Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 132 (07 Apr 2021)
Sequence version 2 (05 Oct 2010)
Previous versions | rss
Add a publicationFeedback
Protein

GIGYF family protein Gyf

Gene

Gyf

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:31114929). In the 4EHP-GYF2 complex, promotes translational repression and decay of mRNA targets by recruiting and bridging the association of the 4EHP complex with decapping effector proteins, such as me31B and Patr-1, and the deadenylation CCR4-NOT complex (PubMed:31114929). Involved in regulating starvation-induced, developmental and physiological autophagy, which is critical for eliminating ubiquitinated proteins and dysfunctional organelles in order to maintain tissue homeostasis (PubMed:26086452).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • translation repressor activity Source: UniProtKB

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GIGYF family protein Gyf1 Publication
Short name:
GigyfImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gyf1 PublicationImported
ORF Names:CG11148Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0039936, Gyf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Larvae and adults display defects in starvation-induced, developmental and physiological autophagy, which result in the accumulation of autophagosomes, autolysosomes, and increased Atg8a expression (PubMed:26086452). Adults display reduced locomotion and decreased life span, likely due to the dysregulation of autophagy which results in the accumulation of ubiquitinated proteins and dysfunctional mitochondria in neuronal and muscle tissues (PubMed:26086452). TORC1 signaling is also inhibited, possibly to compensate for the loss of autophagy (PubMed:26086452).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58Y → A in C; impairs interaction with eIF4EHP but has no effect on translational repression or induction of mRNA decay; when associated with A-60 and a-65. 1 Publication1
Mutagenesisi60Y → A in C; impairs interaction with eIF4EHP but has no effect on translational repression or induction of mRNA decay; when associated with A-58 and a-65. 1 Publication1
Mutagenesisi65M → A in C; impairs interaction with eIF4EHP but has no effect on translational repression or induction of mRNA decay; when associated with A-58 and A-60. 1 Publication1
Mutagenesisi331 – 374Missing : Abolishes interaction with me31B and impairs translational repression and induction of mRNA decay. 1 PublicationAdd BLAST44
Mutagenesisi349W → A: Abolishes interaction with me31B. 1 Publication1
Mutagenesisi361F → A in FF; abolishes interaction with me31B; when associated with A-367. 1 Publication1
Mutagenesisi367F → A in FF; abolishes interaction with me31B; when associated with A-361. 1 Publication1
Mutagenesisi571Y → A in GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-582, A-590 and A-596. 1 Publication1
Mutagenesisi582F → A in GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-571, A-590 and A-596. 1 Publication1
Mutagenesisi590W → A in GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-571, A-582,and A-596. 1 Publication1
Mutagenesisi596F → A in GYF; impairs interaction with Patr-1 but has no effect on translational repression or induction of mRNA decay, and does not affect interaction with me31B or Not1; when associated with A-571, A-582 and A-590. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003728401 – 1574GIGYF family protein GyfAdd BLAST1574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei272Phosphoserine1 Publication1
Modified residuei291Phosphoserine1 Publication1
Modified residuei399Phosphoserine1 Publication1
Modified residuei403Phosphoserine1 Publication1
Modified residuei407Phosphoserine1 Publication1
Modified residuei412Phosphothreonine1 Publication1
Modified residuei1007Phosphoserine1 Publication1
Modified residuei1370Phosphoserine1 Publication1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q7KQM6

PRoteomics IDEntifications database

More...
PRIDEi
Q7KQM6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q7KQM6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0039936, Expressed in embryo and 40 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q7KQM6, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the 4EHP-GYF2 complex, composed of at least eIF4EHP and Gyf (PubMed:31114929).

Interacts (via N-terminus) with eIF4EHP; interaction is required for eIF4EHP-mediated translational repression and mRNA decay (PubMed:31114929).

Interacts (via me31B binding motif) with the decapping activator DDX6/ME31B (via RecA-like domain 2), and also interacts (via GYF domain) with the decapping effector protein Patr-1 (PubMed:31114929, PubMed:31439631).

Also interacts with other decapping effector proteins, such as Edc3 and Ge-1 (PubMed:31114929).

Interacts with CCR4-NOT deadenylase complex members Not1, Not3, Pop2 and twin, and other components of the deadenylation complexes such as Rga, PAN2 and PAN3 (PubMed:31114929).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
68666, 25 interactors

Protein interaction database and analysis system

More...
IntActi
Q7KQM6, 7 interactors

Molecular INTeraction database

More...
MINTi
Q7KQM6

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0290107

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q7KQM6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini566 – 614GYFPROSITE-ProRule annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 640Important for promoting translational repression1 PublicationAdd BLAST640

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi341 – 369me31B binding motif1 PublicationAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1028 – 1121Gln-richAdd BLAST94

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GIGYF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1862, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168947

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002878_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q7KQM6

