
UCSCiCG5462-RB d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23513
FlyBaseiFBgn0263289 scrib

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
InParanoidiQ7KRY7
KOiK16175
PhylomeDBiQ7KRY7

Enzyme and pathway databases

ReactomeiR-DME-438066 Unblocking of NMDA receptors, glutamate binding and activation
R-DME-6798695 Neutrophil degranulation
SignaLinkiQ7KRY7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
scrib fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
44448

Protein Ontology

More...
PROi
PR:Q7KRY7

Gene expression databases

BgeeiFBgn0263289 Expressed in 45 organ(s), highest expression level in embryo
ExpressionAtlasiQ7KRY7 baseline and differential
GenevisibleiQ7KRY7 DM

Family and domain databases

Gene3Di3.80.10.10, 3 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
PF00595 PDZ, 4 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 13 hits
SM00228 PDZ, 4 hits
SUPFAMiSSF50156 SSF50156, 4 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 15 hits
PS50106 PDZ, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLAP4_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KRY7
Secondary accession number(s): A0A0B4K7L2
, A4V3G5, Q59DT7, Q59DT8, Q6AWK8, Q7K9X1, Q7KA36, Q86QS7, Q86QS8, Q86QS9, Q86QT0, Q8IMR8, Q8IMR9, Q8T003, Q95SV4, Q9VBE4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: September 18, 2019
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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