UniProtKB - Q7KQM4 (PLM1_PLAF7)
Protein
Plasmepsin-1
Gene
PF14_0076
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
Participates in the digestion of the host hemoglobin. Initial cleavage at the hinge region of hemoglobin, than cleaves at other sites, leading to denaturation of the molecule and to further degradation (By similarity).By similarity
Catalytic activityi
- Hydrolysis of the 33-Phe-|-Leu-34 bond in the alpha-chain of hemoglobin, leading to denaturation of molecule. EC:3.4.23.38
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 157 | PROSITE-ProRule annotation | 1 | |
Active sitei | 337 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- aspartic-type endopeptidase activity Source: GeneDB
GO - Biological processi
- hemoglobin catabolic process Source: GeneDB
Keywordsi
Molecular function | Aspartyl protease, Hydrolase, Protease |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF14_0076 |
Organismi | Plasmodium falciparum (isolate 3D7) |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1407900 |
Subcellular locationi
- Vacuole By similarity Note: Could be first anchored to the membrane through its propeptide before being released.By similarity
GO - Cellular componenti
- food vacuole Source: GeneDB
Keywords - Cellular componenti
VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – ? | Sequence analysis | ||
PropeptideiPRO_0000233400 | ? – 124 | Activation peptideBy similarity | ||
ChainiPRO_0000233401 | 125 – 452 | Plasmepsin-1Add BLAST | 328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 170 ↔ 175 | By similarity | ||
Glycosylationi | 184 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 218 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 326 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 372 ↔ 408 | By similarity | ||
Glycosylationi | 440 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
PRIDEi | Q7KQM4 |
PTM databases
SwissPalmi | Q7KQM4 |
Expressioni
Developmental stagei
Erythrocytic stages.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 139 – 446 | Peptidase A1PROSITE-ProRule annotationAdd BLAST | 308 |
Sequence similaritiesi
Belongs to the peptidase A1 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
HOGENOMi | CLU_013253_3_2_1 |
InParanoidi | Q7KQM4 |
OMAi | MNVQYYG |
PhylomeDBi | Q7KQM4 |
Family and domain databases
CDDi | cd05471, pepsin_like, 1 hit |
Gene3Di | 2.40.70.10, 2 hits |
InterProi | View protein in InterPro IPR001461, Aspartic_peptidase_A1 IPR001969, Aspartic_peptidase_AS IPR034164, Pepsin-like_dom IPR033121, PEPTIDASE_A1 IPR021109, Peptidase_aspartic_dom_sf |
PANTHERi | PTHR13683, PTHR13683, 2 hits |
Pfami | View protein in Pfam PF00026, Asp, 1 hit |
PRINTSi | PR00792, PEPSIN |
SUPFAMi | SSF50630, SSF50630, 1 hit |
PROSITEi | View protein in PROSITE PS00141, ASP_PROTEASE, 2 hits PS51767, PEPTIDASE_A1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q7KQM4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSIKEDFS SAFAKNESAV NSSTFNNNMK TWKIQKRFQI LYVFFFLLIT
60 70 80 90 100
GALFYYLIDN VLFPKNKKIN EIMNTSKHVI IGFSIENSHD RIMKTVKQHR
110 120 130 140 150
LKNYIKESLK FFKTGLTQKP HLGNAGDSVT LNDVANVMYY GEAQIGDNKQ
160 170 180 190 200
KFAFIFDTGS ANLWVPSAQC NTIGCKTKNL YDSNKSKTYE KDGTKVEMNY
210 220 230 240 250
VSGTVSGFFS KDIVTIANLS FPYKFIEVTD TNGFEPAYTL GQFDGIVGLG
260 270 280 290 300
WKDLSIGSVD PVVVELKNQN KIEQAVFTFY LPFDDKHKGY LTIGGIEDRF
310 320 330 340 350
YEGQLTYEKL NHDLYWQVDL DLHFGNLTVE KATAIVDSGT SSITAPTEFL
360 370 380 390 400
NKFFEGLDVV KIPFLPLYIT TCNNPKLPTL EFRSATNVYT LEPEYYLQQI
410 420 430 440 450
FDFGISLCMV SIIPVDLNKN TFILGDPFMR KYFTVFDYDN HTVGFALAKK
KL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A144A171 | A0A144A171_PLAF7 | Plasmepsin I | PF3D7_1407900 | 452 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014187 Genomic DNA Translation: AAN36688.1 |
RefSeqi | XP_001348249.1, XM_001348213.1 |
Genome annotation databases
EnsemblProtistsi | CZT99786; CZT99786; PF3D7_1407900 |
GeneDBi | PF3D7_1407900.1:pep |
GeneIDi | 811658 |
KEGGi | pfa:PF3D7_1407900 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014187 Genomic DNA Translation: AAN36688.1 |
RefSeqi | XP_001348249.1, XM_001348213.1 |
3D structure databases
SMRi | Q7KQM4 |
ModBasei | Search... |
Chemistry databases
DrugBanki | DB11638, Artenimol |
PTM databases
SwissPalmi | Q7KQM4 |
Proteomic databases
PRIDEi | Q7KQM4 |
Genome annotation databases
EnsemblProtistsi | CZT99786; CZT99786; PF3D7_1407900 |
GeneDBi | PF3D7_1407900.1:pep |
GeneIDi | 811658 |
KEGGi | pfa:PF3D7_1407900 |
Organism-specific databases
EuPathDBi | PlasmoDB:PF3D7_1407900 |
Phylogenomic databases
HOGENOMi | CLU_013253_3_2_1 |
InParanoidi | Q7KQM4 |
OMAi | MNVQYYG |
PhylomeDBi | Q7KQM4 |
Family and domain databases
CDDi | cd05471, pepsin_like, 1 hit |
Gene3Di | 2.40.70.10, 2 hits |
InterProi | View protein in InterPro IPR001461, Aspartic_peptidase_A1 IPR001969, Aspartic_peptidase_AS IPR034164, Pepsin-like_dom IPR033121, PEPTIDASE_A1 IPR021109, Peptidase_aspartic_dom_sf |
PANTHERi | PTHR13683, PTHR13683, 2 hits |
Pfami | View protein in Pfam PF00026, Asp, 1 hit |
PRINTSi | PR00792, PEPSIN |
SUPFAMi | SSF50630, SSF50630, 1 hit |
PROSITEi | View protein in PROSITE PS00141, ASP_PROTEASE, 2 hits PS51767, PEPTIDASE_A1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLM1_PLAF7 | |
Accessioni | Q7KQM4Primary (citable) accession number: Q7KQM4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 102 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries