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Protein

Proliferating cell nuclear antigen

Gene

PF3D7_1226600

Organism
Plasmodium falciparum (isolate 3D7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, NucleotidyltransferaseImported, Transferase
Biological processDNA replicationUniRule annotation

Enzyme and pathway databases

ReactomeiR-PFA-110320 Translesion Synthesis by POLH
R-PFA-174411 Polymerase switching on the C-strand of the telomere
R-PFA-4615885 SUMOylation of DNA replication proteins
R-PFA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-PFA-69091 Polymerase switching
R-PFA-69166 Removal of the Flap Intermediate
R-PFA-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cell nuclear antigenUniRule annotation
Gene namesi
ORF Names:PF3D7_1226600Imported
OrganismiPlasmodium falciparum (isolate 3D7)Imported
Taxonomic identifieri36329 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)
Proteomesi
  • UP000001450 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1226600

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: GeneDB
  • PCNA complex Source: GeneDB

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiQ7KQJ9

Structurei

3D structure databases

SMRiQ7KQJ9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

KOiK04802
OMAiMDNSHIS

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q7KQJ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFECRIDGQF FKKLFETLKD ICTEVNLECD ENGIKMQSMD CSHVSLVDLN
60 70 80 90 100
IVSDFFQHYR CDKNCVLGIS INFMLKILSV IKEKSTVFLF KEDNENDAVL
110 120 130 140 150
NIGIIDEEEQ SSADDSLEIQ VKLINAQKEH LEIPQSEYHC QCTMKSKKFQ
160 170 180 190 200
EFTKYLNSIG DNVSISMKKD AMILSTTGSD IKVTKQFTND MTDISITCTK
210 220 230 240 250
SVSQEFATRY LVMFSRASSL SDEVLISLSP HIPISIKFNF KQQLTDLQDP
260
SHLTFFLAPK IGDY
Length:264
Mass (Da):30,163
Last modified:July 5, 2004 - v1
Checksum:i6C5DF3EE6498CCF6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99425.1
RefSeqiXP_001350663.1, XM_001350627.1

Genome annotation databases

EnsemblProtistsiCZT99425; CZT99425; PF3D7_1226600
GeneDBiPF3D7_1226600.1:pep
GeneIDi811309
KEGGipfa:PF3D7_1226600

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LN999947 Genomic DNA Translation: CZT99425.1
RefSeqiXP_001350663.1, XM_001350627.1

3D structure databases

SMRiQ7KQJ9
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ7KQJ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiCZT99425; CZT99425; PF3D7_1226600
GeneDBiPF3D7_1226600.1:pep
GeneIDi811309
KEGGipfa:PF3D7_1226600

Organism-specific databases

EuPathDBiPlasmoDB:PF3D7_1226600

Phylogenomic databases

KOiK04802
OMAiMDNSHIS

Enzyme and pathway databases

ReactomeiR-PFA-110320 Translesion Synthesis by POLH
R-PFA-174411 Polymerase switching on the C-strand of the telomere
R-PFA-4615885 SUMOylation of DNA replication proteins
R-PFA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-PFA-69091 Polymerase switching
R-PFA-69166 Removal of the Flap Intermediate
R-PFA-69183 Processive synthesis on the lagging strand

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ7KQJ9_PLAF7
AccessioniPrimary (citable) accession number: Q7KQJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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