Identification of Orthologs from Complete Genome Data

More...
OMAi
MLQDQYL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q7KQM6

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00072, GYF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02213, GYF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00444, GYF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55277, SSF55277, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50829, GYF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform G (identifier: Q7KQM6-1) [UniParc]FASTAAdd to basket
Also known as: H

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDSMKFGPE WLRNMSAEPS GSPSTYNVGN AAQNNSIGGH NLGNNTAASA
60 70 80 90 100
SRNLFPEYRY GREEMLSLFD RNCLLPQILP SFKKLFVEKV QCPLALTPSS
110 120 130 140 150
EEDINQNSLG NNSRPAWLQR SPSGFGSASR GSGRGGTVDR GRMRGKSAYH
160 170 180 190 200
PIYQRPSGLY DESLSVISKA ERTWSDRNGT GDSAATTTST SGSGALDWNG
210 220 230 240 250
TPSSSPRKDY SNNHRNLENW RRTRNEDGSG DGPSSSGSMS GPDIAGWRSG
260 270 280 290 300
VVGGSTNAGF GTNSHRWGRS TSWRDEDPSV DNAASLQRSI STVATLSTDR
310 320 330 340 350
TGNNKGSGIG AAEGVGSISH PRLSSSKISQ LWTVNNAAGV DADENLPEWA
360 370 380 390 400
IENPSKLGGS FDASGAFHGD TDLKPIKSSH NTLKTKSLDS YDDVKRPKSK
410 420 430 440 450
DLSDPDSGND ITPETSLTKD TNTTAVQEEV ESSLSPISST TTKEVIHGDI
460 470 480 490 500
SDRIKEVADE VEKLIMDDDH KISSNQSQHQ NHDGFTAALP RMADIEINVK
510 520 530 540 550
PSVTAVHRQA PSTMPIQITP TITDVAPPSH AVVSFSDHET MQHHNMHHLP
560 570 580 590 600
QFPMIPTPHI ITPNLNELWF YRDPQANVQG PFSAVEMTEW YRAGYFNENL
610 620 630 640 650
FVRRYSDNRF RPLGELIKFC HGNMPFTHSH LLPSPIELEN IPVGQIPAPL
660 670 680 690 700
TASLSITPHK PSPIPIALSV VEQQLQQQRD EQLKANVTAT AEALRAAIKG
710 720 730 740 750
SFGGNSIGNT SHLLTMRFQM LQDQYIQHQE YQILAELSKN ECFQRLSAVE
760 770 780 790 800
QETVVRRKVQ LLGLPEYLIS LNGLSNSLSV LNPVAGRQLY RAVVEHAKKD
810 820 830 840 850
QQHIFANTEQ QRSVGNLLDA NNFILNAQIM IQQSQQEVGP LVSSVDCIMQ
860 870 880 890 900
GGTAADLNKP NEIPRNELDL INEYNLRMLL RGQPTSTQQQ PPALTNSATE
910 920 930 940 950
NLPGVDFLTE TQLLERQNLM IPIWLPPNNN KQQETDQQWA EMSNADASLW
960 970 980 990 1000
ETANLNEERN EDQQLLIQKS SEACFADTEK DVKIAQLFQV QSGNVVNHTA
1010 1020 1030 1040 1050
LEELDQSPQN LKGSHNQKIV KSLVSDIQQN HNEELNSHQH QVKQANKQNL
1060 1070 1080 1090 1100
NTKQNAAQSA LKPINNENDR KREQTEEKKR QREERKRQQL EDDKRRALNE
1110 1120 1130 1140 1150
SEEQTRQIQE EKERQQQIQA QRRKALLGNV HSLSVQNGMS GTLASAQSKK
1160 1170 1180 1190 1200
NDDAKTAEPQ VSSRLPSTSV APWSFQLQNS MRSAPGLAEI QKAERRERRA
1210 1220 1230 1240 1250
DQQRHQELLD KQLRANAAAA AEANDALLKW QSTPASAPVM SLAEIQAEEA
1260 1270 1280 1290 1300
RRLANDLVDR QRRRELEHHQ QAPLSSAVLV TSATSNIWGN ANKAWSSSAA
1310 1320 1330 1340 1350
QSLSLKTSSG TGLWDEPNPL GSNGSGTSGT SSVTAAAVLA GGLNSANKST
1360 1370 1380 1390 1400
LQAQNKSSAL FASPRNLRKS QTLPALSNPE KSNKNGPGQR PEKQKLAQTR
1410 1420 1430 1440 1450
SKGAAVSIEE KDRERKLNAK SQQSSTDQAI SKVNEYENEF TSWCIKSLDN
1460 1470 1480 1490 1500
MSAKVDVPTF VAFLQDLEAP YEVKDYVRIY LGDGKDSLDF AKQFLERRSK
1510 1520 1530 1540 1550
YKSLQRAQKA HNDDMCKPAP AITPSANDYA DSKNKQKKIK KNKMTKMDAR
1560 1570
ILGFSVTAAE GRINVGIRDY VEGP
Length:1,574
Mass (Da):173,730
Last modified:October 5, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE378F20E6DA4474
GO
Isoform D (identifier: Q7KQM6-2) [UniParc]FASTAAdd to basket
Also known as: E, F

The sequence of this isoform differs from the canonical sequence as follows:
     113-119: Missing.

