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Entry version 111 (26 Feb 2020)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Apical membrane antigen 1

Gene

PF3D7_1133400

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PLASMO:PF11_0344-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Apical membrane antigen 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:PF3D7_1133400Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparum (isolate 3D7)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri36329 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001450 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
PlasmoDB:PF3D7_1133400

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3559647

DrugCentral

More...
DrugCentrali
Q7KQK5

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi149 ↔ 302Combined sources
Disulfide bondi217 ↔ 247Combined sources
Disulfide bondi263 ↔ 275Combined sources
Disulfide bondi320 ↔ 418Combined sources
Disulfide bondi337 ↔ 409Combined sources

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q7KQK5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q7KQK5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q7KQK5

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni577 – 607DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi577 – 606PolyampholyteSequence analysisAdd BLAST30

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_490483_0_0_1

KEGG Orthology (KO)

More...
KOi
K13845

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDEMLDP

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1010.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003298 Apmem_Ag1
IPR024056 Apmem_Ag1_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02430 AMA-1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01361 MEROZOITESA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00815 AMA-1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82910 SSF82910, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7KQK5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKLYCVLLL SAFEFTYMIN FGRGQNYWEH PYQNSDVYRP INEHREHPKE
60 70 80 90 100
YEYPLHQEHT YQQEDSGEDE NTLQHAYPID HEGAEPAPQE QNLFSSIEIV
110 120 130 140 150
ERSNYMGNPW TEYMAKYDIE EVHGSGIRVD LGEDAEVAGT QYRLPSGKCP
160 170 180 190 200
VFGKGIIIEN SNTTFLTPVA TGNQYLKDGG FAFPPTEPLM SPMTLDEMRH
210 220 230 240 250
FYKDNKYVKN LDELTLCSRH AGNMIPDNDK NSNYKYPAVY DDKDKKCHIL
260 270 280 290 300
YIAAQENNGP RYCNKDESKR NSMFCFRPAK DISFQNYTYL SKNVVDNWEK
310 320 330 340 350
VCPRKNLQNA KFGLWVDGNC EDIPHVNEFP AIDLFECNKL VFELSASDQP
360 370 380 390 400
KQYEQHLTDY EKIKEGFKNK NASMIKSAFL PTGAFKADRY KSHGKGYNWG
410 420 430 440 450
NYNTETQKCE IFNVKPTCLI NNSSYIATTA LSHPIEVENN FPCSLYKDEI
460 470 480 490 500
MKEIERESKR IKLNDNDDEG NKKIIAPRIF ISDDKDSLKC PCDPEMVSNS
510 520 530 540 550
TCRFFVCKCV ERRAEVTSNN EVVVKEEYKD EYADIPEHKP TYDKMKIIIA
560 570 580 590 600
SSAAVAVLAT ILMVYLYKRK GNAEKYDKMD EPQDYGKSNS RNDEMLDPEA
610 620
SFWGEEKRAS HTTPVLMEKP YY
Length:622
Mass (Da):72,042
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60FE442074C38E94
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LN999945 Genomic DNA Translation: CZT98996.1

NCBI Reference Sequences

More...
RefSeqi
XP_001348015.1, XM_001347979.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
CZT98996; CZT98996; PF3D7_1133400

GeneDB pathogen genome database from Sanger Institute

More...
GeneDBi
PF3D7_1133400.1:pep

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
810891

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfa:PF3D7_1133400

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999945 Genomic DNA Translation: CZT98996.1
RefSeqiXP_001348015.1, XM_001347979.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z40X-ray1.90A/E104-438[»]
2Q8AX-ray2.40A104-438[»]
2Q8BX-ray2.30A104-438[»]
2Z8VX-ray2.35A/B104-438[»]
2Z8WX-ray2.45A/B104-438[»]
3SRJX-ray2.15A/B97-442[»]
3ZWZX-ray2.10A103-438[»]
4R19X-ray1.80A/B104-438[»]
4R1BX-ray1.60A104-438[»]
4R1CX-ray2.00A/B104-438[»]
SMRiQ7KQK5
ModBaseiSearch...
PDBe-KBiSearch...

Chemistry databases

BindingDBiQ7KQK5
ChEMBLiCHEMBL3559647
DrugCentraliQ7KQK5

Proteomic databases

PRIDEiQ7KQK5

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q7KQK5

Genome annotation databases

EnsemblProtistsiCZT98996; CZT98996; PF3D7_1133400
GeneDBiPF3D7_1133400.1:pep
GeneIDi810891
KEGGipfa:PF3D7_1133400

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1133400

Phylogenomic databases

HOGENOMiCLU_490483_0_0_1
KOiK13845
OMAiKDEMLDP

Enzyme and pathway databases

BioCyciPLASMO:PF11_0344-MONOMER

Family and domain databases

Gene3Di4.10.1010.10, 1 hit
InterProiView protein in InterPro
IPR003298 Apmem_Ag1
IPR024056 Apmem_Ag1_dom_sf
PfamiView protein in Pfam
PF02430 AMA-1, 1 hit
PRINTSiPR01361 MEROZOITESA
SMARTiView protein in SMART
SM00815 AMA-1, 1 hit
SUPFAMiSSF82910 SSF82910, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7KQK5_PLAF7
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KQK5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 26, 2020
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

3D-structureCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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