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UniProtKB - Q7KN94 (Q7KN94_DROME)

Entry version 143 (07 Apr 2021)
Sequence version 1 (03 Oct 2006)
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Protein

Electron transfer flavoprotein subunit alpha

Gene

wal

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).UniRule annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FADUniRule annotationNote: Binds 1 FAD per dimer.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseImported
Biological processElectron transportUniRule annotation, Transport
LigandFADUniRule annotationARBA annotation, Flavoprotein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-611105, Respiratory electron transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Electron transfer flavoprotein subunit alphaUniRule annotation
Short name:
Alpha-ETFUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:walImported
Synonyms:BcDNA.LD07532Imported, BcDNA:GH09945Imported, BcDNA:LD07532Imported, Dmel\CG8996Imported, EP2253Imported, ETFImported, EtfImported, ETFAImported, l(2)02516Imported, P447Imported
ORF Names:CG8996Imported, Dmel_CG8996Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0010516, wal

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

MitochondrionUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q7KN94

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0010516, Expressed in arthropod fat body and 53 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of an alpha and a beta subunit.

UniRule annotation

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q7KN94, 7 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0087186

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q7KN94

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 203ETFInterPro annotationAdd BLAST183

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETF alpha-subunit/FixB family.UniRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3954, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000167435

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034178_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		WRPHSEH

Database of Orthologous Groups

More...OrthoDBi		1128607at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd01715, ETF_alpha, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.50.620, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR014730, ETF_a/b_N
IPR001308, ETF_a/FixB
IPR033947, ETF_alpha_N
IPR014731, ETF_asu_C
IPR018206, ETF_asu_C_CS
IPR014729, Rossmann-like_a/b/a_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01012, ETF, 1 hit
PF00766, ETF_alpha, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000089, Electra_flavoP_a, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00893, ETF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52467, SSF52467, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00696, ETF_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q7KN94-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFASNTRNLM RSSILQRCKS TLVVAEHNNE VLNPITLNTI SAAKKIGGDV 
        60         70         80         90        100
TVLVAGTKCG PASEALSKVD GVTKVLVAEN AAFNGFTAES LTPLVLAAQS 
       110        120        130        140        150
QFKFTHILAG ASAFGKNVLP RVAAKLDVSP ISEIIDVKSD DTFVRTIYAG 
       160        170        180        190        200
NAILTLKSKD AVKVITVRST NFPPAATSGG SGAVEQAPAG DFASSLSEFV 
       210        220        230        240        250
SQELTKSDRP ELAGAKVIVS GGRGLKSGDN FKLLYDLADK FGAAVGASRA 
       260        270        280        290        300
AVDAGFVPND LQIGQTGKIV APELYIAVGI SGAIQHLAGM KDSKTIVAIN 
       310        320        330
KDPEAPIFQV ADIGIVADLF KAVPELTGKL
Length:330
Mass (Da):34,181
Last modified:October 3, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i295B309583B7B63D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF132155 mRNA Translation: AAD34743.1
AE013599 Genomic DNA Translation: AAF58627.1
AE013599 Genomic DNA Translation: AAM68717.1

NCBI Reference Sequences

More...RefSeqi		NP_476975.1, NM_057627.4
NP_725073.1, NM_165847.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0088082; FBpp0087186; FBgn0010516
FBtr0088083; FBpp0087187; FBgn0010516

Database of genes from NCBI RefSeq genomes

More...GeneIDi		36252

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG8996

UCSC genome browser

More...UCSCi		CG8996-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132155 mRNA Translation: AAD34743.1
AE013599 Genomic DNA Translation: AAF58627.1
AE013599 Genomic DNA Translation: AAM68717.1
RefSeqiNP_476975.1, NM_057627.4
NP_725073.1, NM_165847.2

3D structure databases

SMRiQ7KN94
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ7KN94, 7 interactors
STRINGi7227.FBpp0087186

Proteomic databases

PRIDEiQ7KN94

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		36252

Genome annotation databases

EnsemblMetazoaiFBtr0088082; FBpp0087186; FBgn0010516
FBtr0088083; FBpp0087187; FBgn0010516
GeneIDi36252
KEGGidme:Dmel_CG8996
UCSCiCG8996-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22372
FlyBaseiFBgn0010516, wal

Phylogenomic databases

eggNOGiKOG3954, Eukaryota
GeneTreeiENSGT00940000167435
HOGENOMiCLU_034178_0_0_1
OMAiWRPHSEH
OrthoDBi1128607at2759

Enzyme and pathway databases

ReactomeiR-DME-611105, Respiratory electron transport

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		36252, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		36252

Gene expression databases

BgeeiFBgn0010516, Expressed in arthropod fat body and 53 other tissues

Family and domain databases

CDDicd01715, ETF_alpha, 1 hit
Gene3Di3.40.50.620, 1 hit
InterProiView protein in InterPro
IPR029035, DHS-like_NAD/FAD-binding_dom
IPR014730, ETF_a/b_N
IPR001308, ETF_a/FixB
IPR033947, ETF_alpha_N
IPR014731, ETF_asu_C
IPR018206, ETF_asu_C_CS
IPR014729, Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01012, ETF, 1 hit
PF00766, ETF_alpha, 1 hit
PIRSFiPIRSF000089, Electra_flavoP_a, 1 hit
SMARTiView protein in SMART
SM00893, ETF, 1 hit
SUPFAMiSSF52467, SSF52467, 1 hit
PROSITEiView protein in PROSITE
PS00696, ETF_ALPHA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ7KN94_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q7KN94
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 3, 2006
Last sequence update: October 3, 2006
Last modified: April 7, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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