Show »
Length:1,567
Mass (Da):172,891
Checksum:i286AA4E34F7B5CB9
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK93031 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence ACL68761 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence ADV15453 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti391Y → K in ADV15453 (Ref. 4) Curated1
Sequence conflicti1331S → T in ACL68761 (Ref. 4) Curated1
Sequence conflicti1536 – 1543QKKIKKNK → KKRLKRIR in ACL68761 (Ref. 4) Curated8

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037201113 – 119Missing in isoform D. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AAF59406.3
AE014135 Genomic DNA Translation: AAS64612.2
AE014135 Genomic DNA Translation: ACZ95096.1
AE014135 Genomic DNA Translation: ACZ95097.1
AY051607 mRNA Translation: AAK93031.1 Different initiation.
BT056314 mRNA Translation: ACL68761.1 Different initiation.
BT125874 mRNA Translation: ADV15453.1 Different initiation.

NCBI Reference Sequences

More...
RefSeqi
NP_001162827.1, NM_001169356.2 [Q7KQM6-1]
NP_001162828.1, NM_001169357.4 [Q7KQM6-1]
NP_651950.3, NM_143693.4 [Q7KQM6-2]
NP_995600.2, NM_205878.3 [Q7KQM6-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0300882; FBpp0290104; FBgn0039936 [Q7KQM6-2]
FBtr0300884; FBpp0290106; FBgn0039936 [Q7KQM6-2]
FBtr0300885; FBpp0290107; FBgn0039936 [Q7KQM6-1]
FBtr0300886; FBpp0290108; FBgn0039936 [Q7KQM6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43842

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG11148

UCSC genome browser

More...
UCSCi
CG11148-RA, d. melanogaster
CG11148-RB, d. melanogaster [Q7KQM6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014135 Genomic DNA Translation: AAF59406.3
AE014135 Genomic DNA Translation: AAS64612.2
AE014135 Genomic DNA Translation: ACZ95096.1
AE014135 Genomic DNA Translation: ACZ95097.1
AY051607 mRNA Translation: AAK93031.1 Different initiation.
BT056314 mRNA Translation: ACL68761.1 Different initiation.
BT125874 mRNA Translation: ADV15453.1 Different initiation.
RefSeqiNP_001162827.1, NM_001169356.2 [Q7KQM6-1]
NP_001162828.1, NM_001169357.4 [Q7KQM6-1]
NP_651950.3, NM_143693.4 [Q7KQM6-2]
NP_995600.2, NM_205878.3 [Q7KQM6-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6S8RX-ray2.41B343-369[»]
SMRiQ7KQM6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi68666, 25 interactors
IntActiQ7KQM6, 7 interactors
MINTiQ7KQM6
STRINGi7227.FBpp0290107

PTM databases

iPTMnetiQ7KQM6

Proteomic databases

PaxDbiQ7KQM6
PRIDEiQ7KQM6

Genome annotation databases

EnsemblMetazoaiFBtr0300882; FBpp0290104; FBgn0039936 [Q7KQM6-2]
FBtr0300884; FBpp0290106; FBgn0039936 [Q7KQM6-2]
FBtr0300885; FBpp0290107; FBgn0039936 [Q7KQM6-1]
FBtr0300886; FBpp0290108; FBgn0039936 [Q7KQM6-1]
GeneIDi43842
KEGGidme:Dmel_CG11148
UCSCiCG11148-RA, d. melanogaster
CG11148-RB, d. melanogaster [Q7KQM6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43842
FlyBaseiFBgn0039936, Gyf

Phylogenomic databases

eggNOGiKOG1862, Eukaryota
GeneTreeiENSGT00940000168947
HOGENOMiCLU_002878_0_0_1
InParanoidiQ7KQM6
OMAiMLQDQYL
PhylomeDBiQ7KQM6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
43842, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CG11148, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43842

Protein Ontology

More...
PROi
PR:Q7KQM6

Gene expression databases

BgeeiFBgn0039936, Expressed in embryo and 40 other tissues
GenevisibleiQ7KQM6, DM

Family and domain databases

CDDicd00072, GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR003169, GYF
IPR035445, GYF-like_dom_sf
PfamiView protein in Pfam
PF02213, GYF, 1 hit
SMARTiView protein in SMART
SM00444, GYF, 1 hit
SUPFAMiSSF55277, SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829, GYF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGGYF1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KQM6
Secondary accession number(s): B8A422
, D1YSG2, E8NH20, Q961G4, Q9V482
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: October 5, 2010
Last modified: April 7, 2021
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again